Article
Immunology
Thomas W. Geisbert, Kathryn Bobb, Viktoriya Borisevich, Joan B. Geisbert, Krystle N. Agans, Robert W. Cross, Abhishek N. Prasad, Karla A. Fenton, Hao Yu, Timothy R. Fouts, Christopher C. Broder, Antony S. Dimitrov
Summary: A human subunit vaccine based on the attachment glycoprotein of Hendra virus was found to provide protection against both Nipah and Hendra viruses in a nonhuman primate model, starting as early as 7 days post immunization with a low dose. This vaccine could potentially serve as an efficient emergency tool to control the spread of Nipah disease during outbreaks.
Article
Immunology
Neeltje van Doremalen, Victoria A. A. Avanzato, Kerry Goldin, Friederike Feldmann, Jonathan E. E. Schulz, Elaine Haddock, Atsushi Okumura, Jamie Lovaglio, Patrick W. W. Hanley, Kathleen Cordova, Greg Saturday, Emmie de Wit, Teresa Lambe, Sarah C. C. Gilbert, Vincent J. J. Munster
Summary: ChAdOx1 NiV vaccine shows strong protection in the lethal African green monkey NiV challenge model, preventing virus replication and inducing a robust immune response.
Article
Veterinary Sciences
Wenjun Zhu, Bradley Pickering, Greg Smith, Mathieu Pinette, Thang Truong, Shawn Babiuk, Darwyn Kobasa, Logan Banadyga, Ming Yang
Summary: A competitive enzyme-linked immunosorbent assay (cELISA) using a monoclonal antibody (mAb) and recombinant NiV glycoprotein (G) was developed and evaluated for the detection of Nipah virus and Hendra virus. The cELISA showed comparable or better results than the commonly used plaque reduction neutralization test (PRNT), making it a suitable screening test for these viruses.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Julien Cappelle, Neil Furey, Thavry Hoem, Tey Putita Ou, Thona Lim, Vibol Hul, Oudam Heng, Veronique Chevalier, Philippe Dussart, Veasna Duong
Summary: Recent studies have shown that coronaviruses are widely circulated in Southeast Asian bat species, with indications that the SARS-CoV-2 virus may have originated in rhinolophid bats in the region. The research from Cambodia indicates a correlation between positive coronavirus detections and juvenile and immature bats, suggesting seasonal patterns in CoV circulation. Long-term monitoring and understanding of bat ecology in Southeast Asia are needed for biodiversity conservation and public health reasons.
SCIENTIFIC REPORTS
(2021)
Review
Microbiology
Sabahat Gazal, Neelesh Sharma, Sundus Gazal, Mehak Tikoo, Deep Shikha, Gulzar Ahmed Badroo, Mohd Rashid, Sung-Jin Lee
Summary: Nipah and Hendra viruses are deadly zoonotic diseases caused by paramyxoviruses. They are primarily transmitted from bats to pigs and horses, and then to humans, resulting in severe respiratory and neurological symptoms. Due to their high pathogenicity, pandemic potential, and lack of effective treatments and vaccines, research on these viruses is highly important.
Article
Virology
Ming Yang, Wenjun Zhu, Thang Truong, Bradley Pickering, Shawn Babiuk, Darwyn Kobasa, Logan Banadyga
Summary: In this study, a detection method for Nipah virus (NiV) and Hendra virus (HeV) was developed, using ephrin B2 as the capture ligand and specific monoclonal antibodies as detection reagents. This method enables rapid and accurate differentiation between these two viruses.
Editorial Material
Immunology
Shania Sanchez, Hinh Ly
Summary: A new virus called Langya henipavirus (LayV) has been found in Shandong and Henan provinces, China, infecting 35 people from April 2018 to August 2021. It is closely related to other known henipaviruses (Nipah and Hendra viruses) that can result in up to 70% human fatality. Although LayV has not been proven fatal in humans or transmitted human-to-human, it is an RNA virus that can genetically evolve in infected hosts (e.g. shrews) and infect humans (e.g. farmers in close contact with shrews), making it important to remain vigilant about this new viral outbreak.
Review
Virology
Declan D. Pigeaud, Thomas W. Geisbert, Courtney Woolsey
Summary: Hendra virus (HeV) and Nipah virus (NiV) are zoonotic paramyxoviruses that emerged nearly thirty years ago and pose a grave threat to public health. Animal models, including nonhuman primates, rodents, and ferrets, have been instrumental in understanding the pathogenesis and transmission of HeV and NiV. Nonhuman primates have shown the closest resemblance to human HNV disease.
