Article
Medicine, General & Internal
Fan Yang, Chaofan Lu, Huilan Liu, Lei Dou, Yanhong Wang, Hongbin Li, Xinwang Duan, Lijun Wu, Yongfu Wang, Xiuying Zhang, Jian Xu, Jinmei Su, Dong Xu, Jiuliang Zhao, Qingjun Wu, Mengtao Li, Xiaomei Leng, Xiaofeng Zeng
Summary: Enthesitis is common in Chinese patients with PsA, and it is important to evaluate both peripheral and axial sites. Compared with other cohorts, Chinese patients with enthesitis tend to be younger, have a lower body mass index, a higher rate of positive HLA-B27, more frequent dactylitis, and a higher proportion of csDMARDs use.
CHINESE MEDICAL JOURNAL
(2023)
Article
Rheumatology
Tariq Aslam, Farrouq Mahmood, Anetha Sabanathan, Robin Waxman, Philip S. Helliwell
Summary: This study compared the clinical and radiographic phenotypes of PsA patients of South Asian and North European origin, finding that South Asian patients tended to have more severe disease and worse impact on their quality of life compared to North European patients.
Review
Immunology
Theo Wirth, Nathalie Balandraud, Laurent Boyer, Pierre Lafforgue, Thao Pham
Summary: PsA diagnosis and treatment is often delayed, resulting in joint damage and disability. Research has identified potential biomarkers to improve PsA diagnosis and prognosis, but further studies are needed to evaluate their performance.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hannah A. Blair
Summary: Secukinumab is an effective treatment for PsA across all key domains, with low rates of adverse effects and sustained long-term efficacy. It is a useful alternative to TNFi and other bDMARDs for adult patients with active PsA.
Review
Polymer Science
Quinten Thijssen, Joseph Toombs, Chi Chung Li, Hayden Taylor, Sandra Van Vlieberghe
Summary: This review comprehensively discusses the potential of volumetric 3D-printing, summarizing the theoretical framework of photopolymerization and highlighting the advancements in light-based 3D-printing techniques. Special attention is given to the subfield of volumetric bioprinting. The review provides important discussions and prospects for those interested in the field of volumetric 3D-printing.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Rheumatology
Milena L. Pachowsky, Maria Gabriella Raimondo, Cong Xu, Simon Rauber, Koray Tascilar, Hannah Labinsky, Mario Vogg, Mina Saad Aziz Saad, David Simon, Juergen Rech, Alina Soare, Lars Braeuer, Arnd Kleyer, Georg Schett, Andreas Ramming
Summary: A minimally invasive biopsy technique was established to retrieve entheseal tissue in patients with psoriatic arthritis. Label-free second harmonic generation microscopy was used to analyze the biopsies, which showed high fraction of entheseal tissue and immune cell infiltration. The technique provides a reliable way to study entheseal tissue in psoriatic arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Chemistry, Multidisciplinary
Francesca Lorandi, Marco Fantin, Krzysztof Matyjaszewski
Summary: This article highlights the significance of atom transfer radical polymerization (ATRP) in polymer chemistry and the latest advances in catalyst and reaction conditions design. The critical role of mechanistic studies in understanding and predicting polymerization outcomes is emphasized.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Rheumatology
Gianluca Smerilli, Andrea Di Matteo, Edoardo Cipolletta, Walter Grassi, Emilio Filippucci
Summary: This review provides an overview of using ultrasound in studying enthesitis in psoriatic arthritis, emphasizing its ability to detect subtle abnormalities and potential to be a first-line method for assessment. Discussions include definitions, scoring systems, and applications in detecting enthesitis, identifying disease subsets, and assessing treatment response.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Review
Medicine, General & Internal
Stephen R. Pennington, Oliver FitzGerald
Summary: Although having skin/nail psoriasis is an important risk factor for developing psoriatic arthritis (PsA), it alone is not sufficient to identify which patients with psoriasis will develop PsA. Further molecular assessment of psoriasis patients may help refine the profile of those at risk of developing PsA, leading to the design of disease prevention studies and new treatment approaches.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Ylenia Ingrasciotta, Valentina Isgro, Valentina Ientile, Michele Tari, Gianluca Trifiro, Claudio Guarneri
Summary: A potential undertreatment of PsO (much less for PsA) in an LHU from Southern Italy, with a particularly low use of more recently marketed drugs, such as biological ones, was shown.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Catarina Tenazinha, Rita Barros, Joao Eurico Fonseca, Elsa Vieira-Sousa
