Article
Agriculture, Dairy & Animal Science
Matthias Gerhard Wagener, Carina Helmer, Patricia Kammeyer, Sven Kleinschmidt, Teresa Maria Punsmann, Johanna Maria Meilwes, Cornelia Schwennen, Alexandra von Altrock, Mirja Wilkens, Barbara Schwert, Nicole von Keyserlingk-Eberius, Martin Ganter
Summary: Alpacas in central Europe often suffer from vitamin D deficiency due to lower UV radiation, leading to additional treatment with vitamin D-3. However, a mix-up in units (mu g and IU) led to several alpaca poisoning incidents with 40 times the intended dosage of vitamin D-3. This resulted in toxicological levels of vitamin D causing organ dysfunction, particularly in the kidneys, lungs, and liver. Individual animals show different levels of sensitivity to vitamin D-3, with some developing severe clinical alterations and others showing no signs despite similar doses.
Article
Health Care Sciences & Services
Maxime Ilzkovitz, Elikyah Esther Kayembe, Caroline Geers, Agnieszka Pozdzik
Summary: This study reported a rare case of kidney stone disease in an Indian woman with a strong association with Sjogren syndrome, highlighting the importance of autoimmune screening in the diagnosis of such conditions.
Article
Pediatrics
A. Caglar, H. Tugce Caglar
Summary: A retrospective analysis of patients with vitamin D intoxication revealed common symptoms including vomiting, loss of appetite, and constipation. Causes of intoxication included prescribed and non-prescribed D3 vials, as well as incorrectly produced supplements. Pamidronate was found to be effective in treating VDI, but caution should be taken with Stoss therapy for children with poor adherence to treatment.
ARCHIVES DE PEDIATRIE
(2021)
Review
Chemistry, Medicinal
Francesco Coccia, Angelo Pietrobelli, Thomas Zoller, Alessandra Guzzo, Paolo Cavarzere, Angelo Fassio, Carl-Erik Flodmark, Davide Gatti, Franco Antoniazzi
Summary: Osteogenesis Imperfecta (OI) is a group of inherited skeletal dysplasias characterized by bone fragility. The study aimed to evaluate the importance of Vitamin D levels in OI bone metabolism, based on a comprehensive review of English-language articles. Contradictory data were found on the relationship between 25OH vitamin D levels and bone parameters in OI, with baseline levels often below the threshold value of 75 nmol/L. Adequate vitamin D supplementation is highlighted as important for children with OI based on literature and experience.
Article
Urology & Nephrology
Hsin-Hsiao Scott Wang, John Panagides, Dylan Cahill, Clement Bottino, Erinn T. Rhodes, Eric Fleegler, Bartley G. Cilento, Michael P. Kurtz, Michelle Baum, Caleb P. Nelson
Summary: This study analyzed the dietary information of pediatric urolithiasis patients and healthy controls and found that higher dietary intake of sodium, calcium, and beta carotene were associated with pediatric urolithiasis, while lower potassium intake had a smaller correlation.
JOURNAL OF UROLOGY
(2022)
Article
Immunology
Leonardo Martinez, Jabulani R. Ncayiyana, Liz Goddard, Maresa Botha, Lesley Workman, Tiffany Burd, Landon Myer, Mark Nicol, Heather J. Zar
Summary: Low vitamin D levels in infancy were not associated with tuberculosis disease in childhood, but very low vitamin D levels were associated with tuberculin conversion in young children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Sabrina Malone Jenkins, Gary Chan, Kimberlee Weaver-Lewis, Tyler Bardsley, Jace Felix, Matthew Grinsell
Summary: This study aimed to investigate the effects of vitamin D supplementation on bone density and the development of NC in preterm infants. The results showed that infants receiving vitamin D supplementation according to AAP guidelines had acceptable serum vitamin D levels, but did not show improvement in bone density or mineral content compared to previously reported values. However, infants with lower birth weight and earlier gestational age were at increased risk of developing NC.