Article
Virology
Camilla M. Donnelly, Olivia A. Vogel, Megan R. Edwards, Paige E. Taylor, Justin A. Roby, Jade K. Forwood, Christopher F. Basler
Summary: Nipah and Hendra viruses are highly pathogenic viruses that cause severe respiratory disease and encephalitis. This study investigates the interaction between viral proteins and cellular structures to gain a better understanding of viral transmission and develop potential therapeutics.
Article
Immunology
Xiaoyan Huang, Yaohui Li, Ruihua Li, Shaoyan Wang, Lu Yang, Shuyi Wang, Ying Yin, Xiaodong Zai, Jun Zhang, Junjie Xu
Summary: The study demonstrates that recombinant vaccine candidates using replication-defective adenovirus vector to deliver NiV attachment glycoprotein can effectively induce specific humoral and cellular immune responses in mice. The Ad5-NiVGe vaccine candidate elicited the strongest immune responses after a single-dose immunization. Additionally, a potent conserved T-cell epitope shared by NiV and HeV was identified, providing valuable information on HNVs-specific cellular immunity mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Hongzhao Li, Ji-Young V. Kim, Bradley S. Pickering
Summary: This article provides a concise update on the epidemiology of Hendra virus (HeV) and Nipah virus (NiV), two zoonotic pathogens that cause severe neurological and respiratory diseases. It discusses the natural reservoir hosts of these viruses, transmission pathways, and the role of intermediate hosts in disease spread.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Yao Yu Yeo, David W. Buchholz, Amandine Gamble, Mason Jager, Hector C. Aguilar
Summary: This study quantitatively demonstrates that CedV is significantly less fusogenic than NiV at equivalent G and F cell surface expression levels. Additionally, it was found that CedV G/F combinations are less fusogenic than NiV or HeV G/F combinations, and the G head/stalk junction plays a key role in modulating cell-cell fusion. These findings support the notion that head domains play central roles in modulating stalk domain fusion promotion in Henipavirus infections.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Mingqing Lu, Yanfeng Yao, Xuekai Zhang, Hang Liu, Ge Gao, Yun Peng, Miaoyu Chen, Jiaxuan Zhao, Xiaoyu Zhang, Chunhong Yin, Weiwei Guo, Peipei Yang, Xue Hu, Juhong Rao, Entao Li, Tong Chen, Sandra Chiu, Gary Wong, Zhiming Yuan, Jiaming Lan, Chao Shan
Summary: A recombinant chimpanzee adenovirus-based vaccine and a DNA vaccine were developed to protect against Nipah virus infection. The vaccines induced strong and sustained antibody production and an effective T-cell response in mice. Syrian golden hamsters immunized with these vaccines were completely protected against a lethal Nipah virus challenge. The results suggest that these vaccines are promising candidates for further development.
Article
Immunology
Kim Halpin, Kerryne Graham, Peter A. Durr
Summary: The Hendra virus (HeV) vaccine, developed for horses in Australia, indirectly protects humans by preventing horse infection. The vaccine has shown good performance in the field, with horses having high neutralizing titres after receiving at least three doses of vaccination.
Article
Virology
Said Mougari, Claudia Gonzalez, Olivier Reynard, Branka Horvat
Summary: Bats serve as natural hosts for many zoonotic viruses and have evolved mechanisms to tolerate and control viral infections, preventing both virus expansion and excessive immune response.
CURRENT OPINION IN VIROLOGY
(2022)
Article
Health Policy & Services
Sarika Pattanasin, Frits van Griensven, Philip A. Mock, Wichuda Sukwicha, Oranuch Kongpechsatit, Chidanan Krasan, Siobhan O'Connor, Andrew C. Hickey, Chaiwat Ungsedhapand, Joseph Woodring, Suzi Connor, Anupong Chitwarakorn, Eileen F. Dunne
Summary: The study reveals higher HIV and syphilis infection rates among TGW compared to MSM, with particular concern for the 15-21 age group of TGW. More HIV/STI prevention efforts, including linkage to care, are needed for TGW.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2022)
Article
Multidisciplinary Sciences
Zhaoqian Wang, Moushimi Amaya, Amin Addetia, Ha Dang, Gabriella Reggiano, Lianying Yan, Andrew C. Hickey, Frank DiMaio, Christopher C. Broder, David Veesler
Summary: A study found that a combination of two non-overlapping G-specific antibodies can synergistically neutralize Nipah and Hendra viruses and limit the emergence of escape mutants. Additionally, analysis of immune responses to NiV G in macaques vaccinated with a vaccine revealed that the receptor binding head domain is immunodominant. These findings provide therapeutic strategies for combating these deadly pathogens.
