Article
Chemistry, Organic
Cong Shen, Yuhang Zhu, Wenzhou Shen, Shuqi Jin, Guofu Zhong, Shuxin Luo, Lixia Xu, Liangjun Zhong, Jian Zhang
Summary: An efficient method for the preparation of aryl 1,3-dienes from styrenes and olefins has been developed, utilizing a transient chiral auxiliary derived from aldehydes. The generality of this protocol was demonstrated by the smooth conversion of various 2-vinyl benzaldehyde derivatives, resulting in high yields and excellent enantioselectivities. The derived axially chiral carboxylic acid was found to be a more efficient ligand in the Cp*Co(iii)-catalyzed asymmetric C(sp(3))-H alkylation.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Bing Zhou, Chen-Xi Ye, Eric Meggers
Summary: N-Boc-protected alpha-amino acids can be synthesized in two steps using linear or branched carboxylic acid feedstocks. The first step involves coupling the carboxylic acid with tert-butyl aminocarbonate (BocNHOH) to generate an azanyl ester (acyloxycarbamate) RCO(2)NHBoc. In the second step, this azanyl ester undergoes a stereocontrolled iron-catalyzed 1,3-nitrogen migration to generate the N-Boc-protected non-racemic alpha-amino acid. This method is versatile and allows for the synthesis of alpha-monosubstituted alpha-amino acids with different side chains, as well as alpha,alpha-disubstituted alpha-amino acids and alpha-deuterated alpha-amino acids.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Ryan A. Kozlowski, Hanh T. Nguyen, Michael E. Lehman, Christopher D. Vanderwal
Summary: The esters of salicylic acid derivatives can undergo Birch reduction and diastereoselective alkylations to form methoxycyclohexadienes with new quaternary stereogenic centers. The use of ester-based auxiliaries is an improvement over prolinol-derived amides, which are expensive and difficult to cleave.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Xiaoping Jin, Li Zhang
Summary: The photoredox-catalysed Giese-type reaction is a useful and powerful platform for radical-based transformations. A novel protocol for the preparation of N-alkylphthalimides has been developed using alkyl silicates or Hantzsch esters as the radical precursors. Deuteration experiments support a proposed mechanism involving radical addition/SET reduction/protonation process. The synthetic application of N-alkylphthalimide has been demonstrated through depotection using the Ing-Manske procedure.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yue Wang, Er-Qing Li, Zheng Duan
Summary: The development of stereodivergent strategies in asymmetric synthesis is crucial for accessing the full range of stereoisomers in products with multiple stereocenters. In this study, a novel P-chirogenic ligand, YuePhos, was developed to achieve precise switching of product stereochemistry in a Pd-catalyzed asymmetric cycloaddition reaction. The method provides an efficient route for the synthesis of pyrrolidines with up to three adjacent stereocenters, with excellent enantiomeric excesses.
Article
Chemistry, Organic
Hong He, Qinhui Wan, Zhong-Wei Hou, Quan Zhou, Lei Wang
Summary: An organoelectrophotocatalytic method for the generation of acyl radicals has been developed to synthesize acylated 3-CF3-2-oxindoles. This method utilizes 9,10-phenanthrenequinone as a catalyst and hydrogen atom transfer reagent, eliminating the need for external reagents and oxidants. A variety of acylated 3-CF3-2-oxindoles have been obtained in satisfactory yields via a tandem radical cyclization.
Article
Chemistry, Organic
Chunhua Ma, Yu Tian, Junyan Wang, Xing He, Yuqin Jiang, Bing Yu
Summary: In this study, a visible-light-driven, transition-metal-free, external-oxidant-free radical-radical cross-coupling reaction was introduced to access N-substituted isonicotinamides via consecutive photoinduced electron transfer (ConPET). The utility of this method was highlighted through the N-terminal modification of peptides and late-stage modification of drugs.
Article
Chemistry, Medicinal
Xuedan Wu, Xinrui Ma, Yaofeng Zhong, Wei Chen, Muyun Xu, He Zhang, Li Wang, Xianshuang Tu, Zhaoguo Han, Weiling Zhao, Zhanhong Wu, Stergios J. Moschos, Zibo Li
Summary: Photoredox radiofluorination is a simple method to synthesize novel tryptophan-based PET agents, which have good uptake in tumor cells, making them a potential tool for precise immunotherapy monitoring.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Jian Liu, Yu Hong, Yin-Ling Liu, Jing-Ying Tan, Hao-Miao Liu, Gang-Liang Dai, Shi-Lu Chen, Ting Liu, Jin-Heng Li, Shi Tang
Summary: A bromoalkane-directed radical 1,4-aryl shift strategy for nickel-catalyzed reductive Heck-type C(sp3)-C(sp2) coupling cascades of alpha-amino-beta-bromocarboxylic acid esters with alpha-trifluoromethyl alkenes is developed. The method enables the synthesis of gem-difluorinated arylalanines by introducing both an aromatic ring and an olefin motif into amino acid backbones through a new radical cascade.
