Article
Biochemistry & Molecular Biology
Lorenzo Barba, Steffen Halbgebauer, Federico Paolini Paoletti, Giovanni Bellomo, Samir Abu-Rumeileh, Petra Steinacker, Federico Massa, Lucilla Parnetti, Markus Otto
Summary: The expression of SerpinA1 isoforms is altered in patients with Alzheimer's disease (AD) and correlates with core biomarkers of the disease. Analysis of SerpinA1 isoforms shows good diagnostic accuracy in distinguishing AD patients from other neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Emelie Andersson, Nina Schultz, Takashi Saito, Takaomi C. Saido, Kaj Blennow, Gunnar K. Gouras, Henrik Zetterberg, Oskar Hansson
Summary: This study investigated the relationship between A beta 42/A beta 40 ratios and cerebral A beta pathology using App knock-in mouse models. The results showed a negative association between A beta 42/A beta 40 ratios and cerebral A beta plaque burden in App(NL-F/NL-F) mice, with stronger correlations observed in CSF compared to serum. Additionally, the decline in A beta 42/A beta 40 ratios in CSF and serum occurred after the deposition of A beta aggregates in the brain reached significance. However, no similar changes were observed in App(NL/NL) mice.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Review
Neurosciences
Chang Xu, Li Zhao, Chunbo Dong
Summary: The number of patients with Alzheimer's disease (AD) and non-AD has increased significantly in recent decades. The amyloid cascade hypothesis highlights the role of amyloid-beta protein in the development of AD. CSF A beta(42/40) has been extensively studied and integrated into diagnostic tools for AD, while blood-based A beta(42/40) has also been found to have abnormal levels in sync with CSF biomarker values.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Anja Hviid Simonsen, Christian Sandoe Musaeus, Gitte Lund Christensen, Steen Gregers Hasselbalch, Gunhild Waldemar
Summary: The study found a significant increase in A beta(1-42) levels in the cerebrospinal fluid over a period of twelve years, independent of changes in tau. Thus, awareness of this upward trend is crucial during diagnosis and selection of historical samples for research purposes.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Sakulrat Mankhong, Sujin Kim, Seongju Lee, Hyo-Bum Kwak, Dong-Ho Park, Kyung-Lim Joa, Ju-Hee Kang
Summary: This article reviews the discovery and development of biomarkers for Alzheimer's disease (AD), discussing the use of cerebrospinal fluid (CSF) and blood-based biomarkers. The proposed ATN scheme may provide a common language for researchers studying AD. Blood-based biomarkers offer a promising alternative to CSF biomarkers.
Article
Biochemistry & Molecular Biology
Hans-Wolfgang Klafki, Oliver Wirths, Brit Mollenhauer, Thomas Liepold, Petra Rieper, Hermann Esselmann, Jonathan Vogelgsang, Jens Wiltfang, Olaf Jahn
Summary: Neurochemical biomarkers can aid in the diagnosis of Alzheimer's disease, and the A beta-3-40/A beta 1-42 ratio in blood plasma can accurately predict cerebral amyloid-beta pathology. The presence of A beta-3-40 and A beta-3-38 in human cerebrospinal fluid has been confirmed, and the ratio of CSF A beta-3-40/A beta 42 appears to be increased in individuals with amyloid-beta PET-positive results.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kamolwan Watcharatanyatip, Somchai Chutipongtanate, Daranee Chokchaichamnankit, Churat Weeraphan, Kanokwan Mingkwan, Virat Luevisadpibul, David S. Newburg, Ardythe L. Morrow, Jisnuson Svasti, Chantragan Srisomsap
Summary: This study employed a translational proteomic approach to discover and develop a multiplex CCA biomarker assay. The identified biomarkers showed strong predictive performance for CCA diagnosis, indicating their potential use in identifying individuals at risk of CCA.
