Cylindromatosis drives synapse pruning and weakening by promoting macroautophagy through Akt-mTOR signaling

Synaptic activity controls autophagic vacuole motility and function in dendrites

(2021) Vineet Vinay Kulkarni et al.   JOURNAL OF CELL BIOLOGY

NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95

(2021) Benjamin Compans et al.   Nature Communications

The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling

(2021) Elisa Colombo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CYLD is a causative gene for frontotemporal dementia – amyotrophic lateral sclerosis

(2020) Carol Dobson-Stone et al.   BRAIN

CYLD variants in frontotemporal dementia associated with severe memory impairment in a Portuguese cohort

(2020) Miguel Tábuas-Pereira et al.   BRAIN

Microglial activation in the dorsal striatum participates in anxiety-like behavior in Cyld knockout mice

(2020) Yuan-Yuan Han et al.   BRAIN BEHAVIOR AND IMMUNITY

CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes

(2020) Lei Qi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Remodeling without destruction: non-proteolytic ubiquitin chains in neural function and brain disorders

(2020) Alexis Zajicek et al.   MOLECULAR PSYCHIATRY

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling

(2020) Hongmei Shen et al.   Nature Communications

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

(2019) Mélissa Glatigny et al.   CURRENT BIOLOGY

Tumor suppressor protein CYLD regulates morphogenesis of dendrites and spines

(2019) Jun Li et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Immune Signaling in Neurodegeneration

(2019) Timothy R. Hammond et al.   IMMUNITY

Autophagy in Neurons

(2019) Andrea K.H. Stavoe et al.   Annual Review of Cell and Developmental Biology

Neuronal Autophagy in Synaptic Functions and Psychiatric Disorders

(2019) Toshifumi Tomoda et al.   BIOLOGICAL PSYCHIATRY

Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains

(2019) Chunmei Jin et al.   JOURNAL OF NEUROCHEMISTRY

The ubiquitin-editing enzyme A20 regulates synapse remodeling and efficacy

(2019) Shaolin Mei et al.   BRAIN RESEARCH

The Synaptic Autophagy Cycle

(2019) Ori J. Lieberman et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagy in the presynaptic compartment

(2018) Patrick Lüningschrör et al.   CURRENT OPINION IN NEUROBIOLOGY

Regulation and Roles of Autophagy at Synapses

(2018) Vassiliki Nikoletopoulou et al.   TRENDS IN CELL BIOLOGY

Activity-dependent trafficking of lysosomes in dendrites and dendritic spines

(2017) Marisa S. Goo et al.   JOURNAL OF CELL BIOLOGY

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Altered striatal rhythmic activity in cylindromatosis knock-out mice due to enhanced GABAergic inhibition

(2016) Jie Zhang et al.   NEUROPHARMACOLOGY

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

(2015) K. M. Huber et al.   JOURNAL OF NEUROSCIENCE

Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory

(2015) M. Jakovcevski et al.   JOURNAL OF NEUROSCIENCE

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

(2015) Myka L. Estes et al.   NATURE REVIEWS NEUROSCIENCE

Dysregulation and restoration of translational homeostasis in fragile X syndrome

(2015) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy and Its Normal and Pathogenic States in the Brain

(2014) Ai Yamamoto et al.   Annual Review of Neuroscience

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

CaMKII Mediates Recruitment and Activation of the Deubiquitinase CYLD at the Postsynaptic Density

(2014) Soe Thein et al.   PLoS One

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner

(2012) Ayse Dosemeci et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Neuronal Stimulation Induces Autophagy in Hippocampal Neurons That Is Involved in AMPA Receptor Degradation after Chemical Long-Term Depression

(2012) M. Shehata et al.   JOURNAL OF NEUROSCIENCE

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

(2012) Jae Hyang Lim et al.   Nature Communications

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

(2010) Lih-Shen Chin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

(2009) Sara A Wickström et al.   EMBO JOURNAL

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

NF- B in the Nervous System

(2009) B. Kaltschmidt et al.   Cold Spring Harbor Perspectives in Biology

SnapShot: Macroautophagy

(2008) Beth Levine et al.   CELL

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins

(2008) Marie W. Wooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice

(2008) Wei Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

Ras Signaling Mechanisms Underlying Impaired GluR1-Dependent Plasticity Associated with Fragile X Syndrome

(2008) H. Hu et al.   JOURNAL OF NEUROSCIENCE

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

(2008) David Komander et al.   MOLECULAR CELL