Article
Pharmacology & Pharmacy
Hao Wu, Tianyi Zhang, Qi Liu, Min Wei, Yuping Li, Qiang Ma, Lianhui Wang, Yufu Zhu, Hengzhu Zhang
Summary: In this study, a feasible nano-drug delivery system based on polydopamine (PDA) nanoparticles loaded with temozolomide (TMZ) and conjugated with Pep-1 was constructed for chemotherapy and photothermal therapy of glioblastoma (GBM). The results showed that the Pep-1@PDA-TMZ nanoparticles had a high inhibitory effect on U87 cells both in vitro (94%) and in vivo (77.13%).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Siaka Fadera, Pin-Yuan Chen, Hao-Li Liu, I-Chi Lee
Summary: This study focuses on identifying glioblastoma stem-like cells and evaluating the impact of differentiation therapy on GBM cancer stem cells using RA and GNPs combined with LIUS. The results demonstrate that differentiation therapy can reduce stem cell properties, enhance drug sensitivity, and provide an opportunity for new therapeutic strategies.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Yan Yang, Xi Zheng, Lu Chen, Xuefeng Gong, Hao Yang, Xingmei Duan, Yuxuan Zhu
Summary: Cancer is the second leading cause of death in the world and poses a serious threat to human health. Nanomedicine, particularly gold nanoparticles (AuNPs), has emerged as a promising technology for overcoming the limitations of conventional cancer therapies. This review discusses the current achievements and clinical trials of AuNPs in anticancer applications, as well as the challenges in translating basic findings into the clinic, providing a reference for future research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Jeswanthi Aishwarya Vibhavari Ravuluri, Vanishree Rao, Gautam Kumar, Suman Manandhar, Sri Pragnya Cheruku, Priya Bisht, Mallikarjuna Rao Chamallmudi, Krishnadas Nandakumar, Lalit Kumar, Nitesh Kumar
Summary: Due to ineffective diagnosis and analysis, glioblastoma multiforme (GBM) remains the most aggressive form of cancer. Standard therapy for GBM is not very effective in treating the malignant nature of glioma. Recent treatment strategies, such as gene therapy, immunotherapy, and angiogenesis inhibition, show promise as alternative therapeutics. The main drawback of chemotherapy is resistance, which is mainly due to the enzymes involved in the therapeutic pathways.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Pharmacology & Pharmacy
Siqi Wang, Yawen Yu, Aiping Wang, Xinliu Duan, Yuchen Sun, Liangxiao Wang, Liuxiang Chu, Yanan Lv, Nan Cui, Xuesong Fan, Chunjie Sha, Lixiao Xu, Kaoxiang Sun
Summary: In this study, anti-EphA3 modified TMZ16e loaded nanoparticles were prepared for targeted glioblastoma therapy. The nanoparticles showed potential in reversing drug resistance and delivering TMZ16e to the brain, effectively treating drug-resistant glioma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Javier Domingo-Diez, Lilia Souiade, Vanesa Manzaneda-Gonzalez, Marta Sanchez-Diez, Diego Megias, Andres Guerrero-Martinez, Carmen Ramirez-Castillejo, Javier Serrano-Olmedo, Milagros Ramos-Gomez
Summary: Gold nanorods of different sizes were used to eliminate melanoma and glioblastoma cells through photothermal therapy, with the larger nanorods showing high efficacy. Apoptosis was found to be the main cell death pathway activated by this therapy. The large nanoparticles also offer potential for biofunctionalization and theranostic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Liangxiao Wang, Shengnan Tang, Yawen Yu, Yanan Lv, Aiping Wang, Xiuju Yan, Nuannuan Li, Chunjie Sha, Kaoxiang Sun, Youxin Li
Summary: The developed Temozolomide-conjugated gold nanoparticle functionalized with an antibody against the ephrin type-A receptor 3 showed enhanced cellular uptake and toxicity towards glioma cells. It bypasses the blood-brain barrier, targets active glioma cells, and improves treatment efficacy while reducing peripheral toxicity. In vitro and in vivo studies demonstrated that the system has potential for efficacious treatment of GBM, including in TMZ-resistant glioma cells.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Sadia Nasir, Sadia Nazir, Rumeza Hanif, Aneela Javed
Summary: This study utilized solid lipid nanoparticles (SLNPs) for targeted delivery of temozolomide (TMZ) against glioblastoma multiforme (GBM). Both in-vitro and in-vivo experiments showed that SLNP-TMZ had higher cytotoxicity and inhibitory effect on cell migration compared to free TMZ. The expression of inflammatory markers was also significantly elevated in resistant cell lines and mouse models, indicating the potential application of SLNP-TMZ for both TMZ-sensitive and resistant GBM therapy.
