Article
Plant Sciences
Reena Rani, Ghulam Raza, Hamza Ashfaq, Muhammad Rizwan, Muhammad Khuram Razzaq, Muhammad Qandeel Waheed, Hussein Shimelis, Allah Ditta Babar, Muhammad Arif
Summary: Soybean is a significant crop globally, and this study used genome-wide association studies to identify genes and functional markers associated with soybean agronomic traits, providing valuable data for future breeding programs.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Genetics & Heredity
Irina Ponomarenko, Evgeny Reshetnikov, Alexey Polonikov, Irina Verzilina, Inna Sorokina, Anna Yermachenko, Volodymyr Dvornyk, Mikhail Churnosov
Summary: This study identified 23 loci associated with uterine leiomyoma (UL) from candidate genes for age at menarche (AAM), of which 16 loci also showed associations with AAM, height and/or body mass index (BMI). These loci have significance for 35 genes involved in pathways related to development of female reproductive organs and hormone-mediated signaling.
FRONTIERS IN GENETICS
(2021)
Article
Plant Sciences
Lovepreet Singh, Rajat Pruthi, Sandeep Chapagain, Prasanta K. Subudhi
Summary: Alkalinity stress is a major obstacle to rice production, and understanding the mechanisms of alkalinity tolerance is limited. A genome-wide association study was conducted to identify tolerant genotypes and candidate genes for alkalinity tolerance in rice seedlings. Principal component analysis revealed the traits with the highest contributions to tolerance, and clustering analysis grouped the genotypes into different subgroups. Several significant SNPs associated with alkalinity tolerance were identified, as well as novel QTLs and candidate genes. These genomic and genetic resources are valuable for investigating alkalinity tolerance mechanisms and improving tolerance in rice.
Article
Biochemistry & Molecular Biology
Sebastian Morales-Pison, Julio C. Tapia, Sarai Morales-Gonzalez, Edio Maldonado, Monica Acuna, Gloria M. Calaf, Lilian Jara
Summary: This study found that specific germline variants in driver genes MAP3K1, SF3B1, and SMAD4 contribute to the risk of breast cancer in the Chilean population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Qi Sun, Lei He, Lei Sun, Hai-Ying Xu, Ya-Qun Fu, Zheng-Yang Sun, Bao-Qing Zhu, Chang-Qing Duan, Qiu-Hong Pan
Summary: The gene VvGGPPS was found to play an important role in controlling the aroma compounds in grape berries, making it a potential target for molecular breeding of aromatic grape varieties.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Genetics & Heredity
Puneet Talwar, Suman Kushwaha, Chitra Rawat, Harpreet Kaur, Ankit Srivastava, Rachna Agarwal, Puneet Chandna, Paolo Tucci, Luciano Saso, Ritushree Kukreti
Summary: This study validated the reliability of the genomic convergence and network analysis approach in identifying candidate genes associated with Alzheimer's disease by studying the association of genetic variants from three critical genes, APOE, EGFR, and ACTB. The results showed significant associations between certain SNPs in these genes and AD, further supporting the utility of this approach in identifying potential AD-related genes.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Shuai Zhao, Shiqian Huang, Qi Zhong, Linlin Han, Yafeng Wang, Feng Xu, Lulin Ma, Yuanyuan Ding, Leiming Xia, Xiangdong Chen
Summary: The genetic polymorphisms in genes involved in pharmacokinetics and pharmacodynamics were found to be associated with individual differences in the sensitivity to the sedative and cardiovascular effects of sevoflurane.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Y. Jia, X. Qi, M. Ma, S. Cheng, B. Cheng, C. Liang, X. Guo, F. Zhang
Summary: This study aimed to explore novel regulatory genetic variants associated with bone mineral density (BMD). Through an integrative analysis of BMD genome-wide association study and regulatory single nucleotide polymorphism (rSNP) annotation information, we identified 36 common genes associated with BMD, such as FAM3C, CCDC170, and SOX6. Additionally, multiple gene ontology terms related to BMD were detected. These findings support the implication of regulatory genetic variants in the development of osteoporosis.
