Article
Biochemistry & Molecular Biology
Mateusz Maszczyk, Klaudia Banach, Marta Karkoszka, Zuzanna Rzepka, Jakub Rok, Artur Beberok, Dorota Wrzesniok
Summary: Glioblastoma is a type of glioma with high mortality rates and resistance to treatment. Research suggests that neobavaisoflavone may enhance the pro-apoptotic activity of chemotherapeutic drugs like etoposide and doxorubicin in glioblastoma cells, indicating potential chemosensitizing properties of this isoflavone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Farid Qoorchi Moheb Seraj, Niloofar Heravi-Faz, Arash Soltani, Seyed Sajad Ahmadi, Fatemeh Shahbeiki, Amir Talebpour, Amir R. Afshari, Gordon A. Ferns, Afsane Bahrami
Summary: Thymol exhibited potential cytotoxic activities on U-87 cells, possibly through increased apoptosis, generation of reactive oxygen species, and cell cycle arrest. Combination therapy of thymol and temozolomide synergistically enhanced cytotoxic effects.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, Research & Experimental
Fatemeh Tirgar, Zahra Azizi, Saereh Hosseindoost, Mahmoudreza Hadjighassem
Summary: This study demonstrates that olfactory ensheathing cells (OECs) can be used as a novel carrier for gene therapy in glioblastoma multiforme (GBM) animal models. OECs have high migration capability and can effectively suppress tumor progression.
Article
Medicine, Research & Experimental
Fatima Belkourchia, Richard R. Desrosiers
Summary: PIMT plays a critical role in glioblastoma growth, especially in U-87 MG cells. Inhibition of PIMT significantly reduces cell migration and invasion, while overexpression of wild-type PIMT enhances these capacities. Conversely, overexpression of mutated PIMT(D83V) does not show the same effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Rossella Rotondo, Maria Antonietta Oliva, Antonietta Arcella
Summary: Cynaropicrin has shown significant inhibitory effects on the growth of human glioblastoma cells, inducing cytotoxicity, apoptosis, and autophagy. It also has the potential to induce cell senescence and enhance the cytotoxic effects of the standard drug TMZ. These findings suggest that Cynaropicrin could serve as a potential adjuvant for the treatment of glioblastoma.
Article
Biochemistry & Molecular Biology
Mohammad Mahdi Vahedi, Ali Shahini, Mehran Mottahedi, Setareh Garousi, Seyed Ali Shariat Razavi, Ghazaleh Pouyamanesh, Amir R. Afshari, Gordon A. Ferns, Afsane Bahrami
Summary: This study investigates the anti-tumor activity of harmaline on glioblastoma cells. The results demonstrate that harmaline inhibits cell proliferation, induces cell cycle arrest and apoptosis. Additionally, harmaline suppresses metastasis and migration of the cells.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Bo Yuan, Jingmei Li, Shin-Ich Miyashita, Hidetomo Kikuchi, Meiyan Xuan, Hirokazu Matsuzaki, Naohiro Iwata, Shinya Kamiuchi, Katsuyoshi Sunaga, Takeshi Sakamoto, Yasuhide Hibino, Mari Okazaki
Summary: Combining As-III with arenobufagin enhances cytotoxicity and DNA damage in glioblastoma cells, likely through increased apoptosis, autophagy, and Notch signaling suppression.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung-Hyun Yang, Yuna Choi, Mirae Park, Hye-Young Son, Yong-Min Huh, Chan Gyu Joo
Summary: This study investigated the potential use of alanine as an MRI contrast agent and measured its relaxation properties in solution. The uptake of alanine in a mouse xenograft model of glioblastoma was measured using MRI and compared with immunohistochemistry staining. Statistically significant differences in ASCT2 distribution were found between regions with strong and weak alanine uptake in MRI.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Cell Biology
Mariam Rado, Brian Flepisi, David Fisher
Summary: This study investigated the modulatory effects of glioblastoma on brain endothelial cells. The results showed that hypoxic and normoxic glioblastoma secretions differentially suppressed mitochondrial activity in brain endothelial cells and increased barrier permeability.
