Article
Environmental Sciences
Priyanka Mathur, Shilpa Choudhary, Pradeep Bhatnagar
Summary: This study investigates the toxic effects of fluoride exposure on pregnancy and fetal development in mice. It suggests that high concentrations of sodium fluoride may be teratogenic, but co-administration of aloe vera can reduce these toxic effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anastasiia Kalinina, Maria Semenova, Alexandra Bruter, Ekaterina Varlamova, Marina Kubekina, Natalia Pavlenko, Yulia Silaeva, Alexey Deikin, Elena Antoshina, Tatyana Gorkova, Lubov Trukhanova, Alla Salmina, Svetlana Novikova, Dmitry Voronkov, Dmitry Kazansky, Ludmila Khromykh
Summary: This study identified CypA as an adverse pro-inflammatory factor negatively affecting fetal development and associated with pregnancy complications. The researchers demonstrated that increased CypA levels during pregnancy caused dramatic embryotoxicity and teratogenicity in different mouse models. Using transgenic models, they showed that CypA overexpression in fetal tissues led to fetal death and complete miscarriage. Furthermore, administering high doses of recombinant human CypA to pregnant females resulted in severe defects in brain and bone development, potentially leading to postnatal behavioral and cognitive disorders in the offspring. The embryotoxic and teratogenic effects were mediated by CypA-induced up-regulation of M1 macrophage polarization via activation of the STAT1/3 signaling pathways. These findings suggest that CypA could serve as a novel marker for complicated pregnancy and a therapeutic target for the correction of pregnancy complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Carmen-Cristina Draghici, Raluca-Gabriela Miulescu, Razvan-Cosmin Petca, Aida Petca, Mihai Cristian Dumitrascu, Florica Sandru
Summary: Isotretinoin, an oral derivative of vitamin A, has been used since 1982 for the treatment of various dermatologic conditions. The most significant adverse effect of isotretinoin is its teratogenicity, which can cause birth defects in infants. Therefore, caution must be exercised when using isotretinoin to prevent potential harm to fetuses.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Analytical
Yun Chen, Dehui Qiu, Xiaobo Zhang, Yuan Liu, Mingpan Cheng, Jianping Lei, Jean-Louis Mergny, Huangxian Ju, Jun Zhou
Summary: In this study, F3T-azaC-hemin, a G4-based construct, was designed to address the low activity issue of G-quadruplex/hemin (G4/hemin) DNAzymes. The performances of the G4-DNAzyme were significantly improved, resulting in a new and highly efficient molecular tool for ultrasensitive chemiluminescent detection of miRNA-221.
ANALYTICAL CHEMISTRY
(2022)
Review
Plant Sciences
German Chamorro-Cevallos, Maria Angelica Mojica-Villegas, Yuliana Garcia-Martinez, Salud Perez-Gutierrez, Eduardo Madrigal-Santillan, Nancy Vargas-Mendoza, Jose A. Morales-Gonzalez, Jose Melesio Cristobal-Luna
Summary: The use of medicinal plants in Mexico is crucial for treating diseases among the economically vulnerable population, but there are potential risks of teratogenic effects from certain plants, especially affecting the nervous system and axial skeleton. Research shows that approximately 0.22% of Mexican plants have teratogenic effects, indicating a need for more evaluation in this area.
Article
Obstetrics & Gynecology
Si Sun, HongYang Qian, Congcong Li, Qiaohong Wang, Aimin Zhao
Summary: This study retrospectively investigated the safety of low dose aspirin (LDA) during pregnancy. The results showed that the use of aspirin did not increase the risk of fetal congenital anomalies. Additionally, a previous history of fetal abnormalities was found to be an independent risk factor for congenital anomalies.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Chemistry, Analytical
Zefeng Mao, Xiaojuan Wang, Ruipeng Chen, Zixuan Zhou, Shuyue Ren, Jun Liang, Zhixian Gao
Summary: The CRISPR-Cas system has made significant breakthroughs in the field of molecular diagnostics. In this study, a biosensing method powered by CRISPR/Cas12a was designed to detect ochratoxin A. Compared to traditional fluorescent probes, this method is faster and has comparable detection capabilities.
Review
Clinical Neurology
Manuel Toledo, Barbara Mostacci, Magdalena Bosak, Joanna Jedrzejzak, Rhys H. Thomas, Javier Salas-Puig, Arnaud Biraben, Bettina Schmitz
Summary: Valproate, a broad-spectrum antiepileptic drug, is particularly effective in certain types of epilepsy syndromes. The European Medicines Agency introduced new restrictions on its use in females of childbearing potential, leading to controversy and debate. Limited information on the teratogenic potential of alternative treatments presents challenges in the clinical management of pregnant women and women of childbearing age.
JOURNAL OF NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Amir Vahedian-Azimi, Vanessa Bianconi, Somayeh Makvandi, Maciej Banach, Seyedeh Momeneh Mohammadi, Matteo Pirro, Amirhossein Sahebkar
Summary: Statin therapy was not associated with stillbirth or induced and elective abortion rates, but significantly increased rates of spontaneous abortion were observed among statin users. A non-significant numerically reduced rate of preterm delivery was also found in this group. Further studies are needed to confirm and validate these results.
Article
Environmental Sciences
Marjan Shariatpanahi, Rand Kulab, Seyed Behnamedin Jameie, Mahsa Sabernavaei, Mehdi Aghsami, Mahdi Tavakolizadeh
Summary: This study found that oral administration of horse chestnut extract in pregnant rats may cause teratogenic effects.
TOXICOLOGY AND ENVIRONMENTAL HEALTH SCIENCES
(2023)
Article
Chemistry, Analytical
Xiujin Chen, Dong Gao, Jiaqi Chen, Xueqing Wang, Chifang Peng, Hongli Gao, Yao Wang, Zhaozhou Li, Huawei Niu
Summary: In this study, an electrochemical aptasensor using PAMAM dendrimers as a signal amplifier was developed for the sensitive detection of OTA. The aptasensor showed high sensitivity, specificity, and a broad linear detection range with a low detection limit. The proposed aptasensor was successfully applied for OTA analysis in red wine and demonstrated good recovery rates and storage stability.
Article
Biophysics
Yahui Wang, Wei Song, Haiyan Zhao, Xin Ma, Shuying Yang, Xiujuan Qiao, Qinglin Sheng, Tianli Yue
Summary: In this study, an aptasensor for detecting Ochratoxin A was successfully constructed using gold nanoparticles decorated molybdenum oxide nanocomposites, hybridization chain reaction, and a restriction endonuclease-aided walker DNA machine. The sensor demonstrated excellent analytical performance and high sensitivity, with a detection limit as low as 3.3 fg mL-1, showing great potential for practical applications in various sample types.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biology
Nicole Walasek, Willem E. Frankenhuis, Karthik Panchanathan
Summary: Sensitive periods, during which experience has a greater impact on phenotype, are crucial in an organism's development, but their evolution is not well understood. This study presents a model where organisms slowly adapt to fluctuating environments and receive imperfect cues about the current environment. The results show that sensitive periods can occur at different stages of development, and organisms retain some plasticity late in ontogeny, contrary to models assuming stable environments. The study suggests that critical periods with zero plasticity are unlikely to be favored in fluctuating environments.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biophysics
Hao Wang, Bianbian Zhao, Yufei Ye, Xiaoyu Qi, Yuting Zhang, Xiaole Xia, Xiaoli Wang, Nandi Zhou
Summary: In this study, a fluorescence and surface-enhanced Raman scattering dual-mode aptasensor was developed for sensitive and rapid detection of Ochratoxin A (OTA). The aptasensor demonstrated low detection limits in both FL and SERS modes, as well as high specificity and good interferent resistance. It showed great potential for OTA detection in coffee and wine samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Hao Yu, Qiang Zhao
Summary: A simple molecular aptamer beacon (MAB) sensor for rapid detection of the carcinogenic fungal secondary metabolite OTA has been developed. The sensor showed high selectivity and sensitivity, enabling detection of OTA in a wide dynamic concentration range. The method demonstrated capability for OTA analysis in practical applications.