BONE & JOINT RESEARCH
(2023)
Article
Environmental Sciences
Xinghai Zhu, Junhao Zhang, Xiujiang Hou, Pingping Liu, Jia Lv, Qiang Xing, Xiaoting Huang, Jingjie Hu, Zhenmin Bao
Summary: GWAS analysis revealed the genetic basis of shell color in bay scallops, identifying key SNPs mainly located on chromosome 7 and three candidate genes involved in shell pigmentation regulation. Gene expression analysis showed significant differences in the expression levels of candidate genes in mantle tissues of individuals with different shell colors, providing insights into the mechanism underlying shell color phenotype differences.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Plant Sciences
Xing Huo, Jian Wang, Luo Chen, Hua Fu, Tifeng Yang, Jingfang Dong, Yamei Ma, Lian Zhou, Jiansong Chen, Dilin Liu, Bin Liu, Junliang Zhao, Shaohong Zhang, Wu Yang
Summary: Grain chalkiness is a crucial factor influencing the market value of rice. This study identified 34 QTLs associated with grain chalkiness in 450 rice accessions through a genome-wide association analysis. Four candidate genes were identified as potential targets for molecular breeding to improve rice quality. These findings contribute to a better understanding of the genetic basis of grain chalkiness and provide gene resources for quality improvement in rice through molecular breeding.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Wencheng Lu, Meinan Sui, Xunchao Zhao, Hongchang Jia, Dezhi Han, Xiaofei Yan, Yingpeng Han
Summary: This study identified 13 QTNs associated with total soluble sugar content in soybean seeds through a genome-wide association study (GWAS) using 278 diverse soybean accessions. These QTNs were distributed on ten chromosomes. Furthermore, gene-based association analysis and haplotype analysis identified 84 significant SNPs from seventeen genes across four chromosomes that were associated with the total soluble sugar content. Additionally, the analysis of differential expression genes based on soybean germplasms confirmed six GWAS-identified genes that were associated with soluble sugar content. These findings provide valuable candidate genes and beneficial alleles for improving the soluble sugar content of soybean.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mohammed F. Al-azzawy, Mohammad Al-Haggar, Afaf M. ElSaid, Omali Y. El-khawaga
Summary: This study discovered the relationship between NPHS2 and ACTN4 in pediatric nephrotic syndrome (PNS) and identified the high risk of AG haplotype NPHS2 rs3829795-rs2274625 allele in PNS.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Agronomy
Xiaoli Zhang, Linglong Zhu, Mengyun Ren, Chao Xiang, Xiumei Tang, Youlin Xia, Dulin Song, Fuzhen Li
Summary: In this study, GWAS was conducted to identify SNPs associated with pod-related traits in 136 peanut accessions. A total of 36 SNPs were identified, and 19 candidate genes related to pod-related traits were predicted. These findings contribute to the understanding of the genetic basis of pod-related traits and provide a theoretical basis for gene cloning and marker-assisted selection in peanut breeding.
Article
Biology
Priya Jarwar, Yar Muhammad Waryah, Muhammad Rafiq, Ali Muhammad Waryah
Summary: This study analyzed the association between SNP variants in CRYAA and CRYAB genes and Congenital Cataract. The results showed that the rs13053109 G > C variant in CRYAA gene is associated with increased risk of congenital cataract in infants. Haplotype analysis indicated weak linkage disequilibrium between the SNPs rs3761382, rs7278468, and rs13051039 of CRYAA gene. These findings suggest that the variation in CRYAA gene may be a risk factor for congenital cataract in infants.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Biochemistry & Molecular Biology
Justyna Lalak-Kanczugowska, Natalia Witaszak, Agnieszka Waskiewicz, Jan Bocianowski, Lukasz Stepien
Summary: Fusarium proliferatum is a common hemi-biotrophic pathogen that infects a wide range of host plants, leading to significant crop losses. In this study, the effects of selected plant metabolites on the metabolism of F. proliferatum were analyzed. The results showed that some metabolites promoted fungal growth while others inhibited it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Tomasz Warzecha, Roman Bathelt, Edyta Skrzypek, Marzena Warchol, Jan Bocianowski, Agnieszka Sutkowska
Summary: The environmental conditions have an impact on the growth and productivity of crop plants. Among the various factors, drought stress is identified as one of the major threats to plant productivity. This research focused on evaluating the physiological, biochemical, and agronomic parameters of OMA plants under soil drought conditions. The results showed that most of the examined lines exhibited reduced photosynthetic pigment content, PSII photosystem activity, and yield-related traits under drought stress. However, two lines (9 and 78b) were found to retain high yielding potential compared to the commercial cv. Bingo under drought stress.
