Review
Biochemistry & Molecular Biology
Marion Turpin, Gilles Salbert
Summary: DNA methylation is a highly dynamic process regulated by the cooperative actions of DNMT and TET enzymes, influenced by factors such as chromatin environment and protein partners. Mathematical models can help explain variable methylation levels during development and reveal cell-type epigenetic heterogeneity. These discoveries hold significant implications for disease treatment and the development of epigenetic drugs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Inkyung Jung, Jungeun An, Myunggon Ko
Summary: Epigenetic modifications play crucial roles in gene expression regulation and are commonly dysregulated in cancers, influencing cell lineage differentiation, survival, and proliferation. Aberrant epigenetic modifications confer unique characteristics to tumor cells, leading to sustained proliferation, resistance to growth-suppressive or cell death signals, replicative immortality, invasion, and metastasis. DNA cytosine methylation-demethylation, among various epigenetic mechanisms in mammals, is frequently disrupted in cancers. Targeting DNA methylation dynamics has gained attention as a promising therapeutic approach to restore normal conditions affected by cancer-specific epigenetic abnormalities. Small molecules targeting DNA (de)methylation regulators have been developed as potential cancer therapeutics, with some already approved for clinical usage and many others undergoing clinical trials.
Review
Developmental Biology
Alex Wei, Hao Wu
Summary: DNA methylation is a conserved epigenetic modification that is crucial for mammalian gene regulation, genome stability, and development. It can exhibit cell-type specificity and dynamic changes in gene regulatory elements during early embryonic development, stem cell differentiation, reprogramming, and tissue maturation. The interaction between DNA methylation and histone modifications plays a vital role in mammalian development and tissue maturation. Recent advances in technology have enabled high-resolution analysis of DNA methylome dynamics.
Review
Biochemistry & Molecular Biology
Stefan Harsanyi, Zuzana Varchulova Novakova, Katarina Bevizova, Lubos Danisovic, Stanislav Ziaran
Summary: Bladder cancer is the 10th most common cancer worldwide, with a variety of diagnostic methods available, including standard cystoscopy and urine cytology. Liquid biopsy as a new trend is proving to be almost equally effective in detecting bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Hematology
Ting Yang, Xiaobo Liu, Shaji K. Kumar, Fengyan Jin, Yun Dai
Summary: This article reviews the alterations in DNA methylome and DNA methylation modifiers in multiple myeloma (MM), with a focus on DNA methyltransferases (DNMTs) and tet methylcytosine dioxygenases (TETs). The authors discuss the regulation and function of these DNA methylation modifiers in MM cells, providing a rationale for the development of novel epigenetic therapies targeting DNA methylation in MM.
Review
Biochemistry & Molecular Biology
Amirhossein Davoodvandi, Banafsheh Nikfar, Russel J. Reiter, Zatollah Asemi
Summary: Melatonin plays important roles in mammals, regulating circadian rhythms, enhancing immunity, and inhibiting cancer. Epigenetic drugs have gained attention for their potential in cancer treatment. This report summarizes the effects of melatonin on DNA methylation in cancer cells and discusses the impact of artificial light on melatonin secretion and cancer cell DNA methylation.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Sara Ferreira Pires, Juliana Sobral de Barros, Silvia Souza da Costa, Marilia de Oliveira Scliar, Andre Van Helvoort Lengert, Erica Boldrini, Sandra Regina Morini da Silva, Ljubica Tasic, Daniel Onofre Vidal, Ana Cristina Victorino Krepischi, Mariana Maschietto