Review
Environmental Sciences
Stoycho D. Stoev
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2015)
Article
Veterinary Sciences
Melinda Kovacs, Roland Posa, Tamas Tuboly, Tamas Donko, Imre Repa, Janos Tossenberger, Judit Szabo-Fodor, Stoycho Stoev, Tibor Magyar
RESEARCH IN VETERINARY SCIENCE
(2016)
Article
Public, Environmental & Occupational Health
Roland Posa, Stoycho Stoev, Melinda Kovacs, Tamas Donko, Imre Repa, Tibor Magyar
TOXICOLOGY AND INDUSTRIAL HEALTH
(2016)
Review
Food Science & Technology
Stoycho D. Stoev, Stefan A. Denev
Article
Food Science & Technology
S. D. Stoev, P. Njobeh, I Zarkov, T. Mircheva, D. Zapryanova, S. Denev, B. Dimitrova
WORLD MYCOTOXIN JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Stoycho D. Stoev
Article
Pharmacology & Pharmacy
Stoycho D. Stoev
Summary: Wistar rats exposed to OTA showed degenerative changes in internal organs, with PHE supplementation demonstrating a protective effect on serum glucose and protein levels. However, the protective effect on serum enzyme activity was not significant. PHE supplementation group exposed to 10 ppm OTA showed similar tumor numbers to the group exposed to lower levels of OTA, suggesting a potential protective effect of PHE.
Article
Food Science & Technology
S. D. Stoev, K. Dimitrov, I Zarkov, T. Mircheva, D. Zapryanova, I Valchev, S. Denev, S. Chobanova, M. Stefanov, R. Arora
Summary: The study showed that the herbs Glycyrrhiza glabra and Tinospora cordifolia, as feed additives, had a protective effect against the growth inhibitory effect of ochratoxin A (OTA) in female broiler chicks. They demonstrated beneficial effects on the immune system, liver, bone marrow, and kidneys, resulting in better feed performance, higher body weight, and lower levels of aspartate transaminase and uric acid in the supplemented chicks compared to those given only OTA.
WORLD MYCOTOXIN JOURNAL
(2021)
Review
Food Science & Technology
Stoycho D. Stoev
Summary: This review examines the carcinogenic effects of ochratoxin A (OTA) on various tissues and internal organs in laboratory and farm animals. It explores ways to differentiate between common spontaneous neoplastic changes in advanced age and characteristic neoplasia caused by OTA exposure in laboratory animals and poultry. The synergistic effects of OTA and penicillic acid, as well as the malignancy and target location of OTA-induced neoplasia, are also investigated. The review also explores the time of appearance of the first neoplasia in long-term OTA-treated animals and the potential for using feed additives or herbs to counteract OTA's toxic and carcinogenic effects. Suggestions are made for prophylaxis and prevention of OTA contamination in feedstuffs, foods, and animal production. The suitability of various laboratory animals as experimental models for OTA-induced tumorigenesis in humans is also explored.
Review
Food Science & Technology
Stoycho D. Stoev
Summary: This review paper evaluates the underestimated hazards of multiple mycotoxin exposure in animals/humans and their impact on foodborne ailments. It discusses the crucial role of low levels of co-contaminated target mycotoxins in inducing foodborne mycotoxicoses. Furthermore, it addresses the importance of hygiene control and risk assessment to mitigate potential hazards for animals and humans, and provides appropriate suggestions. The paper also examines internationally recognized prophylactic measures, risk management, and the need for new international regulations regarding maximum permitted levels in cases of multiple mycotoxin contaminations. Additionally, it highlights the necessity of harmonizing mycotoxin regulations and control measures at international levels to facilitate food trade and ensure global food safety.
Article
Pharmacology & Pharmacy
Bojana Dimitrova, Rumyana Vitanska, Reneta Gevrenova, Dimitrina Zheleva-Dimitrova, Vessela Balabanova, Stoycho Stoev
Summary: The aim of this study was to explore the protective potential of the methanol-aqueous extract from Gypsophila glomerata Pall. on CCl4-induced liver and kidney damage in rats. The extract showed significant protective effects, reducing oxidative stress markers and improving liver and kidney function. These effects may be attributed to the flavonoid glycosides present in the extract.
ACTA PHARMACEUTICA
(2022)
Review
Integrative & Complementary Medicine
Miroslav Stefanov, Stoycho Stoev, Jungdae Kim, Sungchul Kim
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2020)
Article
Agriculture, Dairy & Animal Science
Stefan Denev, Lilyan Sotirov, Sashka Chobanova, Tsvetoslav Koynarski, Veselin Ivanov, Nadya Bozakova, Stoicho Stoev
JOURNAL OF CENTRAL EUROPEAN AGRICULTURE
(2020)
Review
Biochemistry & Molecular Biology
Stoycho D. Stoev
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.
