Article
Biochemistry & Molecular Biology
Fengqi Yang, Jimin Hyun, D. P. Nagahawatta, Young Min Kim, Moon-Soo Heo, You-Jin Jeon
Summary: Ishige okamurae Celluclast extract (IOC), a sulfated polysaccharide extracted from brown algae, possesses antioxidant, anti-inflammatory, and photoprotective activities, making it suitable for the cosmeceutical and functional food industries.
Article
Pharmacology & Pharmacy
Bomi Ryu, Seyeon Oh, Hye-Won Yang, Batsukh Sosorburam, Dong-Min Chung, Minyoung Seo, Shin-Jae Park, Kyunghee Byun, You-Jin Jeon
Summary: The study found that the extract of Ishige okamurae and its active component can potentially prevent muscle atrophy caused by corticosteroids and may be used to treat skeletal muscle degeneration. This provides new ideas for the prevention and treatment of muscle atrophy.
Article
Medicine, Research & Experimental
Jimin Hyun, Bomi Ryu, Seyeon Oh, Dong-Min Chung, Minyoung Seo, Shin Jae Park, Kyunghee Byun, You-Jin Jeon
Summary: With the increase in elderly population worldwide, sarcopenia has become a major medical and social issue. Current pharmaceutical and exercise therapy options for treating sarcopenia have limitations. This study explores the potential of using Ishige okamurae extract and its active substance, diphloroethohydroxycarmalol, to treat age-related sarcopenia. The study demonstrates that these natural agents can reverse sarcopenia by improving muscle regeneration imbalance in an aging model.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Thilina U. Jayawardena, D. P. Nagahawatta, Yu-An Lu, Hye-Won Yang, Jun-Geon Je, Seo-Young Kim, You-Jin Jeon
Summary: The study found that the use of Ishige okamurae and purified diphloroethohydoxycarmalol can improve skeletal muscle damage caused by palmitic acid, increase levels of muscle markers, and reduce negative effects through regulation of growth factors.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Medicinal
Seung Tae Im, Hyun-Soo Kim, Won-Kyo Jung, Seung-Hong Lee
Summary: This study found that Ishophloroglucin A (IPA) has a high inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) and can attenuate adipogenesis. The molecular docking analysis revealed a stable binding affinity between IPA and PTP1B, suggesting their interaction. These findings suggest that IPA may be a promising natural compound for the treatment of obesity and related diseases.
Article
Chemistry, Medicinal
Su-Hyeon Cho, Hyun-Soo Kim, Hye-Yeon Jung, Jae-Il Park, You-Jee Jang, Juhee Ahn, Kil-Nam Kim
Summary: The study found that Ishophloroglucin A (IPA) has an effect on osteoclasts and osteoblasts in vitro. IPA inhibited osteoclastogenesis in RAW 264.7 cells and promoted osteoblastogenesis in MG-63 cells. This study suggests that IPA may be effective in treating bone diseases such as osteoporosis.
Article
Biochemistry & Molecular Biology
Ling Qin, Junhan Cao, Hui Xu, Nianxu Li, Kai Wang, Liping Zhang, Changfeng Qu, Jinlai Miao
Summary: A sulfated polysaccharide (IOY) from the brown alga Ishige okamurae Yendo, identified as a fucoidan, was isolated and characterized. IOY showed potent immunomodulatory effects in vitro and in vivo, including increasing spleen and thymus indexes, alleviating chemotherapeutic-induced damage, promoting hematopoietic function recovery, and enhancing immune response. IOY could be a promising candidate for drug development or application in functional foods to counteract chemotherapy-induced immunosuppression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Genetics & Heredity
Xixi Wang, Changfeng Qu, Jianjun Dong, Jinlai Miao
Summary: Ishige okamurae plays an important role in marine ecosystem and biological resource utilization. Its chloroplast genome consists of a total of 136 genes and confirmed its position within the Phaeophyta through phylogenetic analysis.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Nutrition & Dietetics
Laurence Lacaze, Sarah Rochdi, Annaelle Couvert, Steve Touboulic, Sylvie Guerin, Gwenaelle Randuineau, David Martin, Veronique Rome, Charles-Henri Malbert, Frederic Derbre, David Val-Laillet, Ronan Thibault
Summary: This study successfully replicated the pathophysiology of marasmus malnutrition in Yucatan minipigs through a low-calorie/low-protein diet. It comprehensively examined body composition, gut microbiota, blood parameters, and muscle tissue. The findings indicate that this experimental model is valid for mimicking severe malnutrition and muscle atrophy associated with malnutrition in humans.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Sae Rom Lee, Ye Li Lee, Sang Yeoup Lee
Summary: This study aims to investigate the effects and safety of IOE consumption on muscle strength and mass in middle-aged and old-aged adults with relatively low skeletal muscle mass through a randomized controlled trial. The results are expected to provide clinical evidence for sarcopenia patients with nutrient treatment.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yu An Lu, Yunfei Jiang, Hye-Won Yang, Jin Hwang, You-Jin Jeon, Bomi Ryu
Summary: This study is the first to investigate the effects of DPHC from Ishige okamurae on calcium levels and vasodilation. The results suggest that DPHC stimulates NO production by modulating calcium levels and expression of AchR and VEGFR2, potentially ameliorating cardiovascular diseases by improving vascular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhenbang Xiao, Shengtao Yang, Yi Liu, Chunxia Zhou, Pengzhi Hong, Shengli Sun, Zhong-Ji Qian
Summary: The study found that IGS effectively suppressed the high expressions and secretions of matrix metalloproteinases (MMPs) and photo-inflammation by blocking MAPKs, AP-1, and NF-kappa B pathways, while also increasing antioxidant enzyme expression. These effects might be attributed to its hydrogen supply, hydrophobic capacity, and enhancement of procollagen production through upregulating the TGF-beta/Smad pathways, indicating the potential of IGS in preventing skin photoaging as skincare products or functional foods.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Oh Yun Kwon, Seung Ho Lee
Summary: The study demonstrated that Ishige okamurae extract could attenuate neurodegenerative processes by regulating MAPKs/Nrf-2/HO-1 antioxidant pathways, inhibiting neuronal dysregulation induced by TMT and glutamate.