Article
Chemistry, Medicinal
Shizue Mito, Benxu Cheng, Benjamin A. Garcia, Daniela Gonzalez, Xin Yee Ooi, Tess C. Ruiz, Francisco X. Elisarraras, Andrew Tsin, Sue Anne Chew, Marco A. Arriaga
Summary: Niclosamide and its derivatives have shown promising anticancer activities against glioblastoma, inducing cell apoptosis and down-regulating cell survival signaling pathways. The phenol OH group of niclosamide plays a significant role in its anti-glioblastoma activity.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Cell Biology
Dania Vazquez-Blomquist, Anette Hardy-Sosa, Saiyet C. Baez, Vladimir Besada, Sucel Palomares, Osmany Guirola, Yassel Ramos, Jacek R. Wisniewski, Luis Javier Gonzalez, Iraldo Bello-Rivero
Summary: This study utilized label-free quantitative proteomics and phospho-proteomics to investigate the effects of HeberFERON on U-87 MG cells. The results revealed that HeberFERON affects cellular proliferation through modulation of IFN signaling, antiviral mechanisms, and various biological processes including cell cycle, cytoskeleton organization, translation/RNA splicing, autophagy, and DNA repair. The study also identified novel phosphorylation sites regulated by HeberFERON and highlighted the central role of mTOR in these processes, as well as its interactions with CDK and ERK kinases.
Article
Clinical Neurology
Saeed Oraee-Yazdani, Mohammadhosein Akhlaghpasand, Fatemeh Rostami, Maryam Golmohammadi, Roozbeh Tavanaei, Gelareh Shokri, Maryam Hafizi, Maryam Oraee-Yazdani, Ali-Reza Zali, Masoud Soleimani
Summary: This study reported a case of a patient with malignant brain tumor who underwent bone marrow-derived MSCs carrying the HSV-TK gene therapy. MRI observation revealed partial recurrence and enlargement of the tumor after injection. The results of this study suggest that gene therapy using the HSV-TK gene may have some effect on the treatment of brain tumors.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Gheidari, Ehsan Arefian, Fatemeh Jamshidi Adegani, Fereshteh Fallah Atanaki, Masoud Soleimani
Summary: The study reveals that miR-142 acts as a tumor suppressor in glioblastoma cells, inhibiting cell proliferation and migration, inducing apoptosis and cell-cycle arrest. Its direct target genes include SHC4, PIK3CA, AKT1, KRAS, and MAPK8 oncogenes.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alireza Poustforoosh, Sanaz Faramarz, Mohammad Hadi Nematollahi, Hassan Hashemipour, Burak Tuzun, Abbas Pardakhty, Mehrnaz Mehrabani
Summary: Flavonoids show potential as a treatment for glioblastoma, with a reliable 3D-QSAR model predicting the activities of different compounds. Molecular docking and MD simulation highlight interactions with Bcl-2 proteins, while ADME/T analysis indicates further potential for investigation. Compound 54 stands out as a promising candidate for glioblastoma treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Azam Izadi, Asie Sadeghi, Mohammad Jalili-Nik, Farshad Mirzavi, Amir R. Afshari, Mohammad Soukhtanloo
Summary: The anticancer effects of the alpha-lipoic acid/ auraptene combination were investigated on glioblastoma cell proliferation and apoptosis. The combination suppressed cell viability, induced apoptosis, caused cell cycle arrest, and increased the generation of reactive oxygen species.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Immunology
A. J. Villatoro, C. Alcoholado, M. C. Martin-Astorga, V Fernandez, M. Cifuentes, J. Becerra
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2019)
Article
Multidisciplinary Sciences
Antonio J. Villatoro, Cristina Alcoholado, Maria del Carmen Martin-Astorga, Gustavo Rico, Viviana Fernandez, Jose Becerra
Article
Agriculture, Dairy & Animal Science
Antonio J. Villatoro, Maria del Carmen Martin-Astorga, Cristina Alcoholado, Maria del Mar Sanchez-Martin, Jose Becerra
Summary: Stem cell research has generated high expectations for the development of new therapies to repair or regenerate damaged tissues. Therapies based on mesenchymal stem cells have become an interesting alternative for the treatment of different complex pathologies in veterinary medicine. This study aimed to determine and compare the protein profile of mesenchymal stem cells to better understand their mechanisms of action and facilitate their potential use in future therapies.
