Article
Immunology
Yaping Chen, Hao Huang, Yuan Li, Wenlu Xiao, Yingting Liu, Rongzhang Chen, Yulan Zhu, Xiao Zheng, Changping Wu, Lujun Chen
Summary: Combination immunotherapy based on immune checkpoint inhibitors (ICIs) has shown great success in cancer treatment, and the combination of ablation and immunotherapy has potential for the treatment of liver metastasis of colorectal cancer (CRC). The expression of TIGIT was up-regulated after microwave ablation (MWA), and the combination of MWA and TIGIT blockade significantly promoted the expansion and functions of CD8(+) tumor-infiltrating lymphocytes (TILs) and reshaped myeloid cells in the tumor microenvironment (TME).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Nathalie Babl, Sonja-Maria Decking, Florian Voll, Michael Althammer, Ada Sala-Hojman, Roberta Ferretti, Clarissa Korf, Christian Schmidl, Lisa Schmidleithner, Benedikt Nerb, Carina Matos, Gudrun E. Koehl, Peter Siska, Christina Bruss, Fabian Kellermeier, Katja Dettmer, Peter J. Oefner, Marvin Wichland, Ines Ugele, Christopher Bohr, Wolfgang Herr, Shivapriya Ramaswamy, Timo Heinrich, Christian Herhaus, Marina Kreutz, Kathrin Renner
Summary: Inhibition of MCT4 alone can improve the efficacy of immune checkpoint blockade therapy, reverse lactic-acid driven immunosuppression, and have potential clinical significance in improving the treatment outcomes of rectal cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Engineering, Environmental
Zheng Chunxiong, Zhao Xinzhi, Wang Ying, Zhao Yu, Zheng Yadan, Zhang Zhanzhan, Liu Qi, Liu Yang, Shi Linqi
Summary: In this study, an immune modulating nanoparticle (IMNP) was designed to achieve spatial control of drug release sites and synergistically deplete tumor-associated macrophages (TAMs). The results showed that the IMNP effectively eliminated TAMs and improved the tumor environment, leading to a significant enhancement of the anti-tumor efficacy of immune checkpoint blocking therapies.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Immunology
Zefan Liu, Yucheng Xiang, Yaxian Zheng, Xin Kang
Summary: This review systematically summarizes the recent applications of nanotechnology in colorectal cancer immunotherapy, including targeting immune checkpoint inhibitors, increasing tumor immunogenicity, remodeling tumor microenvironment, and pre-sensitizing immune systems. The advantages of nanotechnology in innovating the mode-of-actions of immune checkpoint blockade, modulating intestinal microbiome, and integrating the whole process of antigen presentation are highlighted in this review.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Environmental
Yue Zhou, Siyu Wang, Xiaoyang Liang, Zbynek Heger, Qiang Lu, Wen Li, Vojtech Adam, Nan Li
Summary: This study demonstrates that combination immune checkpoint blockade of ADAR1 and PD-1 can improve the tumor immune microenvironment and enhance immune response. By delivering shADAR1 using a nanosystem and combined treatment with an anti-PD-1 antibody, immune evasion is reduced and antitumor immunity is activated. Mechanistic and transcriptomic analysis confirm that this combination therapy regulates the abundance of immune cells.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Immunology
Xiao Pan, Antian Gao, Zitong Lin
Summary: In the past decade, immunotherapy using immune checkpoint blockades has greatly impacted clinical oncology. Immunoimaging techniques, particularly fluorescence imaging, have emerged as potential methods to evaluate immune cell infiltration in tumors and monitor treatment efficacy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Soheila Shirinbak, Randall Y. Chan, Shilpa Shahani, Sakunthala Muthugounder, Rebekah Kennedy, Long T. Hung, G. Esteban Fernandez, Michael D. Hadjidaniel, Babak Moghimi, Michael A. Sheard, Alan L. Epstein, Muller Fabbri, Hiroyuki Shimada, Shahab Asgharzadeh
Summary: The study reveals that immune checkpoint therapy using anti-PD-1 and anti-CTLA-4 antibodies individually or in combination, alongside chemotherapy, can enhance immune responses in pediatric cancers. It shows that the combination of immune checkpoint blockade and chemotherapy may promote tumor rejection, improve survival, and establish long-term immune memory in cancer models.
