Article
Biochemistry & Molecular Biology
Chiara Baggio, Roberto Luisetto, Carlotta Boscaro, Anna Scanu, Roberta Ramonda, Mattia Albiero, Paolo Sfriso, Francesca Oliviero
Summary: Genomic damage is associated with autoimmune processes, chronic inflammation, and apoptosis. The T cell compartment may exhibit overall genomic instability in certain rheumatological diseases. However, there is limited knowledge regarding leukocyte abnormalities in synovial fluid (SF) and their connection to inflammation. This study aimed to investigate cellular phenotypes in SF from patients with various inflammatory arthropathies. The results showed that inflammatory SF is associated with genomic instability and abnormal cell subsets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Kai Sun, Zhou Guo, Liangcai Hou, Jingting Xu, Ting Du, Tao Xu, Fengjing Guo
Summary: Iron is essential for cell functioning within mammalian organ systems, but excess iron can lead to oxidative stress damage. Patients with joint diseases often have excess iron content, which is closely associated with various pathological changes. Maintaining iron homeostasis is emphasized for potential therapeutic benefits in these arthropathies.
AGEING RESEARCH REVIEWS
(2021)
Article
Rheumatology
David Harris, Christopher Frampton, Sandeep Patel, Douglas White, Uri Arad
Summary: This retrospective cohort study aimed to investigate the association between acute CPP crystal arthritis and structural joint damage. The study found a significant increase in the rate of hip and knee joint arthroplasties in patients with acute CPP crystal arthritis, suggesting that it may be a chronic condition leading to joint damage.
Article
Rheumatology
Yanghuan Ou, Ting Xiong, Na Li, Shuaigang Liu, Xuan Yi, Xueqiang Deng, Douhui Guo, Shenliang Chen, Tao Cheng, Liang Hao
Summary: This study analyzed a multicenter database to investigate the efficacy of knee arthroscopy in improving symptoms of knee osteoarthritis. The results showed that knee arthroscopy did not have a significant impact on the improvement of knee symptoms, but increased the probability of new-onset grinding or clicking and frequent knee pain, aching, or stiffness symptoms compared to non-arthroscopy patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huan Deng, Haobiao Liu, Zhihao Yang, Miaoye Bao, Xue Lin, Jing Han, Chengjuan Qu
Summary: Selenium plays a crucial role in maintaining physiological homeostasis of bone and cartilage, and its deficiency is closely associated with the pathogenesis of arthropathies.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Orthopedics
Laura M. Krivicich, Kyle N. Kunze, Kevin C. Parvaresh, Kyleen Jan, Annie DeVinney, Amar Vadhera, Robert F. LaPrade, Jorge Chahla
Summary: Medial meniscus posterior root repair significantly reduces rates of radiographic OA progression and conversion to TKA at >60-month follow-up. These findings suggest consideration of repair of MMPRTs for improved outcomes when degenerative changes are not severe.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shani Austin-Williams, Mohammed T. Hussain, Silvia Oggero, Lucy Norling
Summary: Extracellular vesicles are small membrane-derived packages that contain regulatory material and play key roles in intercellular communication, including in the context of inflammatory and degenerative joint conditions. They offer a promising therapeutic strategy for musculoskeletal diseases and can be manipulated to enhance their regenerative properties.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Jinwei Xie, Yan Wang, Lingyun Lu, Lu Liu, Xijie Yu, Fuxing Pei
Summary: Cellular senescence plays a significant role in the onset and progression of osteoarthritis, but the link between cellular senescence and the disease remains unclear. Current evidence supports the involvement of senescent cells of different cell types in osteoarthritis, with a focus on the underlying mechanisms of senescence in chondrocytes.
AGEING RESEARCH REVIEWS
(2021)
Article
Surgery
Zhijia Wang, Rui Wang, Congliang Gao
Summary: This study aims to evaluate the impact of knee arthroscopic debridement combined with peripatellar denervation on restoring knee function in patients with knee osteoarthritis and analyze the risk factors affecting treatment outcomes. The results show that this combined treatment significantly improves knee function and reduces pain in patients with knee osteoarthritis.