Article
Chemistry, Multidisciplinary
Mi-Bo Kim, Hyeju Lee, Chaehyeon Lee, Yuqing Tan, Sang Gil Lee
Summary: The antioxidant activity of Ishige sinicola ethanol extract (ISE) and its fractions, particularly the butanol (BuOH) fraction, can protect against lipopolysaccharide (LPS)-induced muscle atrophy by attenuating the diameter of muscle cells and inhibiting muscle-specific E3 ubiquitin ligase expression. This protection may be mediated through the inhibition of pro-inflammatory cytokine and inflammation-inducible enzyme expression via the p38/extracellular signal-regulated kinase signaling pathway.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Chi Heung Cho, Guijae Yoo, Mingyeong Kim, Chang Jun Lee, In-Wook Choi, Bomi Ryu, Byoung-Mok Kim, Sang-Hoon Lee
Summary: In this study, the therapeutic potential of diphlorethohydroxycarmalol (DPHC) in the treatment of AGE-induced diabetic nephropathy (DN) was evaluated. DPHC exhibited anti-glycation ability by inhibiting AGE formation and AGE-collagen cross-linking. It also suppressed AGE-receptor for AGE (RAGE) interaction and regulated apoptosis-related protein expression.
Review
Food Science & Technology
Thilina U. Jayawardena, Seo-Young Kim, You-Jin Jeon
Summary: This review addresses the current understanding of age-related skeletal muscle changes and discusses mechanisms regulating protein turnover, as well as the factors contributing to reduced muscle regeneration. Nutritional intervention, particularly seafood, is highlighted as a potential preventive factor against sarcopenia. Understanding multiple factors will provide therapeutic targets for preventing, treating, and overcoming the adverse effects of sarcopenia.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biotechnology & Applied Microbiology
Jimin Hyun, Hye-Won Yang, Jun-Geon Je, Hyo-Geun Lee, Gwang Hoon Kim, You-Jin Jeon
Summary: Increased oceanic temperature is affecting the production of Pyropia yezoensis in South Korea, leading to a decrease in its global supply. This study explores the antioxidant properties of a newly developed heat-resistant P. yezoensis and its enzymatically hydrolyzed fractions, showing potential as a nutraceutical antioxidant. The hydrolysate containing the highest protein content displayed significant protection against oxidative stress in cells and embryos.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Food Science & Technology
Hyo-Geun Lee, Min-Cheol Kang, You-Jin Jeon, Young-Sang Kim
Summary: This study investigated the In vitro lipid inhibitory effects of sulfated polysaccharide fractions derived from Sargassum thunbergii and found that it has a beneficial effect on intracellular lipid metabolism, suggesting its potential as a functional ingredient in the functional food industry.
Article
Food Science & Technology
Hyo-Geun Lee, You-Jin Jeon, Min-Cheol Kang
Summary: This study investigated the lipid inhibitory and anti-obesity effects of compounds derived from Sargassum thunbergii in vitro and in vivo. The results showed that the compounds significantly reduced intracellular lipid accumulation and had profound anti-obesity effects on high fat diet-fed obesity model mice. These effects were achieved by regulating adipogenesis, lipolysis, and fatty acid oxidation pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Chemistry, Medicinal
H. H. A. C. K. Jayawardhana, Thilina U. Jayawardena, K. K. A. Sanjeewa, N. M. Liyanage, D. P. Nagahawatta, Hyo-Geun Lee, Jae-Il Kim, You-Jin Jeon
Summary: The skin, as the outermost anatomical barrier, is important for maintaining internal homeostasis and protecting against various threats. The use of natural ingredients, particularly polyphenolic compounds derived from marine macroalgae, is gaining attention in the cosmetic industry due to concerns about synthetic compounds. These compounds have demonstrated promising biological activities, making them potential candidates for a wide range of cosmetic applications. This review highlights the beneficial properties and future prospects of utilizing marine macroalgae-derived polyphenolic compounds in advancing the cosmetic industry.
