Journal
JOURNAL OF BONE AND MINERAL METABOLISM
Volume 40, Issue 4, Pages 623-635Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00774-022-01324-8
Keywords
Locomotive syndrome; Prevalence; Incidence; ROAD study; Disability
Funding
- Ministry of Health, Labour and Welfare [H17-Men-eki-009, H20-Choujyu-009, H23-Choujyu-002, H25-Choujyu-007, 19FA1401, 19FA0701, 19FA1901, H25-Nanchitou (Men)-005]
- NSF
- Ministry of Education, Culture, Sports, Science and Technology in Japan [08033011-00262]
- Japan Agency for Medical Research and Development [17dk0110028h0001, 17gk0210007h0003, 19gk0210018h0002]
- Japan Osteoporosis Society
- Japan Osteoporosis Foundation
- Japanese Orthopaedic Association (JOA-Subsidized Science Project Research) [2006-1, 2010-2, 2014-1]
- Japanese Society for Musculoskeletal Medicine
- Mitsui Sumitomo Insurance Welfare Foundation
- Japan Dairy Association
- [B19H03895]
- [B26293139]
- [B23390172]
- [B20390182]
- [21K19631]
- [18K18447]
- [15K15219]
- [24659317]
- [21K19291]
- [B26293331]
- [B23390356]
- [C20591774]
- [26670307]
- [23659580]
- [24659666]
- [21659349]
- [A18689031]
- [B26293329]
- [B23390357]
- [C20591737]
- [25670293]
- [S50282661]
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The study investigated the prevalence and incidence of locomotive syndrome at various stages, with stage 3 being a sensitive indicator of future disability and mortality.
Introduction Locomotive syndrome (LOCOMO) is defined by the Japanese Orthopaedic Association (JOA) as a condition requiring nursing care due to a decline in mobility resulting from musculoskeletal disorders. In 2020, the JOA announced the new definition of LOCOMO stage 3 and revision of clinical decision limits in stages of LOCOMO. However, there are few reports on the epidemiological indices of LOCOMO. This prospective cohort study aimed to investigate the prevalence, incidence, and association of poor prognosis with LOCOMO stages. Materials and methods The third survey of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted during 2012-2013, examining a population-based cohort of 1575 participants (513 men and 1062 women, mean age 65.6 years). Three LOCOMO risk tests were performed, and patients were classified into LOCOMO stages 0, 1, 2, and 3. They were followed up for 6 years, and identical examination of LOCOMO was performed in 3- and 6-year follow-ups. Data on patients' prognoses, including disability and death, were collected. Results The prevalence of LOCOMO stages 1, 2, and 3 was 41.3, 14.9, and 11.6%, respectively. The incidence of LOCOMO stages 1, 2, and 3 were 83.7, 23.0, and 18.6 per 1000 person-years, respectively. Compared with LOCOMO stage 0, logistic regression analysis showed that LOCOMO stage 3 significantly increased the risk of disability and mortality. In addition, each value of LOCOMO risk tests for LOCOMO stage 3 increased the risk of poor prognosis. Conclusion LOCOMO stage 3 is a sensitive indicator of future disability and mortality.
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