Article
Cell Biology
Karolina Nowak, Ewa Jablonska, Marzena Garley, Piotr Radziwon, Wioletta Ratajczak-Wrona
Summary: The study found that MeP modulated the expression of ER alpha, activated the NF-kappa B pathway while being inhibited by ERs, decreased NO production, and did not influence IL-8 secretion.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Michael C. Velarde, Alison Faye O. Chan, Ma Easter Joy Sajo, Igor Zakharevich, Jonathan Melamed, Gemma Leonora B. Uy, Joji Marie Y. Teves, Allen Joy M. Corachea, Apple P. Valparaiso, Shiela S. Macalindong, Nelson D. Cabaluna, Rodney B. Dofitas, Linda C. Giudice, Roy R. Gerona
Summary: This study found that perfluoroalkyl substances (PFAS) were significantly associated with breast cancer risk in women living in the Greater Manila Area of the Philippines. Long-chain PFAS levels were positively correlated with age and were significantly higher in women from the heavily industrialized Region IV-A compared to the National Capital Region.
Article
Environmental Sciences
Aline Murawski, Carolin Tschersich, Enrico Rucic, Gerda Schwedler, Rebecca K. Moos, Monika Kasper-Sonnenberg, Thomas Bruning, Holger M. Koch, Marike Kolossa-Gehring
Summary: The study found that children and adolescents in Germany were exposed to various parabens through consumer products, with higher detection rates of methylparaben in urine samples. Higher concentrations of parabens in urine were associated with frequent usage of personal care products and cosmetics. Cumulative exposure to parabens raised concern in up to 14% of the population, mainly driven by n-propyl paraben.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Emily Hager, Jiangang Chen, Ling Zhao
Summary: There is growing recognition that environmental exposure to endocrine-disruptive chemicals (EDCs), such as parabens, contributes to the development of breast cancer. Although evidence linking paraben exposure and breast cancer is limited, current findings suggest that parabens may interfere with endocrine and intracrine targets relevant to breast carcinogenesis. Further research is needed to investigate the effects of paraben mixtures and their interaction with other EDCs and signaling pathways in the context of breast cancer development.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
E. M. Ngigi, P. N. Nomngongo, J. C. Ngila
Summary: Parabens are commonly used as preservatives in pharmaceutical and personal care products, but are considered endocrine disruptors with potential effects on aquatic ecosystems and human health. Various methods have been developed for the removal of these compounds, including UV, ozonation, and photocatalysis. This study provides an overview of methodologies for the degradation of parabens, discussing different catalysts and degradation mechanisms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Jankiben R. Patel, Bipika Banjara, Afia Ohemeng, A. Michael Davidson, Stephen M. Boue, Matthew E. Burow, Syreeta L. Tilghman
Summary: Breast cancer cells that become resistant to letrozole overexpress EGFR, MAPK, and HER2, while also acquiring enhanced motility and EMT-like characteristics, which can be attenuated and reversed by glyceollin treatment. Glyceollin inhibits the proliferation and tumor progression of TNBC and estrogen-independent breast cancer cells, but it may not effectively target AI-resistant metastatic breast cancer in clinical settings. Combination therapy of glyceollin and lapatinib induces apoptosis in hormone-dependent AI-resistant breast cancer cells, and it may also be beneficial for letrozole-resistant breast cancer cells by decreasing proliferation and cell cycle progression-associated proteins. This unique opportunity could lead to the development of novel combination therapies for hormone-refractory breast tumors.
Article
Biochemistry & Molecular Biology
Humberto Parada, Leili Sahrai, Mary S. Wolff, Regina M. Santella, Jia Chen, Alfred Neugut, Susan L. Teitelbaum
Summary: This study examined the interactions between parabens, global DNA methylation, and breast cancer risk. It found that exposure to parabens may increase the risk of breast cancer among women with hypomethylated global DNA methylation and tumors with gene-specific hypomethylated promoter regions.
MOLECULAR CARCINOGENESIS
(2022)
Article
Environmental Sciences
Samarasinghe Vidane Arachchige Chamila Samarasinghe, Kannan Krishnan, Robert John Aitken, Ravi Naidu, Mallavarapu Megharaj
Summary: The study found that methyl-, propyl-, and butyl parabens do not negatively affect the survival, growth, and reproduction of Eisenia fetida up to a concentration of 1000 mg Kg(-1), and that these compounds exhibit low persistence in soil, with over 90% disappearing within three days. Moreover, microbial activity in frozen soil was found to only degrade 16-54% of parabens, indicating rapid degradation of these compounds in terrestrial environments and minimal threat to species like Eisenia fetida. This study represents the first report on the toxicity of parabens to earthworms.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Francisca Vale, Catia A. Sousa, Henrique Sousa, Lucia Santos, Manuel Simoes
Summary: The study investigated the effects of different concentrations of methylparaben on Chlorella vulgaris and found that it can be removed through biodegradation and photodegradation at lower concentrations, but only through photodegradation at higher concentrations.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Noelia Miret, Carolina A. Pontillo, Sol Bujan, Florencia A. Chiappini, Andrea S. Randi
Summary: This literature review addresses the role of the aryl hydrocarbon receptor (AhR) and its ligands in breast cancer. The study explores the biological mechanisms of AhR agonists in interfering with breast endocrine functions and their impact on breast cancer development and progression. The findings suggest that exposure to AhR agonists stimulates pathways that promote breast cancer and contribute to tumor progression. Therefore, the evaluation and regulation of industrial and agricultural chemicals and other toxicants are essential in reducing the risk of breast cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Toxicology
Carmine Merola, Tyrone Lucon-Xiccato, Cristiano Bertolucci, Monia Perugini
Summary: This study aimed to investigate the effects of early exposure to three types of parabens on the nervous system of zebrafish larvae. Results showed that high concentrations of BuP and EtP exposure may lead to behavioral changes, while exposure to MeP did not significantly affect the behavioral models of the larvae.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Environmental Sciences
Denisa Medkova, Aneta Hollerova, Barbora Riesova, Jana Blahova, Nikola Hodkovicova, Petr Marsalek, Veronika Doubkova, Zuzana Weiserova, Jan Mares, Martin Faldyna, Frantisek Tichy, Zdenka Svobodova, Pavla Lakdawala
Summary: This study aimed to investigate the effects of widely used pesticides and parabens on aquatic non-target biota, using model organisms of fish and amphibians. The results show that even low concentrations of these chemicals can impact gene expression, detoxification, sex hormone production, and cell stress.
Article
Environmental Sciences
Henrique Sousa, Catia A. Sousa, Francisca Vale, Lucia Santos, Manuel Simoes
Summary: Anthropogenic activities have increased the presence of emerging contaminants, particularly parabens, in wastewater. Current wastewater treatment technologies are not efficient in removing these contaminants. However, using microalgae-based systems and microalgae-bacteria consortia can improve the efficiency of wastewater treatment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Saurabh Sharma, Lakshay Malhotra, Paromita Mukherjee, Navneet Kaur, Thammineni Krishanlata, Chittur V. Srikanth, Vandana Mishra, Basu Dev Banerjee, Abdul Samath Ethayathulla, Radhey Shyam Sharma
Summary: This study compared the blood levels and protein signatures of organochlorine pesticides (OCPs) among breast cancer patients using a case-control study. It was found that five pesticides were in significantly higher concentrations in breast cancer patients. The study also revealed that there is a competitive affinity between endosulfan II and transthyretin (TTR), leading to endocrine disruption and breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Electrical & Electronic
Nguyen Thanh Binh, Nguyen Nho Dung, Nguyen Mau Thanh, Dao Ngoc Nhiem, Doan Manh Dung, Le Lam Son, Nguyen Duc Vu Quyen, Tran Ngoc Tuyen, Nguyen Hoang Tuan, Dinh Quang Khieu
Summary: Manganese ferrite/rice husk-derived activated carbon (MF/AC) was synthesized and characterized. The obtained MF/AC showed excellent magnetic properties and was used as an electrode modifier for determining methylparaben in cosmetic products.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Oncology
Shanshan Deng, Raisa I. Krutilina, Qinghui Wang, Zongtao Lin, Deanna N. Parke, Hilaire C. Playa, Hao Chen, Duane D. Miller, Tiffany N. Seagroves, Wei Li
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Oncology
Iram Fatima, Ikbale El-Ayachi, Hilaire C. Playa, Jackelyn A. Alva-Ornelas, Aysha B. Khalid, William L. Kuenzinger, Peter Wend, Jackelyn C. Pence, Lauren Brakefield, Raisa Krutilina, Daniel L. Johnson, Ruth M. O'Regan, Victoria Seewaldt, Tiffany N. Seagroves, Susan A. Krum, Gustavo A. Miranda-Carboni
Article
Oncology
Leonard Lothstein, Judith Soberman, Deanna Parke, Jatin Gandhi, Trevor Sweatman, Tiffany Seagroves
Article
Endocrinology & Metabolism
Aysha B. Khalid, Jacquelyn Pence, Sarocha Suthon, Jianjian Lin, Gustavo A. Miranda-Carboni, Susan A. Krum
Summary: GATA4 is a transcription factor that plays a role in osteoblast differentiation, with its knockout in mice resulting in decreased trabecular bone properties and reduced MSCs, along with decreased expression of WNT signalosome components.
