Article
Clinical Neurology
Rui Li, Ji-Hong Tang, Bing-Bing Zhang, Xiao-Yan Shi, Yuan-Yuan Dai, Rui Qu
Summary: The clinical characteristics of epileptic seizures in children with acute lymphoblastic leukemia (ALL) during treatment were analyzed. Epileptic seizures mainly occurred in the induction remission period, maintenance treatment period, and after bone marrow transplantation. The common causes were MTX-related demyelinating encephalopathy and reversible posterior encephalopathy syndrome (PRES). Convulsion was the first symptom. Early neuroimaging and EEG examination are important for early diagnosis and treatment.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Marina Oldenburg, Nadine Ruechel, Stefan Janssen, Arndt Borkhardt, Katharina L. Goessling
Summary: The concept of holobionts emphasizes the complex interactions between a host and other species, which, if disturbed may lead to disease and premature aging. The impact of chemotherapy on the microbiome and long-term dysbiosis in survivors of acute lymphoblastic leukemia requires further research.
Article
Medicine, Research & Experimental
Yizhen Li, Wentao Yang, Meenakshi Devidas, Stuart S. Winter, Chimene Kesserwan, Wenjian Yang, Kimberly P. Dunsmore, Colton Smith, Maoxiang Qian, Xujie Zhao, Ranran Zhang, Julie M. Gastier-Foster, Elizabeth A. Raetz, William L. Carroll, Chunliang Li, Paul P. Liu, Karen R. Rabin, Takaomi Sanda, Charles G. Mullighan, Kim E. Nichols, William E. Evans, Ching-Hon Pui, Stephen P. Hunger, David T. Teachey, Mary Relling, Mignon L. Loh, Jun J. Yang
Summary: Genetic alterations in the RUNX1 gene are associated with various blood disorders, especially those of the megakaryocyte and myeloid lineages. Germline RUNX1 variants have different effects on B-ALL and T-ALL, with the latter showing severe damaging effects. Additionally, JAK3 mutation is a common somatic genomic abnormality in T-ALL with germline RUNX1 variants.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Yuting Zhu, Xiaopeng Ma, Heng Zhang, Yijun Wu, Meiyun Kang, Yongjun Fang, Yao Xue
Summary: The study revealed that circADD2 is down-regulated in ALL, and its overexpression inhibits cell proliferation while promoting apoptosis. circADD2 functions by directly sponging miR-149-5p.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jesus Alonso Gandara-Mireles, Ismael Lares-Asseff, Elio Aaron Reyes Espinoza, Javier G. Blanco, Isaias Chairez Hernandez, Lourdes Patricia Cordova Hurtado, Veronica Loera Castaneda, Leslie Patron Romero, Cristina Venzor Sanchez, Hugo Payan Gandara, Dinora Arechiga Gurrola, Horacio Almanza Reyes
Summary: This study identified an evident impact of the NCF4 rs1883112 and CBR3 rs1056892 polymorphisms in increasing the risk of susceptibility to ALL. Additionally, the protective effect of the CBR3 rs1056892 gene variation against ALL was evaluated using a codominant inheritance model.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Maria Kourti, Michalis Aivaliotis, Emmanouel Hatzipantelis
Summary: Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-directed therapy based on clinical, biologic and genetic features has played a significant role in its treatment. Despite improvement in survival rates, ALL remains a leading cause of cancer-related deaths. Proteomics is a cutting-edge technology that aims to understand the impact of the proteome on leukemia subtypes and identify new biomarkers and targets for therapy.
Article
Oncology
Marco Severgnini, Mariella D'Angio, Silvia Bungaro, Giovanni Cazzaniga, Ingrid Cifola, Grazia Fazio
Summary: In this study, RNA-seq technology was used to comprehensively profile the transcriptional landscape of childhood BCP-ALL cases. The analysis revealed a subset of conjoined genes (CGs) that were exclusively expressed in leukemic cases, suggesting a potential novel mechanism of transcriptional regulation in childhood leukemia and potential leukemia-specific biomarkers.