Review
Oncology
Alexander Chi, Xia He, Lin Hou, Nam P. Nguyen, Guangying Zhu, Robert B. Cameron, Jay M. Lee
Summary: This review discusses the relationship between immune checkpoint blockade and TIME in EGFR and ALK wild-type NSCLC patients, as well as how to treat unresponsive TIME types to ICB, with significant implications for future research in lung cancer immunotherapy.
Article
Oncology
Yuting Tang, Qian Xu, Liang Hu, Xiaomei Yan, Xiaomin Feng, Asumi Yokota, Weinan Wang, Di Zhan, Durga Krishnamurthy, David E. Ochayon, Lijun Wen, Li Huo, Huimin Zeng, Yingwan Luo, Mark Wunderlich, Jiwang Zhang, Eric Vivier, Jianfeng Zhou, Stephen N. Waggoner, Gang Huang
Summary: R-spondin 3 expression is associated with favorable prognosis and enhances infiltration and function of NK cells and T cells in tumors, leading to tumor regression, and also increases tumor sensitivity to anti-PD-1 therapy.
Review
Oncology
Adria Archilla-Ortega, Carla Domuro, Juan Martin-Liberal, Purificacion Munoz
Summary: Immunotherapy is a promising strategy for enhancing antitumoral immunity. However, many patients do not respond to current immunotherapy. An integrative understanding of tumor-immune infiltrate and immune cell IC expression and function is crucial for designing effective therapies. Simultaneous blockade of newly identified ICs, as well as previously described ICs, could improve antitumor response.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Xinlun Dai, Xin Li, Yahui Liu, Fei Yan
Summary: This article discusses the progress in anti-tumor immune checkpoint blockade (ICB) therapy and nanoparticle-mediated photothermal therapy (PTT), as well as the pre-clinical trials of combined PTT/ICB therapy. Nanoparticles offer advantages such as increased tumor-targeting ability, high drug-loading capacity, and satisfactory biocompatibility, which can enhance the anti-tumor effects when combined with ICB therapy.
MATERIALS & DESIGN
(2022)
Review
Oncology
Bonnie L. Russell, Selisha A. Sooklal, Sibusiso T. Malindisa, Lembelani Jonathan Daka, Monde Ntwasa
Summary: Cancer cells present a variety of antigens to the immune system through genetic and epigenetic alterations, activating naive T cells to mount an anticancer response. Maintaining a balance between costimulatory and inhibitory signals at the immune synapse is crucial for optimum activation signal amplitude. Immune checkpoint inhibitors have emerged as a powerful anticancer therapy, but resistance mechanisms pose a challenge.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Byung Min Lee, Jinsil Seong
Summary: ICIs have shown clinical efficacy against most solid cancers, and recent success in combination therapy with targeted agents in hepatocellular carcinoma has accelerated the search for novel combination strategies. Additionally, radiotherapy can be combined with ICIs to modulate the tumor immune microenvironment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Cell Biology
Lara Heij, Jan Bednarsch, Xiuxiang Tan, Mika Rosin, Simone Appinger, Konrad Reichel, Dana Pecina, Michail Doukas, Ronald M. van Dam, Juan Garcia Vallejo, Florian Ulmer, Sven Lang, Tom Luedde, Flavio G. Rocha, Shivan Sivakumar, Ulf Peter Neumann
Summary: Background: The tumor microenvironment (TME) in cholangiocarcinoma (CCA) influences the immune environment, but reliable biomarkers to predict treatment response are lacking. This study assessed the levels of checkpoint molecules, macrophages, and T cells in 50 intrahepatic CCA cases. Results showed that high densities of PD-L1 were more abundant in the sclerotic tumor region. Lymph node metastasis correlated with CD4_ICOS_TIGIT co-expression and CD8_PD-L2 expression, indicating a poor prognosis for patients with these checkpoint expression profiles. Multiple co-expressions occurred, suggesting the potential for combination therapy.