Summary: DNA methylation may play a role in the development of osteosarcomas. Aberrant DNA methylation was found throughout the osteosarcomas genomes, with high methylation heterogeneity, global hypomethylation, and focal hypermethylation at CpG islands. Differentially methylated regions (DMRs) were detected in the promoter regions of 350 genes, enriched for biological processes related to skeletal system morphogenesis, proliferation, inflammatory response, and signal transduction. Tumor suppressor genes showed deletions or promoter hypermethylation, while oncogenes exhibited gains or hypomethylation. Copy-number changes and overexpression of certain genes provided a possible explanation for the observed CpG island hypermethylation, which may result in silencing of tumor suppressors and DNA repair genes.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Ecology
Marco Gerdol, Claudia La Vecchia, Maria Strazzullo, Pasquale De Luca, Stefania Gorbi, Francesco Regoli, Alberto Pallavicini, Enrico D'Aniello
Summary: DNA methylation is a crucial epigenetic mechanism that regulates gene expression in all organisms. In metazoans, the pattern of DNA methylation changes during embryogenesis and adulthood, leading to the development of a stable and unique methylation pattern in differentiated cells. The study sheds light on DNA methylation regulators in Mytilus galloprovincialis, providing insights into the role of this mechanism in bivalve genome regulation.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Review
Food Science & Technology
Nadir Mustafa Qadir Nanakali, Parisa Maleki Dana, Fatemeh Sadoughi, Zatollah Asemi, Mehran Sharifi, Reza Asemi, Bahman Yousefi
Summary: Natural products such as curcumin, quercetin, and resveratrol have antitumor effects and can affect cancer-related mechanisms, including DNA methylation. These compounds have the potential to be used as cancer treatments by targeting DNA methylation and modifying the expression of tumor suppressor genes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Chemistry, Medicinal
Shoghag Panjarian, Jean-Pierre J. Issa
Summary: Triple-negative breast cancers (TNBCs) are highly heterogeneous and molecularly diverse, with a distinct DNA methylation profile characterized by hypomethylation and lower gains of methylations compared to other subtypes. The balance between DNA methylases (DNMTs) and DNA demethylases (TETs) plays a crucial role in regulating DNA methylation in TNBCs.
Article
Biotechnology & Applied Microbiology
Shijia Wang, Rendong Wang, Fang Gao, Jun Huang, Xiaoxiao Zhao, Dongguo Li
Summary: This study comprehensively described the methylation patterns of ADM-lncRNA in pan-cancer and constructed a co-expression network, revealing the internal connection among different cancers. Functional analysis also identified the pan-carcinogenic pathway of ADM-lncRNA and suggested its potential as cancer biomarkers.
Review
Genetics & Heredity
John P. Brabson, Tiffany Leesang, Sofia Mohammad, Luisa Cimmino
Summary: DNA methylation is regulated by TET enzymes through oxidation, while vitamin C acts as a cofactor to promote DNA demethylation. This interaction plays a crucial role in maintaining genomic stability.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Ohanes Ashekyan, Samira Abdallah, Ayman Al Shoukari, Ghada Chamandi, Hayat Choubassy, Abdul Rahman S. Itani, Nisreen Alwan, Rihab Nasr
Summary: Breast cancer is the most common cancer type worldwide, and metastatic disease is the main cause of death. Non-coding RNAs found in exosomes have been found to play important roles in breast cancer progression, drug sensitivity/resistance, and have the potential to be used as diagnostic, prognostic, and predictive biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hiroaki Tachiwana, Noriko Saitoh
