Metformin combats obesity by targeting FTO in an m6A-YTHDF2-dependent manner

Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway

(2021) Lin Cheng et al.   Oncogenesis

The N 6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response

(2021) Xin Zong et al.   NUCLEIC ACIDS RESEARCH

Restoration of TET2 deficiency inhibits tumor growth in head neck squamous cell carcinoma

(2020) Rong Huang et al.   Annals of Translational Medicine

METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1/STAT5/C/EBPβ pathway via an m6A-YTHDF2–dependent manner

(2019) Yongxi Yao et al.   FASEB JOURNAL

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

(2019) Xinxia Wang et al.   Autophagy

m6A methylation modulates adipogenesis through JAK2-STAT3-C/EBPβ signaling

(2019) Ruifan Wu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Dual Effects of Metformin on Adipogenic Differentiation of 3T3-L1 Preadipocyte in AMPK-Dependent and Independent Manners

(2018) Dian Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m6A-YTHDF2-dependent manner

(2018) Ruifan Wu et al.   INTERNATIONAL JOURNAL OF OBESITY

Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

(2018) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metformin improves obesity-associated inflammation by altering macrophages polarization

(2018) Yuanyuan Jing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Reducing diabetes risk at an early age

(2018) Daniel S. Hsia et al.   NATURE MEDICINE

Effects of liraglutide, metformin, and gliclazide on body composition in patients with both type 2 diabetes and non-alcoholic fatty liver disease: a randomized trial

(2018) Wen-Huan Feng et al.   Journal of Diabetes Investigation

FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism

(2018) Ruifan Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

(2018) Di Wu et al.   NATURE

Efficacy of Metformin Treatment with Respect to Weight Reduction in Children and Adults with Obesity: A Systematic Review

(2018) Y. E. Lentferink et al.   DRUGS

Metformin exerts anti-obesity effect via gut microbiome modulation in prediabetics: A hypothesis

(2017) Kunal Maniar et al.   MEDICAL HYPOTHESES

Obesity and hypertension

(2017) Gino Seravalle et al.   PHARMACOLOGICAL RESEARCH

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

(2016) Jaehong Kim et al.   MEDIATORS OF INFLAMMATION

Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus

(2016) Argyro Syngelaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-β/Smad3 signaling

(2015) Byung-Hak Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FTO influences adipogenesis by regulating mitotic clonal expansion

(2015) Myrte Merkestein et al.   Nature Communications

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

(2015) Xu Zhang et al.   Scientific Reports

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell cycle control across the eukaryotic kingdom

(2013) Hirofumi Harashima et al.   TRENDS IN CELL BIOLOGY

Adipogenesis: From Stem Cell to Adipocyte

(2012) Qi Qun Tang et al.   Annual Review of Biochemistry

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Unraveling the Obesity-Cancer Connection

(2012) G. Taubes   SCIENCE