Article
Endocrinology & Metabolism
Seung Won Burm, Namki Hong, Seunghyun Lee, Gi Jeong Kim, Sang Hyun Hwang, Jongju Jeong, Yumie Rhee
Summary: Lower thoracic skeletal muscle mass was associated with elevated preoperative PTH levels in patients with PHPT, and lower skeletal muscle mass was associated with lesser BMD gain after parathyroidectomy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Urology & Nephrology
Alia Hassan, Yael E. E. Pollak, Rachel Kilav-Levin, Justin Silver, Nir London, Morris Nechama, Iddo Z. Z. Ben-Dov, Tally Naveh-Many
Summary: This study reveals that kidney failure leads to the loss of Pin1 activity in the parathyroid glands, resulting in increased production of PTH. Pin1 and KSRP phosphorylation, as well as the Pin1-KSRP-PTH mRNA axis, play important roles in secondary hyperparathyroidism.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Charles Ginsberg, Lindsay M. Miller, Norma Ofsthun, Lorien S. Dalrymple, Joachim H. Ix
Summary: The study found that PTH and phosphate concentrations before dialysis session varied with the time of day in patients receiving maintenance hemodialysis, highlighting the potential impact on treatment decisions.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Magali Colombat, Beatrice Barres, Claire Renaud, David Ribes, Sarah Pericard, Mylene Camus, Rodica Anesia, Nathalie van Acker, Dominique Chauveau, Odile Burlet-Schiltz, Pierre Brousset, Sophie Valleix
Summary: This study identified fibril protein PTH in a subset of parathyroid adenomas associated with amyloid aggregation, shedding new insights into the pathophysiology of the disease and adding PTH to the list of amyloid proteins derived from hormones.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2021)
Article
Surgery
Whitney Sutton, Xiaomeng Chen, Palak Patel, Shkala Karzai, Jason D. Prescott, Dorry L. Segev, Mara McAdams-DeMarco, Aarti Mathur
Summary: This study evaluated the prevalence and risk factors of tertiary hyperparathyroidism after kidney transplantation. It found that persistent hyperparathyroidism affected 61.7% of recipients, while tertiary hyperparathyroidism affected 21.5% of recipients. Many patients did not receive any treatment at 1-year post-kidney transplantation.
Article
Endocrinology & Metabolism
Shilpa Sharma, Ronit Katz, Charles Ginsberg, Alexander Bullen, Volker Vallon, Scott Thomson, Orson W. Moe, Andrew N. Hoofnagle, Peter W. de Leeuw, Abraham A. Kroon, Alfons J. H. M. Houben, Joachim H. Ix
Summary: The relative abundance of fibroblast growth factor-23 (FGF23) varies depending on kidney function in humans. This study found that the kidney clearance of FGF23 is higher than that of creatinine, and the clearance of intact FGF23 is higher than that of C-terminal fragments. The reduction of FGF23 by the kidney is associated with kidney function decline.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jiao Zuo, Ahmed A. Hasan, Carl-Friedrich Hocher, Philipp Kalk, Burkhard Kleuser, Bernhard K. Kraemer, Berthold Hocher
Summary: This study investigated the relationship between 25(OH)D and 1,25(OH)2D with PTH. The results showed a negative correlation between all forms of PTH and 25(OH)D, while there was no significant correlation between 1,25(OH)2D and PTH. This finding suggests an inhibitory effect of 25(OH)D on the synthesis of all forms of PTH in the chief cells of the parathyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Won-Taek Oh, Yeon-Suk Yang, Jun Xie, Hong Ma, Jung-Min Kim, Kwang-Hwan Park, Daniel S. Oh, Kyung-Hyun Park-Min, Matthew B. Greenblatt, Guangping Gao, Jae-Hyuck Shim
Summary: Recombinant adeno-associated virus (rAAV)-mediated gene therapy shows promise as a long-lasting and targeted treatment for osteoporosis and associated bone fractures. By silencing the expression of WNT antagonists, SHN3 and SOST, and enhancing WNT/β-catenin signaling, osteoblast function, and bone formation, this approach effectively reverses bone loss and improves fracture healing. These findings demonstrate the clinical potential of bone-specific gene silencers for treating skeletal disorders.
Article
Urology & Nephrology
Pablo Rios, Ricardo Silvarino, Laura Sola, Alejandro Ferreiro, Veronica Lamadrid, Laura Fajardo, Liliana Gadola
Summary: This study evaluated the association between serum calcium, phosphate, intact parathyroid hormone, and vitamin D levels with mortality risk in patients with chronic kidney disease. The findings suggest that elevated phosphate, intact parathyroid hormone levels, and low vitamin D levels are associated with higher mortality risk.
Article
Plant Sciences
Jaekyeong Kim, Mei Tong He, Jae-Seoun Hur, Jin Woo Lee, Kyo Bin Kang, Ki Sung Kang, Sang Hee Shim
Summary: Feature-based molecular networking analysis revealed the presence of naphthol tetramers in a different strain of Daldinia childae (047219) compared to the one previously used for the discovery of naphthol trimers. These new tetramers were composed of 5-methoxy-4-naphthol connected in various positions. Six previously unreported naphthol tetramers and 13 known polyketides, including naphthol monomers, dimers, and trimers, were isolated and their structures were determined through NMR and mass spectroscopic analysis. The new compounds exhibited less anti-inflammatory activity compared to nodulisporin A, nodulisporin B, and 1,1',3,3'-ternaphthalene-5,5',5''-trimethoxy-4,4',4''-triol.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Transplantation
Marko Ugrica, Carla Bettoni, Soline Bourgeois, Arezoo Daryadel, Eva-Maria Pastor-Arroyo, Nicole Gehring, Nati Hernando, Carsten A. Wagner, Isabel Rubio-Aliaga
Summary: The study showed that chronic high phosphate intake did not cause major renal alterations in healthy mice, but it negatively affected bone health, increasing bone resorption and decreasing bone mineral density.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Michael Oster, Henry Reyer, Christian Gerlinger, Nares Trakooljul, Puntita Siengdee, Jonas Keiler, Siriluck Ponsuksili, Petra Wolf, Klaus Wimmers
Summary: Knowledge of gene expression profiles of PTGs contributes to understanding mineral homeostasis and PTH regulation. Long-term dietary intervention in pig offspring reveals molecular pathways controlling PTH levels in response to varying P supplies during fetal and postnatal life. The study highlights the importance of PTG mRNA profiles in reflecting physiological responses to different dietary P supplies.
Article
Chemistry, Multidisciplinary
Jiao Wu, Chunmei Liang, Xin Wang, Yida Huang, Wanshan Liu, Ruimin Wang, Jing Cao, Xun Su, Tao Yin, Xiaolei Wang, Zhikang Zhang, Lingchao Shen, Danyang Li, Weiwei Zou, Ji Wu, Lihua Qiu, Wen Di, Yunxia Cao, Dongmei Ji, Kun Qian
Summary: Metabolic fingerprinting of follicular fluid (MFFF) using particle-assisted laser desorption/ionization mass spectrometry (PALDI-MS) is performed to encode ovarian reserve (OR) and fertility. Machine learning analysis of MFFF allows for the diagnosis of diminished OR and identification of high-quality oocytes/embryos. Metabolic biomarkers from MFFF also contribute to fertility prediction in clinics.
Article
Nutrition & Dietetics
Aiko Ono-Ohmachi, Yuko Ishida, Yoshikazu Morita, Ken Kato, Hitoki Yamanaka, Ritsuko Masuyama
Summary: The study found that adaptive calcium homeostasis is essential for the protective effects of milk basic protein (MBP) on bone mineral metabolism. While MBP supplementation can improve bone conditions when vitamin D activity is affected, severe hyperparathyroidism limits the activity of MBP in bone.
Article
Multidisciplinary Sciences
Nankun Qin, Ming Qin, Wenjun Shi, Lingbo Kong, Liting Wang, Guang Xu, Yuying Guo, Jiayu Zhang, Qun Ma
Summary: Metabolomics research is of great significance in finding biomarkers and exploring the pathogenesis of Hyperuricemia (HUA). The combination of untargeted and targeted metabolomics can provide more reliable results.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Kittrawee Kritmetapak, Rajiv Kumar
Summary: Phosphorus is crucial for various biological processes, and its regulation is essential for organism well-being. Organisms respond to changes in inorganic phosphorus concentrations by adjusting uptake and biochemical processes, with unicellular and multicellular organisms adapting at cellular and endocrine levels respectively. Excessive phosphorus exposure, particularly in chronic kidney disease patients, can lead to various health issues.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Michael P. Whyte, Fan Zhang, Deborah Wenkert, Steven Mumm, Theresa J. Berndt, Rajiv Kumar
Article
Medical Laboratory Technology
Kittrawee Kritmetapak, Louis A. Losbanos, Jolaine M. Hines, Katherine L. O'Grady, Candice Z. Ulmer, Hubert W. Vesper, Felicity T. Enders, Ravinder J. Singh, Rajiv Kumar
Summary: The LC-HRMS method identified full-length PTH1-84 and 8 PTH fragments in patients with progressive renal failure, showing significant increase as eGFR declined. PTH concentrations measured using LC-HRMS tended to be lower than those measured using an iPTH immunoassay, particularly in severe chronic renal failure. Circulating PTH7-84 and oxidized forms of PTH1-84 were not detected.
