Review
Nutrition & Dietetics
Valeria Calcaterra, Hellas Cena, Vittoria Carlotta Magenes, Alessandra Vincenti, Giulia Comola, Alice Beretta, Ilaria Di Napoli, Gianvincenzo Zuccotti
Summary: Sugar-sweetened beverages (SSBs) are a major source of free sugars in the diet and are strongly associated with weight gain and obesity-related complications. Factors influencing SSB consumption in children include economic variables, individual attributes and behaviors, environmental factors, and parental characteristics. Decreased satiety and incomplete compensatory reduction in energy intake after consuming liquid calories are leading mechanisms linking SSB intake to weight gain. SSBs also have impacts on gut microbiota and eating behaviors, and are associated with cardiometabolic risks.
Review
Endocrinology & Metabolism
Tung-Sung Tseng, Wei-Ting Lin, Gabrielle Gonzalez, Yu-Hsiang Kao, Lei-Shih Chen, Hui-Yi Lin
Summary: This literature review provides an overview of the association between sugar-sweetened beverage consumption and the risk of type 2 diabetes mellitus, types of SSB consumption and T2DM, the impact of obesity and inflammation on the link between SSB consumption and T2DM risk, and SSB consumption in T2DM patients. Current research shows promising results in identifying the connection between SSB consumption and T2DM risk, suggesting the need for further studies to explore more effective interventions for diabetes prevention and management related to SSB intake.
WORLD JOURNAL OF DIABETES
(2021)
Article
Medicine, General & Internal
Longgang Zhao, Xinyuan Zhang, Mace Coday, David O. Garcia, Xinyi Li, Yasmin Mossavar-Rahmani, Michelle J. Naughton, Melissa Lopez-Pentecost, Nazmus Saquib, Aladdin H. Shadyab, Michael S. Simon, Linda G. Snetselaar, Fred K. Tabung, Deirdre K. Tobias, Trang VoPham, Katherine A. McGlynn, Howard D. Sesso, Edward Giovannucci, Joann E. Manson, Frank B. Hu, Lesley F. Tinker, Xuehong Zhang
Summary: This study examined the associations between intake of sugar-sweetened beverages, artificially sweetened beverages, and the incidence of liver cancer and chronic liver disease mortality. The results showed that postmenopausal women who consumed 1 or more servings of sugar-sweetened beverages per day had a higher risk of developing liver cancer and dying from chronic liver disease compared to those who consumed 3 or fewer servings per month. There was no significant association between intake of artificially sweetened beverages and liver cancer or chronic liver disease mortality.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Andrea Romanos-Nanclares, Laura C. Collins, Frank B. Hu, Walter C. Willett, Bernard A. Rosner, Estefania Toledo, A. Heather Eliassen
Summary: The study found no significant association between consumption of sugar-sweetened beverages and breast cancer risk overall, but a slightly higher risk among lean women. On the other hand, consumption of artificially sweetened beverages appeared to reduce the risk of certain types of breast cancer.
JOURNAL OF NUTRITION
(2021)
Article
Oncology
Maryam S. Farvid, Nicholas D. Spence, Bernard A. Rosner, Wendy Y. Chen, A. Heather Eliassen, Walter C. Willett, Michelle D. Holmes
Summary: The study found that postdiagnostic consumption of sugar-sweetened beverages was associated with higher breast cancer-specific mortality and all-cause mortality among breast cancer survivors, while consumption of artificially sweetened beverages showed no association with mortality rates.
Review
Dentistry, Oral Surgery & Medicine
Vandana Gupta, Anika Dawar, Upendra Singh Bhadauria, Bharathi M. Purohit, Nilima Nilima
Summary: This systematic review found an association between the consumption of sugar-sweetened beverages (SSBs) and periodontal disease. The study revealed that consuming SSBs may increase the risk of gingival bleeding, gingivitis, and periodontitis. Further research is needed to establish additional evidence of this association.
Article
Medicine, General & Internal
Chayakrit Krittanawong, Yusuf Kamran Qadeer, Zhen Wang, Karl Nadolsky, Salim Virani, Carl J. Lavie
Summary: This study investigated the effects of consuming sugar-sweetened and artificially sweetened beverages on cardiovascular health, and found that higher consumption of these beverages is associated with an increased risk of cardiovascular issues.
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Nema D. McGlynn, Tauseef Ahmad Khan, Lily Wang, Roselyn Zhang, Laura Chiavaroli, Fei Au-Yeung, Jennifer J. Lee, Jarvis C. Noronha, Elena M. Comelli, Sonia Blanco Mejia, Amna Ahmed, Vasanti S. Malik, James O. Hill, Lawrence A. Leiter, Arnav Agarwal, Per B. Jeppesen, Dario Rahelic, Hana Kahleova, Jordi Salas-Salvado, Cyril W. C. Kendall, John L. Sievenpiper
Summary: This systematic review and meta-analysis found that using LNCSBs as a substitute for SSBs in overweight or obese adults at risk for or with diabetes was associated with small improvements in body weight and cardiometabolic risk factors without evidence of harm, and had a similar direction of benefit as water substitution.
