Journal
PLANT CELL
Volume 34, Issue 5, Pages 1479-1496Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/plcell/koac035
Keywords
-
Funding
- Max-Planck Society
- Germany's Excellence Strategy CEPLAS [EXC-2048/1, 390686111]
- Deutsche Forschungsgemeinschaft (DFG) [SFB 680, SFB-1403-414786233]
- IMPRS Ph.D. fellowship
Ask authors/readers for more resources
Protein domains play a crucial role in immune signaling in both prokaryotes and eukaryotes. TIR-based signaling in plants is essential for host defenses and balanced for healthy tissues. Specialized protein modules have evolved in seed plants to connect TIR domain signaling with effective defense responses.
A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of TIR evolution and the molecular versatility of TIR domains in different protein architectures for host protection against microbial attack. Plant TIR-based signaling emerges as being central to the potentiation and effectiveness of host defenses triggered by intracellular and cell-surface immune receptors. Equally relevant for plant fitness are mechanisms that limit potent TIR signaling in healthy tissues but maintain preparedness for infection. We propose that seed plants evolved a specialized protein module to selectively translate TIR enzymatic activities to defense outputs, overlaying a more general function of TIRs. Plants have evolved specialized protein modules to connect TIR domain signaling to Ca2+ influx and mount effective defense responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available