Review
Chemistry, Applied
Hao-Qiang Cao, Jun-Kuan Li, Fa-Guang Zhang, Dominique Cahard, Jun-An Ma
Summary: This review comprehensively summarizes modern synthetic methods towards asymmetric construction of chiral amino carboxylic-phosphonic acid derivatives, including phosphono-containing amino acid derivatives and catalytic enantioselective synthesis as a potent strategy. Topics such as chiral resolution protocols, chiral auxiliary-directed syntheses, and valorization of abundant chiral amino acid resources are also discussed.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Analytical
Datong Wu, Cong Ma, Ting Wan, Pengfen Zhu, Yong Kong
Summary: In this study, an ionic helical polymer with right-or left-handed configuration was prepared and characterized for its structure and absolute handedness. The polymer was found to be effective as an electrochemical enantioselector for chiral electroanalysis, capable of recognizing different configurations of amino acids. This research offers great promise for the synthesis and application of ionic helical polymers with multiple stereogenic centers.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Organic
Eliott Le Du, Julien Borrel, Jerome Waser
Summary: In this study, a copper-catalyzed alkynylation of azadipeptides using ethynylbenziodoxolone (EBX) reagents was reported. Nonsymmetrical ynehydrazides could be obtained in high yields using azaglycine derivatives as nucleophiles. The reaction is compatible with various functional groups naturally occurring on amino acid side chains and allows the transfer of different substituents. The obtained products can be further functionalized.
Editorial Material
Chemistry, Multidisciplinary
Bao-Le Qu, Mao-Mao Zhang, Liang-Qiu Lu, Wen-Jing Xiao
Summary: The study presents an iridium-catalyzed reaction for asymmetric synthesis of Z-allyl esters, allowing for the elegant preparation of important chiral Z-olefins.
Article
Chemistry, Multidisciplinary
Fu-Sheng He, Chun Zhang, Minghui Jiang, Lujun Lou, Jie Wu, Shengqing Ye
Summary: This study develops a photoinduced organocatalytic enantioselective radical reaction, which allows for the efficient synthesis of chiral beta-sulfonyl carbonyl compounds with high yield and excellent enantioselectivity.
Article
Agriculture, Dairy & Animal Science
Rosana C. Maia, Luiz F. T. Albino, Horacio S. Rostagno, Maurilio L. Xavier Junior, Bruna S. Kreuz, Raully L. Silva, Bruno D. Faria, Arele A. Calderano
Summary: The aim of this study was to evaluate the effects of essential-to-total nitrogen ratios supplemented with nonessential amino acids in low-protein diets on the performance, nitrogen retention, and blood parameters of broiler chickens. The results showed that diets with an eN-to-tN ratio of 50% or less were more beneficial in maintaining broiler performance and efficient nitrogen metabolism.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunpeng Chen, Chenxi Ye, Jingwen Chen, Dongming Lin, Hao Wang, Shen Wang
BIOSCIENCE REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Chenhao Zhang, Shuming Chen, Chen-Xi Ye, Klaus Harms, Lilu Zhang, K. N. Houk, Eric Meggers
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Multidisciplinary
Chen-Xi Ye, Shuming Chen, Feng Han, Xiulan Xie, Sergei Ivlev, K. N. Houk, Eric Meggers
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Environmental Sciences
Qi Jinghui, Niu Shuwen, Ye Chenxi, Wang Luojia, Wei Yongna, Wen Yuzhao, Zhao Shuling
Summary: The study found that the spatial development of O2O online retailers in Zhengzhou is characterized by high-value agglomeration, mainly concentrated in the old urban area. Regions with high e-commerce development levels are mainly located in specific areas of the city, and the commercial pattern heavily relies on physical businesses.