Review
Orthopedics
Tarun Goyal, Sujit Kumar Tripathy, Alexander Schuh, Souvik Paul
Summary: The study aimed to investigate the outcomes and complication rates after total knee arthroplasty in patients with a history of knee arthroscopy for osteoarthritis. Results showed that prior knee arthroscopy may increase the risk of complications such as prosthetic joint infections, revision, and re-operations following total knee arthroplasty, although no significant differences were observed in functional outcomes and range of joint motion.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Automation & Control Systems
Xiaolong Zeng, Ye Zhu, Zhenyan Xie, Guoqing Zhong, Wenhan Huang, Limin Ma, Yu Zhang, Chuanbin Mao
Summary: This study demonstrates the use of 3D knee gait parameters in diagnosing and guiding therapeutic strategies for knee osteoarthritis (KOA). The establishment of diagnostic and predictive models using artificial intelligence (AI) provides new insights into knee kinematics and KOA diagnosis, offering a new approach for accurate diagnosis and assessment of KOA.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Review
Dermatology
Fujie Zhang, Jinlei Zhang, Tengyun Wang
Summary: Knee osteoarthritis is a prevalent and serious condition that significantly impacts the quality of life of elderly individuals. This study found that combining arthroscopy with sodium hyaluronate can effectively improve wound healing, manage pain, enhance knee function, and reduce inflammation in elderly patients with knee osteoarthritis.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Yunpeng Bai, Binhui Lin, Miao Wang, Haoliang Ding, Weibing Sun, Jian Sun
Summary: This study demonstrated that MOWHTO combined with arthroscopic microfracture can effectively improve clinical outcomes in the treatment of varus medial compartmental knee osteoarthritis. Cartilage regeneration can be promoted by correcting varus deformities, which affects clinical outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
M. Jarraya, A. Guermazi, J. W. Liew, I. Tolstykh, J. A. Lynch, P. Aliabadi, D. T. Felson, M. Clancy, M. Nevitt, C. E. Lewis, J. Torner, T. Neogi
Summary: The aim of this study was to report the prevalence of CT-detected intra-articular mineralization. It was found that 9.8% of knees had intra-articular mineralization based on CT imaging. Mineralization predominantly occurred in the three compartments of the joint, especially the patellofemoral compartment.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Biochemistry & Molecular Biology
Emad A. Ahmed, Abdullah M. Alzahrani
Summary: Osteoarthritis (OA) and rheumatoid arthritis (RA) are common disorders that significantly impact the quality of life of millions of people worldwide. This article summarizes the current knowledge about the involvement of SOXC transcription factors in arthritis progression and their potential use as diagnostic biomarkers and therapeutic targets. Studies have shown that dysregulation of SOX11 may promote arthritic progression, while SOX4 upregulation is consistently observed in OA and RA, making it a potential diagnostic biomarker and therapeutic target for arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Sindhu R. Johnson, Dafna D. Gladman, Hermine Brunner, David Isenberg, Ann E. Clarke, Megan R. W. Barber, Laurent Arnaud, Paul R. Fortin, Marta Mosca, Alexandre E. Voskuyl, Susan Manzi, Cynthia Aranow, Anca Askanase, Graciela S. Alarcon, Sang-Cheol Bae, Nathalie Costedoat-Chalumeau, Jessica A. English, Guillermo J. Pons-Estel, Bernardo A. Pons-Estel, Rebecca Gilman, Ellen M. Ginzler, John G. Hanly, Soren Jacobsen, Kenneth Kalunian, Diane L. Kamen, Chynace Lambalgen, Alexandra Legge, S. Sam Lim, Anselm Mak, Eric F. Morand, Christine A. Peschken, Michelle Petri, Anisur Rahman, Rosalind Ramsey-Goldman, John A. Reynolds, Juanita Romero-Diaz, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Elisabet Svenungsson, Zahi Touma, Murray Urowitz, Evelyne Vinet, Ronald F. van Vollenhoven, Heather Waldhauser, Daniel J. Wallace, Asad Zoma, Ian N. Bruce
Summary: The SLICC, ACR, and Lupus Foundation of America are developing a revised SLE damage index (SDI) due to shifts in the concept of damage in SLE. A qualitative study was conducted to evaluate contemporary constructs in SLE damage and develop a conceptual framework for the revised SDI.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Philip M. Carlucci, Jessica Li, Andrea Fava, Kristina K. Deonaraine, David Wofsy, Judith A. James, Chaim Putterman, Betty Diamond, Anne Davidson, Derek M. Fine, Jose Monroy-Trujillo, Mohamed G. Atta, Wade DeJager, Joel M. Guthridge, Kristin Haag, Deepak A. Rao, Michael B. Brenner, James A. Lederer, William Apruzzese, H. Michael Belmont, Peter M. Izmirly, Devyn Zaminski, Ming Wu, Sean Connery, Fernanda Payan-Schober, Richard Furie, Maria Dall'Era, Kerry Cho, Diane Kamen, Kenneth Kalunian, Jennifer Anolik, Jennifer Barnas, Mariko Ishimori, Michael H. Weisman, Jill P. Buyon, Michelle Petri
Summary: This study found that despite an inactive sediment or normal serologies, three-quarters of patients with UPCR <1 revealed histology showing class III, IV, V or mixed with accompanying activity and chronicity. These data support renal biopsy at thresholds lower than a UPCR of 1.
