Article
Obstetrics & Gynecology
Reeva Makhijani, Prachi Godiwala, James Grady, Alicia Christy, Kim Thornton, Daniel Grow, Lawrence Engmann
Summary: This retrospective cohort study aimed to evaluate if racial/ethnic differences persist in pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. The results showed that Black women had a significantly lower live birth rate and implantation rate, as well as higher clinical loss rate compared to other racial/ethnic groups.
FERTILITY AND STERILITY
(2022)
Review
Biology
Cui-Hua Wang, Xiao-Qing Hu
Summary: The study found that there was no significant difference in biochemical pregnancy, clinical pregnancy, and ongoing pregnancy rates between frozen-thawed embryo transfer and fresh embryo transfer. However, frozen-thawed embryos had higher implantation and live birth rates. Additionally, babies born from frozen-thawed embryo transfer had greater birth weight and lower rate of low birth weight compared to fresh embryos.
Article
Endocrinology & Metabolism
Jian-Chun Li, Yan-Hong Wang, Li-Ying Peng, Yun Zhou, Shi-Bin Chao
Summary: The DROI protocol showed significantly higher implantation rate and clinical pregnancy rate compared to the mNC protocol in frozen-thawed embryo transfer, suggesting it may be a more efficient and promising approach for improving pregnancy outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Margeaux Oliva, Taraneh G. Nazem, Joseph A. Lee, Alan B. Copperman
Summary: In women undergoing IVF treatment, there were differences in certain parameters between the low body mass index (BMI) group and the normal BMI group, but no significant differences were found in embryological and clinical outcomes of IVF treatment.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Biochemistry & Molecular Biology
Paolo Giovanni Artini, Giorgia Scarfo, Ilaria Marzi, Jonathan Fusi, Maria Elena Obino, Ferdinando Franzoni, Elisa Zappelli, Elisa Chelucci, Claudia Martini, Vito Cela, Simona Daniele
Summary: The molecular/metabolic composition of follicular fluid (FF) has a significant impact on oocyte development and fertilization. The antioxidant potential of FF is correlated with the number of retrieved/mature oocytes and fertilized ones. FF from normal fertilized oocytes exhibits elevated antioxidant capability, lower levels of pro-inflammatory molecules, and higher IL-10 concentration. Samples giving rise to top-quality embryos display a unique antioxidant capability and further decrease in pro-inflammatory molecules compared to FF from poor-quality embryos. Successful embryo implantation is associated with lower pro-inflammatory molecules and high antioxidant capability. Antioxidant capability and IL-10 show good predictive ability for fertilization and embryo quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Jenna Friedenthal, Tamar Alkon-Meadows, Carlos Hernandez-Nieto, Dmitry Gounko, Joseph A. Lee, Alan Copperman, Erkan Buyuk
Summary: The study found that a previous cesarean delivery is significantly associated with reduced implantation, ongoing pregnancy, and live birth rates in patients undergoing a single frozen-thawed euploid embryo transfer after in vitro fertilization. This underscores the importance of reducing primary cesarean delivery rates at a national level and elucidating the mechanisms behind the substantially lower implantation rates after a cesarean delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Xiaoyan Yang, Beihong Zheng, Yun Wang
Summary: Pre-pregnancy BMI in women undergoing autologous FET affects neonatal outcomes of singletons, with overweight and obese categories showing significant increases in PTB, macrosomia, and LGA. Underweight status is associated with increased risk of SGA, while there is no association between prepregnancy BMI and birth defects in FET cycles.
FERTILITY AND STERILITY
(2021)
Article
Reproductive Biology
Naomi Nakagata, Satohiro Nakao, Nobuyuki Mikoda, Katsuma Yamaga, Toru Takeo
Summary: This study used an inverted microscope to observe the process of fertilization and subsequent development of frozen-thawed rat sperm in vitro. It was found that the sperm attached to the zona pellucida 2-3 hours after thawing, penetrated into the oocytes after 3-5 hours, and formed pronuclei in the cytoplasm 5-9 hours after insemination. The frozen-thawed sperm from SD, Wistar, LE, and F344 strains showed higher fertility rates, while the sperm from the BN strain exhibited lower motility and fertility rates.
