Article
Behavioral Sciences
Qing Ma, Edmund T. Rolls, Chu-Chung Huang, Wei Cheng, Jianfeng Feng
Summary: This study analyzed the functional connectivity of the human hippocampal memory system and found complex connections between the hippocampus and other brain regions, which contributes to a deeper understanding of the operation of the human hippocampal memory system.
Article
Psychology, Developmental
Vladislav Ayzenberg, Michael C. Granovetter, Sophia Robert, Christina Patterson, Marlene Behrmann
Summary: Hemispherectomy is a surgical procedure used to treat drug-resistant epilepsy. This study found that pediatric patients who undergo hemispherectomy show a high level of perceptual function despite losing certain visual pathways. The study also discovered that the ventral visual pathway has a greater ability to reorganize compared to the dorsal pathway.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Benjamin N. Conrad, Courtney Pollack, Darren J. Yeo, Gavin R. Price
Summary: A spatially consistent inferior temporal numeral area (ITNA) in the occipitotemporal cortex appears to preferentially process Arabic digits in adults. The reasons for the spatial segregation of ITNA from regions processing other orthographic stimuli and its consistency across individuals remain unknown. The study found stronger structural and functional connectivity of left ITNA with inferior parietal regions involved in numerical magnitude representation and arithmetic, while the right ITNA showed stronger connectivity with the ipsilateral inferior parietal cortex and bilateral IPS. These results suggest that the left ITNA may be more involved in mapping digits to verbal number representations, while the right ITNA may support the mapping of digits to quantity representations.
Article
Neurosciences
Edmund T. Rolls, Josef P. Rauschecker, Gustavo Deco, Chu-Chung Huang, Jianfeng Feng
Summary: Study investigated effective connectivity between auditory cortical regions and other cortical regions using data from 171 Human Connectome Project participants. A hierarchy of auditory cortical processing was identified, from core regions to belt regions and onward to higher-level regions. The study also found connections between auditory regions, visual regions, and language-related semantic regions, suggesting the involvement of multimodal processing in object identification and language comprehension.
Article
Geriatrics & Gerontology
Yi Chen, Qingze Zeng, Yunyun Wang, Xiao Luo, Yan Sun, Lumi Zhang, Xiaoyan Liu, Kaicheng Li, Minming Zhang, Guoping Peng
Summary: Patients with PCA and SD show global cognitive impairment, with distinct patterns of abnormal FC in language, visual, and salience networks. The FC changes are related to cognitive deficits in both syndromes.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Mingtong Liu, Chang Hong Liu, Shuang Zheng, Ke Zhao, Xiaolan Fu
Summary: This study used an ALE method to meta-analyze 96 neuroimaging studies and found that the left fusiform face area plays a crucial role in facial expression processing. A revised model was constructed with prominent roles assigned to the amygdala, FFA, occipital gyrus, and inferior frontal gyrus in a co-activating neural network.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Neha Atulkumar Singh, Peter R. Martin, Jonathan Graff-Radford, Mary M. Machulda, Minerva M. Carrasquillo, Nilufer Ertekin-Taner, Keith A. Josephs, Jennifer L. Whitwell
Summary: The presence of APOE e4 is associated with a higher risk of medial temporal involvement in PCA and LPA. This study examined the influence of APOE e4 on memory network connectivity in PCA and LPA patients. The results showed that APOE e4 carriers had reduced memory and language within-network connectivity in LPA, and increased salience within-network connectivity in PCA. Additionally, there was evidence of reduced DMN connectivity in APOE e4 carriers, with specific reductions in DMN-to-salience and DMN-to-language network connectivity in PCA, and DMN-to-visual network connectivity in LPA.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Cornelius Weiller, Marco Reisert, Volkmar Glauche, Mariachristina Musso, Michel Rijntjes
Summary: Intelligible communication and covert conscious thought require the integration of external representations and inner abstract concepts. Through studying participants in the Human Connectome Project, researchers have identified two hub regions in the brain that connect different cognitive processes, facilitating recursion and forethought.
Article
Radiology, Nuclear Medicine & Medical Imaging
Florence L. Chiang, Max Feng, Rebecca S. Romero, Larry Price, Crystal G. Franklin, Shengwen Deng, Jodie P. Gray, Fang F. Yu, Bundhit Tantiwongkosi, Susie Y. Huang, Peter T. Fox
Summary: The study defined the atrophy-based functional network model using coordinate-based meta-analysis, revealing the association of functional network disruption in multiple sclerosis and finding a strong positive correlation with clinical disability on resting-state functional MRI scans.
