Review
Biochemistry & Molecular Biology
Tianyuan Shi, Martin Cheung
Summary: Using rodents for modeling neurological diseases has limitations due to differences in genetics, neural development, and physiology between humans and rodents. In the past decade, induced pluripotent stem cells and induced neural stem cells generated through reprogramming somatic cells have offered a powerful alternative for studying disease pathogenesis and testing regenerative medicines. Urine-derived stem cells are an ideal cell source for reprogramming due to their proliferation, multipotency, epithelial nature, and ease of reprogramming.
CELL AND BIOSCIENCE
(2021)
Article
Multidisciplinary Sciences
Soumitra Mitra, Sulochana Devi, Mi-Sun Lee, Jonathan Jui, Aresh Sahu, Daniel Goldman
Summary: In the zebrafish retina, Muller glia can regenerate retinal neurons through a signaling pathway involving microglia/macrophages, Muller glia, and vascular endothelial cells. This pathway regulates gene expression, Notch signaling, proliferation, and neuronal regeneration in Muller glia. The interaction between Muller glia-derived Vegfaa and Pgfa and Flt1 and Kdrl receptors on vascular endothelial cells plays a crucial role in this process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Yaiza Potes, Cristina Cachan-Vega, Eduardo Antuna, Claudia Garcia-Gonzalez, Nerea Menendez-Coto, Jose Antonio Boga, Jose Gutierrez-Rodriguez, Manuel Bermudez, Veronica Sierra, Ignacio Vega-Naredo, Ana Coto-Montes, Beatriz Caballero
Summary: Melatonin has beneficial effects on adult brain neurogenesis, including cell proliferation, neural differentiation, and neuronal maturation, making it a potential treatment for neurological disorders. Its antioxidant, anti-inflammatory, and pro-survival effects, as well as its ability to modulate neurogenesis processes, contribute to its therapeutic potential. Further research is needed to fully understand the benefits of melatonin in brain disorders related to glucose and insulin homeostasis impairments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Giulia Paolini Sguazzi, Valentina Muto, Marco Tartaglia, Enrico Bertini, Claudia Compagnucci
Summary: Gene therapy traditionally used viral vectors for gene delivery, but recent advances in stem cell and gene therapy fields have revolutionized this approach, particularly with the combination of stem cell replacement therapy and gene editing technology, leading to a new era in gene therapy for neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mariana Bresque, Daniel Esteve, Mariana Pehar, Marcelo R. Vargas
Summary: NAD(+) metabolism plays a significant role in neuronal function and its dysregulation is associated with neurological disorders. Modulating NAD(+) availability could be a promising therapeutic approach for these disorders.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Clinical Neurology
Juanmei Gao, Yuan Liao, Mengsheng Qiu, Wanhua Shen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating the balance of neural stem/progenitor cells (NSCs) proliferation and differentiation, which is essential for the development and maintenance of the nervous system. Recent findings suggest that components of the Wnt/beta-catenin signaling pathway are involved in the regulation of functional brain circuits, providing potential therapeutic targets for neurological diseases.
Review
Cell Biology
Mehrdad Hajinejad, Sajad Sahab-Negah
Summary: Neuroinflammation plays a crucial role in neurological disorders, and mesenchymal stem cells can modulate inflammation and microglia/macrophage polarization through exosome secretion. Studies have shown that miRNAs contained in exosomes have the potential to impact recipient cell behavior, providing a novel therapeutic approach for addressing inflammatory pathways in neurological diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Barbara Kutryb-Zajac, Ada Kawecka, Khrystyna Nasadiuk, Alicja Braczko, Klaudia Stawarska, Elisabetta Caiazzo, Patrycja Koszalka, Carla Cicala
Summary: Adenosine is an endogenous nucleoside that regulates various physiological and pathological processes. It plays a significant role in protecting against cell damage and preventing organ dysfunction in pathological states. Targeting adenosine metabolism and receptor signaling has potential therapeutic applications for various human diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Alessandra Mirarchi, Elisabetta Albi, Tommaso Beccari, Cataldo Arcuri
Summary: Microglia, accounting for 5-20% of glial cells in the adult brain, have multiple functions in maintaining neural environment, responding to injury, and regulating immune response. They are involved in various neurological disorders and neurodegenerative diseases. Vitamin D3 (VD3) plays a role in the brain's pathophysiology, influencing neurotrophic and neuroprotective actions, neurotransmission, and synaptic plasticity. Studies have focused on the involvement of VD3 and microglia in neurodegeneration and aging-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jie Li, Yiqian Ding, Jianhua Zhang, Yating Zhang, Yiduo Cui, Yi Zhang, Shiyang Chang, Yan-Zhong Chang, Guofen Gao