Article
Food Science & Technology
D. P. Nagahawatta, Hyo-Geun Lee, N. M. Liyanage, H. H. A. C. K. Jayawardhana, Lei Wang, Hyun-Soo Kim, You-Jin Jeon
Summary: The study evaluated the anti-inflammatory potential of alginate isolated from Ecklonia maxima stipes (EMSA) against lung inflammation caused by particulate matter exposure. Results showed that EMSA has potential anti-inflammatory activity and can be used in various fields such as functional foods, pharmaceuticals, and nutraceuticals.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Polymer Science
Lei Wang, Jae-Young Oh, Hye-Won Yang, Jimin Hyun, Ginnae Ahn, Xiaoting Fu, Jiachao Xu, Xin Gao, Seon-Heui Cha, You-Jin Jeon
Summary: This study evaluated the protective effect of fucoidan from Sargassum fusiforme against ethanol-induced oxidative damage. Results showed that fucoidan effectively decreased the damage to liver cells and increased the survival rate of zebrafish. These findings suggest the potential of fucoidan as an ingredient in the functional food industry.
Article
Food Science & Technology
D. P. Nagahawatta, N. M. Liyanage, Thilina U. Jayawardena, H. H. A. C. K. Jayawardhana, Jae-Young Oh, K. K. Asanka Sanjeewa, Sang In Kang, You-Jin Jeon
Summary: The study found that digested flounder meat has the potential to promote skeletal muscle growth and can be used as a functional food ingredient.
Review
Biology
N. M. Liyanage, D. P. Nagahawatta, Thilina U. U. Jayawardena, You-Jin Jeon
Summary: Inflammatory bowel disease (IBD) is a global public health issue. Current treatments such as anti-inflammatory medications and immunosuppressants have limitations, leading to a demand for natural substances like seaweed polysaccharides. The study reviewed the potential therapeutic effects of algal polysaccharides on IBD and highlighted their significant potential in complementary IBD therapy.
Review
Chemistry, Medicinal
N. M. Liyanage, D. P. Nagahawatta, Thilina U. Jayawardena, Kalu Kapuge Asanka Sanjeewa, H. H. A. C. K. Jayawrdhana, Jae-Il Kim, You-Jin Jeon
Summary: Seaweed polysaccharides have shown great potential as a source of antiviral agents for the treatment of viral diseases. They inhibit viral infections through various mechanisms, including interfering with DNA or RNA synthesis, viral entry, and replication. However, the development of polysaccharide-based antiviral therapies still faces challenges such as drug delivery and formulation.
Article
Food Science & Technology
Hyo-Geun Lee, Jimin Hyun, H. H. A. C. K. Jayawardhana, N. M. Liyanage, D. P. Nagahawatta, Min-Cheol Kang, You-Jin Jeon
Summary: The study found that sulfated polysaccharides from brown seaweed have various biological activities and significantly reduce lipid accumulation in 3T3-L1 cells. The results suggest that crude polysaccharides from brown seaweed have intracellular lipid-inhibitory activity and can be utilized as a candidate for lipid-lowering functional food products.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Jimin Hyun, Sang-Woon Lee, R. P. G. S. K. Amarasiri, Jun-Geon Je, Lei Wang, You-Jin Jeon, Bomi Ryu
Summary: The prevalent sedentary lifestyle of adults has led to decreased physical activity and increased health risks. This study investigated the effects of Ishige okamurae extract (IO) and its active compound diphlorethohydroxycarmalol (DPHC) on muscle characteristics of physically inactive adult male mice. The results showed that IO and DPHC supplementation improved muscle strength, hypertrophy, and mitochondrial activity in sedentary mice. Moreover, algal consumption was found to be beneficial for muscle health and prevention of muscle deterioration in sedentary individuals. Understanding the mechanisms behind these effects could contribute to the development of interventions to enhance muscle health in individuals with limited physical activity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Jimin Hyun, Sang-In Kang, Sang-Woon Lee, R. P. G. S. K. Amarasiri, D. P. Nagahawatta, Yujin Roh, Lei Wang, Bomi Ryu, You-Jin Jeon
Summary: This research investigates the potential of enzymatic hydrolysis of olive flounder by-products (OFB) to produce functional ingredients. Various enzymatic hydrolysates of OFB (OFBEs) were generated using 11 commercial enzymes, and OFBEs showed enhanced physiological usability and muscle regenerative potential, particularly with Prozyme 2000P-assisted OFBE (OFBP).
Article
Chemistry, Medicinal
Seon Gyeong Bak, Hyung Jin Lim, Eun Jae Park, Yeong-Seon Won, Seung Woong Lee, Bomi Ryu, Hyun Joo Ha, Sun-Hee Cheong, Seung Jae Lee
Summary: Diphlorethohydroxycarmalol extracted from Ishigeokamurae has potential anti-inflammatory and anti-atopic dermatitis effects, reducing inflammation and immune response. It may be a promising therapeutic option for the treatment of inflammatory skin diseases.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)