Article
Multidisciplinary Sciences
William W. Ho, Igor L. Gomes-Santos, Shuichi Aoki, Meenal Datta, Kosuke Kawaguchi, Nilesh P. Talele, Sylvie Roberge, Jun Ren, Hao Liu, Ivy X. Chen, Patrik Andersson, Sampurna Chatterjee, Ashwin S. Kumar, Zohreh Amoozgar, Qixian Zhang, Peigen Huang, Mei Rosa Ng, Vikash P. Chauhan, Lei Xu, Dan G. Duda, Jeffrey W. Clark, Mikael J. Pittet, Dai Fukumura, Rakesh K. Jain
Summary: Liver metastasis of mismatch repair-proficient (pMMR) CRCs is unresponsive to immune checkpoint blockade (ICB) therapy, while the same tumors are sensitive to ICB therapy when grown subcutaneously. Dendritic cells play a crucial role in increasing the efficacy of immuno-therapies against pMMR CRC liver metastases, as evidenced by increased infiltration and improved survival in mouse models. Compared to subcutaneous tumors, orthotopic liver metastases of pMMR CRCs show a paucity of activated T cells and dendritic cells, indicating the importance of utilizing orthotopic tumor models in guiding human clinical trials.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Allergy
Weimin Sun, Shijie Song, Guangmeng Li, Linghui Zhou, Junmou Xie, Yuhe Guo, Jun Zeng, Junyan Zhang, Linmei Li, Ying He, Jie Yan, Xintao Shuai, Ailin Tao
Article
Engineering, Biomedical
Sitong Liu, Chen Zhang, Yuanyuan Zhou, Fang Zhang, Xiaohui Duan, Yang Liu, Xibang Zhao, Jie Liu, Xintao Shuai, Jiali Wang, Zhong Cao
Summary: Since the progression of osteoarthritis is associated with synovitis and cartilage destruction, inhibiting inflammatory responses and chondrocyte apoptosis is crucial for ameliorating this condition. Mesoporous polydopamine nanoparticles loaded with dexamethasone were prepared and shown to suppress synovial inflammation, inhibit toll-like receptor 3 production in chondrocytes, and prevent chondrocyte apoptosis. These nanoparticles also effectively removed reactive oxygen species in chondrocytes and attenuated osteoarthritis development in a mouse model. Moreover, the nanoparticles possessed MRI-visible signals, making them suitable for clinical applications.
Article
Biochemistry & Molecular Biology
Yuanyuan Yuan, Yiyao Wang, Huiling Huang, Shuiliang Tao, Jinsheng Huang
Summary: The successful application of siRNA in liver-associated diseases has renewed interest in RNAi therapeutics and delivery vectors, particularly for anticancer combination therapy. Fine-tuning the assembly configuration of copolymer-based systems is crucial for achieving a synergistic cancer cell-killing effect via the co-delivery of chemotherapeutic drugs and siRNA. In this study, an amphiphilic triblock copolymer (mPEG-PLys-PDPA or PLD) consisting of a hydrophilic diblock mPEG-PLys and a hydrophobic block PDPA was synthesized. The copolymer self-assembled into three distinct structures (nanosized micelle, nanosized polymersome, and microparticle), with the micelle size increasing with the length of the PDPA block. Furthermore, the obtained polymersome efficiently co-delivered doxorubicin hydrochloride (DOX) as a hydrophilic chemotherapeutic and siRNA against ADP-ribosylation factor 6 (siArf6) into cancer cells via lysosomal pH-triggered release. The DOX- and siArf6-loaded polymersome (PLD@DOX/siArf6) exhibited synergistic killing of PC-3 prostate cancer cells, highlighting its potential as a robust nanomedicine for anticancer therapy.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Fan Zhang, Liwen Feng, Changchang Jia, Yingjian Wu, Jie Liu, Xintao Shuai, Zhong Cao
Summary: The study developed a novel synthetic strategy to fabricate metallic nanoassemblies by introducing an imine group and reducing moiety. These nanoassemblies not only exhibit high catalytic efficiency, but also possess radiosensitization and anti-tumor immune response functions. The results of the study indicate that metallic nanoassemblies could be a potential theranostic nanoplatform for radiation therapy.
