Review
Pharmacology & Pharmacy
Gisele Nishiguchi, Sourav Das, Jason Ochoada, Heather Long, Richard E. Lee, Zoran Rankovic, Anang A. Shelat
Summary: The quality of lead compounds is crucial for the success of chemical probe and drug discovery programs, especially with high-throughput screening being a dominant lead generation paradigm. This article discusses a strategy implemented a decade ago to build one of the largest compound collections in academia, and a recent multidisciplinary effort aimed at enhancing and expanding the collection.
DRUG DISCOVERY TODAY
(2021)
Article
Cardiac & Cardiovascular Systems
Evangelos K. Oikonomou, David Van Dijk, Helen Parise, Marc A. Suchard, James de Lemos, Charalambos Antoniades, Eric J. Velazquez, Edward J. Miller, Rohan Khera
Summary: The study introduces a novel decision support tool derived from phenomapping to standardize the selection of anatomical vs. functional testing in the evaluation of stable chest pain, validated in two large and geographically diverse clinical trial populations.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rachel A. O'Leary, Julie Burn, Samuel G. Urwin, Andrew J. Sims, Anna Beattie, Alan Bagnall
Summary: The study evaluated the impact of introducing CT fractional flow reserve (FFRCT) on stable chest pain patients, including adherence to NICE guidelines, resource usage, and revascularization. The results showed that the use of CT coronary angiography (CTCA) as the first-line investigation increased after FFRCT adoption, and more patients reached the pathway endpoint after one test. Additionally, there were reductions in stress and rest myocardial perfusion scans, diagnostic-only angiograms, and invasive procedures, leading to decreased inpatient admissions.
Article
Computer Science, Artificial Intelligence
Mailson Ribeiro Santos, Bruno Sielly Jales Costa, Clauber Gomes Bezerra, Goran Andonovski, Luiz Affonso Guedes
Summary: This work proposes an online evolving approach for fault identification of dynamic systems. The approach consists of three stages: pre-processing, processing, and post-processing. The processing stage, which is the central part of the approach, utilizes an online learning evolving algorithm called AutoCloud for clustering different types of faults. The proposed methodology has been validated using data from a real-level control process, demonstrating its adequacy for fault identification of dynamic systems.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Health Care Sciences & Services
Yadu Gautam, Elisabet Johansson, Tesfaye B. Mersha
Summary: This article provides an overview of the current status and development of omics studies in asthma, including genomics, transcriptomics, epigenomics, proteomics, exposomics, and metabolomics. Biomarker discovery through multi-omics profiling can be useful for better phenotyping and subtyping of asthma, ultimately leading to advances in precision medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Ali Seyed Shirkhorshidi, Teh Ying Wah, Seyed Mohammad Reza Shirkhorshidi, Saeed Aghabozorgi
Summary: This article introduces a new perspective in clustering by defining an approach for data pruning and using multiple sets of prototypes to improve clustering accuracy. The evolving fuzzy clustering approach breaks down clustering into epochs and has the ability for postpruning, which eliminates obscure data points to enhance clustering accuracy.
IEEE TRANSACTIONS ON FUZZY SYSTEMS
(2021)
Article
Computer Science, Artificial Intelligence
Huan Wang, Ziwen Cui, Shun Liu, Qiufen Ni, Zhiguo Gong
Summary: Despite the popularity of social network analysis, existing research often overlooks the credibility of observed edges in evolving noisy social networks, leading to erroneous estimates of social properties. To address this issue, we propose a method called MEFM, which evaluates the credibility of observed edges by analyzing their evolutional fluctuations.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Letter
Medicine, General & Internal
Rita Redberg, Diane Jeon
Summary: This article presents the results of a trial conducted ten years ago on coronary computed tomographic angiography, which aimed to evaluate whether this method could shorten emergency department stays more quickly than usual testing. The article also raises a question for discussion regarding the necessity of further diagnostic testing.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Pal Maurovich-Horvat, Maria Bosserdt, Klaus F. Kofoed, Nina Rieckmann, Theodora Benedek, Patrick Donnelly, Jose Rodriguez-Palomares, Andrejs Erglis, Cyril Stechovsk, Gintare Sakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schroder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Inaki Gutierrez-Ibarluzea, Kristian Schultz Hansen, Jacqueline Muller-Nordhorn, Bela Merkely, Andreas D. Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchanek, Laura Zajanckauskiene, Flip Adic, Michael Woinke, Mark Hensey, Inigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Gudrun Feuchtner, Donata Kugrnierz, Mikko Pietila, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Gildo Matta, Michael Fisher, Balint Szilveszter, Linnea Larsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Zsofia D. Drobni, Birgit Jurlander, Ioana Rodean, Susan Regan, Hug Cuellar Calabria, Melinda Boussoussou, Thomas Engstrom, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Marc Dewey
Summary: This study compared the effectiveness of CT and ICA in diagnosing obstructive CAD. The results showed that among patients with stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar between the CT group and the ICA group. However, the frequency of major procedure-related complications was lower in the CT group.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sangjoon Park, Gwanghyun Kim, Yujin Oh, Joon Beom Seo, Sang Min Lee, Jin Hwan Kim, Sungjun Moon, Jae-Kwang Lim, Chang Min Park, Jong Chul Ye
Summary: In this study, a framework called DISTL is proposed to improve the performance of vision transformer through self-supervision and self-training. The DISTL model shows gradually improved performance in diagnosing tuberculosis, pneumothorax, and COVID-19, even better than fully supervised models with the same amount of labeled data. The model obtained with DISTL is also shown to be robust to real-world nuisances, making it more applicable in a clinical setting.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Jia Zhou, Chunjie Li, Hongliang Cong, Lixiong Duan, Hao Wang, Chengjian Wang, Yahang Tan, Yujie Liu, Ying Zhang, Xiujun Zhou, Hong Zhang, Xing Wang, Yanhe Ma, Junjie Yang, Yundai Chen, Zhigang Guo
Summary: This study aimed to compare different investigation strategies to defer cardiac testing in patients with stable chest pain. The results showed that the strategy of combining coronary artery calcium score (CACS) with clinical risk features had stronger associations and better diagnostic accuracy compared to other strategies.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Kristian Taekker Madsen, Karsten Tange Veien, Pia Larsen, Majed Husain, Lone Deibjerg, Anders Junker, Martin Weber Kusk, Kristian Korsgaard Thomsen, Allan Rohold, Lisette Okkels Jensen, Niels Peter Ronnow Sand
Summary: This study aimed to evaluate the association between CCTA-derived FFRCT and recurrent chest pain in patients with SAP. The results showed that an abnormal FFRCT test result was associated with an increased risk of recurrent chest pain, independent of coronary calcification and stenosis. Additionally, a negative association between per-patient minimal d-FFRCT and recurrent chest pain was demonstrated, highlighting the importance of FFRCT testing in predicting long-term outcomes for patients with SAP.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Thermodynamics
Bodin Singpai, Desheng Dash Wu
Summary: This study used an integrative approach to analyze the causes of changes in energy consumption and CO2 emissions in countries involved in the Belt and Road Initiative, identifying labor market, demographic change, and economic situation as main drivers. Higher-income countries perform better in energy and economic efficiencies, but should focus on manufacturing.
Article
Chemistry, Inorganic & Nuclear
Xiaojian Zhang, Chao Feng, Zeyu Fan, Beibei Zhang, Yequan Xiao, Andraz Mavric, Nadiia Pastukhova, Matjaz Valant, Yi-Fan Han, Yanbo Li
Summary: By suppressing competitive reactions and precipitating alkaline-earth metal ions through an alkaline treatment of seawater, a self-healing catalyst for oxygen evolution reaction (OER) has been demonstrated. The self-healing catalyst showed stable seawater oxidation under highly-alkaline conditions, paving the way for large-scale seawater electrolysis.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Marine & Freshwater Biology
Koushik Saha, Prasanta Sanyal, Swarnadip Saha
Summary: Recent increases in sea level pose a major threat to coastal wetland ecosystems and their biodiversity. Changes in salinity conditions due to rising sea levels adversely affect vegetation communities and organic carbon content. The contribution of organic sources to salt marsh sediments is impacted by salinity, with vegetation contribution decreasing and tidal/marine water derived particulate organic matter (POM) contribution increasing as salinity increases. Salinity is the main determining factor for both marshland vegetation development and their contribution to organic carbon.
ESTUARINE COASTAL AND SHELF SCIENCE
(2022)