Summary: LncRNAs are a class of non-coding RNAs widely present in mammalian cells, involved in regulating cellular functions. Their dysregulation in cancer is closely related to disease development and they have diagnostic and therapeutic potential.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Valentina Miano, Azzurra Codino, Luca Pandolfini, Isaia Barbieri
Summary: Post-synthesis modification is an efficient way to regulate and optimize the functions of biomolecules. Modifications of non-coding RNAs can directly affect their structure and function, playing a crucial role in cancer.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2021)
Article
Biochemical Research Methods
Bin Sun, Shuai Song, Chen-Zhou Hao, Wan-Xu Huang, Chun-Chi Liu, Hong-Lei Xie, Bin Lin, Mao-Sheng Cheng, Dong-Mei Zhao
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2015)
Article
Chemistry, Multidisciplinary
Ruijuan Li, Xiaolin Su, Zheng Chen, Wanxu Huang, Yali Wang, Kaibo Wang, Bin Lin, Jian Wang, Maosheng Cheng
Article
Chemistry, Organic
Chenzhou Hao, Xiaodong Li, Shuai Song, Bingyu Guo, Jing Guo, Jian Zhang, Qiaoling Zhang, Wanxu Huang, Jian Wang, Bin Lin, Maosheng Cheng, Feng Li, Dongmei Zhao
ORGANIC & BIOMOLECULAR CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Chenzhou Hao, Wanxu Huang, Xiaodong Li, Jing Guo, Meng Chen, Zizheng Yan, Kai Wang, Xiaolin Jiang, Shuai Song, Jian Wang, Dongmei Zhao, Feng Li, Maosheng Cheng
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Chenzhou Hao, Fan Zhao, Hongyan Song, Jing Guo, Xiaodong Li, Xiaolin Jiang, Ran Huan, Shuai Song, Qiaoling Zhang, Ruifeng Wang, Kai Wang, Yu Pang, Tongchao Liu, Tianqi Lu, Wanxu Huang, Jian Wang, Bin Lin, Zhonggui He, Haitao Li, Feng Li, Dongmei Zhao, Maosheng Cheng
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Biochemical Research Methods
Bin Sun, Wanxu Huang, Min Liu
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2017)
Article
Biochemical Research Methods
Bin Sun, Wanxu Huang, Min Liu, Kang Lei
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2017)
Article
Chemistry, Medicinal
Rui-Juan Li, Jian Wang, Zhen Xu, Wan-Xu Huang, Jia Li, Sheng-Fei Jin, Dong-Mei Zhao, Mao-Sheng Cheng
Article
Biochemistry & Molecular Biology
Sanqi An, Wanxu Huang, Xiang Huang, Yixian Cun, Weisheng Cheng, Xiang Sun, Zhijun Ren, Yaxin Chen, Wenfang Chen, Jinkai Wang
NUCLEIC ACIDS RESEARCH
(2020)
Review
Oncology
Chengwu Zeng, Wanxu Huang, Yangqiu Li, Hengyou Weng
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2020)
Correction
Oncology
Wanxu Huang, Hua Li, Qingsong Yu, Wei Xiao, Dan Ohtan Wang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Hao Wu, Ying Li, Qian Zhang, Hanxun Wang, Wenyu Xiu, Pu Xu, Yujie Deng, Wanxu Huang, Dan Ohtan Wang
Summary: This study demonstrates that crocetin, a natural antioxidant compound from saffron, antagonizes parthanatos in ischemic stroke. In the early stage of parthanatos, crocetin inhibits the activation of NOX2 to reduce the production of ROS and PAR. In the later stage of parthanatos, crocetin interacts with HK-I to prevent mitochondrial dysfunction and DNA damage, ultimately preventing irreversible cell death. This study supports the further development of crocetin as a potential drug candidate for preventing and/or treating ischemic stroke.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Weiyue Ban, Mengchi Sun, Hanwei Huang, Wanxu Huang, Siwei Pan, Pengfei Liu, Bingwu Li, Zhenguo Cheng, Zhonggui He, Funan Liu, Jin Sun
Summary: Bacterial outer membrane vesicles (OMVs)-encapsulating adenovirus (Ad) are engineered for autophagy-cascade-augmented immunotherapy, promoting tumor autophagy and enhancing antitumor immune response by altering the tumor microenvironment.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jing Guo, Mingyue Zhu, Tianxiao Wu, Chenzhou Hao, Kai Wang, Zizheng Yan, Wanxu Huang, Jian Wang, Dongmei Zhao, Maosheng Cheng
BIOORGANIC & MEDICINAL CHEMISTRY
(2017)
