Article
Clinical Neurology
Binyin Li, Huidong Tang, Guiying He, Zhijia Jin, Yixi He, Pei Huang, Naying He, Shengdi Chen
Summary: Cognitive training combined with Tai Chi has positive effects on delaying mild cognitive impairment (MCI) progression to dementia. Prolonged mixed training further delays decline in global cognition and memory. Functional magnetic resonance imaging shows increased regional activity in both cognitive training and Tai Chi group.
ALZHEIMERS & DEMENTIA
(2023)
Article
Behavioral Sciences
Ning Zhao, Xiuxia Yao, Yafei Wang, Xiao Chen, Zhaoxia Wang
Summary: Aerobic exercise combined with memory strategy training can effectively improve memory and cognitive function in patients with type 2 diabetes mellitus.
BRAIN AND BEHAVIOR
(2023)
Article
Medicine, Research & Experimental
Dereck Salisbury, Tom Plocher, Fang Yu
Summary: This study aims to test the synergistic efficacy of an exergame intervention (simultaneous moderate-intensity aerobic cycling and cognitive training) on cognition and aerobic fitness in community-dwelling older adults with SCD. The study will evaluate the efficacy of exergame in older adults with SCD and assess the distraction effect of exergame on aerobic fitness. Data will be analyzed using ANOVA following intention-to-treat, providing effect-size estimates for future trials in AD prevention research.
Article
Health Care Sciences & Services
Ran Li, Jiawei Geng, Runze Yang, Yumeng Ge, Therese Hesketh
Summary: This systematic review suggests that computerized cognitive training (CCT) interventions could improve global cognitive function in patients with mild cognitive impairment (MCI), although the evidence is still limited. More comprehensive trials are needed to evaluate the impact of CCT on cognitive decline, especially in the longer term, and to determine whether CCT should be recommended for use in clinical practice.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Geriatrics & Gerontology
Ismail Uysal, Selda Basar, Suleyman Aysel, Devrim Kalafat, Ali Onder Buyuksunnetci
Summary: The aim of this study was to investigate the effects of different exercise combinations on cognitive status, muscle strength, mobility, physical performance, mood, and quality of life in older adults with mild cognitive impairment. The results showed that aerobic exercise and dual-task training is the best combination for improving cognitive status, mobility, and physical performance.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Jong-Hyeon Kim, Jin-Hyuck Park
Summary: There is controversy over the effectiveness of dual-task training in improving cognitive function in people with mild cognitive impairment. This study developed and verified the effects of a cognitive-physical dual-task training program on executive function in older adults with MCI. The results showed that cognitive-physical dual-task training is clinically beneficial in improving executive function and daily instrumental activities for older adults with MCI.
Article
Geriatrics & Gerontology
Yi Zhu, Yaxin Gao, Chuan Guo, Ming Qi, Ming Xiao, Han Wu, Jinhui Ma, Qian Zhong, Hongyuan Ding, Qiumin Zhou, Nawab Ali, Li Zhou, Qin Zhang, Ting Wu, Wei Wang, Cuiyun Sun, Lehana Thabane, Ling Zhang, Tong Wang
Summary: This study demonstrates that aerobic dance can increase the right and total hippocampal volumes and improve episodic memory in elderly individuals with amnestic mild cognitive impairment (aMCI).
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Geriatrics & Gerontology
Baiqing Huang, Kang Chen, Ying Li
Summary: Aerobic exercise is a promising intervention for mild cognitive impairment (MCI), showing both clinical and molecular benefits. It can help mitigate hypertension and type 2 diabetes mellitus, which increase the risk of MCI. At a molecular level, aerobic exercise modulates the activation of microglia and astrocytes, and promotes the release of exercise factors that enhance synaptic plasticity and neuroprotection. However, further validation and research are needed to understand the precise molecular mechanisms and develop targeted therapeutics for MCI.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Maria M. Costello, Christine E. McCarthy, Conor Judge, Karen Dennehy, Clodagh Mc Dermott, Tomas O. Flatharta, Martin J. O'Donnell, Michelle D. Canavan
Summary: Interventions targeting household lifestyle may benefit cognitive function in later life, although current studies focus on dyads with unclear effects on cognitive outcomes, functional outcomes, or long-term care admissions. Further research is needed to explore the effects of lifestyle interventions on dementia prevention at the household level.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Endocrinology & Metabolism
Cindy K. K. Barha, Samantha Y. Y. Starkey, G. Y. Robin Hsiung, Roger Tam, Teresa Liu-Ambrose
Summary: This study investigated the effects of aerobic exercise on cognitive function in older adults and found that the BDNF gene and biological sex may influence exercise outcomes. The study suggests that future research should consider the BDNF gene and biological sex to better understand the benefits of aerobic exercise on cognitive function and establish exercise as a medicine for cognitive health.
BIOLOGY OF SEX DIFFERENCES
(2023)
Review
Cell Biology
Tibor Hortobagyi, Tomas Vetrovsky, Guilherme Moraes Balbim, Narlon Cassio Boa Sorte Silva, Andrea Manca, Franca Deriu, Mia Kolmos, Christina Kruuse, Teresa Liu-Ambrose, Zsolt Radak, Mark Vaczi, Hanna Johansson, Paulo Cezar Rocha dos Santos, Erika Franzen, Urs Granacher
Summary: This article investigates the effects of low- vs. high-intensity exercise on neuroplasticity, motor and cognitive function in different populations. The results suggest that exercise intensity is positively correlated with neuroplasticity in healthy young individuals, but not necessarily in healthy older adults and neurological patients. Additionally, improvements in neuroplasticity induced by exercise are associated with changes in motor outcomes, but not cognitive outcomes.
AGEING RESEARCH REVIEWS
(2022)
Article
Psychology, Multidisciplinary
Marina Maffoni, Antonia Pierobon, Cira Fundaro
Summary: This paper proposes a new screening tool called MASCoD, with English and Italian versions, and explores its preliminary adoption on a pilot sample. The tool shows promise in helping professionals make differential diagnosis and predict the risk of developing severe cognitive impairment over time, allowing for personalized care. It is brief, easily embeddable in usual clinical assessment, and can be administered by different professionals.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Sara Arlati, Simona Gabriella Di Santo, Flaminia Franchini, Marta Mondellini, Beatrice Filiputti, Matilde Luchi, Federica Ratto, Giancarlo Ferrigno, Marco Sacco, Luca Greci
Summary: The study evaluated the acceptance and usability of an immersive virtual reality environment requiring real walking and active interaction for older adults with cognitive impairments. Results showed that older adults found the immersive VR environment to be well-accepted and enjoyable, but cognitive deficits could lead to risky behaviors and issues in interacting with virtual items.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Geriatrics & Gerontology
Ting Liu, Na Li, Zongjie Hou, Linsheng Liu, Lihong Gao, Lin Wang, Jiying Tan
Summary: Nutrition combined physical exercise interventions can improve global cognitive function in the aged with cognitive decline, but no statistical differences were found in specific cognitive domains. Further research is needed to clarify the effects of these interventions, particularly in older adults.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Psychology, Multidisciplinary
Julie A. Cantelon, Grace E. Giles
Summary: The current research on the effects of acute aerobic exercise on cognitive function has primarily focused on the long-term effects, while giving less attention to cognitive changes during exercise. Effects on working memory and cognitive flexibility during exercise remain unclear, while effects on inhibition are more pronounced.
FRONTIERS IN PSYCHOLOGY
(2021)