Exosome engineering for efficient and targeted drug delivery: Current status and future perspective

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

(2022) Asma Akbar et al.   Cells

Microbubbles versus Extracellular Vesicles as Therapeutic Cargo for Targeting Drug Delivery

(2021) Mujib Ullah et al.   ACS Nano

Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System

(2021) Monique C. P. Mendonça et al.   MOLECULAR PHARMACEUTICS

Exploring the utility of extracellular vesicles in ameliorating viral infection-associated inflammation, cytokine storm and tissue damage

(2021) Nagavalli Pillalamarri et al.   Translational Oncology

Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response

(2021) Mujib Ullah et al.   Oncotarget

Artificial intelligence and guidance of medicine in the bubble

(2021) Asma Akbar et al.   Cell and Bioscience

Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells

(2021) Mujib Ullah et al.   World Journal of Stem Cells

Microvesicles and exosomes in metabolic diseases and inflammation

(2020) L. Dini et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Exosomes as drug delivery vehicle and contributor of resistance to anticancer drugs

(2020) Mahendran Chinnappan et al.   CANCER LETTERS

State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review

(2020) Javier Donoso-Quezada et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Thermosensitive Exosome–Liposome Hybrid Nanoparticle‐Mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer

(2020) Qijun Lv et al.   Advanced Science

Exosome engineering: Current progress in cargo loading and targeted delivery

(2020) Shengyang Fu et al.   NanoImpact

Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway

(2020) Kai Chen et al.   CIRCULATION RESEARCH

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

(2019) Bahman Homayun et al.   Pharmaceutics

Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery

(2019) Sagar Rayamajhi et al.   Acta Biomaterialia

Mannose‐Modified Serum Exosomes for the Elevated Uptake to Murine Dendritic Cells and Lymphatic Accumulation

(2019) Eun Seo Choi et al.   MACROMOLECULAR BIOSCIENCE

Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration

(2019) Mattaka Khongkow et al.   Scientific Reports

Exosomal DNA aptamer targeting α-synuclein aggregates reduced neuropathological deficits in a mouse Parkinson’s Disease model

(2019) Xiaoxi Ren et al.   Molecular Therapy-Nucleic Acids

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

(2019) Sophie A. Dusoswa et al.   Journal of Extracellular Vesicles

Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

(2019) Mengyu Yu et al.   CANCER SCIENCE

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy

(2019) Minkyung Kim et al.   Journal of Biomedical Nanotechnology

Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine

(2019) Qing Lin et al.   JOURNAL OF CONTROLLED RELEASE

SPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response

(2019) Manjiao Zhuang et al.   Small

Stem cell-derived extracellular vesicles: role in oncogenic processes, bioengineering potential, and technical challenges

(2019) Mujib Ullah et al.   Stem Cell Research & Therapy

Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance

(2019) Jia Liu et al.   BIOMATERIALS

2D magnetic MoS2–Fe3O4 hybrid nanostructures for ultrasensitive exosome detection in GMR sensor

(2019) Feng Zhu et al.   BIOSENSORS & BIOELECTRONICS

Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes

(2019) Gyeungyun Kim et al.   JOURNAL OF CONTROLLED RELEASE

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

(2018) Song-pei Li et al.   ACTA PHARMACOLOGICA SINICA

Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells

(2018) Shabanali Khodashenas Limoni et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

(2018) Yan Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles

(2018) Andrea Longatti et al.   Nanoscale

Mathematical Modeling of the Function of Warburg Effect in Tumor Microenvironment

(2018) Milad Shamsi et al.   Scientific Reports

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

(2018) Adam Vandergriff et al.   Theranostics

A designer self-assembled supramolecule amplifies macrophage immune responses against aggressive cancer

(2018) Ashish Kulkarni et al.   Nature Biomedical Engineering

pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery

(2018) Hyuk Lee et al.   CARBOHYDRATE POLYMERS

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach

(2018) Sander A. A. Kooijmans et al.   Nanoscale

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

(2018) Hosna Gomari et al.   OncoTargets and Therapy

Nano based drug delivery systems: recent developments and future prospects

(2018) Jayanta Kumar Patra et al.   JOURNAL OF NANOBIOTECHNOLOGY

I-motif-coated exosomes as a pH-sensitive carrier for anticancer drugs

(2018) Jun Yeong Kim et al.   Applied Biological Chemistry

Purinergic receptors in multiple sclerosis pathogenesis

(2018) M. Domercq et al.   BRAIN RESEARCH BULLETIN

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

(2018) Sophia Antimisiaris et al.   Pharmaceutics

Recent progress in GM-CSF-based cancer immunotherapy

(2017) Wan-Lun Yan et al.   Immunotherapy

Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia

(2017) Ursula Altanerova et al.   International Journal of Nanomedicine

Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes

(2017) Shuo Wan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide

(2017) Masaki Morishita et al.   MOLECULAR PHARMACEUTICS

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Exosome-Based Cancer Therapy: Implication for Targeting Cancer Stem Cells

