Lower antioxidative capacity of multidrug-resistant cancer cells confers collateral sensitivity to protoflavone derivatives

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

(2014) Doriane Lorendeau et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

(2014) Gergely Szakács et al.   CHEMICAL REVIEWS

Collateral sensitivity: ABCG2-overexpressing cells are more vulnerable to oxidative stress

(2014) Damian Krzyżanowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Glutathione Peroxidase Mediates the Collateral Sensitivity of Multidrug-resistant Cells to Tiopronin

(2014) Matthew D. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle

(2013) Ehab H. Sarsour et al.   ANTIOXIDANTS & REDOX SIGNALING

Total Synthetic Protoapigenone WYC02 Inhibits Cervical Cancer Cell Proliferation and Tumour Growth through PIK3 Signalling Pathway

(2013) Yun-Ju Chen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing

(2013) Ana Podolski-Renić et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling

(2013) Yun-Ju Chen et al.   GYNECOLOGIC ONCOLOGY

The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway

(2013) Yun-Ju Chen et al.   LIFE SCIENCES

Protoflavones: a class of unusual flavonoids as promising novel anticancer agents

(2013) A. Hunyadi et al.   PHYTOCHEMISTRY REVIEWS

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

(2012) Ziwei Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Collateral sensitivity as a strategy against cancer multidrug resistance

(2012) Kristen M. Pluchino et al.   DRUG RESISTANCE UPDATES

Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link-Generating Agents In Vitro and In Vivo

(2012) H.-C. Wang et al.   MOLECULAR CANCER THERAPEUTICS

The role of paclitaxel in the development and treatment of multidrug resistant cancer cell lines

(2011) Ana Podolski-Renić et al.   BIOMEDICINE & PHARMACOTHERAPY

A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species

(2011) Huei-Mei Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

ABC transporters affect the detection of intracellular oxidants by fluorescent probes

(2011) Jiřina Procházková et al.   FREE RADICAL RESEARCH

Direct Semi-Synthesis of the Anticancer Lead-Drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives

(2011) Attila Hunyadi et al.   PLoS One

Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π

(2010) Wen-Ying Chen et al.   INVESTIGATIONAL NEW DRUGS

Antitumor Agents. 280. Multidrug Resistance-Selective Desmosdumotin B Analogues

(2010) Kyoko Nakagawa-Goto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fern Plant–Derived Protoapigenone Leads to DNA Damage, Apoptosis, and G2/M Arrest in Lung Cancer Cell Line H1299

(2009) Chien-Chih Chiu et al.   DNA AND CELL BIOLOGY

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis

(2009) Lavinia Nardinocchi et al.   Molecular Cancer

Is resistance useless? Multidrug resistance and collateral sensitivity

(2009) Matthew D. Hall et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo

(2008) Hsueh-Ling Chang et al.   CANCER LETTERS

Manganese Superoxide Dismutase Modulates Hypoxia-Inducible Factor-1  Induction via Superoxide

(2008) S. Kaewpila et al.   CANCER RESEARCH

Protoapigenone, a Novel Flavonoid, Induces Apoptosis in Human Prostate Cancer Cells through Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase 1/2

(2008) H.-L. Chang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS