Article
Biochemical Research Methods
Shaun T. Lancaster, Thomas Prohaska, Johanna Irrgeher
Summary: This study proposes the use of nitrous oxide (N2O) as a non-corrosive and non-toxic alternative for calcium isotope analysis. Instrument performance testing shows that N2O can achieve equivalent detection limits and background concentrations compared to traditional gases. Further testing with synthetic standards highlights N2O's advantage in separating interferences from potassium and magnesium.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Hong-lin Liu, Qing Meng, Xin Zhao, Yu-long Ye, Hua-rong Tong
Summary: The study utilized multi-element and stable isotopes analysis combined with chemometrics to establish a model for discriminating the authenticity of teas, and through validation and testing, confirmed the high accuracy and feasibility of this method in identifying the authenticity of teas.
Article
Biochemical Research Methods
Hai-Ou Gu, He Sun, Chao Huang, Fangyue Wang, Can Ge
Summary: The study developed a Continuous-Acquisition-Method (CAM) MC-ICP-MS Run mode to improve stability when determining K isotopes. Experiments showed that the CAM Run mode provided higher stability and better precision compared to the traditional Sequence Run mode, making it suitable for high-precision K isotope measurements.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2021)
Article
Biochemistry & Molecular Biology
Liang Fu, Hualin Xie, Jianhua Huang, Lin Chen
Summary: The study investigated the feasibility of using ICP-MS/MS to determine non-metallic elements in herbal tea, with O-2 and H-2 as reaction gases in MS/MS mode. The developed method successfully analyzed 20 herbal teas, showing a range of values for Si, P, S, Cl, Br, and I, indicating the potential health benefits of drinking herbal tea containing essential non-metallic elements.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Environmental Sciences
Andy Schmied, Aline Murawski, Marike Kolossa-Gehring, Peter Kujath
Summary: A method utilizing inductively coupled plasma-tandem mass spectrometry was developed and validated for multi-element analyses of human urine samples. The method's combination of simple sample preparation and state-of-the-art technique allows high-throughput and lowest limits of quantification up to 1 ng/L. The method's performance was demonstrated by successful participation in international interlaboratory comparison programs, showing its suitability for measuring the general population's exposure to various metals and metalloids.
Article
Spectroscopy
Yang Wu, Yihong Xu, Shan Xing, Xiongxin Dai, Ni Yuan, Maoyi Luo
Summary: A rapid bioassay method for plutonium in urine samples was developed using tandem quadrupole ICP-MS combined with a high-efficiency sample introduction system. The method was validated by analyzing urine samples spiked with known amounts of Pu-239 and Pu-240, with detection limits estimated to be 0.83fg for Pu-239 and 0.14fg for Pu-240 in 1L of urine.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Yue Luo, Gang Chen, Xiuqing Deng, Hanqing Cai, Xueheng Fu, Fujian Xu, Xiaonian Xiao, Yumeng Huo, Jin Luo
Summary: A method using high performance liquid chromatography-inductively coupled plasma-tandem mass spectrometry (HPLC-ICP-MS/MS) was developed for the speciation of six selenium species. The six species could be completely separated within 20 minutes under optimized conditions, and the method showed low detection limits and good recovery for selenium-enriched foods.
Article
Chemistry, Analytical
Thomas E. Lockwood, Mika T. Westerhausen, Philip A. Doble
Summary: Open-sourced software is crucial in the field of mass spectrometry imaging, and Pew2 is a specific and feature-rich open-source image processing software for LA-ICP-MS, designed to be fast, user-friendly, and in line with modern visualization philosophies.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Makoto Matsueda, Tomohiko Kawakami, Kazuma Koarai, Motoki Terashima, Kenso Fujiwara, Kazuki Iijima, Makoto Furukawa, Yoshitaka Takagai
Summary: Conventional ICP-MS struggles with simultaneous speciation of different Pu isotopes due to isobaric interferences, but ICP-MS/MS with CO2 gas reactions in a dynamic reaction cell effectively eliminates background noise caused by isotopic interference, enabling simultaneous analysis of Pu isotopes.
Article
Biochemical Research Methods
Maria S. Jimenez, Mariam Bakir, Daniel Isabal, Maria T. Gomez, Josefina Perez-Arantegui, Juan R. Castillo, Francisco Laborda
Summary: In this study, hydrodynamic chromatography coupled to inductively coupled plasma mass spectrometry was used to simultaneously determine dissolved and nanoparticulate species of gold and silver, with optimized mobile phase for resolution and recovery. The developed methods allowed for quick and accurate detection of nanoparticulate and dissolved species of gold and silver in dietary supplements, showing good agreement with other analysis methods. Due to achievable resolution, the quality of quantitative results is influenced by the relative abundance and size of nanoparticles present.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Shuji Yamashita, Shin-ichi Miyashita, Takafumi Hirata
Summary: Single particle inductively coupled plasma mass spectrometry was used to measure the size of individual nanoparticles. Two calibration approaches, particle size standard and ion standard solution, were evaluated for their uncertainties in size analysis. The relative uncertainties for 50 nm silver nanoparticles using particle size standards of 30 nm, 60 nm, and 100 nm were 15.0%, 9.9%, and 10.8% respectively. For the ion standard solution approach, the relative uncertainties for the 50 nm silver nanoparticles in solutions of 1 ng/g, 10 ng/g, and 100 ng/g were 18.5%, 7.6%, and 4.7% respectively. A high concentration working standard solution is recommended to improve precision on particle size determinations by spICP-MS.
Article
Chemistry, Analytical
Zichao Zhou, Ahmed Al Hejami, Mirah J. Burgener, John Burgener, Diane Beauchemin
Summary: This study optimized a total consumption infrared-heated sample introduction system for single particle inductively coupled plasma mass spectrometry, achieving efficient sample transport, improved detection sensitivity, and method size detection limit.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Analytical
Liang Fu, Guangsheng Huang, Yaobo Hu, Fusheng Pan
Summary: A new strategy using ICP-MS/MS was proposed for the determination of metal impurities in Mg(TFSI)(2) electrolytes. N2O was employed as the reaction gas and mass shift methods were used to achieve high sensitivities and low LODs. The method showed high accuracy and precision, as demonstrated by spike recovery experiments and comparative analyses with SF-ICP-MS.
ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Mariana Baptistao, Rodolfo Lorencatto, Marcos Nogueira Eberlin, Ana Valeria Colnaghi Simionato
Summary: A method using ICP-MS was developed and validated to analyze the elemental composition of urucum seeds. It was found that elements such as Ca, Mg, and K were present in higher levels, while elements like Al, Ba, Co, Cu, Fe, Mn, Mo, Ni, and Zn were present in lower concentrations. Statistical analysis revealed correlations between certain elements and the uneven distribution of Mo in the samples, potentially caused by soil treatment. This study provides useful information for future research on nutritional composition and farming procedures.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Claude Degueldre
Summary: The study proposes adapting the SP-ICP-MS method for identification and counting of single viruses, with analysis and identification achieved through counting of master and key ions. The counting of virus units can be completed in 20 seconds, with analysis of main and key ions recommended to be carried out in Ar torch.
Article
Chemistry, Analytical
D. Turiel-Fernandez, L. Gutierrez-Romero, M. Corte-Rodriguez, J. Bettmer, M. Montes-Bayon
Summary: Ultrasmall iron oxide nanoparticles were used as nanotransporters for cisplatin prodrug in cellular models, forming stable conjugates. Different techniques were used to characterize the nanoconjugate, and single cell-ICP-MS was employed to explore cellular uptake. The nanoconjugate exhibited higher intracellular platinum concentrations and DNA platination levels compared to cisplatin, showing potential for overcoming drug resistance.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biology
Cristina Sanchez-Gonzalez, Laura Moreno, Pilar Aranda, Maria Montes-Bayon, Juan Llopis, Lorenzo Rivas-Garcia
Summary: The study found that diabetes alters the metabolism of zinc, copper, and manganese, and treatment with vanadium(IV) can reverse the changes in zinc and copper homeostasis caused by hyperglycemia. This effect is possibly mediated by a decrease in DMT1 gene expression.
