Article
Plant Sciences
Jung Min Kim, Jae Il Lyu, Dong-Gun Kim, Nguyen Ngoc Hung, Ji Su Seo, Joon-Woo Ahn, You Jin Lim, Seok Hyun Eom, Bo-Keun Ha, Soon-Jae Kwon
Summary: This study used genome-wide association mapping to identify and validate quantitative trait nucleotides (QTNs) related to isoflavone contents in soybean seeds. Several QTNs related to isoflavone contents were detected, and significant differences in the transcript levels of core genes in the isoflavone biosynthetic pathway were found between the original cultivar and its mutant. These findings are important for breeding soybean lines with high and stable concentrations of isoflavones.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agricultural Engineering
Abdelraheem Abdelraheem, Vasu Kuraparthy, Lori Hinze, David Stelly, Tom Wedegaertner, Jinfa Zhang
Summary: In this study, an association mapping panel of 376 Upland cotton accessions was evaluated to identify QTL for thrips resistance, drought tolerance, and salt tolerance. Using 26,301 polymorphic SNPs, 53 QTL for drought tolerance, 78 QTL for salt tolerance, and 8 QTL for thrips resistance were detected. Thirteen QTL clusters were also found, containing QTL for different traits.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Abdelraheem Abdelraheem, Gregory N. Thyssen, David D. Fang, Johnie N. Jenkins, Jack C. McCarty, Tom Wedegaertner, Jinfa Zhang
Summary: This study utilized a multi-parent advanced generation inter-cross population to identify QTL for drought and salt tolerance in cotton. It found candidate genes related to abiotic stress tolerance in Upland cotton. Common genetic basis for drought and salt tolerance was observed between DT and ST.
MOLECULAR GENETICS AND GENOMICS
(2021)
Article
Fisheries
Liyuan Lv, Chenxin Hu, Hongqiang Xu, Jianfen Ren, Biao Wu, Yinghui Dong, Zhihua Lin
Summary: With the development of high-density integrated farming, the razor clam Sinonovacula constricta is facing pressure from environmental factors, especially ammonia nitrogen, which threatens the growth and survival of aquatic animals. To cultivate new strains with ammonia tolerance, the genetic basis underlying ammonia tolerance of S. constricta needs to be comprehensively dissected. In this study, a genome wide association study (GWAS) was performed to identify the single nucleotide polymorphisms (SNPs) and genes associated with ammonia tolerance. The results provide valuable markers for selective breeding of ammonia-tolerant strains in S. constricta.
Article
Agronomy
Martin Enrique Tagliotti, Sofia Irene Deperi, Maria Cecilia Bedogni, Marcelo Atilio Huarte
Summary: The study evaluated the response of physiological and agronomical traits in a diverse potatoes panel under contrasting water regimes using genome-wide association analysis. QTL associated with drought tolerance were identified on chromosomes 1, 4 and 10, with diverse linkage disequilibrium blocks. These QTL could be included in future marker-assisted selection programmes for drought tolerance in potatoes.
Article
Agriculture, Multidisciplinary
Mei-qi Shi, Xi-liang Liao, Qian Ye, Wei Zhang, Ya-kai Li, Javaid Akhter Bhat, Gui-zhen Kan, De-yue Yu
Summary: Salinity has negative effects on soybean germination, growth, and production. This study identified genetic loci in wild soybean that are active during seed germination under salt stress. Using SNP markers and linkage mapping, 25 QTLs and several SNPs related to salt tolerance were detected. The candidate gene GsAKR1 was identified based on gene functional annotations and salt-induced gene expression analysis. These findings contribute to understanding the genetic networks of salt tolerance in wild soybean and can aid in marker-assisted selection for salt-tolerant soybean breeding.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Maolin Sun, Yue Li, Jiqiang Zheng, Depeng Wu, Chunxia Li, Zeyang Li, Ziwei Zang, Yanzheng Zhang, Qingwei Fang, Wenbin Li, Yingpeng Han, Xue Zhao, Yongguang Li
Summary: Through a genome-wide association study and linkage analysis, this study identified several SNPs and QTLs significantly associated with soybean drought tolerance. One of the loci, qGI10-1, showed differentiation between wild and cultivated soybean. Further analysis revealed that the GmNFYB17 gene, located in the differentiated region of qGI10-1, and its homologous genes play a role in drought stress. Over-expression of GmNFYB17 enhanced drought resistance and yield accumulation in soybean by promoting root growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Lin Liu, Lu-Guang Jiang, Jin-Hong Luo, Ai-Ai Xia, Li-Qun Chen, Yan He
Summary: This study investigated the phenotypic diversity and genetic basis of root hair length in maize using a diverse association panel. Through GWAS analysis, candidate genes related to cellular signaling, polar growth, disease resistance, and metabolic pathways were identified, shedding light on the genetic mechanisms underlying root hair growth in maize.
