A carcinoembryonic antigen-specific cell therapy selectively targets tumor cells with HLA loss of heterozygosity in vitro and in vivo

Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells

(2022) Talar Tokatlian et al.   Journal for ImmunoTherapy of Cancer

Targeting loss of heterozygosity for cancer-specific immunotherapy

(2021) Michael S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers

(2021) Xueyin Wang et al.   JOURNAL OF IMMUNOTHERAPY

491 BASECAMP-1: an observational study to identify relapsed solid tumor patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH) and leukapheresis for future CAR T-cell therapy

(2021) Julian Molina et al.   Journal for ImmunoTherapy of Cancer

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

(2020) Martina Geiger et al.   Nature Communications

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

(2020) Patrick A. Ott et al.   CELL

Structure-function relationships of chimeric antigen receptors in acute T cell responses to antigen

(2020) Han Xu et al.   MOLECULAR IMMUNOLOGY

Engineered T cells directed at tumors with defined allelic loss

(2020) Agnes E. Hamburger et al.   MOLECULAR IMMUNOLOGY

Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies

(2020) Ruth Dannenfelser et al.   Cell Systems

HITM-SURE: Hepatic immunotherapy for metastases phase Ib anti-CEA CAR-T study utilizing pressure enabled drug delivery

(2020) Steven C Katz et al.   Journal for ImmunoTherapy of Cancer

Re-examination of MAGE-A3 as a T-cell Therapeutic Target

(2020) Aaron D. Martin et al.   JOURNAL OF IMMUNOTHERAPY

Precise T cell recognition programs designed by transcriptionally linking multiple receptors

(2020) Jasper Z. Williams et al.   SCIENCE

Carcinoembryonic antigen reduction after medical treatment in patients with metastatic colorectal cancer: a systematic review and meta-analysis

(2019) Giuseppe Antonio Colloca et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting

(2019) Shivani Srivastava et al.   CANCER CELL

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

(2019) Reyes Gonzalez-Exposito et al.   Journal for ImmunoTherapy of Cancer

Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood

(2019) Songming Peng et al.   Cell Reports

Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

(2018) Chungyong Han et al.   Nature Communications

Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA + Metastatic Colorectal Cancers

(2017) Chengcheng Zhang et al.   MOLECULAR THERAPY

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

(2016) Kole T. Roybal et al.   CELL

A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

(2016) M. Bacac et al.   CLINICAL CANCER RESEARCH

FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing

(2016) Ronglai Shen et al.   NUCLEIC ACIDS RESEARCH

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

Novel Approaches to Enhance the Specificity and Safety of Engineered T Cells

(2014) Victor D. Fedorov et al.   CANCER JOURNAL

Leukopak PBMC sample processing for preparing quality control material to support proficiency testing programs

(2014) Ambrosia Garcia et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index

(2013) L. R. Desnoyers et al.   Science Translational Medicine

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

T Cells That Target Carcinoembryonic Antigen Eradicate Orthotopic Pancreatic Carcinomas Without Inducing Autoimmune Colitis in Mice

(2012) Markus Chmielewski et al.   GASTROENTEROLOGY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

(2009) Michael C. Milone et al.   MOLECULAR THERAPY

Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells

(2008) M. R. Parkhurst et al.   CLINICAL CANCER RESEARCH