Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy

Anti-tumor activity of NLG207 (formerly CRLX101) in combination with enzalutamide in preclinical prostate cancer models

(2021) Keith T Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Angiogenesis and chemotherapy resistance: optimizing chemotherapy scheduling using mathematical modeling

(2021) Mariusz Bodzioch et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Vascular Bursts Act as a Versatile Tumor Vessel Permeation Route for Blood‐Borne Particles and Cells

(2021) Kazunori Igarashi et al.   Small

Combining microenvironment normalization strategies to improve cancer immunotherapy

(2020) Fotios Mpekris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating tumor immunity by metronomic dosing of oxaliplatin incorporated in multiple oral nanoemulsion

(2020) Jeong Uk Choi et al.   JOURNAL OF CONTROLLED RELEASE

Chemotherapy efficacy after first-line immunotherapy in 18 advanced melanoma patients

(2020) Mélanie Saint-Jean et al.   MEDICINE

Metronomic chemotherapy for patients with metastatic breast cancer: Review of effectiveness and potential use during pandemics

(2020) Johny E. Fares et al.   CANCER TREATMENT REVIEWS

Improvements in the Oral Absorption and Anticancer Efficacy of an Oxaliplatin-Loaded Solid Formulation: Pharmacokinetic Properties in Rats and Nonhuman Primates and the Effects of Oral Metronomic Dosing on Colorectal Cancer

(2020) Rudra Pangeni et al.   International Journal of Nanomedicine

Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum-based doublet

(2020) Emilia Kozłowska et al.   PLoS Computational Biology

Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano‐immunotherapy in Breast Cancer Lung Metastasis

(2020) Fotios Mpekris et al.   Advanced Science

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma

(2019) Yanxia Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience

(2019) Cem Simsek et al.   Journal of Oncology

Treating advanced breast cancer with metronomic chemotherapy: what is known, what is new and what is the future?

(2019) Marina Elena Cazzaniga et al.   OncoTargets and Therapy

Response to salvage chemotherapy after progression on immune checkpoint inhibitors in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck

(2019) Khalil Saleh et al.   EUROPEAN JOURNAL OF CANCER

Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors

(2018) Benjamin Theek et al.   JOURNAL OF CONTROLLED RELEASE

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atezolizumab Plus nab-Paclitaxel in the Treatment of Metastatic Triple-Negative Breast Cancer With 2-Year Survival Follow-up

(2018) Sylvia Adams et al.   JAMA Oncology

Response rates to single-agent chemotherapy after exposure to immune checkpoint inhibitors in advanced non-small cell lung cancer

(2017) Gustavo Schvartsman et al.   LUNG CANCER

Role of vascular normalization in benefit from metronomic chemotherapy

(2017) Fotios Mpekris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner

(2017) Panagiotis Papageorgis et al.   Scientific Reports

Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer

(2016) E. Pham et al.   CANCER RESEARCH

CRLX101, a Nanoparticle–Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α

(2016) Xi Tian et al.   CANCER RESEARCH

Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model

(2016) Diego S. Rodrigues et al.   PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

(2016) F. Pucci et al.   SCIENCE

Evaluation of Perfusion Quantification Methods with Ultrasound Contrast Agents in a Machine-Perfused Pig Liver

(2016) Michalakis Averkiou et al.   ULTRASCHALL IN DER MEDIZIN

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Remodeling Tumor Vasculature to Enhance Delivery of Intermediate-Sized Nanoparticles

(2015) Wen Jiang et al.   ACS Nano

Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery

(2015) Fotios Mpekris et al.   Biomechanics and Modeling in Mechanobiology

CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer

(2015) Sarah J. Conley et al.   BREAST CANCER RESEARCH AND TREATMENT

Dynamical properties of a minimally parameterized mathematical model for metronomic chemotherapy

(2015) Heinz Schättler et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Design considerations for nanotherapeutics in oncology

(2015) Triantafyllos Stylianopoulos et al.   Nanomedicine-Nanotechnology Biology and Medicine

Rationale for metronomic chemotherapy in phase III trials

(2015) Robert S. Kerbel et al.   Nature Reviews Clinical Oncology

Postsurgical adjuvant or metastatic renal cell carcinoma therapy models reveal potent antitumor activity of metronomic oral topotecan with pazopanib

(2015) Christopher Jedeszko et al.   Science Translational Medicine

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Role of Constitutive Behavior and Tumor-Host Mechanical Interactions in the State of Stress and Growth of Solid Tumors

(2014) Chrysovalantis Voutouri et al.   PLoS One

A mathematical model for the administration of temozolomide: comparative analysis of conventional and metronomic chemotherapy regimens

(2013) C. Faivre et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

(2013) Triantafyllos Stylianopoulos et al.   CANCER RESEARCH

Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells

(2013) Marta Vives et al.   INTERNATIONAL JOURNAL OF CANCER

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Strategies for Improving the Clinical Benefit of Antiangiogenic Drug Based Therapies for Breast Cancer

(2012) Robert S. Kerbel   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An EFSUMB Introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for Quantification of Tumour Perfusion

(2012) C. Dietrich et al.   ULTRASCHALL IN DER MEDIZIN

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Metronomic gemcitabine suppresses tumour growth, improves perfusion and reduces hypoxia in human pancreatic ductal adenocarcinoma

(2010) K K Y Cham et al.   BRITISH JOURNAL OF CANCER

Indicator dilution models for the quantification of microvascular blood flow with bolus administration of ultrasound contrast agents

(2010) Costas Strouthos et al.   IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Increased Tumor Oxygenation and Drug Uptake During Anti-Angiogenic Weekly Low Dose Cyclophosphamide Enhances the Anti-Tumor Effect of Weekly Tirapazamine (Supplementry Material)

(2009) J. Doloff et al.   CURRENT CANCER DRUG TARGETS

A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors

(2009) Steffen Eikenberry   Theoretical Biology and Medical Modelling