Review
Pharmacology & Pharmacy
Panangattukara Prabhakaran Praveen Kumar, Dong-Kwon Lim
Summary: Gold nanoparticles have been extensively studied for their promising applications in various biomedical fields. By combining with polymers, the functionality and biocompatibility of gold nanoparticles can be further enhanced. Additionally, design of responsive nanocomposites has potential for novel therapeutic applications.
Article
Instruments & Instrumentation
Rui Zhang, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Summary: Gold nanoparticles with unique physicochemical features are being investigated for therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are transitioning into clinical trials. The current consensus is to focus on specific disorders for therapeutic applications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Agnieszka Pasciak, Aleksandra Pilch-Wrobel, Lukasz Marciniak, P. James Schuck, Artur Bednarkiewicz
Summary: Localized photothermal therapy is a promising method for combating cancer and enhancing other treatment modalities, but there is currently no consensus on how to accurately compare the light-to-heat conversion efficiency of different nanomaterials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Hongqing Yao, Jian-Ying Zhou
Summary: We report the development of chlorin e6 (Ce6)-conjugated iron oxide (Fe3O4-Ce-6) nanoparticles for combinational ablation of glioblastoma cells via photothermal therapy (PTT) and photodynamic therapy (PDT). Under laser irradiation, Fe3O4-Ce-6 nanoparticles exhibited good photothermal stability and produced singlet oxygen to mediate PDT. The combinational effect of PTT and PDT effectively killed glioblastoma cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lena Radtke, Aleksandra Majchrzak-Celinska, Charles Awortwe, Inga Vater, Inga Nagel, Susanne Sebens, Ingolf Cascorbi, Meike Kaehler
Summary: This study demonstrates the significance of ABCB1 in GBM cells, affecting the response to temozolomide and carmustine treatment, while ABCG2 plays a marginal role.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Polymer Science
Emanuel A. Glitscher, Julian Bergueiro, Marcelo Calderon
Summary: The novel strategy of incorporating anisotropic gold nanoparticles into polymeric thermoresponsive nanogels has expanded their potential applications in the field of nanomedicine.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Puja Sandbhor, Jayant Goda, Bhabani Mohanty, Pradip Chaudhari, Shilpee Dutt, Rinti Banerjee
Summary: The study suggests that targeted nanovesicles delivered through the intranasal route have the potential to bypass the blood-brain barrier, significantly increase brain drug bioavailability, and achieve better therapeutic outcomes in the treatment of glioblastoma.
Article
Medicine, Research & Experimental
Liangxiao Wang, Shengnan Tang, Yawen Yu, Yanan Lv, Aiping Wang, Xiuju Yan, Nuannuan Li, Chunjie Sha, Kaoxiang Sun, Youxin Li
Summary: The developed Temozolomide-conjugated gold nanoparticle functionalized with an antibody against the ephrin type-A receptor 3 showed enhanced cellular uptake and toxicity towards glioma cells. It bypasses the blood-brain barrier, targets active glioma cells, and improves treatment efficacy while reducing peripheral toxicity. In vitro and in vivo studies demonstrated that the system has potential for efficacious treatment of GBM, including in TMZ-resistant glioma cells.
MOLECULAR PHARMACEUTICS
(2021)