Article
Immunology
Pan Lai, Fengjie Liu, Xiangjun Liu, Jingru Sun, Yang Wang
Summary: The study identified distinct clinicopathological features and gene expression programs between cALCL and CD30+ TMF, with CD30+ TMF showing enrichment in T cell receptor signaling pathways and an exhausted T cell phenotype, while cALCL cells expressed high levels of HLA class II genes and polarized towards a Th17 phenotype. An IHC algorithm using BATF3 and TCF7 staining emerged as potential diagnostic markers for distinguishing these two entities.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Taekwoon Kim, Jisung Kim, Joonsoo Park
Summary: A 60-year-old woman with multiple erythematous umbilicated nodules on her back was diagnosed with cutaneous metastasis of T cell/histiocyte-rich large B cell lymphoma. Further evaluation and treatment are needed.
Review
Biochemistry & Molecular Biology
Shuichi Nakai, Eiji Kiyohara, Rei Watanabe
Summary: CTCL is a heterogeneous group of non-Hodgkin lymphoma, mainly including MF and SS, with malignant cells possibly originating from different T cell phenotypes. The pathogenesis and therapeutic strategies for CTCL remain unclear due to the similar characteristics between malignant cells and anti-tumor T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah A. Teichmann, Fan Bai, Yang Wang
Summary: Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin lymphoma characterized by clonal malignant T cells. This study analyzed CTCL patient samples using single-cell RNA-seq, TCR and whole-exome sequencing, revealing the molecular profiles of malignant T cells and their association with the microenvironment and clinical outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Zhen Han, Renee J. Estephan, Xiwei Wu, Chingyu Su, Yate-Ching Yuan, Hanjun Qin, Sung Hee Kil, Corey Morales, Daniel Schmolze, James F. Sanchez, Lei Tian, Jianhua Yu, Marcin Kortylewski, Steven T. Rosen, Christiane Querfeld
Summary: Cutaneous T cell lymphoma (CTCL) is a malignant tumor characterized by chronic inflammation. This study found that miR-155-5p, miR-130b-3p, and miR-21-3p positively correlated with immune checkpoint gene expression in CTCL and were enriched in the IL-6/Jak/signal transducer and activator of transcription signaling pathway.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Sara Peru, Martina Prochazkova-Carlotti, Floriane Cherrier, Joanne Velazquez, Elodie Richard, Yamina Idrissi, David Cappellen, Lamia Azzi-Martin, Anne Pham-Ledard, Marie Beylot-Barry, Jean-Philippe Merlio, Sandrine Poglio
Summary: Cutaneous T-cell lymphoma (CTCL) is characterized by abnormal infiltration of T lymphocytes in the skin. In this study, the researchers found that the expression of cutaneous lymphocyte antigen (CLA) in CTCL cells is crucial for their migration and survival. The use of a CLA antibody significantly reduced the migration and survival of CTCL cells both in vitro and in vivo. These findings suggest that inhibiting CLA could be a potential therapeutic strategy for CTCL patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Veterinary Sciences
Jevgenija Kondratjeva, Florie Julien, Celine Coutelier, Louis Humeau, Fabien Moog, Daniel Combarros, Isabelle Fourquaux, Charline Pressanti, Maxence Delverdier, Peter F. Moore, Marie Christine Cadiergues
Summary: This case report presents the first evidence of clinical, histopathological, immunophenotypic features, electron microscopy findings, and molecular analysis of a cutaneous epitheliotropic T-cell lymphoma (mycosis fungoides) in a donkey. Our observations suggest that cutaneous T-cell lymphoma should be considered in the differential diagnoses of exfoliative dermatitis, even those with a chronic pattern and/or minimal or no pruritus.