CLINICAL CHEMISTRY
(2021)
Article
Urology & Nephrology
Kittrawee Kritmetapak, Louis Losbanos, Taylor E. Berent, Susan L. Ashrafzadeh-Kian, Alicia Algeciras-Schimnich, Jolaine M. Hines, Ravinder J. Singh, Rajiv Kumar
Summary: In early stages of chronic kidney disease, compensatory decreases in circulating 1,25-hydroxyvitamin D and increases in circulating intact FGF23 and PTH facilitate the normalization of serum phosphate concentration, while no significant changes were observed in circulating intact FGF7. Further studies are needed to investigate whether other circulating phosphaturic peptides change in response to phosphate retention in CKD patients.
Editorial Material
Urology & Nephrology
Kittrawee Kritmetapak, Rajiv Kumar
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kittrawee Kritmetapak, Ravinder J. Singh, Theodore A. Craig, Jolaine M. Hines, Rajiv Kumar
Summary: The experiment showed that the short carboxyl-terminal peptides of human PTH, hPTH38-84 and hPTH45-84, increased the amount of cellular cAMP generated in cultured osteoblasts in response to treatment with full-length hPTH1-84. In contrast, human PTH28-84 had no effect on cAMP activity. Additionally, these short carboxyl peptides reduced the induction of alkaline phosphatase activity by full-length hPTH1-84 in osteoblasts.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Physiology
Hawley E. Kunz, John D. Port, Kenton R. Kaufman, Aminah Jatoi, Corey R. Hart, Kevin J. Gries, Ian R. Lanza, Rajiv Kumar
Summary: Reductions in skeletal muscle mass and function are often observed in cancer patients, leading to decreased quality of life, impaired treatment tolerance, and increased mortality. This study found that cancer patients had decreased physical activity, cardiorespiratory fitness, leg strength, and increased leg neuromuscular fatigue compared to healthy controls. Additionally, cancer patients exhibited lower mitochondrial oxidative capacity and ATP production, indicating mitochondrial abnormalities. These findings highlight the importance of studying mitochondria in muscle deficits associated with cancer.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Nittha Arrayasillapatorn, Palinee Promsen, Kittrawee Kritmetapak, Siriluck Anunnatsiri, Wijittra Chotmongkol, Sirirat Anutrakulchai
Summary: This study demonstrated a high incidence of AKI following colistin administration, which had a significant impact on patient mortality. Risk factors for colistin-induced AKI included advanced age, high serum bilirubin levels, colistin dosage, and concomitant use of nephrotoxic drugs. Prevention and early correction of these factors are crucial for patient outcomes.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2021)
Review
Endocrinology & Metabolism
Michael T. Collins, Gemma Marcucci, Hans-Joachim Anders, Giovanni Beltrami, Jane A. Cauley, Peter R. Ebeling, Rajiv Kumar, Agnes Linglart, Luca Sangiorgi, Dwight A. Towler, Ria Weston, Michael. P. Whyte, Maria Luisa Brandi, Bart Clarke, Rajesh V. Thakker
Summary: This review discusses the main regulators of mineralization and crystallization processes in human physiology, as well as related disorders. Advances in the past decade have improved understanding of these disorders and their genetic, molecular, and cellular mechanisms, leading to potential new therapeutic approaches.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kittrawee Kritmetapak, Rajiv Kumar
Summary: This review summarizes the current knowledge about phosphate homeostasis, phosphatonin pathophysiology, and the clinical implications of FGF23-related hypophosphatemic disorders, with specific focus on burosumab treatment. Research suggests that burosumab is effective and safe for pediatric and adult patients with X-linked hypophosphatemia or tumor-induced osteomalacia.
ENDOCRINE PRACTICE
(2023)
Correction
Endocrinology & Metabolism
Michael T. Collins, Gemma Marcucci, Hans-Joachim Anders, Giovanni Beltrami, Jane A. Cauley, Peter R. Ebeling, Rajiv Kumar, Agnes Linglart, Luca Sangiorgi, Dwight A. Towler, Ria Weston, Michael. P. Whyte, Maria Luisa Brandi, Bart Clarke, Rajesh V. Thakker
NATURE REVIEWS ENDOCRINOLOGY
(2022)
