Journal
LEUKEMIA & LYMPHOMA
Volume 63, Issue 7, Pages 1598-1606Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2022.2043303
Keywords
Mycosis fungoides; cutaneous T-cell lymphoma; hyperpigmented; pigmented
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Funding
- 'Elimination of Cancer Project Fund', from the Asan Cancer Institute of Asan Medical Center, Seoul, Korea
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This study retrospectively evaluated the clinicopathologic features and survival outcomes of patients with hyperpigmented MF. The results showed that hyperpigmented MF often accompanies other atypical MF variants and is frequently associated with atypical immunophenotypes. The outcomes of hyperpigmented MF are comparable to those of other MF subtypes.
In this study, the clinicopathologic features and survival outcomes of patients with hyperpigmented MF from a single tertiary referral center database were retrospectively evaluated. Hyperpigmented MF accounted for 10.9% (14/128) of all MF cases. The mean age at diagnosis was 46.9 years, and the female-to-male ratio was 1:1.3. Concurrent hypopigmented, ichthyosiform, and poikilodermatous lesions were detected in 21.4%, 14.3%, and 14.3% of the patients, respectively. Histopathologically, most patients (85.7%) showed interface change with pigment incontinence. Double negative (CD4- and CD8-) immunophenotypes were more frequent in patients with hyperpigmented MF (25%) than in those with other MF subtypes (9.8%). Most patients (85.7%) had early-stage disease at diagnosis. The survival outcomes did not differ significantly between hyperpigmented and other MF subtypes. In conclusion, hyperpigmented MF often accompanies other atypical MF variants and is frequently associated with atypical immunophenotypes. The outcomes of hyperpigmented MF are comparable to those of other MF subtypes.
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