Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Isoorientin Induces Apoptosis and Autophagy Simultaneously by Reactive Oxygen Species (ROS)-Related p53, PI3K/Akt, JNK, and p38 Signaling Pathways in HepG2 Cancer Cells

(2014) Li Yuan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

AKT inhibition synergistically enhances growth-inhibitory effects of gefitinib and increases apoptosis in non-small cell lung cancer cell lines

(2014) M. Puglisi et al.   LUNG CANCER

Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-mediated pathway and mitochondrial dysfunction in hepatoblastoma cancer (HepG2) cells

(2014) Mohammad Ali Esmaeili et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Natural daucane esters induces apoptosis in leukaemic cells through ROS production

(2014) Stefano Dall’Acqua et al.   PHYTOCHEMISTRY

α-Lipoic acid protected cardiomyoblasts from the injury induced by sodium nitroprusside through ROS-mediated Akt/Gsk-3β activation

(2014) Surong Jiang et al.   TOXICOLOGY IN VITRO

Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways

(2014) V Gunda et al.   Cell Death & Disease

An Approach to Chemotherapy-Associated Toxicity

(2013) Zhanna Livshits et al.   EMERGENCY MEDICINE CLINICS OF NORTH AMERICA

Warburg effect increases steady-state ROS condition in cancer cells through decreasing their antioxidant capacities (Anticancer effects of 3-bromopyruvate through antagonizing Warburg effect)

(2013) Salah Mohamed El Sayed et al.   MEDICAL HYPOTHESES

ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells

(2013) Mahandranauth A. Chetram et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Deguelin Induces Both Apoptosis and Autophagy in Cultured Head and Neck Squamous Cell Carcinoma Cells

(2013) Yan-li Yang et al.   PLoS One

Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells

(2013) Rajeshwari Mehta et al.   PLoS One

Deguelin, an Akt Inhibitor, Down-Regulates NF-κB Signaling and Induces Apoptosis in Colon Cancer Cells and Inhibits Tumor Growth in Mice

(2012) Hyoun Woo Kang et al.   DIGESTIVE DISEASES AND SCIENCES

Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer

(2012) Baorui Liu et al.   International Journal of Nanomedicine

Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2)

(2012) Hao Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Curcumin delivery by methoxy polyethylene glycol–poly(caprolactone)  nanoparticles inhibits the growth of C6 glioma cells

(2011) Junfei Shao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K

(2011) Juan-Cheng Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Paclitaxel/Tetrandrine Coloaded Nanoparticles Effectively Promote the Apoptosis of Gastric Cancer Cells Based on “Oxidation Therapy”

(2011) Xiaolin Li et al.   MOLECULAR PHARMACEUTICS

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Resveratrol Suppresses Constitutive Activation of AKT via Generation of ROS and Induces Apoptosis in Diffuse Large B Cell Lymphoma Cell Lines

(2011) Azhar R. Hussain et al.   PLoS One

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

Enhanced cytotoxicity and activation of ROS-dependent c-Jun NH2-terminal kinase and caspase-3 by low doses of tetrandrine-loaded nanoparticles in Lovo cells – A possible Trojan strategy against cancer

(2010) Xiaolin Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells

(2009) Ji Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evaluation of the Antioxidant Properties of N-acetylcysteine in Human Platelets: Prerequisite for Bioconversion to Glutathione for Antioxidant and Antiplatelet Activity

(2009) Kyle R Gibson et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice

(2009) Chun-Gen Xing et al.   WORLD JOURNAL OF GASTROENTEROLOGY

AKT and Oxidative Stress Team Up to Kill Cancer Cells

(2008) Ignacio Dolado et al.   CANCER CELL