Review
Clinical Neurology
Kyu Hwan Shim, Min Ju Kang, Young Chul Youn, Seong Soo A. An, SangYun Kim
Summary: The study reviews and summarizes the physiological and pathophysiological functions, structures, and genetics of alpha-syn in Alzheimer's disease (AD). Numerous associations of alpha-syn with A beta and tau suggest its significance as a partner in the pathological roles of AD. Understanding the involvement of alpha-syn in the pathology of A beta and tau could help address unresolved issues of AD. Specifically, the current status of CSF alpha-syn in AD recommends it as an additional biomarker in AD diagnosis.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Review
Engineering, Biomedical
Sohui Park, YoungSoo Kim
Summary: Alzheimer's disease is the most common cause of dementia worldwide, however, the lack of reliable diagnostic biomarkers is a major obstacle. A beta levels in CSF and plasma show promise for early diagnosis of AD patients, but variations in concentrations within and between individuals highlight the need for reevaluation and standardization of detection methods.
BIOMEDICAL ENGINEERING LETTERS
(2021)
Article
Clinical Neurology
Anniina Snellman, Juan Lantero-Rodriguez, Andreja Emersic, Agathe Vrillon, Thomas K. Karikari, Nicholas J. Ashton, Milica Gregoric Kramberger, Sasa Cucnik, Claire Paquet, Uros Rot, Henrik Zetterberg, Kaj Blennow
Summary: The study develops new N-terminal-directed CSF total tau assays, which show increased levels ahead of standard t-tau in the Alzheimer's disease continuum, higher levels in patients with CJD or acute neurological diseases, and better potential as Alzheimer's disease blood biomarkers compared to Quanterix total tau.
Article
Biochemistry & Molecular Biology
Jin Song, Lori J. Sokoll, Daniel W. Chan, Zhen Zhang
Summary: A study identified a two-marker panel (CA19-9 and CA-125) that significantly improved the detection performance of PDAC. Another two-marker panel (HE4 and CEA) also outperformed CA19-9 in distinguishing IPMN from chronic pancreatitis. These biomarker panels showed potential complementarity in detecting early PDAC, and further clinical validation is warranted.
Article
Neurosciences
Silvia Rodrigo-Herrero, Andrea Luque-Tirado, Carlota Mendez-Barrio, David Garcia-Solis, Maria Bernal Sanchez-Arjona, Juan Manuel Oropesa-Ruiz, Didier Maillet, Emilio Franco-Macias
Summary: The Memory Associative Test TMA-93 can be used to detect early-stage Alzheimer's disease and has reasonable diagnostic utility, similar to the Free and Cued Selective Reminding Test (FCSRT). The total score of TMA-93 has the potential to improve the prediction of AD biomarker results when added to FCSRT variables.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Immunology
Kevin D. Rynearson, Moorthi Ponnusamy, Olga Prikhodko, Yuhuan Xie, Can Zhang, Phuong Nguyen, Brenda Hug, Mariko Sawa, Ann Becker, Brian Spencer, Jazmin Florio, Michael Mante, Bahar Salehi, Carlos Arias, Douglas Galasko, Brian P. Head, Graham Johnson, Jiunn H. Lin, Steven K. Duddy, Robert A. Rissman, William C. Mobley, Gopal Thinakaran, Rudolph E. Tanzi, Steven L. Wagner
Summary: The potent gamma-secretase modulator has shown robust time- and dose-dependent efficacy in animal studies, with a >40-fold safety margin in rats.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Clinical Neurology
Feng Gao, Xinyi Lv, Linbin Dai, Qiong Wang, Peng Wang, Zhaozhao Cheng, Qiang Xie, Ming Ni, Yan Wu, Xianliang Chai, Wenjing Wang, Huaiyu Li, Feng Yu, Yuqin Cao, Fang Tang, Bo Pan, Guoping Wang, Kexue Deng, Shicun Wang, Qiqiang Tang, Jiong Shi, Yong Shen