(2017) Jinheng Wang et al.   Frontiers in Pharmacology

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer

(2017) et al.   Nanomaterials

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

(2016) Hongzhao Qi et al.   ACS Nano

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment

(2016) Sander A.A. Kooijmans et al.   PHARMACOLOGICAL RESEARCH

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

A survey of advancements in nucleic acid-based logic gates and computing for applications in biotechnology and biomedicine

(2015) Cuichen Wu et al.   CHEMICAL COMMUNICATIONS

DNA Aptamer Based Nanodrugs: Molecular Engineering for Efficiency

(2015) Sena Cansiz et al.   Chemistry-An Asian Journal

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

(2015) Michelle E. Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

(2015) Murugan Kalimutho et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A draft network of ligand–receptor-mediated multicellular signalling in human

(2015) Jordan A. Ramilowski et al.   Nature Communications

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery

(2015) Ming Wang et al.   PLoS One

Functional DNA-Containing Nanomaterials: Cellular Applications in Biosensing, Imaging, and Targeted Therapy

(2014) Hao Liang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

(2014) Kasper Bendix Johnsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Surface Functionalization of Exosomes Using Click Chemistry

(2014) Tyson Smyth et al.   BIOCONJUGATE CHEMISTRY

Current Approaches for RNA Labeling in Vitro and in Cells Based on Click Reactions

(2014) Daniela Schulz et al.   CHEMBIOCHEM

A rational approach for generating cardiac troponin I selective Spiegelmers

(2014) Zsuzsanna Szeitner et al.   CHEMICAL COMMUNICATIONS

AT2 Receptors Targeting Cardiac Protection Post-Myocardial Infarction

(2014) Elena Kaschina et al.   CURRENT HYPERTENSION REPORTS

The importance of nanoparticle shape in cancer drug delivery

(2014) Nghia P Truong et al.   Expert Opinion on Drug Delivery

Ipilimumab Plus Sargramostim vs Ipilimumab Alone for Treatment of Metastatic Melanoma

(2014) F. Stephen Hodi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Exosomes: mediators of communication in eukaryotes

(2013) María A Lopez-Verrilli et al.   BIOLOGICAL RESEARCH

A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment

(2013) Xifei Yu et al.   BIOMATERIALS

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Toll-Like Receptors: Sensor Molecules for Detecting Damage to the Nervous System

(2013) Hyunkyoung Lee et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

More efficient induction of antitumor T cell immunity by exosomes from CD40L gene-modified lung tumor cells

(2013) JIAOLI WANG et al.   Molecular Medicine Reports

The Role of Angiotensin II Receptors in Stroke Protection

(2012) Steven G. Chrysant   CURRENT HYPERTENSION REPORTS

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Direct identification of ligand-receptor interactions on living cells and tissues

(2012) Andreas P Frei et al.   NATURE BIOTECHNOLOGY

Targeting pattern recognition receptors in cancer immunotherapy

(2012) Nadège Goutagny et al.   Targeted Oncology

Biotin-decorated fluorescent silica nanoparticles with aggregation-induced emission characteristics: fabrication, cytotoxicity and biological applications

(2012) Min Li et al.   Journal of Materials Chemistry B

Comparison of the Energetics of Avidin, Streptavidin, NeutrAvidin, and Anti-Biotin Antibody Binding to Biotinylated Lipid Bilayer Examined by Second-Harmonic Generation

(2011) Trang T. Nguyen et al.   ANALYTICAL CHEMISTRY

Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy

(2011) Dong Nyoung Heo et al.   BIOMATERIALS

Disconnecting the Yin and Yang Relation of Epidermal Growth Factor Receptor (EGFR)-Mediated Delivery: A Fully Synthetic, EGFR-Targeted Gene Transfer System Avoiding Receptor Activation

(2011) A. Schäfer et al.   HUMAN GENE THERAPY

Epidermal Growth Factor Receptor-targeted 131I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene

(2011) Kathrin Klutz et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Mechanism-Based Tumor-Targeting Drug Delivery System. Validation of Efficient Vitamin Receptor-Mediated Endocytosis and Drug Release

(2010) Shuyi Chen et al.   BIOCONJUGATE CHEMISTRY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Targeting cancer cells with biotin–dendrimer conjugates

(2008) Wenjun Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo

(2008) Shuxian Song et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus

(2008) Vladimir V. Temchura et al.   VACCINE