Emerging concepts of miRNA therapeutics: from cells to clinic

Correction to: Clinical practice recommendations for the diagnosis and management of Alport syndrome in children, adolescents, and young adults–an update for 2020

(2021) Clifford E. Kashtan et al.   PEDIATRIC NEPHROLOGY

Artificial miRNAs as therapeutic tools: Challenges and opportunities

(2021) Anna Kotowska‐Zimmer et al.   Wiley Interdisciplinary Reviews-RNA

The Risks of miRNA Therapeutics: In a Drug Target Perspective

(2021) Song Zhang et al.   Drug Design Development and Therapy

Comment on: “MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19”

(2021) Song Zhang et al.   DRUGS

Enhanced miRNA-140 expression of osteoarthritis-affected human chondrocytes cultured in a polymer based three-dimensional (3D) matrix

(2021) Shojiro Katoh et al.   LIFE SCIENCES

New technologies for improved relevance in miRNA research

(2021) Karine Jacquet et al.   TRENDS IN GENETICS

Overview of the Main Anti-SARS-CoV-2 Vaccines: Mechanism of Action, Efficacy and Safety

(2021) Maria Teresa Mascellino et al.   Infection and Drug Resistance

Emerging Immunogenicity and Genotoxicity Considerations of Adeno-Associated Virus Vector Gene Therapy for Hemophilia

(2021) Paul E. Monahan et al.   Journal of Clinical Medicine

Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

(2021) Tsuyoshi Yamamoto et al.   Pharmaceutics

Life of RISC: Formation, action, and degradation of RNA-induced silencing complex

(2021) Hiro-oki Iwakawa et al.   MOLECULAR CELL

Inhibition of miR‐155 in MCF‐7 breast cancer cell line by gold nanoparticles functionalized with antagomir and AS1411 aptamer

(2020) Arefeh Kardani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

(2020) David S. Hong et al.   BRITISH JOURNAL OF CANCER

Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy

(2020) Annadoray Lavenniah et al.   MOLECULAR THERAPY

GeneTrail 3: advanced high-throughput enrichment analysis

(2020) Nico Gerstner et al.   NUCLEIC ACIDS RESEARCH

miRViz: a novel webserver application to visualize and interpret microRNA datasets

(2020) Pierre Giroux et al.   NUCLEIC ACIDS RESEARCH

miEAA 2.0: integrating multi-species microRNA enrichment analysis and workflow management systems

(2020) Fabian Kern et al.   NUCLEIC ACIDS RESEARCH

Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

(2020) Ozge Saatci et al.   Nature Communications

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology

(2020) Le Chang et al.   NUCLEIC ACIDS RESEARCH

A critical analysis of methods used to investigate the cellular uptake and subcellular localization of RNA therapeutics

(2020) Kirsten Deprey et al.   NUCLEIC ACIDS RESEARCH

Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study

(2020) Wesley Tyler Abplanalp et al.   Nucleic Acid Therapeutics

3D Printed Drug Delivery Systems Based on Natural Products

(2020) Ángela Aguilar-de-Leyva et al.   Pharmaceutics

CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure

(2020) Sandor Batkai et al.   EUROPEAN HEART JOURNAL

The nonalcoholic steatohepatitis (NASH) drug development graveyard: established hurdles and planning for future success

(2020) Joost P.H. Drenth et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Quantitative and time-resolved miRNA pattern of early human T cell activation

(2020) Caroline Diener et al.   NUCLEIC ACIDS RESEARCH

Inhaled RNA Therapy: From Promise to Reality

(2020) Michael Y.T. Chow et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cross-Kingdom Regulation by Plant microRNAs Provides Novel Insight into Gene Regulation

(2020) Abdul Fatah A Samad et al.   Advances in Nutrition

Validation of human microRNA target pathways enables evaluation of target prediction tools

(2020) Fabian Kern et al.   NUCLEIC ACIDS RESEARCH

A general fragment-based approach to identify and optimize bioactive ligands targeting RNA

(2020) Blessy M. Suresh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules with big roles in microRNA chemical biology and microRNA-targeted therapeutics

