Article
Cell Biology
Zhiyuan Li, Xin Zhang
Summary: The study found that mitotic ULK1 and ATG13 are substrates of the key cell cycle regulator CDK1-CCNB, and CDK1-induced phosphorylation promotes cell cycle progression and tumor cell proliferation, significantly affecting both processes.
Article
Biochemistry & Molecular Biology
Ashari R. Kannangara, Daniel M. Poole, Colten M. McEwan, Joshua C. Youngs, Vajira K. Weerasekara, Alex M. Thornock, Misael T. Lazaro, Eranga R. Balasooriya, Laura M. Oh, Erik J. Soderblom, Jonathan J. Lee, Daniel L. Simmons, Joshua L. Andersen
Summary: ATG9A, a multi-pass transmembrane protein, plays a crucial role in regulating autophagy. It interacts with members of the ULK1 complex and regulators of membrane fusion and vesicle trafficking, marking pathways of ATG9A trafficking through different cellular systems. ATG9A interacts with ATG13-ATG101 independently of ULK1, and deletion of ATG13 or ATG101 causes abnormal accumulation of ATG9A at stalled clusters of certain proteins, which can be rescued by a mutant form of ATG13 lacking ULK1 binding capability.
Article
Biochemistry & Molecular Biology
Joanna J. Moss, Martina Wirth, Sharon A. Tooze, Jon D. Lane, Chrissy L. Hammond
Summary: This study demonstrates the important role of autophagy in regulating the timely maturation of chondrocytes and extracellular matrix formation, with autophagy dysregulation potentially leading to various skeletal disorders.
Article
Medicine, Research & Experimental
Gabriella Bernhoff, Eva Rasmussen-Barr, Lina Bunketorp Kaell
Summary: Patients diagnosed with ME/CFS showed impaired physical and mental exertion ability, worse pain, and poorer overall health compared to individuals with similar symptoms but no ME/CFS diagnosis. These results support the focus on patients' self-care, particularly in terms of energy management.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Cell Biology
Wenzhi Feng, Orlando Arguello-Miranda, Suhong Qian, Fei Wang
Summary: The coordination of autophagy activity during meiosis progression is regulated by the phosphatase Cdc14, which stimulates autophagy initiation and facilitates meiotic divisions.
Editorial Material
Cell Biology
Ashari R. Kannangara, Joshua L. Andersen
Summary: This study used BioID and quantitative LC-MS/MS techniques to investigate the proximity interactome of ATG9A, revealing interactions with protein complexes involved in protein trafficking and autophagy. Additionally, an unexpected interaction between ATG9A and the ULK1-independent ATG13-ATG101 dimer was discovered, which promotes autophagy in fed cells.
Article
Plant Sciences
Qiuling Wang, Suiwen Hou
Summary: Autophagy is a conserved system for degradation and renewal of cellular components from yeast to mammals. The ATG1/ATG13 complex plays a crucial role in initiating autophagy, sensing nutritional signals, and governing autophagosome formation in plants.
JOURNAL OF PLANT PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiawei Zhou, Rong Shen, Hai-Bing Zhou, Jian Huang
Summary: Breast cancer, mostly estrogen receptor a positive, can benefit from endocrine therapy to reduce risk; Autophagy plays a protective role in breast cancer; ERa may regulate autophagy through Atg13, and compound OBHS could affect breast cancer cell viability by suppressing ERa and autophagy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Weijing Yao, Yixing Li, Yingcong Chen, Yuting Chen, Pengwei Zhao, Yi Zhang, Qiang Jiang, Yuyao Feng, Fan Yang, Choufei Wu, Huiming Zhong, Yiting Zhou, Qiming Sun, Liqin Zhang, Wei Liu, Cong Yi
Summary: The DNA damage sensor Mec1 plays an essential role in the DNA damage response pathway and glucose starvation-induced autophagy. It forms puncta and contacts both mitochondria and the phagophore assembly site (PAS) through interactions with the adaptor protein Ggc1 and direct binding with Atg13, respectively. These interactions are mediated by specific protein regions, MBR on Atg13 and ABR on Mec1, and disruption of these regions impairs the recruitment of Mec1 puncta and Atg13 to the PAS, blocking glucose starvation-induced autophagy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Health Care Sciences & Services
Leah R. Williams, Carol Isaacson-Barash
Summary: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multi-system disease with varied onset and severity. The illness can range from mild to very severe, impacting daily life and posing challenges for treatment.
Review
Immunology
Rahel S. Konig, Werner C. Albrich, Christian R. Kahlert, Lina Samira Bahr, Ulrike Lober, Pietro Vernazza, Carmen Scheibenbogen, Sofia K. Forslund
Summary: Myalgic encephalomyelitis (ME) or Chronic Fatigue Syndrome (CFS) is a neglected, debilitating disease with unclear etiology and pathophysiology. The gut microbiome may play a role in CFS and further research is needed to explore potential diagnostic and therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Whitney Dafoe
Summary: This personal account provides insights into the experience of living with Extremely Severe ME/CFS from the perspective of a bedridden patient, covering illness progression, medical history, description of various aspects of the condition, and essays on specific experiences.
Article
Fisheries
Kaiyu Chen, Yina Shao, Chenghua Li
Summary: This study found that miR-137 can promote autophagy in sea cucumbers to limit bacterial invasion by targeting AjAtg13, as identified through high-throughput sequencing and dual-luciferase reporter gene analysis.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Cell Biology
Wenzhi Feng, Orlando Arguello-Miranda, Suhong Qian, Fei Wang
Summary: In this study, a meiosis-specific autophagy mechanism was discovered and the molecular regulatory mechanism of this mechanism was elucidated. The results showed that cells with higher levels of autophagy complete meiosis faster and have increased efficiency in sporulation.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Cell Biology
Piero Dalle Pezze, Eleftherios Karanasios, Varvara Kandia, Maria Manifava, Simon A. Walker, Nicolas Gambardella Le Novere, Nicholas T. Ktistakis
Summary: The study found that the translocation of ATG13 during autophagy is influenced by different stimuli and drugs, with multiple translocations observed during mitophagy. The mathematical model supports the hypothesis that the number of ATG13 translocations is directly proportional to the diameter of the targeted mitochondrial fragments, providing new insights into the early dynamics of selective and nonselective autophagy.