Article
Environmental Sciences
Aryana T. Amoon, John Swanson, Corrado Magnani, Christoffer Johansen, Leeka Kheifets
Summary: The latest pooled analysis indicates that exposure to extremely low-frequency magnetic fields does not increase the risk of childhood leukemia, and there is a decreasing trend in risk over time.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yao Xue, Jing Chen, Siyuan Gao, Xiaowen Zhai, Ningling Wang, Ju Gao, Yu Lv, Mengmeng Yin, Yong Zhuang, Hui Zhang, Xiaofan Zhu, Xuedong Wu, Chi Kong Li, Shaoyan Hu, Changda Liang, Runming Jin, Hui Jiang, Minghua Yang, Lirong Sun, Kaili Pan, Jiaoyang Cai, Jingyan Tang, Xianmin Guan, Yongjun Fang
Summary: Tumor lysis syndrome (TLS) is a common and fatal complication of childhood hematologic malignancies, with age, white blood cell count, and tumor type being risk factors for TLS occurrence. Hyperphosphatemia and hypocalcemia are common in TLS children with hyperleukocytosis, and significant differences in levels of potassium, calcium, phosphorus, and uric acid were observed in different groups of TLS patients. Older age, infant, a higher level of white blood cells, and T-ALL were identified as risk factors for TLS occurrence.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Sofie Gottschalk Hojfeldt, Kathrine Grell, Jonas Abrahamsson, Bendik Lund, Kim Vettenranta, Olafur G. Jonsson, Thomas L. Frandsen, Benjamin O. Wolthers, Hanne Vibeke Marquart, Goda Vaitkeviciene, Kristi Lepik, Mats Heyman, Kjeld Schmiegelow, Birgitte Klug Albertsen
Summary: Truncation of asparaginase treatment due to toxicity or silent inactivation may increase relapse risk in children with acute lymphoblastic leukemia, highlighting the importance of therapeutic drug monitoring and appropriate adjustment of therapy.
Article
Oncology
Jaqueline Calderon-Hernandez, Lizet Jarquin-Yanez, Luis Reyes-Arreguin, Luis A. Diaz-Padilla, Jose Luis Gonzalez-Compean, Pablo Gonzalez-Montalvo, Rebeca Rivera-Gomez, Jairo R. Villanueva-Toledo, Kristal Pech, Oscar Arrieta, Yelda A. Leal
Summary: This study identified clusters of acute lymphoblastic leukemia (ALL) at the community level in four urban areas of Mexico and characterized the sources of environmental carcinogens. The study found excess risk in certain areas due to small-scale carcinogen sources, such as brick kilns and gas stations. The levels of PM2.5 in outdoor air exceeded the World Health Organization guidelines.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Lilly Velentza, Farasat Zaman, Lars Savendahl
Summary: GCs are widely used in the treatment of childhood ALL but their long-term use is associated with bone-related morbidities. Unfortunately, there is currently no efficient treatment for bone health impairment in patients and survivors. The review aims to discuss how GCs impact bone health in pediatric ALL and efforts made to minimize these side effects.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Unai Illarregi, Jaione Telleria, Nerea Bilbao-Aldaiturriaga, Elixabet Lopez-Lopez, Javier Ballesteros, Idoia Martin-Guerrero, Angela Gutierrez-Camino
Summary: Childhood acute lymphoblastic leukemia is a heterogeneous disease with multiple molecular subtypes, and long non-coding RNAs (lncRNAs) have the potential to serve as novel diagnostic, classification, and treatment response markers to improve survival rates and refine patient classification.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kinga Panuciak, Emilia Nowicka, Angelika Mastalerczyk, Joanna Zawitkowska, Maciej Niedzwiecki, Monika Lejman
Summary: Recent years have seen significant progress in the treatment of B-cell acute lymphoblastic leukemia (ALL), with improved conventional therapy schemes and the development of new treatment forms. The 5-year survival rates now exceed 90% in pediatric patients. However, at the molecular level, there are still many variations that need to be analyzed in more detail, including aneuploidy, which is among the most common genetic changes in B-cell ALL. Our work will focus on summarizing the current state of knowledge on aneuploidy and its correlates with the treatment of B-cell ALL patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Mary H. Ward, Jessica M. Madrigal, Rena R. Jones, Melissa C. Friesen, Roni T. Falk, David Koebel, Catherine Metayer
Summary: Based on the California Childhood Leukemia Study, this research evaluated the relationship between residential pesticide use and the risk of childhood acute lymphoblastic leukemia (ALL). The study found that glyphosate concentrations in house dust were associated with occupational pesticide exposure, nearby agricultural use, treatment for lawn weeds and bees/wasps, and sampling season. However, increasing glyphosate concentrations were not associated with an increased ALL risk. This study highlights the potential risk of young children being exposed to pesticides in residential settings and the need for further research.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Oncology
Sam Egger, David P. Smith, Manish Patel, Michael G. Kimlin, Bruce K. Armstrong, Visalini Nair-Shalliker
Summary: A large cohort study found an association between cutaneous melanoma and subsequent risk of prostate cancer. Men diagnosed with melanoma had an increased risk of subsequent prostate cancer, especially if the melanoma diagnosis was 10 to 15 years before study recruitment.