Article
Nutrition & Dietetics
Bo Yang, Andrea J. Glenn, Qing Liu, Tracy Madsen, Matthew A. Allison, James M. Shikany, JoAnn E. Manson, Kei Hang Katie Chan, Wen-Chih Wu, Jie Li, Simin Liu, Kenneth Lo
Summary: There is still much unknown about the role of added sugar in cardiovascular disease and the effects of sugar-sweetened beverages and artificially sweetened beverages on cardiovascular disease risk. The study found a positive association between high intake of added sugar, sugar-sweetened beverages, and artificially sweetened beverages with cardiovascular disease incidence. However, there was heterogeneity in the results of different studies, suggesting that further investigation is needed to determine the relative contributions of added sugar, sugar-sweetened beverages, and artificially sweetened beverages to cardiovascular disease risk.
Review
Nutrition & Dietetics
Jiawei Yin, Yalun Zhu, Vasanti Malik, Xiaoqin Li, Xiaolin Peng, Fang Fang Zhang, Zhilei Shan, Liegang Liu
Summary: The study found that consuming sugar-sweetened beverages is positively associated with cardiovascular disease incidence and mortality. Similarly, intake of low-calorie sweetened beverages is also linked to cardiovascular disease incidence, but the results may be complicated by reverse causation and residual confounding.
ADVANCES IN NUTRITION
(2021)
Review
Medicine, General & Internal
Tatiana Andreyeva, Keith Marple, Samantha Marinello, Timothy E. Moore, Lisa M. Powell
Summary: The systematic review and meta-analysis of implemented SSB taxes worldwide found that these taxes were associated with higher prices and lower sales of taxed beverages. Results indicated that consumers were highly sensitive to price increases and there was no evidence of substitution to untaxed beverages.
Review
Nutrition & Dietetics
Fjorida Llaha, Mercedes Gil-Lespinard, Pelin Unal, Izar de Villasante, Jazmin Castaneda, Raul Zamora-Ros
Summary: The consumption of sweet beverages, including sugar-sweetened beverages and fruit juices, is significantly associated with the risk of breast and prostate cancer. This study recommends limiting sweet beverage consumption and further investigating the role of different beverages in carcinogenesis.
Review
Nutrition & Dietetics
Zeinab Khademi, Alireza Milajerdi, Bagher Larijani, Ahmad Esmaillzadeh
Summary: This study aimed to summarize the association of dietary carbohydrates, sugar, and sugar-sweetened beverages consumption with the risk of inflammatory bowel disease. The results indicated a significant positive association between sugar intake and the risk of both ulcerative colitis and Crohn's disease, while no significant association was found between dietary carbohydrates and SSBs intake with the risk of inflammatory bowel disease and its subtypes.
FRONTIERS IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Samuel Muli, Jantje Goerdten, Kolade Oluwagbemigun, Anna Floegel, Matthias Schmid, Ute Noethlings
Summary: Assessment of added sugar intake is challenging, and reliance on self-reported dietary data may be biased. Consumption of sugar-sweetened beverages is associated with poor overall diet quality, weight gain, and cardiometabolic risks, while intake of low-calorie sweetened beverages may also increase the risk of metabolic dysfunction.
Article
Nutrition & Dietetics
Xue-Ting Liu, Jing-Yuan Xiong, Yu-Jie Xu, Li Zhao, Lars Libuda, Guo Cheng
Summary: The study investigated the association between parental and siblings' sugar-sweetened beverage (SSB) intake and children's SSB consumption, with a focus on potential sex differences in these associations. The results showed that parental SSB consumption was relevant to children's SSB intake, with a stronger influence in boys than girls. Fathers seemed to have a greater impact on children's SSB consumption than mothers. Additionally, children's SSB intake was prospectively associated with their older siblings' SSB consumption.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Regina Brunauer, Ian G. Xia, Shabistan N. Asrar, Lindsay A. Dawson, Connor P. Dolan, Ken Muneoka
Summary: The study revealed for the first time how aging affects epimorphic regeneration in mammals, showing that aging exacerbates tissue histolysis, delays wound closure, impairs blastema differentiation, and hinders skeletal regrowth. Aging does not limit stem cell availability in the blastema but reduces osteoblast-dependent bone formation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Developmental Biology
Ling Yu, Yu-Lieh Lin, Mingquan Yan, Tao Li, Emily Y. Wu, Katherine Zimmel, Osama Qureshi, Alyssa Falck, Kirby M. Sherman, Shannon S. Huggins, Daniel Osorio Hurtado, Larry J. Suva, Dana Gaddy, James Cai, Regina Brunauer, Lindsay A. Dawson, Ken Muneoka
Summary: This study identifies fibroblasts as a cell source for engineering articular cartilage and establishes a novel experimental strategy that bridges the gap between regeneration biology and regenerative medicine. The findings show that BMP9 treatment stimulates joint regeneration and induces fibroblast differentiation into hyaline cartilage.
Article
Biotechnology & Applied Microbiology
Dario R. Gomez-Linton, Arturo Navarro-Ocana, Silvestre Alavez, Ricardo Lobato-Ortiz, Angelica Roman-Guerrero, Jose Alberto Mendoza-Espinoza, Juan Manuel Villa-Hernandez, Laura J. Perez-Flores
Summary: Tomato fruit is rich in antioxidants, and the application of digestive enzymes and sonication individually increases carotenoid content and antioxidant activity, while combining them with isopropyl acetate enhances the effects to the maximum level.
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Connor P. Dolan, Felisha Imholt, Tae-Jung Yang, Rihana Bokhari, Joshua Gregory, Mingquan Yan, Osama Qureshi, Katherine Zimmel, Kirby M. Sherman, Alyssa Falck, Ling Yu, Eric Leininger, Regina Brunauer, Larry J. Suva, Dana Gaddy, Lindsay A. Dawson, Ken Muneoka
Summary: Mechanical loading plays a crucial role in mammalian digit tip regeneration, as reducing mechanical loading inhibits blastema formation and diminishes the rate of de novo bone formation. The effects of mechanical unloading on wound healing and regeneration are reversible, highlighting the dependence of bone regenerative response on mechanical load. Enhancing wound healing response in mechanically unloaded digits partially rescues digit tip regeneration, indicating the importance of mechanical load in de novo bone regeneration.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Connor P. Dolan, Tae-Jung Yang, Katherine Zimmel, Felisha Imholt, Osama Qureshi, Alyssa Falck, Joshua Gregory, Macie Mayes, Kayla Ritchie, Hannah Koester, Benjamin Daniel, Mingquan Yan, Ling Yu, Larry J. Suva, Dana Gaddy, Lindsay A. Dawson, Ken Muneoka, Regina Brunauer
Summary: This study found that the regenerative ability of distal mouse digits is limited, with the regeneration progressively attenuated with each regeneration cycle. It was also discovered that when the unamputated digits adjacent to the repeatedly amputated digits were themselves amputated, the new amputations exhibited a similarly attenuated regeneration response, suggesting a systemic component to the amputation injury response.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Developmental Biology
Connor P. Dolan, Felisha Imholt, Mingquan Yan, Tae-Jung Yang, Joshua Gregory, Osama Qureshi, Katherine Zimmel, Kirby M. Sherman, Hannah M. Smith, Alyssa Falck, Eric Leininger, Ling Yu, Regina Brunauer, Larry J. Suva, Dana Gaddy, Lindsay A. Dawson, Ken Muneoka
Summary: It has been long-established that innervation-dependent production of neurotrophic factors is necessary for the regeneration of fish and amphibian appendages. However, it is unclear whether limb denervation in terrestrial vertebrates impairs regeneration through loss of neurotrophic signaling, loss of mechanical load, or both. This study developed a new surgical procedure to specifically denervate individual digits in mice and found that mouse digit tip regeneration is not dependent on peripheral nerves, which challenges the current understanding of mammalian epimorphic regeneration and has implications for regenerative medicine research.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Paulina D. Ketcham, Felisha Imholt, Mingquan Yan, Hannah M. Smith, Shabistan Asrar, Ling Yu, Connor P. Dolan, Osama Qureshi, Yu-Lieh Lin, Ian Xia, Patrick C. Hall, Alyssa R. Falck, Kirby M. Sherman, Dana Gaddy, Larry J. Suva, Ken Muneoka, Regina Brunauer, Lindsay A. Dawson
Summary: Humans and mice have the ability to regenerate the distal digit tip, and this regeneration process can be divided into stages to reduce inter-individual variability. Micro CT scanning can be used to classify the stages of digit regeneration and infer the tissue and cell generation processes involved.
WOUND REPAIR AND REGENERATION
(2022)
Article
Developmental Biology
Yu-Lieh Lin, Ling Yu, Mingquan Yan, Katherine Zimmel, Osama Qureshi, Felisha Imholt, Tao Li, Ivan Ivanov, Regina Brunauer, Lindsay Dawson, Ken Muneoka
Summary: A mouse organoid culture model utilizing BMP2 and BMP9 was developed to regenerate articular cartilage, successfully differentiating clonal cell lines into articular chondrocytes and hypertrophic chondrocyte progenitor cells. By enhancing cell aggregation using BMP2 and inducing chondrogenesis with BMP9, organized layers of articular chondrocytes similar to native cartilage were differentiated and maintained their phenotype after transplantation. Additionally, a connective tissue layer containing chondrocyte progenitor cells demonstrated the coupling of progenitor cell sequestration with articular cartilage differentiation at a clonal level.
Letter
Geriatrics & Gerontology
Carmen Arroyo-Quiroz, Regina Brunauer, Silvestre Alavez
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Chemistry, Medicinal
Dario R. Gomez-Linton, Arturo Navarro-Ocana, Ricardo Lobato-Ortiz, Juan Manuel Villa-Hernandez, Silvestre Alavez, Laura J. Perez-Flores
Summary: Researchers have found that tomato extract can increase the antioxidant and anti-stress abilities of nematodes, as well as extend their lifespan, through the insulin/insulin-like signaling pathway and transcription factors.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