Article
Neurosciences
Edmund T. Rolls, Gustavo Deco, Chu-Chung Huang, Jianfeng Feng
Summary: This study investigates the effective connectivity in the human hippocampal memory system, revealing the directionality and strength of the connections between different brain regions. By connecting different information streams with the hippocampus, the hippocampal function is optimized.
Article
Neurosciences
Xinjun Suo, Hao Ding, Xi Li, Yaodan Zhang, Meng Liang, Yongqiang Zhang, Chunshui Yu, Wen Qin
Summary: The functional connector hubs anatomically bridge the DAN and VAN, with unique connectivity patterns resembling their functional connectivity, and the strength of anatomical connectivity is positively associated with functional connectivity at group- and individual-levels.
Article
Clinical Neurology
Tian Li, Dazhi Cheng, Chuansheng Chen, Gaolang Gong, Jing Lv, Xinlin Zhou
Summary: This study investigated the neurocognitive mechanisms underlying developmental dyscalculia in patients with Turner syndrome. The results showed that these patients have both visuospatial impairments and deficits in frontal cortex-based higher cognitive processing, with the latter being responsible for the development of dyscalculia.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Dror Shir, Jonathan Graff-Radford, Mary M. Machulda, Nha Trang Thu Pham, Clifford R. Jack, Val J. Lowe, Jennifer L. Whitwell, Keith A. Josephs
Summary: This study found that primary occipital posterior cortical atrophy (PCA) is characterized by an older age at onset, more color perception dysfunction, less severe ideomotor apraxia, and less hypometabolism in the temporo-parietal meta-ROI compared to established phenotypes.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Weifang Yin, Anming Li, Baiyuan Yang, Chao Gao, Yanfei Hu, Zhenglong Luo, Yuxia Li, Yongyun Zhu, Chuanbin Zhou, Hui Ren, Shimei Li, Xinglong Yang
Summary: This study investigates the association of altered cortical thickness and functional connectivity with depression in Parkinson's disease. The findings suggest that cortical thickness and functional connectivity may serve as neuroimaging-based diagnostic biomarkers for depression in Parkinson's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Athena Taymourtash, Ernst Schwartz, Karl-Heinz Nenning, Daniel Sobotka, Roxane Licandro, Sarah Glatter, Mariana Cardoso Diogo, Polina Golland, Ellen Grant, Daniela Prayer, Gregor Kasprian, Georg Langs
Summary: Measuring and understanding functional fetal brain development in utero is critical for the study of the developmental foundations of our cognitive abilities. Thalamocortical connections play an important role in shaping the cortical layout, but evidence for their normal in-utero development in humans is missing. In this study, we used in-utero functional magnetic resonance imaging to model fetal functional thalamocortical connectome development and observed peak connectivity strength between 29th and 31st gestational weeks.
Article
Neurosciences
Antonio Cerrato, Daniela Pacella, Francesco Palumbo, Diane Beauvais, Michela Ponticorvo, Orazio Miglino, Paolo Bartolomeo
Summary: E-TAN is a technology-enhanced platform for assessing visual neglect patients, which records the location, sequence, and timing of objects through an automatized process, effectively discriminating patients with visual neglect from those without. Patients can use this platform at home to track the effects of rehabilitation.
NEUROPSYCHOLOGICAL REHABILITATION
(2021)
Article
Neurosciences
Katarzyna Siuda-Krzywicka, Christoph Witzel, Paolo Bartolomeo, Laurent Cohen
Summary: The study found that naming and categorization of colors rely on different neural mechanisms, supported by networks with minimal overlap.
Article
Biochemistry & Molecular Biology
Cyril Atkinson-Clement, Camille-Albane Porte, Astrid de Liege, Yanica Klein, Cecile Delorme, Benoit Beranger, Romain Valabregue, Cecile Gallea, Trevor W. Robbins, Andreas Hartmann, Yulia Worbe
Summary: Tourette disorder (TD) is not generally considered a product of impulsivity, but unmedicated TD patients show increased waiting impulsivity compared to controls, which correlates with tic severity. Waiting impulsivity is related to functional connectivity of orbito-frontal cortex with caudate nucleus and structural changes within limbic areas in TD patients. The study suggests that waiting impulsivity in TD is specifically related to tic severity and certain brain structures.
