Journal
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Volume 48, Issue 7, Pages 1978-1982Publisher
WILEY
DOI: 10.1111/jog.15302
Keywords
coronavirus disease 2019; fetal heart rate monitoring; intrauterine fetal death; placentitis; pregnancy; severe acute respiratory syndrome coronavirus 2
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This report presents a case of intrauterine fetal death caused by SARS-CoV-2 infection during the second trimester, emphasizing the association between COVID-19 placentitis and placental insufficiency. It highlights the importance of longitudinal assessment of fetal well-being through fetal heart rate monitoring and early detection of maternal coagulation dysfunction.
Although various perinatal outcomes in coronavirus disease 2019 (COVID-19) pregnancies have been reported, the fetal and neonatal consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unclear. Several reports of miscarriages and stillbirths have been recorded, but vertical transmission by SARS-CoV-2 is considered very rare, and the cause remains unknown. We report a case of a 22-year-old uncomplicated Japanese woman infected with SARS-CoV-2 during the second trimester, resulting in intrauterine fetal death due to placental insufficiency associated with COVID-19 placentitis. This report emphasizes the importance of longitudinal assessment of fetal well-being by fetal heart rate monitoring and early detection of maternal coagulation dysfunction representing SARS-CoV-2 inflammation to manage COVID-19 in pregnancy.
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