Meeting Abstract
Rheumatology
K. C. Kalunian, Y. Tanaka, I. Hupka, L. J. Zhang, M. Shroff, S. Werther, G. Abreu, C. Lindholm, R. Tummala
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Ronald F. van Vollenhoven, Kenneth C. Kalunian, Thomas Doerner, Bevra H. Hahn, Yoshiya Tanaka, Robert M. Gordon, Cathye Shu, Kaiyin Fei, Sheng Gao, Loqmane Seridi, Patrick Gallagher, Kim Hung Lo, Pamela Berry, Qing C. Zuraw
Summary: This study evaluated the efficacy and safety of ustekinumab in patients with active systemic lupus erythematosus (SLE). The results showed that ustekinumab did not demonstrate superiority over placebo in terms of efficacy, and there were no significant differences in adverse events between the treatment groups.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
R. van Vollenhoven, R. Furie, V. Werth, K. Kalunian, X. Huang, C. Musselli, C. Barbey, N. Franchimont
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
E. F. Morand, Y. Tanaka, R. Furie, E. Vital, R. van Vollenhoven, K. Kalunian, M. Mosca, T. Doerner, D. J. Wallace, M. Silk, C. Dickson, I. De la Torre, G. Meszaros, B. Jia, B. Crowe, M. A. Petri
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Ann E. Clarke, John G. Hanly, Murray B. Urowitz, Yvan St. Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. Van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Vernon Farewell
Summary: The objective of this study was to estimate the costs associated with neuropsychiatric events in SLE. The study found that new/ongoing SLE or non-SLE NP events incurred higher direct and indirect costs. Indirect costs exceeded direct costs by 3.0 to 5.2 fold.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Kenneth C. Kalunian, Richard Furie, Eric F. Morand, Ian N. Bruce, Susan Manzi, Yoshiya Tanaka, Kevin Winthrop, Ihor Hupka, Lijin Jinny Zhang, Shanti Werther, Gabriel Abreu, Micki Hultquist, Raj Tummala, Catharina Lindholm, Hussein Al-Mossawi
Summary: This study investigates the long-term safety and tolerability of anifrolumab 300 mg compared with placebo in patients with systemic lupus erythematosus (SLE). The results show that anifrolumab is well-tolerated and has a favorable benefit-risk profile in patients with moderate-to-severe SLE receiving standard therapy.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Michelle Petri, Ian N. Bruce, Thomas Doerner, Yoshiya Tanaka, Eric F. Morand, Kenneth C. Kalunian, Mario H. Cardiel, Maria E. Silk, Christina L. Dickson, Gabriella Meszaros, Lu Zhang, Bochao Jia, Youna Zhao, Conor J. McVeigh, Marta Mosca
Summary: Baricitinib, an oral inhibitor of Janus kinase 1 and 2, was evaluated as a treatment for patients with systemic lupus erythematosus (SLE) in a 52-week phase 3 study. The study found that baricitinib did not significantly improve SLE disease activity compared with placebo, and there were no new safety concerns.
Article
Rheumatology
Joy Buie, Lauren Bloch, Eric F. Morand, Ronald F. van Vollenhoven, Victoria P. Werth, Zahi Touma, Peter Lipsky, Kenneth Kalunian, Anca D. Askanase, L. Ines, Christopher Reed, MaryBeth Son, Timothy Franson, Karen Costenbader, Laura Eve Schanberg
Summary: Drug development in lupus has improved but lags behind other rheumatic diseases. Challenges in assessing lupus therapies include disease heterogeneity, study design limitations, and lack of validated biomarkers impacting regulatory decision-making. The meeting report addresses the need for standardized outcome measures to accelerate lupus therapeutics development and highlights ongoing efforts in outcome measure development.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Rashmi Dhital, Monica Guma, Dilli R. Poudel, Christina Chambers, Kenneth Kalunian
Summary: Care of young adults with SLE is challenging due to major life transitions co-occurring with chronic healthcare needs. This study found that young adults with SLE had higher rates of serious infection-related hospitalization compared to adults with SLE and young adults without SLE. Race/ethnicity and comorbidities were associated with hospitalization in young adults with SLE.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Yann Nguyen, Benoit Blanchet, Murray B. Urowitz, John G. Hanly, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Ann E. Clarke, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Joensen, Graciela S. Alarcon, Ronald F. Van Vollenhoven, Cynthia Aranow, Veronique Le Guern, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Jill Buyon, Nathalie Costedoat-Chalumeau
Summary: The study aimed to assess the association between severe nonadherence to hydroxychloroquine (HCQ), analyzed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality rates. Severe nonadherence was found to be independently associated with increased risk of SLE flares, early damage, and five-year mortality.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Maria Dall'Era, Kenneth Kalunian, Michael Eaddy, Augustina Ogbonnaya, Eileen Farrelly, Eric Turowski, Vanessa Birardi, Neil Solomons, Simrat Randhawa, Paola Mina-Osorio
Summary: This study aimed to evaluate treatment utilization and health care costs associated with active disease, low disease activity, and end-stage renal disease (ESRD) in patients with lupus nephritis (LN). The results showed that the treatment burden and costs were high for patients with active disease and ESRD, and treatments that allow patients to achieve and maintain low disease activity may help improve patient outcomes and reduce overall health care costs.
JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY
(2023)