Article
Biochemistry & Molecular Biology
Francesca Maselli, Salvatore D'Antona, Mattia Utichi, Matteo Arnaudi, Isabella Castiglioni, Danilo Porro, Elena Papaleo, Paolo Gandellini, Claudia Cava
Summary: This study used a computational approach to investigate the shared genetic factors and specific gene loci of multiple neurodegenerative diseases. The results revealed genetic correlations between certain SNPs and the diseases, and identified differentially expressed miRNAs that may be involved in the regulation of genes associated with selected SNPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Plant Sciences
Ajmal Mandozai, Abdourazak Alio Moussa, Qi Zhang, Jing Qu, Yeyao Du, Gulaqa Anwari, Noor Al Amin, Piwu Wang
Summary: This study analyzed root-related traits in 260 spring soybean varieties using GWAS, identifying significant SNPs and regulating genes associated with root traits. Insights into the genetic architecture of soybean roots were provided, with potential implications for future breeding of high-efficient root systems in soybean.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biology
Xingzhen Zhao, Zhangxiong Liu, Huihui Li, Yanjun Zhang, Lili Yu, Xusheng Qi, Huawei Gao, Yinghui Li, Lijuan Qiu
Summary: Drought stress inhibits seed germination and affects food security. This study identified loci and candidate genes related to drought tolerance in soybean during germination.
Article
Agronomy
Xukai Li, Zhiyong Shi, Jianhua Gao, Xingchun Wang, Kai Guo
Summary: Haplotype blocks reduce genotyping effort and assist in mapping candidate genes. The CandiHap software allows rapid and robust haplotype analysis and candidate identification from sequencing data. It can be used on various operating systems and any species.
MOLECULAR BREEDING
(2023)
Article
Agriculture, Dairy & Animal Science
Arnav Mehrotra, Bharat Bhushan, Amit Kumar, Manjit Panigrahi, A. Karthikeyan, Akansha Singh, Ashok K. Tiwari, Hubert Pausch, Triveni Dutt, Bishnu P. Mishra
Summary: A study identified a region significantly associated with antibody response to CSF vaccination in a mixed pig population, containing genes involved in Pestivirus replication and host immune response. This region may be a suitable candidate for future functional investigations in understanding the immune response of pigs.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiurong Zhao, Changsheng Nie, Jinxin Zhang, Xinghua Li, Tao Zhu, Zi Guan, Yu Chen, Liang Wang, Xue Ze Lv, Weifang Yang, Yaxiong Jia, Zhonghua Ning, Haiying Li, Changqing Qu, Huie Wang, Lujiang Qu
Summary: This study utilized genome-wide association study to identify 148 SNPs associated with egg number traits and 32 candidate genes related to hormone regulation, follicle development, and reproductive system development. The study also highlighted a genomic region on GGA5 as a potential candidate region underlying egg number traits.
Article
Cell Biology
Shizheng Qiu, Peigang Cao, Yu Guo, Haoyu Lu, Yang Hu
Summary: Through genome-wide association study and Mendelian randomization analysis, the study found a significant correlation between hypothyroidism and NAFLD, with hypothyroidism patients at significantly higher risk of developing NAFLD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)