CHINESE GEOGRAPHICAL SCIENCE
(2021)
Article
Energy & Fuels
Zhengxu Wang, Qingfeng Guo, Qing Zhao, Hongwei Jiang, Bo Li, Jingtian Zhang, Liping Zhao, Minglei Men, Guowei Wang, Chenxi Ye, Xianwei Qu
Summary: A hybrid technique combining radio frequency heating and injection of conductive medium into hydraulic fractures is proposed in this study. A mathematical model is established to describe the heating process and analyze the factors influencing temperature distribution, which are verified by experiment results.
JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Chenhao Zhang, Anthony Z. Gao, Xin Nie, Chen-Xi Ye, Sergei I. Ivlev, Shuming Chen, Eric Meggers
Summary: This study demonstrates the catalytic deracemization of ketones with alpha-stereocenters in a single reaction through photoredox deprotonation and enantioselective protonation. By utilizing a photoredox catalyst and a tertiary amine, nonracemic carbonyl compounds with up to 97% enantiomeric excess can be obtained. This light-driven strategy provides a blueprint for deracemizations of common carbonyl compounds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Plant Sciences
Erhui Xiong, Chen Zhang, Chenxi Ye, Yaohuang Jiang, Yanli Zhang, Fei Chen, Guojun Dong, Dali Zeng, Yanchun Yu, Limin Wu
Summary: The study identifies a new molecular mechanism of tetrahydrofolate deformylase in the salt response, affecting mitochondrial and chloroplast function by regulating energy metabolism and accumulation of reactive oxygen species.
Article
Chemistry, Physical
Feng Han, Peter H. Choi, Chen-Xi Ye, Yvonne Grell, Xiulan Xie, Sergei I. Ivlev, Shuming Chen, Eric Meggers
Summary: A cyclometalated ruthenium complex with exclusively metal-centered chirality has been developed for the catalytic conversion of diazoketones to chiral flavanones. The reaction exhibits high yields (up to 99%) and high enantioselectivity (up to 96%). The unwanted C-O formation pathway was successfully suppressed in favor of a catalytic enantioselective ring-closing C(sp(3))-H carbene insertion, as supported by density functional theory calculations. This method provides access to a variety of chiral flavanones, which are privileged scaffolds with diverse biological activities.
Article
Chemistry, Multidisciplinary
Xin Nie, Chen-Xi Ye, Sergei I. Ivlev, Eric Meggers
Summary: A new synthetic method for the preparation of non-racemic 5-membered cyclic carbonates from abundant alcohols has been reported. The conversion of the alcohol into an azanyl carbonate, followed by a chiral-at-ruthenium catalyzed cyclization, resulted in chiral cyclic carbonates with yields of up to 95% and enantiomeric excess (ee) of up to 99%. This method involves a nitrene-mediated intramolecular C(sp(3))-H oxygenation, which includes an unusual 1,7-hydrogen atom transfer within a ruthenium nitrene intermediate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nursing
Huafang Zhang, Li Zheng, Mengling Tang, Fanjia Guo, Lili Yang, Suxiang Liu, Jinyun Wang, Jie Chen, Chenxi Ye, Yajun Shi, Sihan Li, Wenfeng Xue, Jie Su
Summary: This study developed a set of evidence-informed strategies to assist older people in improving swallowing functions and preventing further damage from complications. Consensus was reached through online survey and expert consultation, resulting in the formation of strategies divided into five sections.
Review
Chemistry, Multidisciplinary
Chen-Xi Ye, Eric Meggers
Summary: Asymmetric transition metal catalysis is an important tool for synthesizing chiral molecules in an enantioselective manner. This article discusses the design and development of a new class of C2-symmetric chiral-at-ruthenium catalysts, which can exhibit high catalytic activity and excellent stereocontrol in asymmetric nitrene C-H insertion reactions.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Luo Chen, Xiaofang Ruan, Yuncao Fan, Youjin Chen, Chenxi Ye, Zhongying Chen, Zi Lin
Summary: The study showed that high-quality nursing interventions have a significant impact on the psychological emotions, heart function, and nursing satisfaction of patients with acute myocardial infarction complicated with arrhythmia. It can improve symptoms, enhance self-care ability, and increase quality of life for these patients.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Proceedings Paper
Automation & Control Systems
Chenxi Ye, Yiduo Wang, Ziwen Lu, Igor Gilitschenski, Martin Parsley, Simon J. Julier
2020 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS)
(2020)
Article
Energy & Fuels
Jiang Guancheng, He Yinbo, Cui Wuge, Yang Lili, Ye Chenxi
PETROLEUM EXPLORATION AND DEVELOPMENT
(2019)