BMC VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Minami Sakamoto, Tomomitsu Miyagaki, Hiroaki Kamijo, Tomonori Oka, Hikari Boki, Naomi Takahashi-Shishido, Hiraku Suga, Makoto Sugaya, Shinichi Sato
Summary: CD147 and CypA are overexpressed in tumor cells of mycosis fungoides and Sezary syndrome patients, and CypA is also expressed by epidermal keratinocytes in lesional skin. Serum CypA levels are elevated and correlated with disease severity markers. Anti-CD147 and/or anti-CypA antibodies can suppress the proliferation of CTCL cell lines by downregulating signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Fengjie Liu, Yumei Gao, Bufang Xu, Shan Xiong, Shengguo Yi, Jingru Sun, Zhuojing Chen, Xiangjun Liu, Yingyi Li, Yuchieh Lin, Yujie Wen, Yao Qin, Shuxia Yang, Hang Li, Trilokraj Tejasvi, Lam Tsoi, Ping Tu, Xianwen Ren, Yang Wang
Summary: This study identified unique transcriptional programs and enriched expression of genes at the chr7q locus in tumors undergoing large-cell transformation (LCT) in late-stage mycosis fungoides (MF). Aberrant expression of the imprinted gene Paternally Expressed Gene 10 (PEG10) in LCT was shown to drive cell size increase, promote proliferation, and confer treatment resistance through a PEG10/KLF2/NF-kappa B axis. Pharmacological targeting of PEG10 reversed the proliferation and treatment resistance phenotypes in LCT, suggesting PEG10 inhibition as a promising therapeutic approach.
Review
Cell Biology
Amy Xiao, Oleg E. Akilov
Summary: The loss of CD47 on aging cells signals macrophages to eliminate the target. CD47 acts as a "do-not-eat-me" sign that prevents macrophagal phagocytosis by interacting with its ligand SIRP alpha. Malignant lymphocytes highly express CD47, making them ideal candidates for targeted anti-CD47 therapies. There are various types of anti-CD47-SIRP alpha therapeutic molecules, including monoclonal antibodies, bioengineered proteins, miRNAs, and bispecific antibodies. Blocking the CD47-SIRP alpha axis in combination with targeting secondary tumor microenvironment (TME) may enhance the effectiveness of current immunotherapeutic approaches.
Article
Cell Biology
Philipp Licht, Volker Mailaender
Summary: Cutaneous T-Cell Lymphomas (CTCL) exhibit clinical variability and transcriptional heterogeneity, with different T-cell subtypes suggested as sources of the disease. The microbiome may play a role in disease progression and transcriptional heterogeneity, and microbial approaches have the potential to aid in diagnosis and treatment of CTCL.
Article
Oncology
Yixin Luo, Maarten H. Vermeer, Frank R. de Gruijl, Willem H. Zoutman, Marjolein Sluijter, Thorbald van Hall, Cornelis P. Tensen
Summary: This study investigates the mechanisms of MF by creating mouse models. The results show that knockout of the Socs1 gene can lead to skin lesions and activation of CD4 T cells. However, single copy loss of Socs1 is insufficient to induce a phenotype resembling early stage MF in the presence of sustained inflammation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Vladimir Vasku, Jan Machal, Filip Zlamal, Anna Vasku
Summary: This study evaluated the survival of CTCL patients and analyzed 19 gene variants. The results showed that the TT genotype at position 2677 of the MDR1 gene is associated with longer survival in CTCL patients.
Review
Dermatology
Kazuyasu Fujii
Summary: Mycosis fungoides (MF) and Sezary syndrome (SS) are representative cutaneous lymphomas, with a shift from Th1 to Th2 environment as the disease progresses. Staphylococcus aureus is highly sensitive in advanced stages, and susceptibility to infection is related to the main symptoms of MF.
JOURNAL OF DERMATOLOGY
(2022)
Review
Oncology
Eirini Kalliara, Emma Belfrage, Urban Gullberg, Kristina Drott, Sara Ek
Summary: While most CTCL patients are diagnosed with early-stage disease, a significant number will progress unexpectedly to advanced-stage disease. Deciphering the biological events behind disease aggressiveness is crucial for identifying high-risk patients and designing personalized treatment strategies. By utilizing advanced single-cell transcriptomics tools, a comprehensive analysis of immune and malignant T-cell populations can be conducted, leading to the development of novel biomarkers and personalized treatments for CTCL patients.
Article
Biochemistry & Molecular Biology
Aline Rangel-Pozzo, Janine Wechsler, Jessica Groult, Laetitia Da Meda, Celeste Lebbe, Sabine Mai
Summary: Tumor-associated macrophages (TAMs) and cancer-associated macrophage-like cells (CAMLs) may play important roles in cancer progression by incorporating genetic material from tumor cells during phagocytosis. This pilot study compared the 3D telomere structure of CAMLs, circulating tumor cells (CTCs), and leukocytes in melanoma patients. It identified significant differences in two telomere parameters between CAMLs and leukocytes, and classified CAMLs into two subpopulations with different levels of genomic instability. Further research is needed to validate these findings and explore their potential prognostic value.