Article
Agriculture, Dairy & Animal Science
Antonio J. Villatoro, Maria del Carmen Martin-Astorga, Cristina Alcoholado, Casimiro Cardenas, Fernando Farinas, Jose Becerra, Rick Visser
Summary: Feline chronic gingivostomatitis (FCGS) is a common pathology in cats associated with aberrant immune response. This study found alterations in the proteomic profile of feline adipose-derived mesenchymal stem cells (fAd-MSC) exosomes from calicivirus-positive FCGS patients, suggesting the presence of new therapeutic targets and specific biomarkers related to disease progression.
Article
Veterinary Sciences
Sayda Perez-Delgado, Pedro J. Ginel, Rafael Guerra, Elena Mozos, Cristina Alcoholado, Maria del Carmen Martin-Astorga, Jose Becerra, Antonio J. Villatoro
Summary: The study aimed to evaluate the effect of canine adipose MSC secretome (cS-MSC) on wound healing of red-eared slider turtles. The results showed that cS-MSC did not have a significant functional activity on the healing of turtle wounds.
JOURNAL OF WILDLIFE DISEASES
(2022)
Article
Virology
Antonio J. Villatoro, Maria del Carmen Martin-Astorga, Cristina Alcoholado, Liliya Kazantseva, Casimiro Cardenas, Fernando Farinas, Jose Becerra, Rick Visser
Summary: This study analyzed the proteomic profile of secretomes produced by feline adipose-tissue-derived MSCs (fAd-MSCs) from cats with feline chronic gingivostomatitis (FCGS) caused by feline calicivirus (FCV). It was found that fAd-MSCs from cats with FCGS showed an increased expression of pro-inflammatory cytokines and an altered proteomic profile. These findings provide insights into the roles of MSCs in FCGS and may contribute to the identification of specific biomarkers and therapeutic targets.
Review
Chemistry, Multidisciplinary
Marta Espada-Sanchez, Rocio Saenz de Santa Maria, Maria del Carmen Martin-Astorga, Clara Lebron-Martin, Maria Jesus Delgado, Ibon Eguiluz-Gracia, Carmen Rondon, Cristobalina Mayorga, Maria Jose Torres, Carlos Jose Aranda, Jose Antonio Canas
Summary: Respiratory diseases, such as asthma and allergic rhinitis, are common airway conditions that cause breathing difficulties and have high mortality rates. They share similar physiological and immunological mechanisms, and early diagnosis and effective treatment are crucial for patient health and quality of life. In recent years, efforts have been made to improve treatments using biological agents and specific allergen immunotherapy, as well as developing more precise diagnostic tools. This review compiles important information for managing asthma and allergic rhinitis, including classical and innovative treatment approaches and diagnostic techniques.
APPLIED SCIENCES-BASEL
(2023)
Letter
Allergy
Jose Antonio Cespedes, Clara Lebron-Martin, Reyes Garcia-Oton, Maria Jesus Delgado, Maria del Carmen Martin-Astorga, Natalia Perez-Sanchez, Francisca Gomez, Maria Jose Torres, Jose Antonio Canas, Carlos Jose Aranda, Cristobalina Mayorga
Article
Veterinary Sciences
Antonio J. Villatoro, Maria del Carmen Martin-Astorga, Cristina Alcoholado, Jose Becerra
BMC VETERINARY RESEARCH
(2020)