(2019) Rengen Fan et al.   RNA Biology

An estimate of the total number of true human miRNAs

(2019) Julia Alles et al.   NUCLEIC ACIDS RESEARCH

SOLAR: A PHASE 2, GLOBAL, RANDOMIZED, ACTIVE COMPARATOR STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF COBOMARSEN IN SUBJECTS WITH MYCOSIS FUNGOIDES (MF)

(2019) A.M. James et al.   HEMATOLOGICAL ONCOLOGY

Systems biology-based investigation of cooperating microRNAs as monotherapy or adjuvant therapy in cancer

(2019) Xin Lai et al.   NUCLEIC ACIDS RESEARCH

miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

(2019) Yun Ji et al.   Nature Communications

Special Issue: MicroRNA Regulation in Health and Disease

(2019) Subbaya Subramanian et al.   Genes

miR-34a as hub of T cell regulation networks

(2019) Martin Hart et al.   Journal for ImmunoTherapy of Cancer

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

(2019) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis

(2019) Valerio Licursi et al.   BMC BIOINFORMATICS

miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database

(2019) Tim Kehl et al.   NUCLEIC ACIDS RESEARCH

What’s the target: understanding two decades of in silico microRNA-target prediction

(2019) Fabian Kern et al.   BRIEFINGS IN BIOINFORMATICS

The biochemical basis of microRNA targeting efficacy

(2019) Sean E. McGeary et al.   SCIENCE

AAV5-miHTT Lowers Huntingtin mRNA and Protein without Off-Target Effects in Patient-Derived Neuronal Cultures and Astrocytes

(2019) Sonay Keskin et al.   Molecular Therapy-Methods & Clinical Development

Extracellular Vesicles–Encapsulated MicroRNA-125b Produced in Genetically Modified Mesenchymal Stromal Cells Inhibits Hepatocellular Carcinoma Cell Proliferation

(2019) Silvia Baldari et al.   Cells

MicroRNA-Based Combinatorial Cancer Therapy: Effects of MicroRNAs on the Efficacy of Anti-Cancer Therapies

(2019) Hyun Ah Seo et al.   Cells

Curcumin as an Adjunct Therapy and microRNA Modulator in Breast Cancer

(2018) Saeed Norouzi et al.   CURRENT PHARMACEUTICAL DESIGN

Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer

(2018) Hongyu Liu et al.   Molecular Cancer

Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver

(2018) Colton M. Miller et al.   Nucleic Acid Therapeutics

Improving siRNA Delivery In Vivo Through Lipid Conjugation

(2018) Maire F. Osborn et al.   Nucleic Acid Therapeutics

Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma

(2018) Anita G. Seto et al.   BRITISH JOURNAL OF HAEMATOLOGY

Plant microRNAs in human sera are likely contaminants

(2018) Bastian Fromm et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A synthetic microRNA-92a inhibitor (MRG-110) accelerates angiogenesis and wound healing in diabetic and non-diabetic wounds

(2018) Corrie L. Gallant-Behm et al.   WOUND REPAIR AND REGENERATION

Modulation of intracellular calcium signaling by microRNA-34a-5p

(2018) Caroline Diener et al.   Cell Death & Disease

Aptamer-miR-34c conjugate affects cell proliferation of non-small cell lung cancer cells

(2018) Valentina Russo et al.   Molecular Therapy-Nucleic Acids

miR-155 expression in anti-tumor immunity: the higher the better?

(2018) Jean-Jacques Michaille et al.   GENES CHROMOSOMES & CANCER

A microRNA-29 mimic (remlarsen) represses extracellular matrix expression and fibroplasia in the skin

(2018) Corrie L. Gallant-Behm et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

miRBase: from microRNA sequences to function

(2018) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Dietary plant miRNAs as an augmented therapy: cross-kingdom gene regulation

