Binding Interaction of Betulinic Acid to α-Glucosidase and Its Alleviation on Postprandial Hyperglycemia

Inhibition of α-glucosidases by tea polyphenols in rat intestinal extract and Caco-2 cells grown on Transwell

(2021) Lijiao Kan et al.   FOOD CHEMISTRY

A new 26-norlanostane from Phlogacanthus turgidus growing in Vietnam

(2021) Mai Dinh Tri et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Comparative study of inhibition mechanisms of structurally different flavonoid compounds on α-glucosidase and synergistic effect with acarbose

(2021) Jichen Yang et al.   FOOD CHEMISTRY

Synthesis and in vitro evaluation of chlorogenic acid amides as potential hypoglycemic agents and their synergistic effect with acarbose

(2021) Nunzio Cardullo et al.   BIOORGANIC CHEMISTRY

Inhibitory effect of triterpenoids from the mushroom Inonotus obliquus against α-glucosidase and their interaction: Inhibition kinetics and molecular stimulations

(2021) Shao-Dan Chen et al.   BIOORGANIC CHEMISTRY

Magnetically anchored antibody-coupled nanocomposite as α-Amylase inhibitor for long-time protection against glycemic variability

(2021) Lichun Guo et al.   CHEMICAL ENGINEERING JOURNAL

Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice

(2021) Lin Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Betulinic acid and its spray dried microparticle formulation: In vitro PDT effect against ovarian carcinoma cell line and in vivo plasma and tumor disposition

(2021) Alessandra F. Serain et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability

(2021) Michael Oboh et al.   MOLECULES

A Combination Approach in Inhibiting Type 2 Diabetes-Related Enzymes Using Ecklonia radiata Fucoidan and Acarbose

(2021) Blessing Mabate et al.   Pharmaceutics

Inhibitory mechanism of vitexin on α-glucosidase and its synergy with acarbose

(2020) Mengting Ni et al.   FOOD HYDROCOLLOIDS

Betulinic acid induces apoptosis and impairs migration and invasion in a mouse model of ovarian cancer

(2020) Lingyun Liao et al.   JOURNAL OF FOOD BIOCHEMISTRY

Evaluation of Cytotoxicity and α-Glucosidase Inhibitory Activity of Amide and Polyamino-Derivatives of Lupane Triterpenoids

(2020) Oxana B. Kazakova et al.   MOLECULES

Therapeutic potential of mushrooms in diabetes mellitus: Role of polysaccharides

(2020) Rubiya Khursheed et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo

(2019) Anqi Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural modifications of 2,3-indolobetulinic acid: Design and synthesis of highly potent α-glucosidase inhibitors

(2019) Elmira F. Khusnutdinova et al.   BIOORGANIC CHEMISTRY

Molecular Docking and Molecular Dynamics Studies on Selective Synthesis of α-Amyrin and β-Amyrin by Oxidosqualene Cyclases from Ilex Asprella

(2019) Zhixue Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α-Glucosidase and α-amylase inhibitory activities of medicinal plants in Thai antidiabetic recipes and bioactive compounds from Vitex glabrata R. Br. stem bark

(2019) Suriyan Thengyai et al.   Journal of Herbal Medicine

Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice

(2019) Zhaoping Ou et al.   BIOMEDICINE & PHARMACOTHERAPY

Surface plasmon resonance (SPR) biosensors for food allergen detection in food matrices

(2019) Jinru Zhou et al.   BIOSENSORS & BIOELECTRONICS

Molecular dynamics simulation exploration of the interaction between curcumin and myosin combined with the results of spectroscopy techniques

(2019) Li Zhang et al.   FOOD HYDROCOLLOIDS

Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on α-glucosidase

(2018) Huafang Ding et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

New Insights into the Inhibition Mechanism of Betulinic Acid on α-Glucosidase

(2018) Huafang Ding et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-α-glucosidase and anti-proliferative activities

(2018) Shaodan Chen et al.   Journal of Functional Foods

Nanoemulsion as a novel carrier system for improvement of betulinic acid oral bioavailability and hepatoprotective activity

(2017) Ranjit K. Harwansh et al.   JOURNAL OF MOLECULAR LIQUIDS

An insight into anti-diabetic properties of dietary phytochemicals

(2017) Ramachandran Vinayagam et al.   PHYTOCHEMISTRY REVIEWS

New Pharmacological Opportunities for Betulinic Acid

(2017) José Ríos et al.   PLANTA MEDICA

α-Glucosidase inhibitory effect of rhinacanthins-rich extract from Rhinacanthus nasutus leaf and synergistic effect in combination with acarbose

(2017) Muhammad Ajmal Shah et al.   Journal of Functional Foods

Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

(2016) Filomena S. G. Silva et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy

(2015) Mohamed Ali-Seyed et al.   Chemical Biology & Drug Design

Antioxidant and α-glucosidase inhibitory activities of constituents from Euonymus alatus twigs

(2015) Chang-Ik Choi et al.   INDUSTRIAL CROPS AND PRODUCTS

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves ofBuddleja salignaWilld

(2015) Jude C. Chukwujekwu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells

(2014) Elke H. Heiss et al.   PLoS One

Betulinic acid and 1,25(OH)2 vitamin D3 share intracellular signal transduction in glucose homeostasis in soleus muscle

(2013) Allisson Jhonatan Gomes Castro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Beneficial Effect of Betulinic Acid on Hyperglycemia via Suppression of Hepatic Glucose Production

(2013) Soo Jung Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enzymes Inhibition and Antidiabetic Effect of Isolated Constituents fromDillenia indica

(2013) Sunil Kumar et al.   Biomed Research International

In Vitro Inhibitory Effect on Pancreatic Lipase Activity of Subfractions from Ethanol Extracts of Fermented Oats (Avena sativa L.) and Synergistic Effect of Three Phenolic Acids

(2012) Shengbao Cai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

α-1-C-Butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a Second-Generation Iminosugar-Based Oral α-Glucosidase Inhibitor for Improving Postprandial Hyperglycemia

(2012) Atsushi Kato et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Practical Synthesis of Betulonic Acid Using Selective Oxidation of Betulin on Aluminium Solid Support

(2012) Nina Melnikova et al.   MOLECULES

Betulinic Acid has an Inhibitory Effect on Pancreatic Lipase and Induces Adipocyte Lipolysis

(2011) Junghyun Kim et al.   PHYTOTHERAPY RESEARCH

Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells

(2009) Do Thi Ha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Betulinic Acid, a Natural Pentacyclic Triterpenoid, Prevents Abdominal Fat Accumulation in Mice Fed a High-Fat Diet

(2009) Célio L. de Melo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Recent developments in anti-inflammatory natural products

(2009) Raju Gautam et al.   MEDICINAL RESEARCH REVIEWS

Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies†

(2008) Xiaoan Wen et al.   JOURNAL OF MEDICINAL CHEMISTRY