Article
Engineering, Biomedical
Xinghua Huang, Jianwei Li, Guanyi Li, Binyu Ni, Ziji Liang, Haodong Chen, Chaozhang Xu, Jianhua Zhou, Jinsheng Huang, Shaohui Deng
Summary: In this study, cation-free polymer-siRNA nanocapsules were developed to overcome the cation-associated cytotoxicity and achieve tumor-targeted gene silencing. The nanocapsules showed efficient siRNA encapsulation, high stability in serum, cancer cell targeting capability, and GSH-triggered siRNA release. In animal experiments, the nanocapsules significantly inhibited tumor growth without cation-associated toxicity side effects and improved the survival rate of tumor-bearing mice.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Zecong Xiao, Yitong Tan, Yujun Cai, Jinsheng Huang, Xiaobin Wang, Bo Li, Liteng Lin, Yong Wang, Xintao Shuai, Kangshun Zhu
Summary: A pH and MMP-2 dual-sensitive polymer/calcium phosphate (CaP) hybrid nanocarrier was used to co-deliver hyaluronidase (HAase), IL-12, and anti-PD-L1 antibody (alpha PD-L1) to overcome the dense extracellular matrix (ECM) barrier in hepatocellular carcinoma (HCC). The nanocarrier released IL-12 and HAase in response to tumor acidity, promoting CTL infiltration and proliferation. In addition, the released alpha PD-L1 prevented tumor cells from escaping CTL killing effects. This combination strategy effectively suppressed HCC growth in mice and reduced immune-related adverse events.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Huihai Zhong, Gengjia Chen, Tan Li, Jinsheng Huang, Minzhao Lin, Bo Li, Zecong Xiao, Xintao Shuai
Summary: In this study, a nanoliposome (GM@LR) was constructed for delivering the GSDME-expressing plasmid and manganese carbonyl (MnCO) into TNBC cells. MnCO generated Mn2+ and carbon monoxide (CO) in the presence of H2O2. CO-activated caspase-3 cleaved the expressed GSDME, converting apoptosis to pyroptosis in 4T1 cells. Additionally, Mn2+ promoted the maturation of dendritic cells (DCs) through the activation of the STING signaling pathway. The increased proportion of intratumoral mature DCs caused massive infiltration of cytotoxic lymphocytes, leading to a robust immune response.
Article
Chemistry, Multidisciplinary
Yuan Ding, Jiali Yang, Huiye Wei, Jiachen Wang, Sicong Huang, Shuguang Yang, Yu Guo, Bo Li, Xintao Shuai
Summary: The immunotherapy strategies for TNBC are limited due to the immunosuppressive TME. A pH-sensitive nanovaccine loaded with TCL and CpG is constructed to overcome these limitations. The nanovaccine neutralizes the acidic TME, activates dendritic cells, and recruits cytotoxic T cells. In vivo studies show that the nanovaccine stays longer in circulation and exhibits high cytotoxicity in tumor cells. Overall, this pH-sensitive nanovaccine holds promise for enhanced immunotherapy of TNBC.
Article
Chemistry, Multidisciplinary
Hong Xiao, Xiaoxia Li, Bo Li, Shuguang Yang, Jingya Qin, Shisong Han, Jie Ren, Xintao Shuai
Summary: A liposome nanodrug co-encapsulating doxycycline hydrochloride and chlorin e6 is developed to enhance tumor photo-immunotherapy. The nanodrug induces autophagy inhibition and mitochondria dysfunction, leading to increased tumor immunogenicity and potent killing effect. This highly efficient strategy combines photodynamic therapy and autophagy inhibition for effective cancer immunotherapy.
