Keratinocytes: From passive targets to active mediators of systemic autoimmunity

Keratinocyte-mediated interferon production in nonlesional skin drives activation of CD16(+) dendritic cells and is associated with cutaneous inflammation in lupus (Billi et al.).

Automated summary

This study found that interferon produced by keratinocytes in nonlesional skin can activate CD16(+) dendritic cells and is associated with cutaneous inflammation in lupus.