Article
Mathematical & Computational Biology
Qian Luo, Weixiang Liu, Lili Jin, Chunqi Chang, Ziwen Peng
Summary: The study compared the ability of Pearson correlation, partial correlation, and distance correlation methods to distinguish between OCD patients and healthy controls. The results showed that distance correlation was the most effective, identifying promising biomarkers of OCD in the brain regions. Distance correlation can discover both linear and non-linear dependencies, making it a valuable tool for OCD research.
FRONTIERS IN NEUROINFORMATICS
(2021)
Review
Clinical Neurology
Amy L. Dostal, Pamela D. Pilkington
Summary: This study conducted a systematic review and meta-analysis to examine the relationships between early maladaptive schemas (EMSs) and obsessive-compulsive disorder (OCD). The findings indicated a positive correlation between all EMSs and OCD, with the largest associations found for the dependence/incompetence, vulnerability to harm or illness, and negativity/pessimism schemas.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Keitaro Murayama, Hirofumi Tomiyama, Sae Tsuruta, Aikana Ohono, Mingi Kang, Suguru Hasuzawa, Taro Mizobe, Kenta Kato, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao
Summary: In patients with OCD, increased functional connectivity between the right lobule VI and the left precuneus was found compared to healthy controls, but this connectivity was not correlated with the severity of OCD symptoms. This suggests that altered functional connectivity between the cerebellum and DMN may contribute to changes in large-scale brain networks associated with OCD traits.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Clinical Neurology
Valerie La Buissonniere-Ariza, Kate Fitzgerald, Avner Meoded, Laurel L. Williams, Gary Liu, Wayne K. Goodman, Eric A. Storch
Summary: The systematic review of functional MRI studies in youths with negative valence disorders suggests that variations in neural functioning may impact response to CBT. However, the overall weak to moderate quality and limited number of studies, as well as the heterogeneity in study designs and results, considerably restrict the conclusions that can be drawn from this literature.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Maral Melkonian, Sarah McDonald, Amelia Scott, Eyal Karin, Blake F. Dear, Bethany M. Wootton
Summary: Obsessive-compulsive disorder (OCD) is a chronic and unremitting condition with low rates of symptom improvement and spontaneous remission in the absence of treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Jianping Yu, Ping Zhou, Shiting Yuan, Yun Wu, Chun Wang, Ning Zhang, Chiang-Shan R. Li, Na Liu
Summary: This study utilized meta-analysis and connectivity modeling to investigate the neural circuits of OCD patients during symptom provocation, revealing different activation patterns in various brain regions and highlighting potentially distinct neural circuits that may underlie the symptoms and etiological subtypes of OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Goi Khia Eng, Katherine A. Collins, Carina Brown, Molly Ludlow, Russell H. Tobe, Dan Iosifescu, Emily R. Stern
Summary: Patients with OCD exhibit abnormality in their internal sensation perception and altered functioning of the insula, and these differences are associated with the connectivity of the insula. The study found that OCD patients showed a three-component solution in their interoceptive sensibility, compared to the two-component solution in controls. Furthermore, the study identified specific network connections in the insula that could be targeted for modulation of interoceptive sensibility in OCD.
Article
Psychology, Multidisciplinary
Silvia Fornaro, Antonino Vallesi
Summary: Obsessive-compulsive disorder (OCD) is associated with cognitive abnormalities in executive processes. Neuroimaging studies have shown functional abnormalities in the executive fronto-parietal network (FPN), default-mode network (DMN), and prefrontal cortex (PFC) in OCD patients. This systematic review found reduced DMN functional connectivity, increased FPN intra-network connectivity, and hyper-connectivity of right-sided prefrontal links in OCD patients. These findings may represent endophenotypes reflecting computational impairments and difficulties in self-referential processes and cognitive control.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Yinhuan Xu, Shaoqiang Han, Yarui Wei, Ruiping Zheng, Jingliang Cheng, Yan Zhang
Summary: This study reveals the characteristics of abnormal brain connectivity in patients with obsessive-compulsive disorder (OCD) and identifies different connectivity patterns within multiple brain networks through a large sample comparison. The results show a dysregulation among the default mode, salience, frontoparietal, and cerebellum networks, highlighting the importance of these four networks in top-down control for goal-directed behavior.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Louise Destree, Mary-Ellen E. Brierley, Lucy Albertella, Laura Jobson, Leonardo F. Fontenelle
Summary: This study conducted a systematic review on the relationships between childhood trauma and obsessive-compulsive symptoms (OCS) severity. The results showed a significant relationship between exposure to childhood trauma and OCS severity in both clinical and non-clinical populations. It was also found that a range of childhood trauma types, rather than a single type, was associated with OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Behavioral Sciences
Jian-Dong Ma, Chang-Hong Wang, Ping Huang, Xunan Wang, Li-Jing Shi, Heng-Fen Li, De-En Sang, Shao-Jie Kou, Zhi-Rong Li, Hong-Zeng Zhao, Hong-Kai Lian, Xian-Zhang Hu
Summary: Cognitive-coping therapy (CCT) has been shown to be effective in treating OCD and altering resting-state brain function. Patients in CCT and pCCT groups demonstrated significant reduction in Y-BOCS scores, while the pharmacotherapy group did not show significant improvement. Changes in ALFF were correlated with the reduction in Y-BOCS scores.
BRAIN AND BEHAVIOR
(2021)
Review
Clinical Neurology
Sophie M. D. D. Fitzsimmons, Ysbrand D. van der Werf, A. Dilene van Campen, Martijn Arns, Alexander T. Sack, Adriaan W. Hoogendoorn, Odile A. van den Heuvel
Summary: This study evaluated the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) for obsessive-compulsive disorder (OCD) and ranked the relative efficacy of different stimulation protocols. The results showed that rTMS is effective for OCD compared to sham stimulation. Different stimulation protocols, such as low frequency right dorsolateral prefrontal cortex (dlPFC) stimulation, high frequency bilateral dlPFC stimulation, and low frequency pre-supplementary motor area (preSMA) stimulation, were all found to be efficacious. However, further studies are needed to explore the relative merits of these protocols.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Behavioral Sciences
Weijie Bao, Yingxue Gao, Lingxiao Cao, Hailong Li, Jing Liu, Kaili Liang, Xinyue Hu, Lianqing Zhang, Xinyu Hu, Qiyong Gong, Xiaoqi Huang
Summary: Studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit decreased functional connectivity within the default mode network (DMN) and between the affective network (AN) and DMN, while hyperconnectivity between the affective network and somatomotor network (SMN), and between the DMN and SMN is specifically related to PTSD. These results emphasize the impact of trauma on alterations in intrinsic brain networks and highlight disease-associated network changes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Mariela Rance, Zhiying Zhao, Brian Zaboski, Stephen A. Kichuk, Emma Romaker, William N. Koller, Christopher Walsh, Cheyenne Harris-Starling, Suzanne Wasylink, Thomas Adams Jr, Patricia Gruner, Christopher Pittenger, Michelle Hampson
Summary: This study aimed to use fMRI neurofeedback as a treatment for OCD. The results showed that neurofeedback targeting the aPFC can reduce symptoms in OCD, but did not significantly affect control over the aPFC. Future studies should optimize the training protocol and clarify the mechanism of action.
PSYCHIATRY RESEARCH
(2023)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Psychiatry
Hengyi Cao, Xia Wei, Wenjing Zhang, Yuan Xiao, Jiaxin Zeng, John A. Sweeney, Qiyong Gong, Su Lui
Summary: This study provides an in-depth characterization of cerebellar dysconnectivity in early schizophrenia, revealing a common bidirectional dysconnectivity pattern that may be related to genetic factors.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Xin Xu, Xue Li, Xu Qi, Xi Jiang, Haoyang Xing, Xiaoqi Huang, Qiyong Gong
Summary: Resting-state functional magnetic resonance imaging (RS-FMRI) was used to evaluate the effects of intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS) on intrinsic brain activity in the precuneus. The results showed that iTBS decreased functional connectivity in the bilateral precuneus, while cTBS decreased functional connectivity in the bilateral insula and increased it in the thalamus.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Xiaoyi Sun, Jinrong Sun, Xiaowen Lu, Qiangli Dong, Liang Zhang, Wenxu Wang, Jin Liu, Qing Ma, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia
Summary: Major depressive disorder is a highly heterogeneous disorder with two reproducible neurophysiological subtypes identified in the study, showing severe and moderate deviation patterns in functional connectivity. These subtypes have predictive value for antidepressant treatment outcomes.
BIOLOGICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Xipeng Long, Lei Li, Xiuli Wang, Yuan Cao, Baolin Wu, Neil Roberts, Qiyong Gong, Graham J. Kemp, Zhiyun Jia
Summary: This study conducted a comprehensive meta-analysis of gray matter volume alterations in adolescents with major depressive disorder and bipolar disorder. The findings suggest that distinct patterns of GMV alterations in these two populations could aid in differentiation and provide potential diagnostic biomarkers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Multidisciplinary
Yuxin Zhang, Jie Zhou, Xiaoting Chen, Zhiqian Li, Lei Gu, Dayi Pan, Xiuli Zheng, Qianfeng Zhang, Rongjun Chen, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: Interaction between carcinoma-associated fibroblasts (CAFs) and tumor cells promotes breast cancer invasion and metastasis. A redox-responsive chondroitin sulfate (CS)-based nanomedicine was developed, containing hydrophobic cabazitaxel (CTX) conjugated to CS backbone via glutathione (GSH)-sensitive dithio-maleimide (DTM) to form an amphipathic CS-DTM-CTX (CDC) conjugate. Dasatinib (DAS) was co-assembled with the CDC conjugate to obtain DAS@CDC. The nanomedicine could reverse CAFs to normal fibroblasts, block their crosstalk with tumor cells, inhibit tumor extracellular matrix protein synthesis, and effectively suppress tumor proliferation and metastasis, demonstrating a synergistic therapy effect against breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Psychology, Clinical
Lekai Luo, Lizhou Chen, Yuxia Wang, Qian Li, Ning He, Yuanyuan Li, Wanfang You, Yaxuan Wang, Fenghua Long, Lanting Guo, Kui Luo, John A. Sweeney, Qiyong Gong, Fei Li
Summary: This study uses sparse canonical correlation analysis to identify four distinct patterns of dynamic functional brain activity associated with attention-deficit/hyperactivity disorder (ADHD). It also finds that cognitive deficits mediate the relationship between brain dynamics and ADHD-related behaviors. These findings provide important insights into the behavioral and cognitive features of ADHD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Huifang Xu, Tongtong Li, Qiyong Gong, Haizhen Xu, Yongbo Hu, Wenqi Lue, Xin Yang, Jin Li, Wenming Xu, Weihong Kuang
Summary: This study investigated the potential role of genetic mutations in the retrograde endocannabinoid (eCB) pathway in Han Chinese patients with major depressive disorder (MDD). Whole-exome sequencing was performed and 146 depression-related mutations were identified, with 37 of them enriched in the eCB pathway. Seven hub genes in the eCB pathway were found to be closely related to mitochondrial function. These results suggest that genetic mutations in the eCB pathway may contribute to the pathogenesis of MDD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Engineering, Biomedical
Zaixiang Fang, Ling Lin, Zhiqian Li, Lei Gua, Dayi Pan, Yunkun Li, Jie Chen, Haitao Ding, Xiaohe Tian, Qiyong Gong, Kui Luo
Summary: This study utilized nanotechnology to co-deliver chemotherapeutic drugs and photosensitizers using heparin as a carrier for synergistic cancer therapy, enhancing the efficacy of combination therapy. The co-assembled HP-PP nanoparticles significantly increased the stability and photostability of the drugs, resulting in enhanced cytotoxicity and a remarkable synergistic antitumor effect.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yunkun Li, Yahui Wu, Zaixiang Fang, Yuxin Zhang, Haitao Ding, Long Ren, Lu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: This study develops a target ligand-modified dendritic nanomedicine for tumor chemo-immunotherapy. The nanomedicine promotes cellular internalization, penetration, and drug release. It triggers immune response and remodels the tumor immune microenvironment, resulting in enhanced therapeutic effect.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhengxiang Gu, Yechuan Zhang, Xuelian Wei, Zhenyu Duan, Qiyong Gong, Kui Luo
Summary: In this study, copper-doped cobalt selenide nanosheets with selenium vacancies were developed as a robust and efficient electrocatalyst for the reduction of nitrate to ammonia. The introduction of Cu dopants and Se vacancies enhanced the electron transfer and led to the formation of electron-deficient Cu sites, accelerating the dissociation of NO3- and stabilizing the *NO2 intermediates, ultimately achieving selective catalysis in the entire NO3RR process.
ADVANCED MATERIALS
(2023)
Article
Psychiatry
Xiqin Liu, Yajun Zhao, Xueling Suo, Xun Zhang, Nanfang Pan, Graham J. J. Kemp, Qiyong Gong, Song Wang
Summary: This study aimed to identify functional brain markers of COVID-specific vicarious traumatization (VT) and explore the psychological mechanism underlying the brain-VT link. The results revealed that VT was negatively correlated with functional connectivity density (FCD) in the right inferior temporal gyrus (ITG), and psychological resilience mediated the associations of ITG FCD and ITG-default mode network (DMN) functional connectivity with VT. This study provides new evidence on the brain basis of VT and underscores the importance of psychological resilience in the brain-VT relationship.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Wenjing Zhang, Naici Liu, Youjin Zhao, Chenyang Yao, Dan Yang, Chengmin Yang, Hui Sun, Xia Wei, John A. Sweeney, Huilou Liang, Miaoqi Zhang, Qiyong Gong, Su Lui
Summary: Repetitive transcranial magnetic stimulation (rTMS) is increasingly used to treat neuropsychiatric disorders. However, the exact mechanism of action remains unclear. In this study, the impact of inhibitory and excitatory rTMS on laminar diffusion profiles of neocortex was investigated. Different patterns of changes were observed, with increased fractional anisotropy (FA) in inhibitory rTMS and decreased FA in excitatory rTMS. Laminar analysis revealed the specific effects of rTMS on different cortical layers. These findings provide novel insights into the acute neurobiological effects of rTMS and its potential applications.
Article
Neurosciences
Simin Zhang, Xibiao Yang, Qiaoyue Tan, Huaiqiang Sun, Di Chen, Yinying Chen, Hongjing Zhang, Yuan Yang, Qiyong Gong, Qiang Yue
Summary: This study investigated the changes in whole-brain cortical myelin and thickness induced by diffuse midline glioma and found significant differences among different groups. Additionally, a short-term survival prediction model was constructed using cortical features and tumor radiomics, which showed high accuracy in predicting patient survival.
Article
Biochemistry & Molecular Biology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: This study demonstrates the successful synthesis of branched polymer contrast agents with high kinetic stability and T-1 relaxivity by introducing rigid carbon chains and PEG into the structure of Gd-DOTA backbone-bound branched polymers.
Review
Chemistry, Multidisciplinary
Xiuli Zheng, Xiaohai Song, Guonian Zhu, Dayi Pan, Haonan Li, Jiankun Hu, Kai Xiao, Qiyong Gong, Zhongwei Gu, Kui Luo, Weimin Li
Summary: Lung cancer, the second most prevalent cancer and the leading cause of cancer-related death, is often accompanied by drug resistance. Nanomedicine, with its multifunctional and tunable physiochemical properties, holds great promise in overcoming drug resistance in lung cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)