Summary: This study tested the utility of the A/T/N system in the Chinese population and investigated core AD biomarkers in a newly established Chinese cohort. The results showed that CSF A beta 42/A beta 40, CSF p-tau, and plasma p-tau had high concordance in discriminating between AD and non-AD dementia or elderly controls. A combination of plasma p-tau, APOE genotype, and MRI measures accurately predicted amyloid PET status.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Guido Domingo, Luisa Benussi, Claudia Saraceno, Michela Bertuzzi, Roland Nicsanu, Antonio Longobardi, Sonia Bellini, Alfredo Cagnotto, Mario Salmona, Giuliano Binetti, Roberta Ghidoni
Summary: A newly developed antibody-free method was used to identify and quantify Aβ isoforms in human CSF, revealing the presence of novel Aβ species. Among these, five Aβ isoforms found in CSF of elderly individuals may serve as potential markers for Alzheimer's disease progression.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jonathan Vogelgsang, Philipp Hessmann, Claus Wolff-Menzler, Stephan Gysser, Gerhard A. Mueller, Jens Wiltfang
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Sarah Teuber-Hanselmann, Jan Rekowski, Jonathan Vogelgsang, Christine von Arnim, Kathrin Reetz, Andreas Stang, Karl-Heinz Joeckel, Jens Wiltfang, Herrmann Esselmann, Markus Otto, Hayrettin Tumani, Arne Herring, Kathy Keyvani
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Article
Clinical Neurology
Charles Timaeus, Jonathan Vogelgsang, Bernhard Kis, Katrin Radenbach, Claus Wolff-Menzler, Kiriaki Mavridou, Stephan Gysser, Philipp Hessmann, Jens Wiltfang
Summary: This study evaluates the current clinical practice of Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation in German psychiatry, indicating a growing demand for both treatments, particularly in cases of depression, with higher rates of ECT in older patients, females, and those with severe and psychotic depression.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Maxine Dibue-Adjei, Marcel Alexander Kamp, Jonathan Vogelsang, Jens Wiltfang, Claus Wolff-Menzler
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2020)
Article
Neurosciences
Tania Soares Martins, Sandra Magalhaes, Ilka Martins Rosa, Jonathan Vogelgsang, Jens Wiltfang, Ivonne Delgadillo, Jose Catita, Odete A. B. da Cruz e Silva, Alexandra Nunes, Ana Gabriela Henriques
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Geriatrics & Gerontology
Moira Marizzoni, Clarissa Ferrari, Claudio Babiloni, Diego Albani, Frederik Barkhof, Libera Cavaliere, Mira Didic, Gianluigi Forloni, Federica Fusco, Samantha Galluzzi, Tilman Hensch, Jorge Jovicich, Camillo Marra, Jose Luis Molinuevo, Flavio Nobili, Lucilla Parnetti, Pierre Payoux, Jean-Philippe Ranjeva, Federica Ribaldi, Elena Rolandi, Paolo Maria Rossini, Marco Salvatore, Andrea Soricelli, Magdalini Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C. Richardson, Regis Bordet, Olivier Blin, Giovanni B. Frisoni
NEUROBIOLOGY OF AGING
(2020)
Article
Psychiatry
Ashley L. Comes, Darina Czamara, Kristina Adorjan, Heike Anderson-Schmidt, Till F. M. Andlauer, Monika Budde, Katrin Gade, Maria Hake, Janos L. Kalman, Sergi Papiol, Daniela Reich-Erkelenz, Farah Kloehn-Saghatolislam, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Georg Juckel, Max Schmauss, Joerg Zimmermann, Jens Reimer, Eva Reininghaus, Ion-George Anghelescu, Carsten Konrad, Andreas Thiel, Christian Figge, Martin von Hagen, Manfred Koller, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Stephanie H. Witt, Sugirthan Sivalingam, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Noethen, Jens Wiltfang, Peter Falkai, Thomas G. Schulze, Urs Heilbronner
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2020)
Review
Neurosciences
Charles Timaeus, Philipp von Gottberg, Sina Hirschel, Claudia Lange, Jens Wiltfang, Niels Hansen
Summary: Autoimmune dementia is a complex field involving various neuropsychiatric disorders, with potential implications of KCNA2 autoantibodies needing further investigation.
