Article
Multidisciplinary Sciences
Yvonne T. Nartey, Kwabena H. Amo-Antwi, Philip M. Hill, Edward Dassah, Richard O. Asmah, Kofi Nyarko, Ramatu Agambire, Thomas Konney, Joel Yarney, Nelson Damale, Brian Cox
Summary: This study aimed to compare the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women with and without cervical cancer in order to develop a population-based prevention strategy for cervical cancer in Ghana. The results showed that the most common HR-HPV genotypes among women with cervical cancer were 16, 18, 45, 35, and 52, while 66, 52, 35, 43, and 31 were frequently detected in women without cancer. HPV DNA testing and multivalent vaccines targeting HPV 16, 18, 45, and 35 genotypes are crucial for cervical cancer control in Ghana.
Article
Medicine, General & Internal
David Robert Grimes, Edward M. A. Corry, Talia Malagon, Ciaran O'Riain, Eduardo L. Franco, Donal J. Brennan
Summary: The study compared different cervical cancer screening modalities on a simulated population of women aged >= 25 years, considering the increasing uptake of the HPV vaccine. HPV-based modalities outperformed LBC-based approaches, with reflex approaches and appropriate test intervals maximizing therapeutic efficacy. Increasing HPV vaccination rates resulted in fewer unnecessary colposcopies with HPV-based screening approaches.
Review
Oncology
Biyuan Xing, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao
Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Howard D. Strickler, Marla J. Keller, Nancy A. Hessol, Isam-Eldin Eltoum, Mark H. Einstein, Philip E. Castle, L. Stewart Massad, Lisa Flowers, Lisa Rahangdale, Jessica M. Atrio, Catalina Ramirez, Howard Minkoff, Adaora A. Adimora, Igho Ofotokun, Christine Colie, Megan J. Huchko, Margaret Fischl, Rodney Wright, Gypsyamber D'Souza, Jason Leider, Olga Diaz, Lorraine Sanchez-Keeland, Sadeep Shrestha, Xianhong Xie, Xiaonan Xue, Kathryn Anastos, Joel M. Palefsky, Robert D. Burk
Summary: The study found that in women living with HIV, primary human papillomavirus screening (PHS) combined with reflex HPV16/18 genotyping can reduce unnecessary colposcopies, potentially serving as an alternative to co-testing.
CLINICAL INFECTIOUS DISEASES
(2021)
Editorial Material
Oncology
Eduardo Franco
Summary: The American Cancer Society (ACS) believes that the time has come for primary human papillomavirus (HPV) screening in the United States, but it requires educating the public and healthcare providers and overcoming logistical barriers. ACS is taking the lead by utilizing its resources to promote primary HPV screening in the US and sharing best practices from other countries through its Primary HPV Screening Initiative.
Article
Obstetrics & Gynecology
Jacquelyn Dillon, Ling Chen, Alexander Melamed, Caryn M. St Clair, June Y. Hou, Fady Khoury-Collado, Allison Gockley, Melissa Accordino, Dawn L. Hershman, Jason D. Wright
Summary: Cervical cancer screening is frequently overused among average-risk Medicaid beneficiaries, with women who do not undergo screening also unlikely to receive routine gynecological examinations.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Oncology
Shreya Desai, Michelle J. Zhu, Ilana Lapidos-Salaiz
Summary: Low- and middle-income countries bear a high burden of preventable cervical cancer cases and deaths, with human papillomavirus DNA-based testing increasingly being the preferred screening method. This commentary discusses next steps and key considerations for the expansion of this screening approach.
Article
Virology
Emel Yilmaz, Carina Eklund, Camilla Lagheden, Karin Dahlin Robertsson, Marina Lilja, Miriam Elfstrom, Laila Sara Arroyo Muhr, Joakim Dillner
Summary: This study provides the first global overview of the proficiency of HPV testing services for cervical cancer screening. The results indicate a high level of sensitivity and few false positives, but specificity still needs further improvement.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Zeni Wu, Tingyuan Li, Yongli Han, Mingyue Jiang, Yanqin Yu, Huifang Xu, Lulu Yu, Jianfeng Cui, Bin Liu, Feng Chen, Jian Yin, Xun Zhang, Qinjing Pan, Youlin Qiao, Wen Chen
Summary: This study developed a more accurate model for cervical cancer screening, utilizing multiple predictors and conducting external validations in different cohorts. The results showed that the model had better clinical performance compared to routine screening methods, leading to reduced referral rates.