Article
Pharmacology & Pharmacy
Zhuxia Zhang, Bingxuan Xu, Tao Lv, Yu Shi, Mengxin Wang, Die Hu, Azhen Hu, Ping Li, Shuping Lin, Shengwei Zhang, Rongquan Yao, Lan Luo, Linlin Wang, Yiping Zhang, Yanni Han, Huiying Hu, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng
Summary: This study investigates the preventive effect of Rb(3)NPs@MBs on 1-methyl-4-phenyl-4-piperidinpropionate ester (MPTP)-induced Parkinson's disease (PD) and its underlying mechanisms. Rb(3)NPs@MBs are able to prevent the decrease of dopaminergic neurons, decrease tyrosine hydroxylase (TH) expression, increase Park2 expression, and decrease α-synaptonucleoprotein expression in the pars compactus nigra (SNc) induced by MPTP. In vitro experiments also show that Rb(3)NPs treatment can reverse MPTP-induced apoptosis and death of PC12/SY5Y cells, and Rb(3)NPs@MBs can prevent the production of reactive oxygen species (ROS) in SNc. Furthermore, the expression of DJ-1 decreases after the introduction of Rb(3)NPs@MBs, indicating that the neuroprotective activity of Rb(3)NPs@MBs may be achieved by increasing the expression of DJ-1 and decreasing the production of ROS.
ADVANCED THERAPEUTICS
(2023)
Article
Engineering, Biomedical
Jinsheng Huang, Huiling Huang, Yiyao Wang, Bin Xu, Minzhao Lin, Shisong Han, Yuanyuan Yuan, Yong Wang, Xintao Shuai
Summary: Activated hepatic stellate cell (aHSC) is responsible for liver fibrosis. In this study, a unique crosslinking nanopolyplex modified by vitamin A was developed. It effectively reduced HSC activation in vitro and in vivo, alleviated liver injury, and restored liver function in mice.
Article
Medicine, Research & Experimental
Ao Hu, Yiyao Pu, Na Xu, Zhongyuan Cai, Ran Sun, Shengxiang Fu, Rongrong Jin, Yingkun Guo, Hua Ai, Yu Nie, Xintao Shuai
Summary: In this study, a system containing pH-controllable charge-reversible magnetic nanoparticles (MNPs) and negatively charged magnetic nanoparticles (MMPs) was designed to induce intracellular aggregation. The aggregation system exhibited a remarkable increase in magnetothermal conversion efficiency and enhanced penetration and retention inside tumor tissues. It also promoted immune activation and achieved significant inhibition of tumor growth and metastasis.
Article
Materials Science, Biomaterials
Haiyang Wang, Minzhao Lin, Gengjia Chen, Zecong Xiao, Xintao Shuai
Summary: This study developed a novel combination therapy for drug-resistant tumors using liposome nanoparticles co-encapsulating atorvastatin and chloroquine. The atorvastatin promoted the sustained generation of ROS by upregulating CPT1 concentration and promoting fatty acid oxidation in tumor cells, while chloroquine disrupted lysosomes and reduced autophagy levels. In both in vivo and in vitro experiments, the combination therapy showed significant enhancement in tumor cell apoptosis.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Physical
Xiuqi Hou, Xi Yang, Yanwen Xu, Jiayin Lin, Fang Zhang, Xiaohui Duan, Sitong Liu, Jie Liu, Jun Shen, Xintao Shuai, Zhong Cao
Summary: A multifunctional nanodrug combining MRI imaging and cancer therapy has been developed, which can release drugs and achieve sensitive MRI imaging in tumor microenvironment, as well as achieve synergistic antitumor effects through immune activation and gas therapy.
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.