PEDIATRIC NEPHROLOGY
(2022)
Article
Pediatrics
Annika Simon
Summary: This article presents a case study of a 3-year-old boy who developed significant hypercalcemia due to vitamin D toxicity. The boy's parents purchased high-dose vitamin D drops online and administered them without following the recommended dosage. Treatment with a bisphosphonate quickly stabilized the boy's serum calcium levels, allowing him to be discharged without any complaints.
MONATSSCHRIFT KINDERHEILKUNDE
(2022)
Article
Nutrition & Dietetics
Matteo Bargagli, Pietro Manuel Ferraro, Matteo Vittori, Gianmarco Lombardi, Giovanni Gambaro, Bhaskar Somani
Summary: Kidney stone disease is a multifactorial condition influenced by genetic predisposition and environmental factors. Dietary advice for kidney stone formers includes elevated fluid intake, dietary restriction, normal body mass index, and increased intake of vegetables and fibers. Calcium consumption plays a role in reducing the risk for kidney stones by affecting oxalate availability, while the impact of vitamin D supplements on stone formation risk remains unclear.
Article
Nutrition & Dietetics
Seunghye Lee, Hye Jin Chung, Sehyun Jung, Ha Nee Jang, Se-Ho Chang, Hyun-Jung Kim, Min-Chul Cho
Summary: Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.
Article
Endocrinology & Metabolism
Karen K. Winer, Shangyuan Ye, Elise M. N. Ferre, Monica M. Schmitt, Bo Zhang, Gordon B. Cutler, Michail S. Lionakis
Summary: This study describes the clinical outcomes of the largest cohort of hypoparathyroid patients followed over 27 years and reveals significant differences in responses to PTH 1-34 injections vs conventional therapy among different etiologies of hypoparathyroidism. Postsurgical patients maintained lower urine calcium excretion during long-term PTH 1-34 therapy.
Article
Pediatrics
Mauras Mathilde, Marine Butin, Roy Pascal, Franck Plaisant, Sophie Laborie, Justine Bacchetta
Summary: The study retrospectively evaluated the effectiveness and safety of a local hospital protocol of vitamin D supplementation for preterm infants in France. The modified protocol successfully prevented underdosing and significant overdosing, but moderate hypervitaminosis D was still frequent. Further urgent studies are needed to determine the optimal supplementation and clinical impact of 25(OH)D on comorbidities in preterm infants.
Article
Endocrinology & Metabolism
Nina Lenherr-Taube, Michelle Furman, Esther Assor, Yesmino Elia, Carol Collins, Kenneth Thummel, Michael A. Levine, Etienne Sochett
Summary: Idiopathic infantile hypercalcemia is a rare disorder with variable clinical features and the response to dietary calcium and vitamin D restriction in mild cases is not able to consistently normalize elevated 1,25(OH)2D concentrations or prevent worsening of renal calcification. Therapeutic options should focus on the defect in vitamin D metabolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Nina Lenherr-Taube, Edwin J. Young, Michelle Furman, Yesmino Elia, Esther Assor, David Chitayat, Tami Uster, Susan Kirwin, Katherine Robbins, Kathleen M. B. Vinette, Alan Daneman, Christian R. Marshall, Carol Collins, Kenneth Thummel, Etienne Sochett, Michael A. Levine
Summary: Mild idiopathic infantile hypercalcemia (IIH) is a common disorder in children with a distinctive vitamin D metabolite profile, primarily associated with heterozygous variants in SLC34A1 and SLC34A3. Most patients have common genetic variants, with only a minority showing variants in genes related to hypercalciuria.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Markus Ketteler, Kristina Chen, Elvira O. Gosmanova, James Signorovitch, Fan Mu, Joshua A. Young, Nicole Sherry, Lars Rejnmark
Summary: This retrospective cohort study using a managed care claims database in the United States found that patients with chronic hypoparathyroidism have a significantly increased risk of nephrolithiasis and nephrocalcinosis compared to those without chronic hypoparathyroidism during a 5-year follow-up period.
ADVANCES IN THERAPY
(2021)