Article
Biochemistry & Molecular Biology
Alonso Rodriguez Pescador, Lucia Gutierrez Romero, Elisa Blanco-Gonzalez, Maria Montes-Bayon, L. Maria Sierra
Summary: This study investigated the cellular uptake, intracellular dissolution, and biological effects of ultra-small iron hydroxide adipate/tartrate coated nanoparticles in various cell lines. The results showed that these nanoparticles had minimal dissolution after uptake, with DNA damage mainly observed in NER deficient cells. The nanoparticles were found to be a safe alternative for anemia management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jorge Toledano-Serrabona, Octavi Camps-Font, Diogo Pompeu de Moraes, Mario Corte-Rodriguez, Maria Montes-Bayon, Eduard Valmaseda-Castellon, Cosme Gay-Escoda, M. Angeles Sanchez-Garces
Summary: This study evaluated the accumulation of ions in blood and organs caused by titanium metal particles in a mandibular defect in rats, and described the local reaction of oral tissues to this debris. The results suggest that titanium metal particles might increase the concentration of metal ions in vital organs and induce a foreign body reaction.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Chemistry, Analytical
J. S. F. Pereira, R. Alvarez-Fernandez Garcia, M. Corte-Rodriguez, A. Manteca, J. Bettmer, K. L. LeBlanc, Z. Mester, M. Montes-Bayon
Summary: This study used SELTM-1 as a certified reference material to compare the selenium concentrations in intra- and extracellular regions using different experimental procedures. The sequential procedure involving cell washing and freeze drying provided the most accurate results for quantifying the selenium content in both regions.
Biographical-Item
Biochemical Research Methods
Maria Montes-Bayon, Jose Manuel Costa Fernandez
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Roberto Alvarez-Fernandez Garcia, Lucia Gutierrez Romero, Jorg Bettmer, Maria Montes-Bayon
Summary: Single cell elemental (SC) analysis of isogenic cell cultures can be done using inductively coupled plasma (ICP-MS) detection. However, 2D cell cultures are just models to simplify the complexity of real tissue samples. In this study, the researchers demonstrated the capabilities of SC-ICP-MS to analyze single cell suspensions of isolated cells from tissues for the first time. They successfully optimized a cocktail of enzymes for tissue disaggregation and showed that the technique can accurately quantify elemental content and protein expression levels in disaggregated cells.
Article
Biochemistry & Molecular Biology
Lorenzo Rivas-Garcia, Alfonso Lopez-Varela, Jose L. Quiles, Maria Montes-Bayon, Pilar Aranda, Juan Llopis, Cristina Sanchez-Gonzalez
Summary: The present study aimed to evaluate the effect of co-treatment with copper (Cu) and bis(maltolato)oxovanadium(IV) (BMOV) on reducing the toxicity of BMOV. The results showed that co-incubation with both metals effectively reduced the toxicity of BMOV and enhanced its potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jorge Toledano-Serrabona, Diogo Pompeu de Moraes, Sara Gonzalez-Morales, M. Angeles Sanchez-Garces, Jorg Bettmer, Maria Montes-Bayon, Mario Corte-Rodriguez
Summary: This study investigates the presence of Ti, Al, and V metal ions and Ti nanoparticles in rat organs after implantoplasty surgery. The authors developed optimized methods for sample preparation and analysis, using microsampling inserts and enzymatic digestion, to quantify the metal contents. The results show a significant increase in Ti concentrations in various tissues of experimental animals compared to the control group, particularly in the brain and spleen. Additionally, Ti-containing nanoparticles were observed in all tissues analyzed.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Chemistry, Analytical
Lucia Gutierrez-Romero, Elisa Blanco-Gonzailez, Maria Montes-Bayon
Summary: This study reports the combination of fluorescence-activated cell sorting (FACS) and single-cell inductively coupled plasma mass spectrometry (SC-ICP-MS) for the first time. The method is used to evaluate the differences in cellular uptake of ultrasmall iron oxide nanoparticles (FeNPs) loaded with cisplatin (IV) prodrug (FeNPs-Pt(IV)) and cisplatin, and their effects on cell viability. FACS is used to separate different cell populations, which are then analyzed using SC-ICP-MS to determine the intracellular amount of platinum. This combined methodology provides a more accurate understanding of the intracellular drug content and cell death mechanisms associated with different drugs, and opens up possibilities for future single-cell experiments.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Kelly L. LeBlanc, Tantima Kumlung, Andres Suarez Priede, Paramee Kumkrong, Thippaya Junvee, Suladda Deawtong, Jorg Bettmer, Maria Montes-Bayon, Zoltan Mester
Summary: Mushrooms are considered a valuable food source due to their high protein and fiber and low fat content. This study showed that selenium-enriched Lingzhi mushrooms contained low levels of selenium, with selenomethionine being the most abundant form. The mycelium of these mushrooms showed significant selenium accumulation and the presence of selenium nanoparticles, which could have potential medicinal value.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
P. Garcia Cancela, N. Gonzalez Quinonez, M. Corte-Rodriguez, J. Bettmer, A. Manteca, M. Montes-Bayon
Summary: This study investigates the incorporation and storage form of copper ions in Streptomyces and reveals the correlation between copper nanoparticles and antibiotic production, suggesting their role in modulating secondary metabolism and preventing copper toxicity.
Article
Chemistry, Analytical
Michelle Buoso, Beatrice Campanella, Massimo Onor, Emanuela Pitzalis, Alessandro D'Ulivo
Summary: The use of BH intermediates as derivatization reagents significantly improves the tolerance to interference from transition metal ions in the generation of SbH3 and BiH3, and shows high tolerance in a wide range of acidity. The method has been successfully applied to the determination of Sb and Bi in complex samples, providing further understanding of the chemical behavior of borohydrides.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2024)
Article
Chemistry, Analytical
Chao-Feng Li, Xuan-Ce Wang, Zhu-Yin Chu, Peng Peng
Summary: Thermal ionization mass spectrometry (TIMS) is the standard method for obtaining precise Sr-87/Sr-86 isotopic ratios. However, our developed hydrofluoric acid coprecipitation method offers a low-cost, rapid, simple, and high-throughput alternative for analyzing red wine samples, effectively eliminating isobaric interference and matrix element inhibition.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2024)
Article
Chemistry, Analytical
Ivan B. Krstic, Bratislav M. Obradovic, Milorad M. Kuraica
Summary: This paper presents the spatio-temporal dynamics of a Grimm-type microsecond pulsed glow discharge (mu PGD) in argon at 6 mbar. The occurrence of a high current peak during the discharge ignition is analyzed and the importance of displacement current is emphasized. The development of electron excitation temperature for argon atoms and ions at various distances from the cathode is measured. The spatio-temporal evolution of selected spectral lines of argon and copper atoms and ions is analyzed during different phases of the discharge. The results suggest that the behavior of spectral line emissions differs between the pre-peak and afterglow periods, with different lines reaching maximum intensity during these phases. The appearance time and decay time of the afterpeak are shorter for ions than for atoms. These findings are explained in terms of three-body recombination processes and ion mobilities.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2024)
Article
Chemistry, Analytical
Qiuyun Wang, Anmin Chen, Xun Gao
Summary: In this paper, the combination of Tesla coil discharge (TCD) and laser-induced breakdown spectroscopy (LIBS) was used to enhance the emission of Al atomic lines and AlO molecular bands. The optimized distance between the TCD tip and the sample surface was found to be 5 mm, and the optimal laser energy was 25.1 mJ. Furthermore, TCD-SELIBS showed lower limits of detection (LoDs) for Cr and Pb elements compared to surface enhanced LIBS (SELIBS). The combination of TCD and LIBS is a promising technology for high-sensitivity analysis of heavy metals in water, with the advantages of simplicity, low cost, ease of operation, industrialization, and commercialization.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2024)
Article
Chemistry, Analytical
Yanwen Tang, Tingguang Lan, Jianfeng Gao, Zhongjie Bai, Xiaowen Huang, Junjie Han, Na Liu
Summary: Titanium is an important metal widely used in various industries. Ilmenite minerals are the main source of titanium metal and can be found in igneous and metamorphic rocks as well as different types of deposits. To accurately determine U-Pb ages of ilmenite, a new calibration method and appropriate reference materials are urgently needed. Laser ablation sector field inductively coupled plasma mass spectrometry has been used to minimize matrix effects and zircon 91500 has been identified as a suitable reference material for measuring the Pb/U ratio in ilmenite. The direct calibration method using zircon 91500 as an external standard has been found to be effective for in situ U-Pb dating of ilmenite samples under different ablation settings.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2024)