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease with a complex pathogenesis. It shares common features of chronic inflammation with rheumatoid arthritis (RA), such as lining hyperplasia, sublining influx of inflammatory cells, and neoangiogenesis. Recognition of disease-specific histopathologic findings can aid in diagnosis and identification of therapeutic targets.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Paras Karmacharya, Kerry Wright, Sara J. Achenbach, Cynthia S. Crowson, Alexis Ogdie, Delamo Bekele, Ali Duarte-Garcia, Floranne C. Ernste, Megha M. Tollefson, John M. Davis
Summary: This population-based study found that approximately 60% of patients developed psoriatic arthritis (PsA) after having psoriasis. Patients who had psoriasis prior to PsA were more likely to have a longer time interval between the two conditions.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Enrico De Lorenzis, Gerlando Natalello, David Simon, Georg Schett, Maria Antonietta D'Agostino
Summary: Pain is the main symptom in entheseal diseases. Eicosanoids, cytokines, and neuropeptides released during inflammation and mechanical challenge stimulate nerves and blood vessels to invade the enthesis. Nociceptive pseudounipolar neurons support this process by releasing neurotransmitters that induce neovascularization and sensitization, which may explain the dissociation between pain and imaging findings.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Simon Krabbe, Thomas Renson, Lennart Jans, Dirk Elewaut, Filip Van den Bosch, Philippe Carron, Mikkel Ostergaard
Summary: The study aims to investigate the reliability, validity, and sensitivity to change of a novel MRI scoring system in early peripheral SpA (pSpA). Results showed that the proposed MRI lower-extremity inflammation index demonstrated good reliability, validity, and sensitivity to change in patients with early pSpA, and was correlated with other measures of disease activity.
Article
Rheumatology
Desiree van der Heijde, Atul Deodhar, Xenofon Baraliakos, Matthew A. Brown, Hiroaki Dobashi, Maxime Dougados, Dirk Elewaut, Alicia M. Ellis, Carmen Fleurinck, Karl Gaffney, Lianne S. Gensler, Nigil Haroon, Marina Magrey, Walter P. Maksymowych, Alexander Marten, Ute Massow, Marga Oortgiesen, Denis Poddubnyy, Martin Rudwaleit, Julie Shepherd-Smith, Tetsuya Tomita, Filip van den Bosch, Thomas Vaux, Huji Xu
Summary: The BE MOBILE 1 and BE MOBILE 2 trials demonstrated that bimekizumab, a dual IL-17A and IL-17F inhibitor, improved efficacy outcomes in patients with axial spondyloarthritis (axSpA) and was well tolerated. These findings support the use of bimekizumab as a potential treatment option for axSpA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Engineering, Biomedical
Roman V. V. Chernozem, Igor Pariy, Maria A. A. Surmeneva, Vladimir V. V. Shvartsman, Guillaume Planckaert, Joost Verduijn, Stef Ghysels, Anatolii Abalymov, Bogdan V. V. Parakhonskiy, Eric Gracey, Amanda Goncalves, Sanjay Mathur, Frederik Ronsse, Diederik Depla, Doru C. C. Lupascu, Dirk Elewaut, Roman A. A. Surmenev, Andre G. G. Skirtach
Summary: This study comprehensively examines the effects of biodegradation on the properties of poly(3-hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO). The addition of 1.0 wt% rGO does not affect the enzymatic biodegradation rate of PHB scaffolds for 30 days. Biodegradation leads to depolymerization of the amorphous phase and an increase in crystallinity. The PHB-0.7rGO fibers exhibit the strongest piezoresponse, making them promising for tissue-engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Rheumatology
Merlijn H. Kaaij, Jan Piet van Hamburg, Charlotte C. N. van Rooijen, Anika Grueneboom, Yik Y. Kan, Desiree Pots, Georg Schett, Leo J. van Ruijven, Leonie M. van Duivenvoorde, Leonie F. A. Huitema, Dominique L. P. Baeten, Sander W. Tas
Summary: This study found that the increase of type H vessels in a transgenic mouse model is closely related to pathologic osteogenesis. This finding provides new insights into the pathophysiology of ankylosing spondylitis and may offer a novel target for intervention.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Larissa Valor-Mendez, Armin Atzinger, Petra Reis, Bernhard Manger, Georg Schett
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anton De Spiegeleer, Amelie Descamps, Srinath Govindarajan, Julie Coudenys, Kevin van der Borght, Hannah Hirmz, Nele van den Noortgate, Dirk Elewaut, Bart De Spiegeleer, Evelien Wynendaele
Summary: This study discovered the potential of quorum-sensing peptides to modulate the immune system in microbiome-host interactions. Through screening 89 peptides, four of them were found to activate immune cells in vitro, and one of them was detected in human plasma. These findings are biologically significant and reveal the immunomodulatory potential of quorum-sensing peptides.
