Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

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Quercetin Induces p53‐independent Cancer Cell Death via TFEB‐mediated Lysosome Activation and ROS‐dependent Ferroptosis

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Genipin enhances the therapeutic effects of oxaliplatin by upregulating BIM in colorectal cancer

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Systemic Therapy for Locally Advanced and Metastatic Non–Small Cell Lung Cancer

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Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway

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Kalantuboside B induced apoptosis and cytoprotective autophagy in human melanoma A2058 cells: An in vitro and in vivo study

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Colorectal cancer

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Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

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Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer

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Targeting the IL-6/JAK/STAT3 signalling axis in cancer

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Artesunate-induced mitophagy alters cellular redox status

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Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

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Targeting colon cancer with the novel STAT3 inhibitor bruceantinol

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Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-γ in colon cancer

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Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells

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Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA

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Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells

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Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics

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Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway

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S-nitrosoglutathione-mediated STAT3 regulation in efficacy of radiotherapy and cisplatin therapy in head and neck squamous cell carcinoma

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Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

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Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy

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Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells

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Colorectal cancer

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NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

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Is it time for a new paradigm for systemic cancer treatment? Lessons from a century of cancer chemotherapy

(2013) Sarah Crawford   Frontiers in Pharmacology

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells

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Selective killing of cancer cells by a small molecule targeting the stress response to ROS

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ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

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Mitochondrial-Mediated Apoptosis in Lymphoma Cells by the Diterpenoid Lactone Andrographolide, the Active Component of Andrographis paniculata

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Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin

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