Summary: This study found that brain iron overload has detrimental effects on adult hippocampal neurogenesis, leading to memory decline and anxiety-like behavior. The damage is possibly caused by iron-mediated downregulation of proprotein convertase furin, resulting in decreased maturation of brain-derived neurotrophic factor (BDNF), which affects neural stem cell differentiation. Thus, modulating iron homeostasis and furin expression could be potential therapeutic strategies for neurological diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biotechnology & Applied Microbiology
Ghufran Lutfi Ismaeel, Olfet Jabbar Makki AlHassani, Reem S. Alazragi, Ammar Hussein Ahmed, Asma'a H. Mohamed, Nisreen Yasir Jasim, Falah Hassan Shari, Haider Abdulkareem Almashhadani
Summary: Neural stem cells (NSCs) have the potential to self-renew and differentiate into neurons, astrocytes, and oligodendrocytes. They also secrete various mediators and show therapeutic effects in neurodegenerative diseases. However, the limitations of NSCs transplantation, including poor migration, survival, and differentiation, can be overcome through genetic engineering. Genetically modified NSCs offer more promising therapeutic benefits, making them a potential option for neurological disease therapy.
BIOTECHNOLOGY PROGRESS
(2023)
Article
Biology
Felicia Reinitz, Elizabeth Y. Chen, Benedetta Nicolis di Robilant, Bayarsaikhan Chuluun, Jane Antony, Robert C. Jones, Neha Gubbi, Karen Lee, William Hai Dang Ho, Sai Saroja Kolluru, Dalong Qian, Maddalena Adorno, Katja Piltti, Aileen Anderson, Michelle Monje, H. Craig Heller, Stephen R. Quake, Michael F. Clarke
Summary: This study identifies cell intrinsic neural precursor cell (NPC) dysfunction as the earliest defect in the progression of Alzheimer's disease (AD) and demonstrates that targeting the histone modifier USP16 can ameliorate this defect and improve memory and learning through regulation of Cdkn2a and BMP signaling.
Article
Behavioral Sciences
Sonalika Bhalla, Sidharth Mehan, Andleeb Khan, Muneeb U. Rehman
Summary: Insulin-like growth factor-1 (IGF-1) and glucagon-like peptide-1 (GLP-1) play crucial roles in CNS development and protection. They prevent neuronal death and promote neuronal function through modulation of various cellular signaling pathways, making them potential therapeutic targets for neurodegenerative diseases.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Cell Biology
Yuan Cao, Hai-ning Wu, Xiu-li Cao, Kang-yi Yue, Wen-juan Han, Zi-peng Cao, Yu-fei Zhang, Xiang-yu Gao, Ceng Luo, Xiao-fan Jiang, Hua Han, Min-hua Zheng
Summary: Ttyh1 is essential for the stemness of neural stem cells (NSCs), with its deficiency leading to activated neurogenesis and enhanced spatial learning and memory in adult mice, and accelerated exhaustion of NSC pool and impaired neurogenesis in aged mice. The regulation of calcium signaling and involvement of transcription factor NFATc3 are critical mechanisms by which Ttyh1 affects quiescence versus activation of NSCs. Our research provides new targets for intervention to activate quiescent NSCs for injury repair during pathology and aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shweta Goyal, Brashket Seth, Rajnish K. Chaturvedi
Summary: This review provides an overview of the pathogenesis of Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS), and focuses on the recent advances in using dietary polyphenols and stem cell therapies to slow down neurodegeneration. Both polyphenols and stem cells exhibit potential neuroprotection through modulation of signal transduction pathways and growth factor levels.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Biochemistry & Molecular Biology
Xin Wang, Di Zhao, Narasimha Murthy Beeraka, Spandana Tatineni, Chiriki Devi Sri, Veera Venkata Nishanth, Chinnappa Apatira Uthiah, Zonunsiami Leihang, Kavya Sugur, Junqi Liu, Vladimir Nikolaevich Nikolenko, Ruitai Fan
Summary: This review discusses the role of epigenetics in cardiometabolic diseases and insulin signaling, and explores the frontier research on the development of epigenetic biomarkers and chromatin-based therapies. The study highlights a range of epigenetic alterations that are associated with oxidative stress, insulin signaling, metabolic cardiomyopathy, and endothelial dysfunction, which can regulate gene transcription and affect inflammation, lipogenesis, and adipogenesis. Furthermore, several drugs show potential as epigenetic modulators. Unraveling cell-specific epigenetic information is crucial for individual risk assessment and the development of chromatin-modifying therapies in patients with cardiometabolic diseases.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Obstetrics & Gynecology
Viktor V. Smirnov, Narasimha M. Beeraka, Dmitry Yu Butko, Vladimir N. Nikolenko, Sergey A. Bondarev, Evgeniy E. Achkasov, Mikhail Y. Sinelnikov, P. R. Hemanth Sinelnikov
Summary: This study aims to investigate the impact of endocrine variables, hyperandrogenism, insulin resistance, oxidative stress, and dietary conditions on polycystic ovarian syndrome (PCOS), as well as to discuss the role of epigenetic factors in PCOS conditions. The comparative therapeutic effects of various PCOS therapies and the importance of metabolic/endocrine variables in PCOS were described. The study also discussed the efficacy of GLP-1 agonists, insulin sensitizers, and diet/exercise regimens in enhancing fertility outcomes in overweight or obese females with PCOS. Furthermore, the study highlighted the significance of DNA methylation as epigenetic changes and the potential for developing chromatin-modifying therapies against PCOS through screening molecular targets.
