Article
Critical Care Medicine
Micaela L. O'Reilly, Eugene Mironets, Tatiana M. Shapiro, Kallon Crowther, Eileen Collyer, John R. Bethea, Veronica J. Tom
Summary: After a severe spinal cord injury, heightened spinal sympathetic reflex activity can lead to autonomic dysreflexia, a life-threatening condition characterized by sudden hypertension. Targeting central sTNF alpha signaling within 2 weeks post-injury is necessary to decrease sympathetic hyperreflexia according to research findings.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Deeptha Vasudevan, Yen-Chyi Liu, Joshua P. Barrios, Maya K. Wheeler, Adam D. Douglass, Richard Dorsky
Summary: Zebrafish are able to recover swimming behavior even after complete spinal cord transection, and the regenerated interneurons have the ability to integrate into existing locomotor circuitry.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Ivana Stetkarova, Jiri Keller
Summary: This study investigated the effects of intrathecal baclofen (ITB) treatment on cortical activation in patients with spinal cord injury (SCI) using functional magnetic resonance imaging (fMRI). The results showed that continuous ITB treatment reduced limb spasticity and increased activation in the primary sensorimotor cortex of the foot. This increased activation may reflect functional reorganization in the brain.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Bharadwaj Nandakumar, Gary H. Blumenthal, Gregory D. Disse, Pierce C. Desmond, Julius O. Ebinu, Jerome Ricard, John R. Bethea, Karen A. Moxon
Summary: Postural control is crucial for locomotion and regaining balance after spinal cord injury (SCI) is a major challenge. This study examined the impact of exercise therapy on cortical reorganization in rats with moderate and severe midthoracic contusion injury. The results showed that both spontaneous recovery and therapy induced recovery of weight-supported stepping involve cortical reorganization. Exercise therapy further enhanced cortical control of lower thoracic muscles, leading to improved interlimb coordination and balance during weight-supported stepping. These findings highlight the importance of cortical control in postural improvement after SCI and can inform the development of better therapeutic strategies.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Engineering, Environmental
Rangrang Fan, Di Chuan, Zhiyong Liu, Hongxu Chen, Caili Chen, Gang Guo, Jianguo Xu
Summary: This study introduces a novel hydrogel system, MnO2/Met@CHD, which shows promising results in the recovery of traumatic spinal cord injury. It promotes the growth of neural stem cells and the regeneration of nerve tissue, improves oxidative stress conditions, and provides optimized microenvironments for axonal regeneration.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Neurosciences
Tara A. Fortino, Margo L. Randelman, Adam A. Hall, Jasbir Singh, David C. Bloom, Esteban Engel, Daniel J. Hoh, Shaoping Hou, Lyandysha Zholudeva, Michael A. Lane
Summary: The spinal cord has neuroplastic potential and its anatomy can change with traumatic injury. Neuroanatomical tracing, especially transneuronal tracing using viral tracers, has advanced our understanding of spinal cord circuitry and interactions between the injured spinal cord and neural transplants.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Neurosciences
Mariah J. Wulf, Veronica J. Tom
Summary: Spinal cord injury damages multiple structures in the lesion site, interrupting the conduction of information in the spinal cord. It also affects the autonomic nervous system and can lead to dysfunction of various organs. Understanding how SCI impacts the sympathetic nervous system and its effects on target organs may provide insights for improving health and quality of life for SCI individuals.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Wanru Duan, Qian Huang, Fei Yang, Shao-Qiu He, Yun Guan
Summary: This study found that both conventional SCS and 1200 Hz, low-intensity SCS modestly attenuated below-level mechanical hypersensitivity in SCI rats. However, the inhibition of WDR neurons by conventional SCS was not associated with pain inhibition.
Article
Clinical Neurology
Ajay Pal, HongGeun Park, Aditya Ramamurthy, Ahmet S. Asan, Thelma Bethea, Meenu Johnkutty, Jason B. Carmel
Summary: In this study, the researchers developed a plasticity protocol in rats that aims to activate both sensory and motor connections in the spinal cord. They found that repeated application of this protocol in rats with spinal cord injury improved their forelimb dexterity and reduced hyperreflexia. This study shows the importance of targeting the sensory and motor systems in the spinal cord for promoting recovery after spinal cord injury.
Review
Neurosciences
Judith Sanchez-Ventura, Michael A. Lane, Esther Udina
Summary: This review summarizes the current knowledge of spinal perineuronal nets (PNNs) and their potential role in traumatic spinal cord injury (SCI). It highlights interventions that target the extracellular matrix, including the glial scar and spinal PNNs, to promote regeneration and stabilization of the spinal circuits.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Soshi Samejima, Richard Henderson, Jared Pradarelli, Sarah E. Mondello, Chet T. Moritz
Summary: Spinal cord injuries often result in permanent physical impairments despite being incomplete disruptions. However, remaining connections between the brain and spinal cord can induce neural plasticity to improve sensorimotor function, even years post-injury. This review provides an overview of evidence for motor recovery, plasticity, and interventions in spinal cord stimulation for motor control restoration. It discusses both open-loop and closed-loop stimulation approaches, as well as mechanisms of spinal cord neuromodulation for sensorimotor recovery, aiming to advance rehabilitation for spinal cord injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Carla. S. S. Sousa, Rui Lima, Jorge. R. R. Cibrao, Eduardo. D. D. Gomes, Luis S. Fernandes, Tiffany. S. S. Pinho, Deolinda Silva, Jonas Campos, Antonio J. Salgado, Nuno. A. A. Silva
Summary: The inability of axons to regenerate after spinal cord injury is a major challenge in neuroscience. A phosphodiesterase-4 inhibitor, Roflumilast, was evaluated in a rat model of thoracic contusion injury and found to promote functional recovery and neuroregeneration.
Article
Neurosciences
D. Leonardo Garcia-Ramirez, Ngoc T. Ha, Steve Bibu, Nicholas J. Stachowski, Kimberly J. Dougherty
Summary: The impact of spinal cord injury on Shox2 interneurons mainly manifests as changes in sensory afferent input pathways and modulation of Shox2 interneurons by 5-HT, enhancing excitatory responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Lasse Christiansen, Bing Chen, Yuming Lei, M. A. Urbin, Michael S. A. Richardson, Martin Oudega, Milap Sandhu, W. Zev Rymer, Randy D. Trumbower, Gordon S. Mitchell, Monica A. Perez
Summary: The study investigated the effects of acute intermittent hypoxia on spinal synaptic plasticity induced by paired corticospinal-motoneuronal stimulation (PCMS). The results suggest that acute intermittent hypoxia can enhance the plasticity induced by PCMS, leading to improvements in spinal and muscular function.
EXPERIMENTAL NEUROLOGY
(2021)