(2018) Sanchita et al.   RNA Biology

MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain

(2017) L Samaranch et al.   GENE THERAPY

Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101

(2017) Femke Stelma et al.   HEPATOLOGY

Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial

(2017) Meike H van der Ree et al.   LANCET

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

(2017) Nico van Zandwijk et al.   LANCET ONCOLOGY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

mirDIP 4.1—integrative database of human microRNA target predictions

(2017) Tomas Tokar et al.   NUCLEIC ACIDS RESEARCH

Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors

(2017) Elena Herrera-Carrillo et al.   Human Gene Therapy Methods

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

(2016) Matthew D. Disney et al.   ACS Chemical Biology

Tools4miRs – one place to gather all the tools for miRNA analysis

(2016) Anna Lukasik et al.   BIOINFORMATICS

miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

(2016) Y. Lu et al.   BLOOD

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia

(2016) N Narayan et al.   LEUKEMIA

Ligand-targeted bacterial minicells: Futuristic nano-sized drug delivery system for the efficient and cost effective delivery of shRNA to cancer cells

(2016) Mehul Jivrajani et al.   Nanomedicine-Nanotechnology Biology and Medicine

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Distribution of miRNA expression across human tissues

(2016) Nicole Ludwig et al.   NUCLEIC ACIDS RESEARCH

Enhancing adoptive T cell immunotherapy with microRNA therapeutics

(2016) Yun Ji et al.   SEMINARS IN IMMUNOLOGY

Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

(2016) Glen Reid et al.   Epigenomics

Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

(2016) Xiaojin Zhang et al.   Nature Communications

Paired proteomics, transcriptomics and miRNomics in non-small cell lung cancers: known and novel signaling cascades

(2016) Christina Backes et al.   Oncotarget

Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease

(2016) Jana Miniarikova et al.   Molecular Therapy-Nucleic Acids

miTALOS v2: Analyzing Tissue Specific microRNA Function

(2016) Martin Preusse et al.   PLoS One

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

siRNA Versus miRNA as Therapeutics for Gene Silencing

(2015) Jenny K W Lam et al.   Molecular Therapy-Nucleic Acids

Transfection of microRNA Mimics Should Be Used with Caution

(2015) Hyun Yong Jin et al.   Frontiers in Genetics

microRNA-34a as a Therapeutic Agent against Human Cancer

(2015) Yoshimasa Saito et al.   Journal of Clinical Medicine

Quantification of Therapeutic miRNA Mimics in Whole Blood from Nonhuman Primates

(2014) Kevin Kelnar et al.   ANALYTICAL CHEMISTRY

In VitroAntiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122

(2014) Søren Ottosen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of microRNA therapeutics is coming of age

(2014) E. van Rooij et al.   EMBO Molecular Medicine

Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

(2014) Ivan G. Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic Delivery of a miR34a Mimic as a Potential Therapeutic for Liver Cancer

(2014) C. L. Daige et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

Mining of public sequencing databases supports a non-dietary origin for putative foreign miRNAs: underestimated effects of contamination in NGS

(2014) J. P. Tosar et al.   RNA

Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma

(2013) G. Reid et al.   ANNALS OF ONCOLOGY

First microRNA mimic enters clinic

(2013) Aaron Bouchie   NATURE BIOTECHNOLOGY

Lack of detectable oral bioavailability of plant microRNAs after feeding in mice

(2013) Brent Dickinson et al.   NATURE BIOTECHNOLOGY

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Miravirsen (SPC3649) can inhibit the biogenesis of miR-122

(2013) Luca F. R. Gebert et al.   NUCLEIC ACIDS RESEARCH

miRTrail - a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases

(2012) Cedric Laczny et al.   BMC BIOINFORMATICS

Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs

(2012) Jingmin Shu et al.   RNA Biology

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

(2011) Lin Zhang et al.   CELL RESEARCH

Chemical modification and design of anti-miRNA oligonucleotides

(2011) K A Lennox et al.   GENE THERAPY

Off-Target Effects Related to the Phosphorothioate Modification of Nucleic Acids

(2010) Johannes Winkler et al.   ChemMedChem

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

(2009) Aly A Khan et al.   NATURE BIOTECHNOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Recombinant Adeno-associated Virus Transduction and Integration

(2008) Brian R Schultz et al.   MOLECULAR THERAPY

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE