Cobicistat versus ritonavir boosting and differences in the drug–drug interaction profiles with co-medications

An unexpected interaction between warfarin and cobicistat-boosted elvitegravir

(2015) Brittany L. Good et al.   AIDS

Twenty years of boosting antiretroviral agents

(2015) Marta Boffito et al.   AIDS

Brief Report

(2015) Joel E. Gallant et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Pharmacokinetics of darunavir in fixed-dose combination with cobicistat compared with coadministration of darunavir and ritonavir as single agents in healthy volunteers

(2014) Thomas N. Kakuda et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat

(2014) Eve-Irene Lepist et al.   KIDNEY INTERNATIONAL

Structure–activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350)

(2013) Lianhong Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340,In Vitro

(2012) Eve-Irene Lepist et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oral Anticoagulant Therapy

(2012) Walter Ageno et al.   CHEST

Effect of Cobicistat on Glomerular Filtration Rate in Subjects With Normal and Impaired Renal Function

(2012) Polina German et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Phase 2 study of cobicistat versus ritonavir each with once-daily atazanavir and fixed-dose emtricitabine/tenofovir df in the initial treatment of HIV infection

(2011) Richard Elion et al.   AIDS

Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

(2011) B. J. Kirby et al.   DRUG METABOLISM AND DISPOSITION

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Pharmacokinetics and Bioavailability of an Integrase and Novel Pharmacoenhancer-Containing Single-Tablet Fixed-Dose Combination Regimen for the Treatment of HIV

(2010) Polina German et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Dose-Related Reduction in Bupropion Plasma Concentrations by Ritonavir

(2010) Joohyun Park et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer

(2010) Lianhong Xu et al.   ACS Medicinal Chemistry Letters

Pharmacokinetics and Pharmacodynamics of GS-9350: A Novel Pharmacokinetic Enhancer Without Anti-HIV Activity

(2009) A A Mathias et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS