Journal
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
Volume 31, Issue 1, Pages 245-251Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ja00298b
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Funding
- Spanish Ministry of Economy and Competitiveness [CTQ2012-33494]
- Aragon Government (Fondo Social Europeo)
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The performance of a mixture of CH3F/He (1/9) as a reaction gas for the determination of As in biological fluids using a quadrupole ICP-MS instrument has been explored. A simple (dilute-and-shoot) interference-free method has been developed to quantify As concentrations at trace and ultra-trace levels in matrices with a high Cl content. As+ reacts with CH3F (through CH3F addition, followed by HF elimination) with high efficiency forming AsCH2+ as the primary reaction product, which can be monitored at a mass-to-charge ratio of 89, free from the Cl-based interferents (e.g., (ArCl+)-Ar-40-Cl-35 and (CaCl+)-Ca-40-Cl-35) that hamper the monitoring of As-75(+). Matrix effects are overcome by the use of Te as an internal standard and the addition of 3% v/v ethanol to all samples and calibration standard solutions. The method presented was validated by analysing a set of reference materials (blood, serum and urine) and by assessing As recovery from a set of real blood samples. With this method, the limit of detection was calculated to be 0.8 ng L-1 As, favourably comparable to the vast majority of values reported in the literature, even with those obtained using more sophisticated sector-field instrumentation.
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