Review
Health Care Sciences & Services
Sok King Ong, Sarah K. Abe, Shyamala Thilagaratnam, Rei Haruyama, Ruchi Pathak, Harindra Jayasekara, Kayo Togawa, Aliza K. C. Bhandari, Abhishek Shankar, Ashrafun Nessa, Uranbolor Jugder, Julyanti Agustina, Mohammed Biglari, Aasim Yusuf, Ugyen Tshomo, Eshani Fernando, Clarito Cairo, Kyaw Kan Kaung, Beauta Rath, Champadeng Vongdala, Kishore Kumar Pradhananga, Jeongseon Kim, Youn Kyung Chung, Tran Thi Thanh Huong, Suleeporn Sangrajran, Yawei Zhang, Partha Basu, Yin Ling Woo, Babu Sukumaran, William Y. K. Hwang
Summary: About 95% of global cervical cancers are caused by HPV. Cervical cancer can be prevented and cured through early detection and treatment. This study reviewed national cervical cancer indicators and barriers to HPV vaccination and cervical cancer screening in 21 Asian countries. It found that half of the countries have introduced HPV vaccination, but only five countries reported screening uptake of over 50%.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Medicine, General & Internal
Veronique Bouvard, Nicolas Wentzensen, Anne Mackie, Johannes Berkhof, Julia Brotherton, Paolo Giorgi-Rossi, Rachel Kupets, Robert Smith, Silvina Arrossi, Karima Bendahhou, Karen Canfell, Z. Mike Chirenje, Michael H. Chung, Marta del Pino, Silvia de Sanjose, Miriam Elfstrom, Eduardo L. Franco, Chisato Hamashima, Francoise F. Hamers, C. Simon Herrington, Raul Murillo, Suleeporn Sangrajrang, Rengaswamy Sankaranarayanan, Mona Saraiya, Mark Schiffman, Fanghui Zhao, Marc Arbyn, Walter Prendiville, Blanca I. Indave Ruiz, Isabel Mosquera-Metcalfe, Beatrice Lauby-Secretan
Summary: This article reviews the best methods of screening for cervical cancer, with HPV nucleic acid testing being superior whether used alone or in combination with other methods.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Rebecca B. Perkins, Nicolas Wentzensen, Richard S. Guido, Mark Schiffman
Summary: Each year in the US, about 100,000 people are treated for cervical precancer, 14,000 are diagnosed with cervical cancer, and 4,000 die from it. Almost all cervical cancers worldwide are caused by certain HPV genotypes. HPV vaccination at ages 9 to 12 can prevent over 90% of cervical precancers and cancers. Cervical cancer can be prevented through screening and treatment of cervical precancer in individuals with a cervix aged 21 to 65.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Federica Inturrisi, Birgit Lissenberg-Witte, Nienke J. Veldhuijzen, Johannes A. Bogaards, Guglielmo Ronco, Chris J. L. M. Meijer, Johannes Berkhof
Summary: The study found that HPV vaccination leads to a significant decline in lifetime CIN3+ risk, with the remaining absolute CIN3+ risk being very low. Even after nonavalent vaccination, primary HPV testing with adjunct cytology at five-year intervals seems feasible.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Immunology
Tomasz Milecki, Maciej Michalak, Jakub Milecki, Michal Michalak, Radoslaw Kadziszewski, Lukasz Kuncman, Piotr Jarzemski, Piotr Milecki, Andrzej Antczak
Summary: The study aimed to evaluate medical students' knowledge of HPV transmission, cancer risk, and vaccination. Results showed gaps in understanding of HPV infection and transmission routes, with intention to recommend HPV vaccine by medical students being linked to their own knowledge and vaccination status.
Review
Medicine, General & Internal
Paddy Ssentongo, Jennifer S. McCall-Hosenfeld, William A. Calo, Jennifer Moss, Eugene J. Lengerich, Vernon M. Chinchilli, Djibril M. Ba
Summary: This study found that HPV vaccination is associated with higher rates of cervical cancer screening, suggesting that vaccinated individuals are more likely to engage in preventive health behaviors.