A Straightforward Approach to Fluorinated Pyrimido[1,2-b]indazole Derivatives via Metal/Additive-Free Annulation with Enaminones, 3-Aminoindazoles, and Selectfluor

A novel and efficient three-component reaction with two C-N bonds and one C-F bond formation has beenreported, which provides a straightforward route to a variety offluorinated pyrimido[1,2-b]indazole derivatives. This transformationhas the advantage of excellent functional group compatibility, including aliphatic and aromatic substituents enaminones. Moreover,metal and additives are not necessary for this reaction, which is of great significance for the synthesis and application offluorinatedheterocycles

Automated summary

A novel and efficient three-component reaction for the synthesis of fluorinated pyrimido[1,2-b]indazole derivatives is reported. This transformation shows excellent functional group compatibility, without the need for metal catalysts or additives. It holds great significance for the synthesis and application of fluorinated heterocycles.