Article
Obstetrics & Gynecology
Prachi Godiwala, Reeva Makhijani, Alison Bartolucci, Daniel Grow, John Nulsen, Claudio Benadiva, James Grady, Lawrence Engmann
Summary: This retrospective cohort study compared the pregnancy outcomes of letrozole ovulation induction, natural cycles, and programmed frozen-thawed embryo transfer (FET) cycles. The results showed that the ongoing pregnancy rate/live birth rate was higher in letrozole FETs than in programmed FETs, but comparable to natural FETs. The ongoing pregnancy rate/live birth rate was comparable between natural and programmed FETs. The clinical loss rate was lower in the natural FET group than in the programmed FET group.
FERTILITY AND STERILITY
(2022)
Article
Cell Biology
Ningxin Qin, Zhiyang Zhou, Wenlong Zhao, Kexin Zou, Weihui Shi, Chuanjin Yu, Xia Liu, Zehan Dong, Yiting Mao, Xinmei Liu, Jianzhong Sheng, Guolian Ding, Yanting Wu, Hefeng Huang
Summary: This study explored the impact of frozen and thawed embryo transfer (FET) on the glucose metabolism of offspring using a mouse model. Male mouse offspring conceived through FET showed impaired glucose tolerance and insulin resistance, along with disruption of hepatic insulin signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Mengxia Ji, Xiaohua Fu, Danni Huang, Ruifang Wu, Yunqing Jiang, Qiongxiao Huang
Summary: The clinical outcomes of TAM and HRT in treating patients with thin endometrium in FET cycles were compared. The results showed that compared to the HRT group, the TAM group had a shorter treatment duration, thicker endometrium on the transfer day, and better performance in terms of early miscarriage and live birth rates.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Lan N. Vuong, Toan D. Pham, Khanh T. Q. Le, Trung T. Ly, Ho L. Le, Diem T. N. Nguyen, Vu N. A. Ho, Vinh Q. Dang, Tuan H. Phung, Robert J. Norman, Ben W. Mol, Tuong M. Ho
Summary: Adding oral dydrogesterone to vaginal progesterone as luteal phase support in frozen embryo transfer cycles may improve pregnancy outcomes, with higher live birth rates and lower miscarriage rates. Prospective cohort studies with limited bias could provide valuable information for clinical practice as an alternative to randomized controlled trials.
HUMAN REPRODUCTION
(2021)
Editorial Material
Genetics & Heredity
Bruce D. Pier, Logan M. Havemann, Alexander M. Quaas, Ryan J. Heitmann
Summary: The increasing use of frozen-thawed embryo transfer (FET) cycles has brought more attention to endometrial preparation protocols in assisted reproduction. Emerging evidence suggests that natural cycle (NC) FETs may lead to better outcomes, leading to a recommendation for healthcare providers to consider increasing the utilization of NC FET over the favored artificial cycle (AC) FET for endometrial preparation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
Jianjun Hu, Emanuela Molinari, Sarah K. Darmon, Lin Zhang, Pasquale Patrizio, David H. Barad, Norbert Gleicher
Summary: The study found that the granulation patterns of donor oocytes are predictive of IVF success rates, with higher quality granulation patterns associated with higher pregnancy and live birth rates in fresh donor oocytes. Similar trends were observed in thawed donor oocytes, but with relatively worse outcomes.
FERTILITY AND STERILITY
(2021)
Article
Agriculture, Dairy & Animal Science
Isabel Gimeno, Pascal Salvetti, Susana Carrocera, Julie Gatien, Pablo Garcia-Manrique, Cristina Lopez-Hidalgo, Luis Valledor, Enrique Gomez
Summary: The selection of competent recipients prior to embryo transfer is crucial for improving pregnancy and birth rates in cattle. Ignoring the competence of the embryo can lead to failed pregnancy predictions. It is hypothesized that the pregnancy potential of biomarkers can be enhanced with information on embryonic competence.
JOURNAL OF DAIRY SCIENCE
(2023)