Journal
TRENDS IN IMMUNOLOGY
Volume 43, Issue 6, Pages 420-422Publisher
CELL PRESS
DOI: 10.1016/j.it.2022.04.005
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- Washington University in St. Louis School of Medicine
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Inflammatory stimuli have a lasting impact on innate immune cells, leading to intensified responses when encountering future challenges. This trained immunity is mediated by hematopoietic stem cells in the bone marrow and is mechanistically linked to inflammatory comorbidities.
Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic stem cells ( HSCs) in the bone marrow primes cells to generate more inflammatory myeloid progeny and, thereby, mechanistically links inflammatory comorbidities.
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