Review
Cell Biology
Sarocha Suthon, Rachel S. Perkins, Vitezslav Bryja, Gustavo A. Miranda-Carboni, Susan A. Krum
Summary: WNT5B, closely related to WNT5A, plays crucial roles in cell migration, proliferation, and differentiation through the non-canonical pathway. It exhibits unique expression patterns and functions, influencing development, bone, adipose tissue, cardiac tissue, the nervous system, and more. Aberrations in WNT5B signaling contribute to diseases like osteoarthritis, osteoporosis, obesity, diabetes, neuropathology, chronic diseases, and cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Sarocha Suthon, Jianjian Lin, Rachel S. Perkins, John R. Crockarell, Gustavo A. Miranda-Carboni, Susan A. Krum
Summary: Genetic factors and estrogen deficiency contribute to the development of osteoporosis. The SNP rs2887571 correlates with WNT5B expression, with different mechanisms in each genotype. WNT5B suppresses alkaline phosphatase expression and activity, inhibiting osteoblast differentiation and mineralization. WNT5B inhibits osteoblast differentiation by activating the ROR1/2 signaling pathway and suppressing beta-catenin activity.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Review
Cell Biology
Rachel S. S. Perkins, Sarocha Suthon, Gustavo A. A. Miranda-Carboni, Susan A. A. Krum
Summary: In this article, the researchers review the current understanding of the regulation of WNT5B signal transduction and its roles in different types of Wnt signaling pathways.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Raisa I. Krutilina, Hilaire Playa, Danielle L. Brooks, Luciana P. Schwab, Deanna N. Parke, Damilola Oluwalana, Douglas R. Layman, Meiyun Fan, Daniel L. Johnson, Junming Yue, Heather Smallwood, Tiffany N. Seagroves
Summary: This study identified creatine kinase, brain isoform (CKB) as a downstream gene of HIF-1 transcription factor that promotes invasion and metastasis in ER-negative breast cancer. Inhibition of CKB or creatine kinase activity using cCr suppressed cell invasion, invadopodia formation, and lung metastasis. In combination with conventional chemotherapy agents, cCr enhanced growth inhibition. These findings suggest that targeting CKB and cellular metabolism may be effective in treating metastatic breast cancer.
Article
Genetics & Heredity
Sarocha Suthon, Rachel S. Perkins, Jianjian Lin, John R. Crockarell, Gustavo A. Miranda-Carboni, Susan A. Krum
Summary: This study reveals the molecular mechanism of SNP rs9921222 in regulating the expression of AXIN1 in human osteoblasts through GATA4 and ER alpha binding. The findings provide important insights into the genetic mechanism underlying osteoporosis and bone density regulation.
Article
Oncology
Raisa Krutilina, Kelli L. Hartman, Damilola Oluwalana, Hilaire C. Playa, Deanna N. Parke, Hao Chen, Duane D. Miller, Wei Li, Tiffany N. Seagroves
Summary: The study demonstrates the effectiveness of sabizabulin in inhibiting the growth and migration of HER2+ breast cancer cells, and inducing cell death. Sabizabulin is a promising alternative to taxanes for the treatment of HER2+ breast cancer, with similar anti-metastatic efficacy but better oral bioavailability and lower toxicity.
Review
Cell Biology
Rachel S. Perkins, Rishika Singh, Amy N. Abell, Susan A. Krum, Gustavo A. Miranda-Carboni
Summary: WNT10B, a member of the WNT family, plays a crucial role in controlling proliferation, stemness, pluripotency, and cell fate decisions through the WNT/beta-catenin signaling cascade. It is involved in various tissues and diseases, including bone, adipocytes, skin, hair, muscle, placenta, and the immune system. Mutations and polymorphisms of WNT10B are associated with phenotypes such as bone mineral density, obesity, pig litter size, dog elbow dysplasia, and cow body size. The regulation of WNT10B using microRNAs and long non-coding RNAs has been a focus of research, and therapeutic implications have also been discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Meeting Abstract
Oncology
Rachel S. Perkins, Sarocha Suthon, Gustavo A. Miranda-Carboni, Susan A. Krum
Article
Oncology
Amy R. Dwyer, Carlos Perez Kerkvliet, Raisa Krutilina, Hilaire C. Playa, Deanna N. Parke, Warner A. Thomas, Branden A. Smeester, Branden S. Moriarity, Tiffany N. Seagroves, Carol A. Lange
Summary: Research shows that in triple-negative breast cancer, the PTK6-driven signaling pathway mediates cell migration via RhoA and AhR signaling pathways, and plays a crucial role in lung metastasis.
MOLECULAR CANCER RESEARCH
(2021)
Meeting Abstract
Endocrinology & Metabolism
Sarocha Suthon, Gustavo A. Miranda-Carboni, Susan A. Krum
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Meeting Abstract
Oncology
Shanshan Deng, Hao Chen, Raisa Krutilina, Najah G. Albadari, Tiffany N. Seagroves, Duane D. Miller, Wei Li