Journal
CANCER INVESTIGATION
Volume 33, Issue 7, Pages 267-275Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2015.1025794
Keywords
miR-148a; Senescence; Pancreatic cancer; DNMT1; p27
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Funding
- Ruijin Hospital, Shanghai Jiaotong University
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We discovered the expression level of miR-148a significantly decreased in pancreatic cancer tissues whereas that of DNMT1 increased. In ASPC-1 cancer cells, the overexpression of miR-148a led to a decreased level of DNMT1 and reduced the proliferation and metastasis of ASPC-1 cells. Moreover, the increased expression of miR-148a arrested the UTR methylation of p27, giving rise to an increased level of p27. Interestingly, it was shown that the DNMT1 inhibition enhanced the expression of miR-148a. In vivo studies demonstrated that the tumorigenesis of ASPC-1 was significantly arrested by either the overexpression of miR-148a or the inhibition of DNMT1.
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