Article
Multidisciplinary Sciences
Dorota Wronska-Pilarek, Irmina Maciejewska-Rutkowska, Kacper Lechowicz, Jan Bocianowski, Maria Hauke-Kowalska, Marlena Baranowska, Robert Korzeniewicz
Summary: The study aimed to determine how herbicides affect the morphological characteristics of Prunus serotina pollen. The results showed that herbicides have an impact on the shape and size of the pollen. This knowledge is crucial for controlling this invasive species.
SCIENTIFIC REPORTS
(2023)
Article
Green & Sustainable Science & Technology
Zahra Abbasi, Abdosattar Darabi, Jan Bocianowski
Summary: This study conducted an experiment on fifteen short day onion genotypes at two locations, Isfahan and Khuzestan, and evaluated them using multivariate methods. The results showed significant differences in the traits among locations, varieties, and the interaction between location and variety. Positive and negative correlations were found between various traits. The Saba and Behbahan improved population varieties were recommended for future crop improvement programs due to their high genetic diversity.
Article
Genetics & Heredity
Aras Turkoglu, Kamil Haliloglu, Seyyed Abolgahasem Mohammadi, Ali Ozturk, Parisa Bolouri, Guller Ozkan, Jan Bocianowski, Alireza Pour-Aboughadareh, Bita Jamshidi
Summary: This study investigated the molecular diversity and population structure of 120 Turkish bread wheat genotypes using 120 microsatellite markers. The results showed that wheat genotypes have rich genetic diversity, which can be used to improve wheat genotypes for food security.
Article
Chemistry, Multidisciplinary
Dariusz Piesik, Jacek Lyczko, Krzysztof Krawczyk, Magdalena Gantner, Jan Bocianowski, Veronika Ruzsanyi, Chris A. A. Mayhew
Summary: This study aims to determine the similarity between the profile of green leaf volatiles (GLVs) naturally produced by undamaged plants and those provoked by chemical stimulants. It also investigates the influence of sex and mating status on the reproductive choices of Apion miniatum beetles. Additionally, it assesses the use of chemically stimulated GLV emissions as a means to attract pests for biological control of Rumex confertus.
APPLIED SCIENCES-BASEL
(2023)
Article
Agronomy
Joanna Horoszkiewicz, Ewa Jajor, Jakub Danielewicz, Marek Korbas, Lech Schimmelpfennig, Marzena Mikos-Szymanska, Marta Klimczyk, Jan Bocianowski
Summary: Poland, like other countries, faces the challenges of climate change. The use of biostimulants in agriculture has shown great potential in combating climate change-induced stresses. Biostimulants are organic compounds or microbes that can regulate plant growth and promote resistance.
Article
Agronomy
Justyna Szwarc, Janetta Niemann, Jan Bocianowski, Joanna Kaczmarek, Mehmet Zafer Dogu, Alicja Nowicka
Summary: The study evaluated the usefulness of markers linked to blackleg resistance and genes influencing major morphological characteristics for the selection of Brassicaceae hybrids. Useful SSR markers were identified, including markers mstg004 and mstg027 connected to flower color, and marker mstg038 associated with stem color. Field trials also helped select rapeseed hybrids with low blackleg infestation. The functionality of resistance-linked markers was confirmed, highlighting the importance of interspecific hybridization and marker-assisted selection.