REPRODUCTIVE SCIENCES
(2023)
Correction
Obstetrics & Gynecology
Viktor V. Smirnov, Narasimha M. Beeraka, Dmitry Yu Butko, Vladimir N. Nikolenko, Sergey A. Bondarev, Evgeniy E. Achkasov, Mikhail Y. Sinelnikov, P. R. Hemanth Vikram
REPRODUCTIVE SCIENCES
(2023)
Review
Microbiology
Siva Dallavalasa, SubbaRao V. Tulimilli, Janhavi Prakash, Ramya Ramachandra, SubbaRao V. Madhunapantula, Ravindra P. Veeranna
Summary: The impact of COVID-19 on people with diabetes is still being researched, but there is emerging evidence that diabetes patients are more susceptible to the virus and experience more severe symptoms. The interaction between COVID-19 and diabetes is bidirectional, with the virus increasing viral entry into cells and reducing immunity in diabetes patients. Diabetes is a common complication in COVID-19 patients, leading to serious consequences such as acute respiratory distress syndrome and multi-organ failure. Further studies are needed to confirm diabetes as a complication of COVID-19.
Article
Surgery
Kuo Chen, Jin Zhang, Narasimha M. M. Beeraka, Dajiang Song, Mikhail Y. Y. Sinelnikov, Pengwei Lu
Summary: This study presents the preliminary results of da Vinci robot XI robot-assisted nipple-sparing mastectomy immediate breast reconstruction (R-NSMIBR) with gel implant and latissimus dorsi muscle flap. The study evaluated 15 patients who underwent R-NSMIBR with gel implant and latissimus dorsi muscle flap surgery for breast cancer between September 2022 and November 2022. The average total operative time for R-NSMIBR was 361.9 +/- 77.0 min, with a rapid decrease in robot arm docking time as the learning curve increased.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Tenzin Adon, Dhivya Shanmugarajan, Hissana Ather, Shaik Mohammad Asif Ansari, Umme Hani, SubbaRao V. V. Madhunapantula, Yogish Kumar Honnavalli
Summary: CDK4/6 and aromatase are key targets for breast cancer treatment. Resistance to aromatase inhibitors can occur through alternative signaling pathways. This study aims to identify molecules that can inhibit both CDK4/6 and aromatase using computational chemistry techniques. Through screening and docking, four potential candidates were selected and their stability and effectiveness were further confirmed through molecular dynamics simulations and calculations. These computational approaches provide potential for developing dual inhibitors for breast cancer therapy.
Article
Oncology
Junqi Liu, Qingzhu Zheng, Narasimha M. Beeraka, Xiao Zhang, Tingxuan Li, Ruixia Song, Di Zhao, Ruitai Fan
Summary: This study assessed the risk factors for secondary malignancies among childhood and adolescent lymphoma survivors and developed a clinically practical predictive nomogram. Through studying 5561 patients diagnosed with primary lymphoma before the age of 20 and survived for at least 5 years, we identified risk factors and established a predictive nomogram. Females, blacks, survivors who underwent radiotherapy, and those with specific types of lymphoma were more likely to develop secondary malignancies. The nomogram provides a convenient and reliable tool for predicting the risk of secondary malignancies among childhood and adolescent lymphoma survivors.
Article
Health Care Sciences & Services
Kanakavalli K. Kundury, Venugopal R. Bovilla, K. S. Prathap Kumar, Smitha M. Chandrashekarappa, SubbaRao V. Madhunapantula, Basavanagowdappa Hathur
Summary: A recent study showed that phone call-based education significantly decreased HbA1C in Type-2 diabetes individuals. To further investigate this, a randomized control trial was conducted to determine the impact of phone call-based educational intervention on glycemic control and diabetes management knowledge.
Article
Chemistry, Analytical
P. R. Hemanth Vikram, Narasimha M. M. Beeraka, Hitesh B. B. Patel, Pramod Kumar
Summary: In this study, a novel, simple, sensitive, accurate, cost-effective, precise, and robust RP-HPLC-DAD method was developed to quantify L-lysine hydrochloride in bulk drug substances and multivitamin oral suspension. The method does not require sample preparation and pretreatment. The analysis can be performed with an available C8 column and HPLC-UV detector, proving its cost-effectiveness compared to currently available methods for L-lysine-based products analysis.
ACCREDITATION AND QUALITY ASSURANCE
(2023)
Article
Medicine, Research & Experimental
Hitesh Kumar, Pallavi Chand, Shantanu Pachal, Sahid Mallick, Rupshee Jain, SubbaRao V. Madhunapantula, Vikas Jain
Summary: Fisetin-loaded nanostructured lipid carriers (NLCs) were developed and optimized for better efficacy against metastatic melanoma. The NLCs showed suitable particle size, stability, sustained drug release, and significantly enhanced antitumor activity in cellular and animal experiments.
MOLECULAR PHARMACEUTICS
(2023)
Article
Oncology
Xiaohong Guo, Li Wang, Narasimha M. Beeraka, Chunying Liu, Xiang Zhao, Runze Zhou, Huiming Yu, Ruitai Fan, Junqi Liu
Summary: This study analyzed the incidence trend of retinoblastoma from 2004 to 2015 and constructed a nomogram to predict overall survival in children.
Article
Multidisciplinary Sciences
Hao Gu, Tingxuan Li, Narasimha M. Beeraka, Yufei Zheng, Xintan Zhang, Ruixia Song, Runze Zhou, Xiaoyan Wang, Olga Sukocheva, Ruitai Fan, Junqi Liu
Summary: By classifying HPV-negative HNSCCs based on cell cycle-related genes, this study identified two subtypes with differences in cell cycle activity, tumor microenvironment, N stage, pathological grade, prognosis, and treatment response. The findings provide new insights for personalized anti-cancer treatment.
Article
Oncology
Prashanth Kumar M. Veeresh, Chaithanya G. Basavaraju, Siva Dallavalasa, Preethi G. Anantharaju, Suma M. Natraj, Olga A. Sukocheva, SubbaRao V. Madhunapantula
Summary: The burden of breast cancer is increasing rapidly, and it is important to develop better treatment strategies. Recent studies have found that low levels of vitamin D may be effective in reducing the cancer burden. However, the molecular mechanisms by which vitamin D induces cancer cell death are not fully understood. This study showed that vitamin D inhibited the proliferation of breast cancer cell lines in vitro and slowed down the growth of breast cancer in mice. The cytotoxic effects of vitamin D were associated with growth inhibition, induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis.
Article
Medicine, General & Internal
Ruitai Fan, Yufei Zheng, Runze Zhou, Narasimha M. Beeraka, Olga A. Sukocheva, Ruiwen Zhao, Shijie Li, Xiang Zhao, Chunying Liu, Song He, P. A. Mahesh, B. M. Gurupadayya, Vladimir N. Nikolenko, Di Zhao, Junqi Liu
Summary: This study evaluated the trial registration status on the Chinese Clinical Trial Registry (ChiCTR). The results showed a consistent upward trend in clinical trial registrations, with a focus on oncological and cardiovascular diseases and public funding as the major source of funding.
FRONTIERS IN MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Prem K. Sreenivasan, Bhojraj Nandlal, Ganganna Aruna, SubbaRao V. Madhunapantula
Summary: This investigation demonstrates the use of biochemical quantitation and a rapid visual test for sialic acid as a measure of oral health. The results show that salivary sialic acid levels correlate with clinical status and can be used for screening and monitoring oral health.
APPLIED SCIENCES-BASEL
(2023)