MOLECULAR PSYCHIATRY
(2021)
Editorial Material
Behavioral Sciences
Paolo Bartolomeo
Review
Geriatrics & Gerontology
Clara Sanches, Chloe Stengel, Juliette Godard, Justine Mertz, Marc Teichmann, Raffaella Migliaccio, Antoni Valero-Cabre
Summary: Research has shown that non-invasive brain stimulation (NIBS) may help limit cognitive decline associated with neurodegenerative conditions, but the current clinical evidence is not yet sufficient to demonstrate its therapeutic benefit and clinical significance. Therefore, more double-blind placebo-controlled randomized clinical trials and reliable biomarkers are needed to strengthen the research.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Anatomy & Morphology
Jianghao Liu, Alfredo Spagna, Paolo Bartolomeo
Summary: This study reviewed evidence of hemispheric laterality of visual mental imagery, finding that both frontoparietal networks in both hemispheres and left inferior temporal lobe are associated with visual mental imagery. Different lateralization patterns were observed when endogenously generated images are compared to those induced by exogenous stimulation, indicating a crucial participation of high-level visual regions in the temporal lobes in visual mental imagery.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Quentin Welniarz, Emmanuel Roze, Benoit Beranger, Aurelie Meneret, Marie Vidailhet, Stephane Lehericy, Pierre Pouget, Mark Hallett, Sabine Meunier, Cecile Gallea
Summary: The modality of movement selection may influence the brain networks involved during the execution phase, with freely chosen movements showing increased activation in the pre-supplementary motor area, parietal, and cerebellar regions. Freely chosen movements also exhibit increased information flow between the right posterior parietal cortex and the cerebellum compared to instructed movements. This suggests that the parieto-cerebellar network is particularly engaged during freely chosen movements to monitor the congruence between intentional content and outcome.
Article
Medicine, Research & Experimental
Paolo Bartolomeo
Summary: This study discusses cognitive deficits caused by stroke and the impact of listening to music on stroke recovery, proposing several hypotheses. It suggests that connectivity within and between hemispheres plays a key role in cognitive recovery, and listening to music may help reconnect isolated brain regions affected by stroke.
MEDICAL HYPOTHESES
(2022)
Article
Anatomy & Morphology
Dounia Hajhajate, Brigitte C. Kaufmann, Jianghao Liu, Katarzyna Siuda-Krzywicka, Paolo Bartolomeo
Summary: This article describes the Fusiform Imagery Node (FIN), a region in the left temporal lobe that is consistently activated during visual mental imagery. The study found that despite extensive damage to the left hemisphere due to stroke, a patient still had normal subjective experience and behavioral performance in visual mental imagery tasks. The FIN was also found to have connections with the anterior temporal lobe and frontal regions, suggesting its role in bridging visual information and semantic knowledge.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Computer Science, Interdisciplinary Applications
Benedetta Franceschiello, Tommaso Di Noto, Alexia Bourgeois, Micah M. Murray, Astrid Minier, Pierre Pouget, Jonas Richiardi, Paolo Bartolomeo, Fabio Anselmi
Summary: This study introduces new methods for preprocessing and classifying eye-movement trajectories in patients with neglect syndrome. Machine learning models performed well in distinguishing neglect patients from healthy individuals, and their scores correlated with the severity of neglect behavior and the integrity of white matter tracts.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Clinical Neurology
Brigitte C. Kaufmann, Dario Cazzoli, Manuela Pastore-Wapp, Tim Vanbellingen, Tobias Pflugshaupt, Daniel Bauer, Rene M. Muri, Tobias Nef, Paolo Bartolomeo, Thomas Nyffeler
Summary: This study found that lesions at a specific white matter intersection can cause a breakdown of the multiple-demand network, leading to impaired cognitive performance. These findings have the potential to influence future rehabilitative approaches.
Letter
Clinical Neurology
Brigitte C. Kaufmann, Dario Cazzoli, Thomas Nyffeler, Paolo Bartolomeo
Editorial Material
Biology
Paolo Bartolomeo, Tal Seidel Malkinson
PHYSICS OF LIFE REVIEWS
(2023)
Editorial Material
Behavioral Sciences
Paolo Bartolomeo, Gabriele Miceli
Article
Behavioral Sciences
Jianghao Liu, Paolo Bartolomeo
Summary: Individuals experience different levels of vividness in their visual mental images. A study with 117 healthy participants found that those with congenital aphantasia, a condition characterized by absent or near-absent visual imagery, had slower response times in both imagery and perceptual tasks, but similar levels of accuracy compared to other groups. These findings support the hypothesis that congenital aphantasia primarily involves a deficit of phenomenal consciousness.