Article
Agronomy
Adrian Cyplik, Ilona Mieczyslawa Czyczylo-Mysza, Joanna Jankowicz-Cieslak, Jan Bocianowski
Summary: This paper suggests using weighted multiple linear regression to estimate the triple interaction of quantitative trait loci (QTLs) effects. The results showed that weighted regression improved the evaluation of the aaa(gw) parameter compared to aaa(p) in most cases, while unweighted regression improved the QTLxQTLxQTL interaction effects. The coefficients of determination for the weighted regression model were significantly higher, indicating the significant effect of the three-way interaction on quantitative traits expression.
Article
Genetics & Heredity
Julia Spychala, Agnieszka Tomkowiak, Aleksandra Noweiska, Roksana Bobrowska, Jan Bocianowski, Michal Ksiazkiewicz, Aleksandra Sobiech, Michal Tomasz Kwiatek
Summary: The main efforts in common wheat breeding focus on yield, grain quality, and resistance to biotic and abiotic stresses. Rust diseases, including leaf rust caused by Puccinia triticina, are a major threat to global wheat cultivation. The study investigated the early transcriptomic responses of two major wheat APR genes, Lr34 and Lr67, and three complementary miRNAs, tae-miR9653b, tae-miR9773, and tae-miR9677b, to inoculation with P. triticina. The expression profiles of the APR genes and miRNAs varied between varieties and time-points, but the expression of Lr34 and Lr67 genes in studied cultivars was significantly higher than in a control line carrying susceptible alleles.
Article
Chemistry, Multidisciplinary
Jan Bocianowski, Kamila Nowosad, Henryk Bujak
Summary: Knowledge of the genetic potential and variation in parental forms is crucial for shortening the breeding process and achieving desired traits in hybrids. The effects of heterosis and specific combining ability can be predicted through selection of genetically diverse parental forms. Preliminary studies suggest that selecting phenotypically equal but genetically diverse parental forms is the best approach for obtaining favorable hybrids.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Fatih Demirel, Aras Turkoglu, Kamil Haliloglu, Baris Eren, Guller Ozkan, Pinar Uysal, Alireza Pour-Aboughadareh, Agnieszka Lesniewska-Bocianowska, Bita Jamshidi, Jan Bocianowski
Summary: This study investigated the effects of mammalian sex hormones on DNA damage and DNA methylation in wheat plants, and found that these hormones can alter the genomic stability and cytosine methylation status of wheat plants.
APPLIED SCIENCES-BASEL
(2023)
Article
Agronomy
Kamila Nowosad, Jan Bocianowski, Farzad Kianersi, Alireza Pour-Aboughadareh
Summary: The assessment of 1000-kernel weight is crucial for determining maize grain yield, and understanding its genetic mechanisms is important for improving overall performance. This study focused on 26 doubled-haploid maize lines and evaluated genotype by environment interaction, selection of stable lines, and estimation of additive and additive-additive gene interaction effects. Results indicated significant effects of genotype and environment, as well as genotype by environment interaction, on 1000-kernel weight. The lines KN07 and KN10 were recommended for further breeding due to their stability and highest average weight.
Article
Biochemistry & Molecular Biology
Agnieszka Wozniak, Jacek Kesy, Paulina Glazinska, Wojciech Glinkowski, Dorota Narozna, Jan Bocianowski, Renata Rucinska-Sobkowiak, Van Chung Mai, Wlodzimierz Krzesinski, Slawomir Samardakiewicz, Beata Borowiak-Sobkowiak, Mateusz Labudda, Philippe Jeandet, Iwona Morkunas
Summary: The study aimed to understand the regulation of phytohormone biosynthesis as signaling molecules in the defense mechanisms of pea seedlings under abiotic and biotic stress factors. The expression levels of genes involved in the biosynthesis of jasmonates, ethylene, and abscisic acid were analyzed. The results showed that the expression of these genes increased in response to stress factors, particularly at sublethal doses of lead and aphid infestation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jan Bocianowski, Agnieszka Tomkowiak, Marianna Bocianowska, Aleksandra Sobiech
Summary: Association analysis using DArTseq technology revealed 105 molecular markers associated with maize heterosis. Three markers were consistently associated with yield improvement across multiple environments.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)