Article
Psychiatry
Bernadette Wendel, Sergi Papiol, Till F. M. Andlauer, Joerg Zimmermann, Jens Wiltfang, Carsten Spitzer, Fanny Senner, Eva C. Schulte, Max Schmauss, Sabrina K. Schaupp, Jonathan Repple, Eva Reininghaus, Jens Reimer, Daniela Reich-Erkelenz, Nils Opel, Susanne Meinert, Carsten Konrad, Farahnaz Kloehn-Saghatolislam, Tilo Kircher, Janos L. Kalman, Georg Juckel, Andreas Jansen, Markus Jaeger, Maria Heilbronner, Martin von Hagen, Katrin Gade, Christian Figge, Andreas J. Fallgatter, Detlef E. Dietrich, Udo Dannlowski, Ashley L. Comes, Monika Budde, Bernhard T. Baune, Volker Arolt, Ion-George Anghelescu, Heike Anderson-Schmidt, Kristina Adorjan, Peter Falkai, Thomas G. Schulze, Heike Bickeboeller, Urs Heilbronner
Summary: The study found that executive functions improved across diagnostic groups and identified nine genome-wide significant SNPs associated with performance change over time. The findings were replicated in a separate study, demonstrating the potential of longitudinally measured phenotypes to reveal novel genetic associations.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Tania Soares Martins, Rui Marcalo, Cristovao B. da Cruz e Silva, Dario Trindade, Jose Catita, Francisco Amado, Tania Melo, Ilka Martins Rosa, Jonathan Vogelgsang, Jens Wiltfang, Odete A. B. da Cruz e Silva, Ana Gabriela Henriques
Summary: Exosomes in blood can serve as biomarkers for the diagnosis of Alzheimer's disease (AD) and monitoring disease progression. Proteomic analysis identified 9 significantly different abundant proteins between healthy controls and AD cases, and their levels were validated using antibody-based approaches. These findings contribute to the development of blood-based tools for AD diagnosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Arkadiusz Komorowski, Matej Murgas, Ramon Vidal, Aditya Singh, Gregor Gryglewski, Siegfried Kasper, Jens Wiltfang, Rupert Lanzenberger, Roberto Goya-Maldonado
Summary: The exploration of the spatial relationship between gene expression profiles and task-evoked response patterns known to be altered in neuropsychiatric disorders can guide the development of more targeted therapies. The identification of stable relationships between spatial gene expression profiles and fMRI data may reshape the prospects for imaging transcriptomics studies.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemical Research Methods
Maria J. Cardoso Ferreira, Tania Soares Martins, Steven R. Alves, Ilka Martins Rosa, Jonathan Vogelgsang, Niels Hansen, Jens Wiltfang, Odete A. B. da Cruz e Silva, Rui Vitorino, Ana Gabriela Henriques
Summary: Aging is the main risk factor for age-related neurodegenerative diseases, such as Alzheimer's disease (AD), which is characterized by the presence of senile plaques (SPs) and neurofibrillary tangles (NFTs). This study conducted a literature review to identify the proteomes of SPs and NFTs, followed by a bioinformatic analysis and validation of potential biomarkers.
Article
Psychology, Multidisciplinary
M. Basilowski, B. Schonfeld, S. Esser, A. Jatho, M. Kownatka, J. Signerski-Krieger, H. Esselmann, M. Grabemann, C. Mette, L. Strunz, M. Zimmermann, E. Lajcsak, N. Scherbaum, J. Wiltfang, B. Kis, M. Abdel-Hamid
CURRENT PSYCHOLOGY
(2020)
Article
Geriatrics & Gerontology
Jonathan Vogelgsang, Bernhard Kis, Katrin Radenbach, Claus Wolff-Menzler, Kiriaki Mavridou, Charles Timaeus, Stephan Gysser, Jens Wiltfang, Philipp Hessmann
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Neuroimaging
Tommaso Ballarini, Franziska Albrecht, Karsten Mueller, Robert Jech, Janine Diehl-Schmid, Klaus Fliessbach, Jan Kassubek, Martin Lauer, Klaus Fassbender, Anja Schneider, Matthis Synofzik, Jens Wiltfang, Markus Otto, Matthias L. Schroeter
NEUROIMAGE-CLINICAL
(2020)