Article
Rheumatology
David Simon, Ioanna Minopoulou, Stephan Kemenes, Sara Bayat, Koray Tascilar, Melek Yalcin Mutlu, Larissa Valor-Mendez, Gerhard Kroenke, Axel J. Hueber, Georg Schett, Arnd Kleyer
Summary: Objective. This study aimed to evaluate the effect of Janus kinase inhibition (JAKi) through baricitinib (BARI) on bone properties and synovial inflammation in rheumatoid arthritis (RA) patients. Results showed that BARI therapy significantly improved disease activity, synovial inflammation, and bone mass of RA patients, with no new safety signals observed.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Xiang Zhou, Thuong Trinh-Minh, Alexandru-Emil Matei, Andrea-Hermina Gyoerfi, Xuezhi Hong, Christina Bergmann, Georg Schett, John Atkinson, Rowann Bowcutt, Jessal Patel, Timothy S. Johnson, Joerg H. W. Distler
Summary: In this study, increased expression and activity of TG2 were observed in systemic sclerosis (SSc) patients. Inhibition of TG2 in dermal fibroblasts resulted in reduced fibrosis, suggesting that targeting TG2 may be a potential antifibrotic approach in SSc.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Manouk de Hooge, Alla Ishchenko, Ann-Sophie De Craemer, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Kurt de Vlam, Filip van den Bosch
Summary: This study aimed to examine radiographic axial damage of the sacroiliac joints and spine in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA) in private and academic Belgian practices. The data comparison between the two patient groups found that patients with SpA tend to have more severe spinal damage compared to those with PsA. In patients with PsA, the cervical spine is more often affected, while in patients with SpA, the location of syndesmophytes is more evenly distributed.
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Georg Schett, Warner Chen, Sheng Gao, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Miriam Zimmermann, Mohamed Sharaf, Laura C. Coates, Stefan Siebert
Summary: In the COSMOS trial, guselkumab demonstrated efficacy in treating TNFi-IR PsA patients by reducing levels of effector cytokines associated with the IL-23/IL-17 pathway.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Sophie von Rohr, Johannes Knitza, Manuel Grahammer, Marc Schmalzing, Sebastian Kuhn, Georg Schett, Andreas Ramming, Hannah Labinsky
Summary: The study aimed to investigate the use of student-led clinics and electronic patient-reported outcomes (ePROs) for the diagnosis and treatment of patients with axial spondyloarthritis (axSpA). The results showed that student-led clinics significantly accelerated patient appointments and NSAID therapy start, and completed the diagnostic workup for all patients. The electronic and paper-administered BASDAI questionnaires showed good correlation. Both student-led clinics and ePRO monitoring were well accepted by patients.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Immunology
Koen Venken, Tine Decruy, Tim Sparwasser, Dirk Elewaut
Summary: Regulatory T cells (Tregs) and invariant natural killer T (iNKT) cells play a crucial role in controlling autoimmune diseases. The study reveals that Treg depletion enhances iNKT cell responses and leads to severe liver and gut pathology in preclinical models of autoimmunity.
Article
Rheumatology
Hannah Labinsky, Latika Gupta, Maria Gabriella Raimondo, Georg Schett, Johannes Knitza
Summary: Mobile health applications and digital therapeutics aim to improve patient care, but real-world data on their efficacy is scarce. This study evaluated the adherence, acceptance, and efficacy of digital therapeutics in a rheumatology setting. Results showed high acceptance of digital therapeutics in rheumatic disease patients, but challenges in onboarding and adherence were observed. A subgroup of patients using exercise-based digital therapeutics reported symptom improvement.
RHEUMATOLOGY INTERNATIONAL
(2023)