BRITISH JOURNAL OF CANCER
(2023)
Article
Ophthalmology
Sabbir T. Rahman, Mary Waterhouse, Briony Duarte Romero, Catherine Baxter, Dallas English, David A. Mackey, Peter R. Ebeling, Bruce K. Armstrong, Donald S. A. McLeod, Gunter Hartel, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Supplementing high-dose vitamin D may not significantly reduce the incidence of cataract surgery, regardless of age, sex, body mass index, serum vitamin D concentration, or ambient ultraviolet radiation.
Article
Oncology
Freddy A. Barragan, Lauren J. Mills, Andrew R. Raduski, Erin L. Marcotte, Kelsey E. Grinde, Logan G. Spector, Lindsay A. Williams
Summary: Black children have lower incidence yet worse survival in B-cell acute lymphoblastic leukemia (B-ALL). Genetic ancestry and differentially expressed genes associated with ancestry play a role in death risk. The impact of reported race/ethnicity on death risk varies after adjusting for genetic ancestry genes. Other factors also contribute to B-ALL survival.
Article
Economics
Martha J. Bailey, Susan H. Leonard, Joseph Price, Evan Roberts, Logan Spector, Mengying Zhang
Summary: This paper describes the digitization of almost 185,000 causes of death for Ohio by combining handwriting recognition, data cleaning algorithms, and semi-automated classification of causes. The methods used in this research can be applied to other collections of handwritten data.
EXPLORATIONS IN ECONOMIC HISTORY
(2023)
Article
Oncology
H. D. Law, B. K. Armstrong, C. D'este, R. Hosking, K. S. Smurthwaite, S. Trevenar, R. M. Lucas, N. Lazarevic, M. D. Kirk, R. J. Korda
Summary: This study examined the potential association between living in Australian communities with PFAS contamination and the risk of cancer and cause-specific deaths. The findings showed elevated rates of certain cancers and coronary heart disease mortality in the contaminated areas. However, there was limited evidence to support a direct link between PFAS exposure and other diseases.
CANCER EPIDEMIOLOGY
(2023)
Editorial Material
Public, Environmental & Occupational Health
Mary K. Schubauer-Berigan, David B. Richardson, Matthew P. Fox, Lin Fritschi, Irina Guseva Canu, Neil Pearce, Leslie Stayner, Amy Berrington de Gonzalez
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Helen D. Bailey, Caitlin Gray, Akilew A. Adane, Natalie A. Strobel, Scott W. White, Rhonda Marriott, Gizachew A. Tessema, Carrington C. J. Shepherd, Mary Sharp
Summary: Having a preterm birth is associated with increased mortality risk for both Aboriginal and non-Aboriginal women up to 38 years after giving birth, highlighting the importance of prevention and screening.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rachel Zmora, Logan Spector, John Bass, Amanda Thomas, Jessica Knight, Kamakshi Lakshminarayan, James St Louis, Lazaros Kochilas
Summary: The study found that procedure-specific center volume is inversely associated with early postoperative mortality for infantile congenital heart surgery (CHS) but has no measurable effect on later mortality.
