Iron-catalyzed cross-couplings of propargylic substrates with Grignard reagents

A B S T R A C T One of the main challenges of modern chemical industry is the inevitable transition to greener, more sustainable manufacturing processes that utilize raw materials more effectively, minimize waste streams, and avoid the use of toxic and hazardous materials. The development of new iron-based catalytic systems can eliminate the need for the currently widely used, costly and potentially toxic heavy metal catalysts in industrially relevant chemical reactions. Prominent examples of such processes include transition metal catalyzed cross-coupling reactions for formation of carbon-carbon (C -C) bonds. This minireview outlines recent developments in the area of iron-catalyzed cross-coupling chemistry during the last couple of decades, with special emphasis on the use of propargylic substrates and Grignard reagents as coupling partners. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

Automated summary

This minireview discusses the recent advances in iron-catalyzed cross-coupling chemistry, with a focus on the use of propargylic substrates and Grignard reagents as coupling partners.