Article
Infectious Diseases
Kandarp K. Patel, Tanja Strive, Robyn N. Hall, Greg Mutze, Bradley Page, Matthew Korcz, Mahalia Booth-Remmers, Ina L. Smith, Nina Huang, John Kovaliski, Ridma M. J. Jayasinghe Ellakkala Appuhamilage, Patrick L. Taggart
Summary: RHDV2 is the dominant calicivirus in wild rabbit populations in Australia, causing high infection and case fatality rates. Wild rabbits show immunity to RHDV2 but are less immune to other strains. In rabbits with previous exposure to RHDV2, K5 has the highest infection rate and case fatality rate.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Alexander W. Gofton, Kim R. Blasdell, Casey Taylor, Peter B. Banks, Michelle Michie, Emilie Roy-Dufresne, Jacqueline Poldy, Jian Wang, Michael Dunn, Mary Tachedjian, Ina Smith
Summary: Tick-borne zoonoses are emerging globally due to changes in climate and land use. In Australia, the diversity of potentially zoonotic agents carried by ticks and their significance to human and animal health is not well understood. In this study, metatranscriptomics was used to analyze tick and wildlife blood samples in New South Wales, Australia, revealing a wide range of tick-borne microorganisms, including novel putative species. These findings highlight the unique and endemic microbial fauna harbored by Australian ticks and the need for further research on their potential risks to human and animal health.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Health Policy & Services
Jasmine M. Truong, Tareerat Chemnasiri, Andrea L. Wirtz, Sandra Hsu Hnin Mon, Anchalee Varangrat, Michele Decker, Surang Janyam, Danai Linjongrat, Pachara Sirivongrangson, Andrew C. Hickey, Brian W. Weir, Chris Beyrer
Summary: Young MSM and TGW engaged in sex work or trade in Thailand face diverse contexts and high HIV risk. Implementing PrEP programs requires considering factors such as HIV stigma, venue management, lack of knowledge, lower perceived risk, and personal health and wellbeing.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2022)
Letter
Virology
Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgyn Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. I. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April van der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young
JOURNAL OF VIROLOGY
(2023)
Letter
Microbiology
Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgyn Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April van der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young
Letter
Microbiology
Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgy Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. I. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April van der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young
Article
Immunology
Alison J. Peel, Claude Kwe Yinda, Edward J. Annand, Adrienne S. Dale, Peggy Eby, John-Sebastian Eden, Devin N. Jones, Maureen K. Kessler, Tamika J. Lunn, Tim Pearson, Jonathan E. Schulz, Ina L. Smith, Vincent J. Munster, Raina K. Plowright
Summary: A new variant of Hendra virus, genotype 2, was recently discovered in a horse and Pteropus flying fox tissues in Australia. The detection of this variant in flying fox urine suggests an expanded geographic range of Hendra virus risk to horses and humans.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Gabriel Duette, Bonnie Hiener, Hannah Morgan, Fernando G. Mazur, Vennila Mathivanan, Bethany A. Horsburgh, Katie Fisher, Orion Tong, Eunok Lee, Haelee Ahn, Ansari Shaik, Remi Fromentin, Rebecca Hoh, Charline Bacchus-Souffan, Najla Nasr, Anthony L. Cunningham, Peter W. Hunt, Nicolas Chomont, Stuart G. Turville, Steven G. Deeks, Anthony D. Kelleher, Timothy E. Schlub, Sarah Palmer
Summary: Through studying CD4(+) T cells of HIV-1 patients, the importance of effector memory T cells in the persistence of HIV-1 has been identified, and Nef has been suggested as a potential therapeutic target.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Edward J. Annand, Bethany A. Horsburgh, Kai Xu, Peter A. Reid, Ben Poole, Maximillian C. de Kantzow, Nicole Brown, Alison Tweedie, Michelle Michie, John D. Grewar, Anne E. Jackson, Nagendrakumar B. Singanallur, Karren M. Plain, Karan Kim, Mary Tachedjian, Brenda van der Heide, Sandra Crameri, David T. Williams, Cristy Secombe, Eric D. Laing, Spencer Sterling, Lianying Yan, Louise Jackson, Cheryl Jones, Raina K. Plowright, Alison J. Peel, Andrew C. Breed, Ibrahim Diallo, Navneet K. Dhand, Philip N. Britton, Christopher C. Broder, Ina Smith, John-Sebastian Eden
Summary: Researchers have identified a novel Hendra virus variant in Australia that evades routine testing, yet is shown to have similarity to the prototypic virus. The current treatments and preventive measures are still effective against this variant. Upgraded surveillance and biosecurity practices are necessary to address the spreading risk of this variant.
EMERGING INFECTIOUS DISEASES
(2022)