ANNALS OF THORACIC SURGERY
(2023)
Article
Dermatology
Stephanie C. Blake, Pascale Guitera, Anne E. Cust, Claire Galea, Serigne N. Lo, Richard A. Scolyer, Bruce K. Armstrong, John F. Thompson, Scott W. Menzies, Christine Madronio, Rachael L. Morton, Graham J. Mann, Caroline G. Watts
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Yuan Ni, Caroline G. Watts, Richard A. Scolyer, Christine Madronio, Bruce K. Armstrong, Rachael L. Morton, Scott W. Menzies, Graham J. Mann, John F. Thompson, Serigne N. Lo, Anne E. Cust
Summary: This cross-sectional survey identified risk factors for developing a second primary melanoma. Patients with melanoma who had characteristics such as male sex, older age, high naevus count, or melanoma on the trunk or upper limbs had a substantially higher risk of subsequent melanoma and should therefore be more intensively monitored.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Environmental Sciences
Nina Lazarevic, Kayla S. Smurthwaite, Catherine D'Este, Robyn M. Lucas, Bruce Armstrong, Archie CA. Clements, Susan M. Trevenar, Imogen Gad, Rose Hosking, Hsei Di Law, Jochen Mueller, Jennifer Braunig, Sandra Nilsson, Jo Lane, Aparna Lal, Brett A. Lidbury, Rosemary J. Korda, Martyn D. Kirk
Summary: This study examined the associations between PFAS and cardiometabolic markers and conditions in communities with contaminated water. The findings suggest that PFAS exposure is associated with higher levels of total cholesterol, but not with liver function markers. There was only a clear association between PFAS and hypercholesterolemia in one of the communities, and no association with type II diabetes, liver disease, or cardiovascular disease.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Marwan Awad Ahmed, Helen D. Bailey, Gavin Pereira, Scott W. White, Kingsley Wong, Bridgette J. McNamara, Paul Rheeder, Rhonda Marriott, Carrington C. J. Shepherd
Summary: This retrospective cohort study examined the impact of diabetes in pregnancy (DIP) on neonatal outcomes in Aboriginal women from Western Australia. It found that DIP increased the risks of fetal overgrowth, shoulder dystocia, and congenital anomalies in Aboriginal babies. Improving diabetes care for Aboriginal women and further research on preventing shoulder dystocia can help reduce these disparities.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Michael Caruana, Roman Gulati, Ruth Etzioni, Alexandra Barratt, Bruce K. Armstrong, Karen Chiam, Visalini Nair-Shalliker, Qingwei Luo, Albert Bang, Paul Grogan, David P. Smith, Dianne L. O'Connell, Karen Canfell
Summary: This study aimed to estimate the benefits and harms of regular prostate specific antigen (PSA) testing in Australia. The findings suggest that testing every 2 years can reduce the risk of dying from prostate cancer, but also carries a risk of overdiagnosis. For every man who avoids death from prostate cancer, two men will be overdiagnosed with the disease.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Philip J. Lupo, Tiffany M. Chambers, Beth A. Mueller, Jacqueline Clavel, John D. Dockerty, David R. Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E. Heck, Claire Infante-Rivard, Alice Y. Kang, Corrado Magnani, Carlotta Malagoli, Catherine Metayer, Helen D. Bailey, Ana M. Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S. Pombo-de-Oliveira, Wafaa M. Rashed, Eve Roman, Joachim Schuz, Catharina Wesseling, Logan G. Spector, Michael E. Scheurer
Summary: The study explores the associations between nonchromosomal birth defects and childhood leukemia using data from the Childhood Cancer and Leukemia International Consortium. The results suggest possible novel genetic and environmental factors associated with birth defects that may also increase leukemia susceptibility.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Health Care Sciences & Services
Danielle Pollock, Helen D. Bailey, Zachary Munn, Sabira Hasanoff, Chelsea Valenzuela, Cindy Stern, Carrie Price, Rhonda Marriott, Janinne Gliddon, Carolyn Lewis, Carol Mitchie, Muriel Bowie, Millie Penny, Tracy Reibel, Jane Warland, Brad Farrant, Scott W. White, Carrington C. J. Shepherd
Summary: This review aims to investigate the perceptions, knowledge, attitudes, beliefs, and myths about stillbirth among First Nations populations. To develop appropriate interventions for these populations, the study will examine the current views of First Nations people from the United States, Canada, Aotearoa/New Zealand, and Australia regarding stillbirth.
JBI EVIDENCE SYNTHESIS
(2023)